LOCUS       NM_001108142            4741 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus SID1 transmembrane family, member 2 (Sidt2),
            mRNA.
ACCESSION   NM_001108142 XM_001068825
VERSION     NM_001108142.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4741)
  AUTHORS   Takahashi,M., Contu,V.R., Kabuta,C., Hase,K., Fujiwara,Y., Wada,K.
            and Kabuta,T.
  TITLE     SIDT2 mediates gymnosis, the uptake of naked single-stranded
            oligonucleotides into living cells
  JOURNAL   RNA Biol 14 (11), 1534-1543 (2017)
   PUBMED   28277980
REFERENCE   2  (bases 1 to 4741)
  AUTHORS   Contu,V.R., Hase,K., Kozuka-Hata,H., Oyama,M., Fujiwara,Y.,
            Kabuta,C., Takahashi,M., Hakuno,F., Takahashi,S.I., Wada,K. and
            Kabuta,T.
  TITLE     Lysosomal targeting of SIDT2 via multiple YxxPhi motifs is required
            for SIDT2 function in the process of RNautophagy
  JOURNAL   J Cell Sci 130 (17), 2843-2853 (2017)
   PUBMED   28724756
REFERENCE   3  (bases 1 to 4741)
  AUTHORS   Aizawa,S., Fujiwara,Y., Contu,V.R., Hase,K., Takahashi,M.,
            Kikuchi,H., Kabuta,C., Wada,K. and Kabuta,T.
  TITLE     Lysosomal putative RNA transporter SIDT2 mediates direct uptake of
            RNA by lysosomes
  JOURNAL   Autophagy 12 (3), 565-578 (2016)
   PUBMED   27046251
REFERENCE   4  (bases 1 to 4741)
  AUTHORS   Gao,J., Yu,C., Xiong,Q., Zhang,Y. and Wang,L.
  TITLE     Lysosomal integral membrane protein Sidt2 plays a vital role in
            insulin secretion
  JOURNAL   Int J Clin Exp Pathol 8 (12), 15622-15631 (2015)
   PUBMED   26884831
  REMARK    GeneRIF: Sdit2 may play a vital role in the regulation of insulin
            secretion via two SNARE proteins synap1 and syanp3.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4741)
  AUTHORS   Li,W., Koutmou,K.S., Leahy,D.J. and Li,M.
  TITLE     Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain
            Selectively Binds Long Double-stranded RNA and Is Required for RNA
            Transport by SID-1
  JOURNAL   J Biol Chem 290 (31), 18904-18913 (2015)
   PUBMED   26067272
REFERENCE   6  (bases 1 to 4741)
  AUTHORS   Gao,J., Gu,X., Mahuran,D.J., Wang,Z. and Zhang,H.
  TITLE     Impaired glucose tolerance in a mouse model of sidt2 deficiency
  JOURNAL   PLoS One 8 (6), e66139 (2013)
   PUBMED   23776622
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4741)
  AUTHORS   Jialin,G., Xuefan,G. and Huiwen,Z.
  TITLE     SID1 transmembrane family, member 2 (Sidt2): a novel lysosomal
            membrane protein
  JOURNAL   Biochem Biophys Res Commun 402 (4), 588-594 (2010)
   PUBMED   20965152
REFERENCE   8  (bases 1 to 4741)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            [WARNING] On Apr 25, 2024 this sequence was replaced by
            NM_001108142.2.
            
            On Oct 4, 2007 this sequence version replaced XM_001068825.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..4741
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /note="SID1 transmembrane family, member 2"
                     /db_xref="GeneID:315617"
                     /db_xref="RGD:1308311"
     exon            1..1001
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..3380
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /codon_start=1
                     /product="SID1 transmembrane family member 2"
                     /protein_id="NP_001101612.1"
                     /db_xref="GeneID:315617"
                     /db_xref="RGD:1308311"
                     /translation="MTSAGGRSPAVYRGAAPGGPEFCAASAALKGPASGKPTGQGHRR
                     LGSPGASGRRVSSRAGPGWGCGSRCRPREPGSARGPGAAPGRGRVLSQAGVKVLVPVR
                     CWKLLRQPQRARSPSRRQPPPPRAMIAWRLPLCVLLVAAVESHLGALGPKNVSQKDAE
                     FERTYADDVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVS
                     FQVPLILRGLYQRKYLYQKVERTLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVNR
                     VDNFVLRTGELFTFNTTAAQPQYFKYEFPDGVDSVIVKVTSKKAFPCSVISIQDVLCP
                     VYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFV
                     EDEPVDQGHRQKTLSVLVSQAVTSEAYVGGMLFCLGIFLSFYLLTVLLACWENWRQRK
