LOCUS       NM_080905               2105 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus siah E3 ubiquitin protein ligase 1 (Siah1), mRNA.
ACCESSION   NM_080905
VERSION     NM_080905.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2105)
  AUTHORS   Tian,X., Gong,L., Jin,A., Wang,Y., Zhou,X. and Tan,Y.
  TITLE     E3 ubiquitin ligase siah-1 nuclear accumulation is critical for
            homocysteine-induced impairment of C6 astroglioma cells
  JOURNAL   Mol Med Rep 20 (3), 2227-2235 (2019)
   PUBMED   31322210
  REMARK    GeneRIF: These findings suggest that siah1 is involved in
            homocysteineinduced cell damage by promoting the nuclear
            translocation of glyceraldehyde 3phosphate dehydrogenase .
REFERENCE   2  (bases 1 to 2105)
  AUTHORS   Huo,J., Ma,R., Chai,X., Liang,H.J., Jiang,P., Zhu,X.L., Chen,X. and
            Su,B.X.
  TITLE     Inhibiting a spinal cord signaling pathway protects against
            ischemia injury in rats
  JOURNAL   J Thorac Cardiovasc Surg 157 (2), 494-503 (2019)
   PUBMED   30195603
REFERENCE   3  (bases 1 to 2105)
  AUTHORS   Huo,J., Zhu,X.L., Ma,R., Dong,H.L. and Su,B.X.
  TITLE     GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and
            could be attenuated by sivelestat sodium
  JOURNAL   Neuroscience 330, 171-180 (2016)
   PUBMED   27256506
  REMARK    GeneRIF: Study reveals GAPDH/Siah1 as a novel signaling pathway in
            apoptosis and function recovery after traumatic spinal cord injury.
            This signaling pathway in the spinal cord can be blocked by
            sivelestat sodium.
REFERENCE   4  (bases 1 to 2105)
  AUTHORS   Kilanczyk,E., Filipek,A. and Hetman,M.
  TITLE     Calcyclin-binding protein/Siah-1-interacting protein as a regulator
            of transcriptional responses in brain cells
  JOURNAL   J Neurosci Res 93 (1), 75-81 (2015)
   PUBMED   25163685
  REMARK    GeneRIF: The results of this study indicated that CacyBP/SIP is a
            novel regulator of CRE- and NFAT-driven transcription.
REFERENCE   5  (bases 1 to 2105)
  AUTHORS   Waites,C.L., Leal-Ortiz,S.A., Okerlund,N., Dalke,H., Fejtova,A.,
            Altrock,W.D., Gundelfinger,E.D. and Garner,C.C.
  TITLE     Bassoon and Piccolo maintain synapse integrity by regulating
            protein ubiquitination and degradation
  JOURNAL   EMBO J 32 (7), 954-969 (2013)
   PUBMED   23403927
REFERENCE   6  (bases 1 to 2105)
  AUTHORS   Wheeler,T.C., Chin,L.S., Li,Y., Roudabush,F.L. and Li,L.
  TITLE     Regulation of synaptophysin degradation by mammalian homologues of
            seven in absentia
  JOURNAL   J Biol Chem 277 (12), 10273-10282 (2002)
   PUBMED   11786535
REFERENCE   7  (bases 1 to 2105)
  AUTHORS   Liu,J., Stevens,J., Rote,C.A., Yost,H.J., Hu,Y., Neufeld,K.L.,
            White,R.L. and Matsunami,N.
  TITLE     Siah-1 mediates a novel beta-catenin degradation pathway linking
            p53 to the adenomatous polyposis coli protein
  JOURNAL   Mol Cell 7 (5), 927-936 (2001)
   PUBMED   11389840
REFERENCE   8  (bases 1 to 2105)
  AUTHORS   Kammermeier,P.J. and Ikeda,S.R.
  TITLE     A role for Seven in Absentia Homolog (Siah1a) in metabotropic
            glutamate receptor signaling
  JOURNAL   BMC Neurosci 2, 15 (2001)
   PUBMED   11686852
  REMARK    GeneRIF: Binds group I metabotropic glutamate receptors and
            calmodulin; calmodulin binding may play a role in the regulation of
            group I mGluR function
REFERENCE   9  (bases 1 to 2105)
  AUTHORS   Ishikawa,K., Nash,S.R., Nishimune,A., Neki,A., Kaneko,S. and
            Nakanishi,S.
  TITLE     Competitive interaction of seven in absentia homolog-1A and
            Ca2+/calmodulin with the cytoplasmic tail of group 1 metabotropic
            glutamate receptors
  JOURNAL   Genes Cells 4 (7), 381-390 (1999)
   PUBMED   10469171
REFERENCE   10 (bases 1 to 2105)
  AUTHORS   Wicker,C. and Puigserver,A.
  TITLE     Rat pancreatic colipase mRNA: nucleotide sequence of a cDNA clone
            and nutritional regulation by a lipidic diet
  JOURNAL   Biochem Biophys Res Commun 167 (1), 130-136 (1990)
   PUBMED   2129524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV213782.1, AF389476.1 and BQ780107.1.
            
            On Dec 1, 2005 this sequence version replaced NM_080905.1.
