LOCUS       NM_001108759            3460 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sialic acid acetylesterase (Siae), mRNA.
ACCESSION   NM_001108759 XM_001057928 XM_001057989 XM_343373
VERSION     NM_001108759.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3460)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   2  (bases 1 to 3460)
  AUTHORS   Chellappa,V., Taylor,K.N., Pedrick,K., Donado,C., Netravali,I.A.,
            Haider,K., Cariappa,A., Dalomba,N.F. and Pillai,S.
  TITLE     M89V Sialic acid Acetyl Esterase (SIAE) and all other
            non-synonymous common variants of this gene are catalytically
            normal
  JOURNAL   PLoS One 8 (1), e53453 (2013)
   PUBMED   23308225
REFERENCE   3  (bases 1 to 3460)
  AUTHORS   Surolia,I., Pirnie,S.P., Chellappa,V., Taylor,K.N., Cariappa,A.,
            Moya,J., Liu,H., Bell,D.W., Driscoll,D.R., Diederichs,S.,
            Haider,K., Netravali,I., Le,S., Elia,R., Dow,E., Lee,A.,
            Freudenberg,J., De Jager,P.L., Chretien,Y., Varki,A.,
            MacDonald,M.E., Gillis,T., Behrens,T.W., Bloch,D., Collier,D.,
            Korzenik,J., Podolsky,D.K., Hafler,D., Murali,M., Sands,B.,
            Stone,J.H., Gregersen,P.K. and Pillai,S.
  TITLE     Functionally defective germline variants of sialic acid
            acetylesterase in autoimmunity
  JOURNAL   Nature 466 (7303), 243-247 (2010)
   PUBMED   20555325
REFERENCE   4  (bases 1 to 3460)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 3460)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   6  (bases 1 to 3460)
  AUTHORS   Butor,C., Higa,H.H. and Varki,A.
  TITLE     Structural, immunological, and biosynthetic studies of a sialic
            acid-specific O-acetylesterase from rat liver
  JOURNAL   J Biol Chem 268 (14), 10207-10213 (1993)
   PUBMED   8486688
REFERENCE   7  (bases 1 to 3460)
  AUTHORS   Higa,H.H., Manzi,A. and Varki,A.
  TITLE     O-acetylation and de-O-acetylation of sialic acids. Purification,
            characterization, and properties of a glycosylated rat liver
            esterase specific for 9-O-acetylated sialic acids
  JOURNAL   J Biol Chem 264 (32), 19435-19442 (1989)
   PUBMED   2808434
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474096.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_343373.3, XM_001057928.1, XM_001057989.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3460
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..3460
                     /gene="Siae"
                     /gene_synonym="RGD1310431"
                     /note="sialic acid acetylesterase"
                     /db_xref="GeneID:363045"
                     /db_xref="RGD:1310431"
     exon            1..108
                     /gene="Siae"
                     /gene_synonym="RGD1310431"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1670
                     /gene="Siae"
                     /gene_synonym="RGD1310431"
                     /EC_number="3.1.1.53"
                     /note="sialate O-acetylesterase; sialic acid-specific
                     9-O-acetylesterase; yolk sac protein 2"
                     /codon_start=1
                     /product="sialate O-acetylesterase precursor"
                     /protein_id="NP_001102229.1"
                     /db_xref="GeneID:363045"
