LOCUS       NM_134457               2109 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus siah E3 ubiquitin protein ligase 2 (Siah2), mRNA.
ACCESSION   NM_134457
VERSION     NM_134457.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2109)
  AUTHORS   DeBruyne,J.P., Baggs,J.E., Sato,T.K. and Hogenesch,J.B.
  TITLE     Ubiquitin ligase Siah2 regulates RevErbalpha degradation and the
            mammalian circadian clock
  JOURNAL   Proc Natl Acad Sci U S A 112 (40), 12420-12425 (2015)
   PUBMED   26392558
REFERENCE   2  (bases 1 to 2109)
  AUTHORS   Huang,J., Cardamone,M.D., Johnson,H.E., Neault,M., Chan,M.,
            Floyd,Z.E., Mallette,F.A. and Perissi,V.
  TITLE     Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate
            in Protecting G Protein Pathway Suppressor 2 (GPS2) from
            Proteasomal Degradation
  JOURNAL   J Biol Chem 290 (31), 19044-19054 (2015)
   PUBMED   26070566
REFERENCE   3  (bases 1 to 2109)
  AUTHORS   Hayes,J.D. and Dinkova-Kostova,A.T.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   4  (bases 1 to 2109)
  AUTHORS   Christian,P.A., Fiandalo,M.V. and Schwarze,S.R.
  TITLE     Possible role of death receptor-mediated apoptosis by the E3
            ubiquitin ligases Siah2 and POSH
  JOURNAL   Mol Cancer 10, 57 (2011)
   PUBMED   21586138
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2109)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   6  (bases 1 to 2109)
  AUTHORS   Hall,J.M. and McDonnell,D.P.
  TITLE     Coregulators in nuclear estrogen receptor action: from concept to
            therapeutic targeting
  JOURNAL   Mol Interv 5 (6), 343-357 (2005)
   PUBMED   16394250
  REMARK    Review article
REFERENCE   7  (bases 1 to 2109)
  AUTHORS   Topol,L., Jiang,X., Choi,H., Garrett-Beal,L., Carolan,P.J. and
            Yang,Y.
  TITLE     Wnt-5a inhibits the canonical Wnt pathway by promoting
            GSK-3-independent beta-catenin degradation
  JOURNAL   J Cell Biol 162 (5), 899-908 (2003)
   PUBMED   12952940
REFERENCE   8  (bases 1 to 2109)
  AUTHORS   Wheeler,T.C., Chin,L.S., Li,Y., Roudabush,F.L. and Li,L.
  TITLE     Regulation of synaptophysin degradation by mammalian homologues of
            seven in absentia
  JOURNAL   J Biol Chem 277 (12), 10273-10282 (2002)
   PUBMED   11786535
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_134457.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB067815.1, AF389477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840118 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-658               JAXUCZ010000002.1  145081018-145081675 c
            659-2109            JAXUCZ010000002.1  145063847-145065297 c
FEATURES             Location/Qualifiers
     source          1..2109
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..2109
                     /gene="Siah2"
                     /note="siah E3 ubiquitin protein ligase 2"
                     /db_xref="GeneID:140593"
                     /db_xref="RGD:620778"
     exon            1..658
                     /gene="Siah2"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..1216
                     /gene="Siah2"
                     /EC_number="2.3.2.27"
                     /note="siah-2; seven in absentia 2; seven in absentia
                     homolog 2; RING-type E3 ubiquitin transferase SIAH2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SIAH2"