            
            Sequence Note: This RefSeq record was created using sequences from
            two different strains, W and Sprague-Dawley, because no single
            transcript from the same strain was available for the full length
            of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV213782.1, CB746687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               DV213782.1         1-189
            190-1635            AF389476.1         10-1455
            1636-2105           BQ780107.1         81-550
FEATURES             Location/Qualifiers
     source          1..2105
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..2105
                     /gene="Siah1"
                     /gene_synonym="SIAH; Siah1a"
                     /note="siah E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:140941"
                     /db_xref="RGD:620449"
     exon            1..178
                     /gene="Siah1"
                     /gene_synonym="SIAH; Siah1a"
                     /inference="alignment:Splign:2.1.0"
     exon            179..2090
                     /gene="Siah1"
                     /gene_synonym="SIAH; Siah1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1029
                     /gene="Siah1"
                     /gene_synonym="SIAH; Siah1a"
                     /EC_number="2.3.2.27"
                     /note="siah-1; siah-1a; seven in absentia homolog 1; seven
                     in absentia 1A; RING-type E3 ubiquitin transferase SIAH1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SIAH1"
                     /protein_id="NP_543181.2"
                     /db_xref="GeneID:140941"
                     /db_xref="RGD:620449"
                     /translation="MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVC
                     FDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYAS
                     SGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQG
                     EDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQA
                     ENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGIN
                     VTISMC"
ORIGIN      
        1 gggaagccgg gctgccgggc gggcgcgctc tcgagggcgg cggcccaggg tgtcccgtcg
       61 gtctcggcgc cgggagaggt ggaggcgcgg tccgcggtgg cggcggtggc ggcggcggca
      121 gctggcgacc gggcgcgtta gacggggccg gggtccgcgg cgcgctctcc gcccacagag
      181 atgagccgtc agactgctac agcattaccc accggcacct caaagtgtcc accatcccag
      241 agggtacctg ccttgactgg cacaactgca tccaacaatg acttggcgag tcttttcgag
      301 tgtcctgtct gctttgacta tgtattgcca cctattcttc agtgtcagag tggccatctt
      361 gtttgtagca actgtcgccc caaacttaca tgttgtccca cctgccgggg cccgttggga
      421 tccattcgca acttggctat ggagaaagtg gccaactccg tactcttccc ttgtaaatat
      481 gcctcttctg gatgtgagat aactctgccg cacaccgaaa aggcagagca cgaggagctc
      541 tgtgagttca ggccttactc ctgcccctgc cctggtgctt cctgtaagtg gcaaggctcc
      601 ttggatgctg tcatgcccca cctgatgcat cagcacaagt ccattaccac cctgcaagga
      661 gaagatatag ttttccttgc tacagacatt aaccttcctg gtgctgttga ctgggtgatg
      721 atgcagtctt gttttggctt tcatttcatg ttagtcttgg agaaacaaga aaaatacgat
      781 ggccatcagc agttctttgc gattgtacag ctgataggaa cacgcaagca agctgaaaat
      841 tttgcatatc gacttgagct gaatggtcat aggcggcgat tgacttggga agccacccct
      901 cggtctattc atgagggaat tgcaacagcc atcatgaata gtgactgcct agtgtttgac
      961 accagcattg cacagctctt tgcagaaaat ggcaatttag gcatcaatgt aactatttcc
     1021 atgtgttgaa acggcaatca aatatttctg gccagtgttt aaaatttgca tttgacttca
     1081 cagagaataa ggcacccatc tgcttgccaa cctaaacctc tcctggtagg tagaagctag
     1141 acatgaaggt aaataaaaag aaaagctgtt aatacaggaa acagttgcat gtagtaacac
     1201 taatatattt aaaaataatt caacagtaaa ccactgaaaa atatatatac ccaagatggg
     1261 catcttttgt attaagaaag gaaacattgt aaaatatttc tgaactttgt gtttgttgta
     1321 gattgattgt attgttgaca attttttggg ggtgtgtgtc tgtgcacgca tgcgtgcacg
     1381 tgtgtggttg gttttccttt aactgacaag ccatctgcgt ggtcatgggc caccgctttc
     1441 cccttgtgag tcaacacaca gtgctgctgt ggggttgttt tttgttttgt tttttgtttt
     1501 gttttttggt gtgtgtgtat ttgctaattt ttattctagt ttttcattaa ataaatttga
     1561 ctttcttttc tgtaattcag gtttttctca cttttgtacc ttttaagtta gcgtcttttt
     1621 gatatccata attgcttaat gtcagaagtt tgtgttcagt acatactttc ttttccttca
     1681 atcaatttat tagacatttt taattcagcc cttctgtgga aataggaatt ccagaaagga
     1741 aagggagcag agcagctcgt cgaggctgaa gcaagtacag gatggtctcg cctcccgact
     1801 gctgtcctac gccgtcaggt caggcttact ctctgaaagg ttagcttagg gagtaaactc
     1861 tgatcactat aaattataaa ataatcaggc ttttcctctc ttcaaatgtc ttgggcaaat
     1921 cacatgttta aattggttct tgtatttatt ggttttgcaa aagagtgcat catcatacac
     1981 agtatttgta attaaagtaa atcatttgtt tttaaaaaaa ggcagtttgc aaaaaaatgt
     2041 ttttggtctt ttataattct cattaaaaga ttatctggca aattaaaaaa aaaaaaaaaa
     2101 aaaaa
//