                     KTLLVAIDRACPESGHPRVLADSFPGSAPYEGYNYGSFENGSGSTDGLVESTGSGDLS
                     YSYQGHDQFKRRLPSGQMRQLCIAMDRSFDPVGARPRLDSMSSVEEDDYDTLTDIDSD
                     KNVIRTKQYLCVADLARKDKRVLRKKYQIYFWNIATIAVFYALPVVQLVITYQTVVNV
                     TGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRND
                     LYALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLK
                     LYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAFWIVFSVIHIISTLLLSTQ
                     LYYMGRWKLDSGIFRRILHVLYTDCIRQCSGPLYTDRMVLLVMGNIINWSLAAYGLIM
                     RPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFF
                     QGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQ
                     RDKIYVF"
     exon            1002..1123
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1288
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1334
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1436
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1520
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1620
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1686
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1780
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1833
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1905
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..1977
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2040
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2159
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2233
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2300
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2374
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2498
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2616
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2753
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2862
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..2939
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..2986
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3092
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3203
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3317
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..4741
                     /gene="Sidt2"
                     /gene_synonym="RGD1308311"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgacagctga gcttcgttca gtgggcaggc gcttcttcgg tttttatgaa ccaatgagga
       61 aaaaaaatga agttggggta atggtttggg ggaacaattc ctgcttgagc agagacaatc
      121 tgtcaacaag acccagcact tactgggcac tgtgaaacta tcctgaaacg ccaacaccaa
      181 gcagtagagg catgaggagg atcaggagtt caagattctc caagcgaaca taaccagttc
      241 caggatagcc tgggttatgt gagcctccgt ctcaaaaaaa caaaaacgcg gaccacaaca
      301 ccaagaatcc aacacttagt tatccttcgt ggaaaaaata tcactctaga cgcccacagg
      361 actgcgaagg aaggaggtgg cgacggtgcg tgggaagcag ttagacgagg tctggccctt
      421 taaatccgcg tcggtttccc atgacgtcag cgggcgggcg cagccccgct gtttaccgcg
      481 gcgcggcgcc tggtggcccc gagttctgtg ccgcgtccgc cgcccttaaa gggcccgcgt
      541 ccgggaagcc tacgggccag ggccaccgcc gcctcggctc tccgggcgcg agcggacgcc
      601 gggtctccag ccgggctggg ccgggctggg gttgcgggtc gcggtgccgc ccacgcgagc
      661 cggggtccgc gcgaggccca ggagcggctc cagggagggg acgcgtccta tctcaggccg
      721 gggttaaagt tctggtcccg gtgagatgct ggaagctgct gcggcagccg caacgcgccc
      781 ggtcgccgtc ccgtcgccag cccccgccgc cccgggccat gatcgcctgg cgtctgccct
      841 tgtgcgtgct cctggtggcc gccgtcgaga gccacctggg ggctctgggg cccaagaacg
      901 tctcgcagaa agacgcggag tttgagcgca cctacgcgga cgacgtcaac agcgagctag
      961 tcaacatcta caccttcaac cacaccgtga cccgcaaccg gaccgagggc gtgcgagtgt
     1021 ctgtgaacgt cctgaacaaa cagaaagggg cgcctttgct gttcgtggtc cgccagaagg
     1081 aggctgttgt gtccttccag gtgcccctaa tcctgcgagg gctataccag cgtaagtacc
     1141 tctaccaaaa agttgaacga actctgtgtc agccccccac caagaatgag tctgagatcc
     1201 agtttttcta tgtggatgtg tctaccctgt caccagtcaa taccacttac cagctccgag
     1261 tcaaccgtgt ggacaatttc gtgctcagga ctggggagct gtttaccttc aataccactg
     1321 cagcccaacc ccagtacttc aaatacgagt ttcctgatgg tgtggactct gtcattgtca
     1381 aggtgacctc caagaaggcc ttcccctgct ctgtcatctc catccaggat gtcctgtgcc