                     /db_xref="RGD:1310431"
                     /translation="MVSPRPVGLMLLLIIARVSRGAGIGFRFASYIDNYMVLQKEPSG
                     AVIWGFGTAGATVTVTLCQGQETIMKKVTSVKGPSNTWMVVLDPMKPGGPFEVMAQQT
                     LETTNLTLRVHDVLFGDVWLCSGQSNMQMTVLQIFNASKELSDTAAYQSVRIFSVSLT
                     QAEEELADLDGVDLSWSKPTAGNLGHGNFTYMSAVCWLFGRYLYDTLQYPIGLVSSSW
                     GGTPIEVWSSRRALKACGVPNTRDERVLQPEIKPMRNGCESKESSCPFRRFVPCDPVA
                     GPATHSVLWNAMIHPLQNMTLKGVVWYQGENNANYNRDLYACMFPALIADWRQTFHSG
                     SQGQTEHFFPFGFVQLSSYLLMNSSDYGFPEIRWHQTADFGSVPNPKMPNTFMAVAMD
                     LCDRDSPFGSIHPRDKQTVAYRLHLGARAVAYGEKNLTFQGPLPKKIELLARNELLNL
                     TYDQEIQVQRKDNKTFEISCCSDHQCKWLPAPVNTFSTQTLILDLSACLGTVDAVRYA
                     WTTWPCEYKQCAVYHTSSVLPAPPFTARITHRGI"
     exon            109..270
                     /gene="Siae"
                     /gene_synonym="RGD1310431"
                     /inference="alignment:Splign:2.1.0"
     exon            271..446
                     /gene="Siae"
                     /gene_synonym="RGD1310431"
                     /inference="alignment:Splign:2.1.0"
     exon            447..585
                     /gene="Siae"
                     /gene_synonym="RGD1310431"
                     /inference="alignment:Splign:2.1.0"
     exon            586..844
                     /gene="Siae"
                     /gene_synonym="RGD1310431"
                     /inference="alignment:Splign:2.1.0"
     exon            845..954
                     /gene="Siae"
                     /gene_synonym="RGD1310431"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1088
                     /gene="Siae"
                     /gene_synonym="RGD1310431"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1246
                     /gene="Siae"
                     /gene_synonym="RGD1310431"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1442
                     /gene="Siae"
                     /gene_synonym="RGD1310431"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..3460
                     /gene="Siae"
                     /gene_synonym="RGD1310431"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctcttcc tgagagcggg taaattagga tcatctcaaa catggtttcc ccccggcctg
       61 ttgggctaat gctgctgctc ataatcgcgc gggtcagcag aggtgcaggt attggttttc
      121 gctttgcttc atacatcgat aattacatgg tgctgcagaa ggagccttcc ggggcggtga
      181 tctggggctt tggtacagct ggggccacag tgacagtgac cttgtgccaa ggtcaggaaa
      241 ccatcatgaa gaaagtgacc agtgtgaaag gaccctccaa cacctggatg gtggtgctgg
      301 atcctatgaa gcccggggga ccttttgaag tgatggcaca acagaccttg gagacaacga
      361 acctcaccct gagagtccac gatgttttat ttggcgatgt ctggctttgc agtgggcaga
      421 gtaacatgca gatgactgtt ttacagatct tcaacgcctc aaaggagttg tcggacaccg
      481 ctgcctacca gtctgtgcgc atcttctctg tctccctcac ccaggcagag gaggagctgg
      541 ctgacctcga tggagttgac ctgtcatggt ccaagcccac tgcaggaaac ctgggtcacg
      601 gaaacttcac atacatgtct gcagtgtgct ggctctttgg gcgttaccta tatgacactc
      661 tgcaatatcc catcgggcta gtctcctcca gttggggtgg gacacccatt gaagtctggt
      721 catctagaag ggcactgaaa gcctgtggag tccctaatac aagggatgaa cgagttcttc
      781 agcctgagat aaagcccatg aggaatggct gtgagagtaa ggagtcctca tgtcctttta