                     /protein_id="NP_604452.1"
                     /db_xref="GeneID:140593"
                     /db_xref="RGD:620778"
                     /translation="MSRPSSTGPSANKPCSKQPPPPQTPHAPSPAAPPAAATISAAGP
                     GSSAVPAAAAVISGPGAGGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVC
                     NQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHED
                     ICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVD
                     WVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLT
                     WEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCQ"
     exon            659..2109
                     /gene="Siah2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggagggc accgcacggc cgcgatcccc gagagcgtcg accactccgg gcgccgccga
       61 gaggatcggc gcggtcgcgt ccccgccctc ccggtgctgg tcgggtccgc gcccggtccc
      121 cggactgggc gccgtggcgt taccccggag cccgccaccc gcggggcgcg caccgcctta
      181 acccgggcgg ccccgcggca ggcagaagcc cgcaggtcca tggtgggctc ggagcgcgat
      241 gagccgcccg tcctccaccg gccccagcgc taacaaaccc tgcagcaagc agccgccgcc
      301 gcctcagacc ccgcacgccc cgtccccggc tgcgcccccg gctgccgcca ccatctcggc
      361 tgcgggcccc ggctcgtccg cggtgcccgc cgcggcagcg gtgatctcag gccccggcgc
      421 cggcggcggg gccggcccag tgtccccgca gcaccacgag ctgacctcgc tcttcgagtg
      481 cccggtctgt tttgactatg tcctgccccc cattctgcag tgccaggccg ggcacctggt
      541 gtgtaaccaa tgccgccaga agttgagctg ctgcccgacg tgcaggggcg ccctaacgcc
      601 cagcatcagg aacctggcta tggagaaggt cgcctcggca gttctgtttc cctgtaagta
      661 tgccaccacg ggctgttccc tgactctaca ccatacagag aaaccagagc atgaagacat
      721 ctgtgaatac cgtccttatt cctgtccctg tcctggtgcc tcctgcaagt ggcaaggatc
      781 cctagaagct gtgatgtccc atctcatgca tgcccacaag agcatcacta cccttcaggg
      841 agaggacata gtctttctag ctacagacat taacctgcca ggggctgtgg actgggtgat
      901 gatgcagtcc tgttttggcc accacttcat gctggtactc gagaagcaag agaagtacga
      961 aggtcaccag cagttctttg ccatcgtcct cctcattggc acccgcaagc aagcagagaa
     1021 ctttgcctac agactggagt tgaatgggaa ccggaggaga ctgacctggg aggccacacc
     1081 ccggtccatt catgatggtg tggctgcagc catcatgaac agtgactgcc ttgtttttga
     1141 cacagccata gcacatctct ttgcagataa tgggaacctt ggaatcaatg tcacaatatc
     1201 tacatgctgt cagtgaggct ccaggaggct ttccgaaccc tgggaagtta tttgggcata
     1261 gcgctctatg tttaataaag ttttttaata gatgttttat ttagtacgtc ttcccaagtc
     1321 aggacccaca actgtcctgt gttttattta aacaacagct tcctgtctgg cactgatgaa
     1381 acaaagttta ctgaactgtg ataagtgggg ttggcctgtt agtaattcgg aggtggttct
     1441 gtgacctcaa atcaaaacta ttctgtttac tttctgaaca gctcttgaca gattcctcag
     1501 ggctgcctcc ccctgcctca tcctgagcca acaaaagcac agtgacattc atgagatccc
     1561 ctttatttct aggaggtagc aattgcttta ataccccatc acctgaccgt agtactcatc
     1621 tccaacacag ccagagaatc aacaaagttg aacaacctcc tcttctcaga gtttgaggat
     1681 cactggcttg aattgtggaa agggtccagg atctaaaggt gctttaaggc catcctctgc
     1741 tgacaccgtt ggtctctaca gtccacacac cacactgaga gcagaactaa aagtccacgg
     1801 ggacacaact cctggggctt gcctgctctt gggttctcag agttctcaca tagttgttgc
     1861 tcaccataat actgatggcc tgtttacata tggcttccct tggaagcccc cttgactata
     1921 actgatgtga aagactagat cagtgcttgg gagaacttga tatccagtat cacatgcttg
     1981 ccactttaaa ggcatgtgtc agatttgtgg ctttagtttt tgttgttttt gtttttatct
     2041 ttacacacac atacacatac acacacacat acattttaat tttttaataa aattttttca
     2101 aaaactgaa
//