     1441 cagtctatga tcttgacaac aatgtagcct tcatcggcat gtaccagaca atgactaaga
     1501 aggcagccat cactgtgcag aggaaagact tccccagcaa cagtttttat gtggtggtgg
     1561 tggtgaagac tgaggaccag gcctgcgggg ggtccttgcc cttctaccct ttcgtggaag
     1621 atgaaccagt ggatcaaggg caccgtcaga aaaccctgtc agtgctggtc tctcaggctg
     1681 tcacttctga ggcctacgtt ggtgggatgc tcttttgcct gggcatattc ctgtcgttct
     1741 acctgctgac tgtgctgctg gcctgttggg agaactggag gcaaaggaag aagaccttgc
     1801 tggtggccat agaccgagcc tgcccagaaa gcggtcaccc tcgggtcttg gctgattcgt
     1861 ttcctggcag tgccccctat gagggttaca actatggctc ctttgagaat ggttccggat
     1921 ccactgacgg gttggttgaa agcacaggtt caggggacct ctcctacagt taccaggggc
     1981 acgaccagtt caagcggcgc cttccctctg gccagatgcg gcagctgtgc attgccatgg
     2041 accgctcctt tgacccagtg ggagctcggc cacgactgga ctccatgagc tccgtggaag
     2101 aggatgacta tgacacactg actgacatcg actcagacaa aaacgtcatt cgaaccaagc
     2161 aatacctctg tgtggctgat ctggcacgaa aggacaaacg tgttttacgg aaaaagtacc
     2221 agatttactt ctggaacata gccaccattg cagtcttcta cgcccttcct gtggtgcagc
     2281 tggtgatcac ctaccagacg gtggtgaatg tcacggggaa ccaggacatc tgctactaca
     2341 acttcctctg tgcccaccca ctgggcaacc tcagcgcctt caacaacatc ctcagcaacc
     2401 tggggtacat tctgcttggt ctgctcttcc tgctcatcat cctgcagcgg gagatcaatc
     2461 ataaccgggc cctgctgaga aatgacctct atgctctgga gtgtgggatc cccaaacact
     2521 ttggtctatt ttatgccatg ggcacagcgt tgatgatgga ggggctactg agtgcctgtt
     2581 accacgtctg ccccaactac accaacttcc agttcgatac ctcgttcatg tacatgattg
     2641 ctggcctctg catgctgaag ctctaccaga agcggcaccc agatatcaac gccagcgcct
     2701 acagcgcata cgcctgcctg gccattgtga tcttcttctc cgtcctgggt gtggtttttg
     2761 gcaaagggaa cacagccttc tggatcgtct tctcagtcat ccatatcatt tccacgcttc
     2821 tcctcagcac tcagctgtat tacatgggcc gctggaagct ggactccgga atcttccgcc
     2881 gcatccttca tgtgctctac acagactgca tccggcagtg cagcgggccc ctttacacgg
     2941 accgcatggt gcttctggtc atgggcaaca ttatcaactg gtcgctggct gcctacggac
     3001 tcatcatgcg cccaaatgac tttgcgtcct acttgctggc aattggcatc tgcaacttgc
     3061 tgctgtattt tgctttctac atcattatga agctccggag cggcgagagg atcaagctca
     3121 tccctctgct ctgcatcgtg tgcacctccg tggtctgggg cttcgcactc ttcttcttct
     3181 tccagggact cagcacgtgg cagaaaaccc ccgcagagtc cagggagcac aaccgagact
     3241 gcatcctcct tgacttcttt gatgaccacg acatctggca cttcctgtcc tccattgcta
     3301 tgtttgggtc cttcctggtt ttattgacgt tggatgacga cttggacact gtacagcggg
     3361 acaagatcta tgtcttctag cagcgtctgt ggtccaggct tcacttcatg ggcccagcgc
     3421 ctctgcgtca ccttccagtt gccacaggag caccaagggt gtgagtccca gctctgctac
     3481 ccagcactgg acgtcgtggc aagacagcga gttccagctc aggcctgact caggacagtt
     3541 actggtgaca ctgaaccttg cagttacctc tgctgcggag gaggcctgct ccgcaacccc
     3601 agacactggc caaattgctg ctgcttgctt ctcagtgtcc ggtcctcccc aggaccctgg
     3661 tctgtccatc tgtcttgttt atccactggc tctccatttg tccctttgga gaggaaggca
     3721 ggaagtcaat gtcctgcccc cttcatgcct tgcattctac ccatcccttc cctccttttg
     3781 gcctaggaca cagcctttct tcttcccgtg ctctgcccca ggacatagtc tggtgcctga
     3841 ttctctgtcc agcaccagga cctacattct ccctgggtct gtagctggct atcactgccc
     3901 actctggcct gccaggatgg atgcaggtag gagactttgg gggctggccg gctggtgcca
     3961 ggctttcggt gctaaggccc acaaggggtc taggtacgac cctcctccct gacctgtgcg
     4021 tggagctggc tctacagcag tgagggccag cccaggctga atcttttgat ctggggactg
     4081 aattcagagg ccacctcatc ctaccagcca ctagaatgat gccagcaccg gggttggtgg
     4141 gaagtggcaa cttactgtcc tcttccgtac cctcagtcct gccaagcccc agatgggggc
     4201 ccctcagtgc cattgacact gcccaagaat gtccagaggc catgggatgg tgccaagcac
     4261 acaacccctt ttgcctcttt caggggagca ggagtcccag tgcctgtctt agaaagggag
     4321 ggacatgcca agtccctgtg agtccttagt cctgtctcac caaaggactc agggctggtt
     4381 tctgagtttc cgtccagtat ttagccaagt tctgtgttag tcacataggc ctaagagcct
     4441 tgacgtttac agagtcaccc agctctggcc cctggccact ctggtccttg gcgtttacag
     4501 agtcacccag ctctaggccc cggccactct agtccttggc tatccttcac tccaccaggt
     4561 ccattccaga tgccaagagt cctctccacc atggttttct agctcttggg ctgggagaag
     4621 aggcaggtct gggcctttgt ttctgagctc tgttctgtgt tcctccatgc tacggttgca
     4681 attctgtttt ctatgaacga gtgcattcaa taaagacagc ccgacctggg atctggtctt
     4741 a
//