      841 ggaggtttgt cccatgtgat cctgtggctg gaccggcaac acactctgtc ctctggaatg
      901 ccatgatcca cccactgcaa aacatgactt tgaaaggggt ggtgtggtat cagggagaga
      961 acaatgcgaa ttataacagg gacctgtatg cctgcatgtt tcctgcactc attgcagact
     1021 ggcgccagac ctttcactcc ggctcccagg gccagacaga gcatttcttt ccatttgggt
     1081 ttgtccagct gtcttcatac ctgttgatga actcatcaga ttatggattt ccagagatcc
     1141 gctggcatca aacagcagac tttggctctg tccccaaccc gaagatgccc aacactttta
     1201 tggccgtcgc tatggatctc tgtgaccgag actcaccttt tgggagcatc caccctcgag
     1261 acaaacagac tgtggcctat cgcctgcact tgggtgctcg agctgtggca tatggtgaga
     1321 aaaatttgac ctttcaagga ccactaccta agaagataga actcttggct cgcaatgagc
     1381 tgctcaacct cacttatgac caggaaatcc aggtgcagag gaaagataac aagacatttg
     1441 agatctcatg ttgcagtgac catcagtgca aatggcttcc agctcctgtg aacactttct
     1501 ccacccagac cctgatcttg gatctcagtg cttgtctggg caccgtggat gctgttcgct
     1561 atgcctggac cacatggccc tgtgaatata aacagtgcgc cgtttaccac accagctctg
     1621 tcttgccagc tcctcccttc actgctcgca ttacacacag ggggatctaa ggacatcatt
     1681 taaatgatga ctgctatcat tcttaagggc aatgggatag acgccttaga tacctcattg
     1741 aatagctccc agctagcata tggctgctcc tgtattctga cataagcact ggctggcaga
     1801 cacttgaaat gctcatctct gtcccctagt tagccaaagc ctctgtgcca gtctaattct
     1861 gaacactggg ccttgttagc attcacttcc tgggtattag tgggagtgaa atgccctatt
     1921 tttgcccttc atccagaact gtggactctc agagcagcaa gagacttaaa ggctgtggag
     1981 gctggtgctt tgtgtactct ttgcaacccc ctgaaaatgg ctatggaagt ttccatgtgt
     2041 ttccttctgt ggtgctgaag tacttctctc atcaaacctt accacaccat gacacgtctt
     2101 tcagatcacc ttagagagac catgtgtttg tatccccagt aagctctcaa aactgttttc
     2161 agcccaagtc ttactccaaa gggaatcttt gcatattgct aagtgctaag gagtggcctt
     2221 aaggaataga gggcccaagg catgttctca ggcaaagggt ggggtaacca caggcacagg
     2281 aacaggaagt cgatgcgctt ggggcaaata catccttaaa tgtaagtctt aggttcctga
     2341 ggtaaaagtt caatgaaggc taattcccac tgaaggaaga agttaggctg aaaggaaagt
     2401 tacaggatat acttagagca acagtgcagg tgagccaaag ggcaggatgc agtttaccac
     2461 ttggttaaag acagctgcca gctctgaaaa gtgcaccgac tagaaattgg aagtccagca
     2521 tggtggcaca cactagtccc agcactcagg cagcagaggg gagctggctg cagaatgagt
     2581 tctaggacac cagttctcta gagaaacact ctcttgaccc tcccccacaa gaaaagaaat
     2641 tggggataaa agtaaataat tagtgctgtg tccacatatc cagtcaaatt gttagggaca
     2701 gacttacacc gtgcccttga aacatgggaa aggaatataa ctgccacctg tgcatagctc
     2761 ttttgttctt gatgtgagaa agtgggcact gaagcaatga ggatttctta ctattctctg
     2821 gagctctggg gcattagaaa cagcaagaga gatgtgtcag gagtttattt ggttaaaaac
     2881 aaagaaagaa accaaaaccc aaaacctgta cattctgcag aggcctttga cctctgaggt
     2941 gtctagcctg catttaattt ctaatgctct ctctgcacct ggccctgtga gaacacaaat
     3001 ctagtaatca tcagctcctg agaaaatgta aaatctactg cctgtcatgc gaagccctgc
     3061 tgttagttat gctgaacaag agaataagaa ccccaagccc aaggtcctct cacacccaat
     3121 aattggtaca tatagtgcat acgtgtcatg tggtacatgt aatgaaatca tgtatgagtc
     3181 aaatttttag tggttgaata gtttaaaaca ttgtgtaggg actgtgtatt tctccaaatg
     3241 gagagaattt ttaactattt gaaaattaat cactgactag caagagggta agaagcagcc
     3301 ttgaatcatc cctgaaggag aaacactgct gtgctgaact ttggtctggc ttattctgtt
     3361 tccttatagc atatgtaaat acacatacta tagttgaaag caacctttcc atgtctgatg
     3421 tgttttagta ggatgcgaac tttctcaaat tattttactt
//
