LOCUS       NM_001389226            6021 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Rattus norvegicus sucrase-isomaltase (Si), mRNA.
ACCESSION   NM_001389226
VERSION     NM_001389226.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6021)
  AUTHORS   Aoki,K., Ebina,K., Shingu,H., Kioka,K., Sugasawa,T., Kawakami,Y.,
            Takekoshi,K. and Omi,N.
  TITLE     Female athlete triad affects rat intestinal morphology and
            sucrase-isomaltase expression
  JOURNAL   Br J Nutr 130 (1), 1-9 (2023)
   PUBMED   36329653
  REMARK    GeneRIF: Female athlete triad affects rat intestinal morphology and
            sucrase-isomaltase expression.
REFERENCE   2  (bases 1 to 6021)
  AUTHORS   Gericke,B., Amiri,M., Scott,C.R. and Naim,H.Y.
  TITLE     Molecular pathogenicity of novel sucrase-isomaltase mutations found
            in congenital sucrase-isomaltase deficiency patients
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (3), 817-826 (2017)
   PUBMED   28062276
REFERENCE   3  (bases 1 to 6021)
  AUTHORS   Inoue,S., Honma,K., Mochizuki,K. and Goda,T.
  TITLE     Induction of histone H3K4 methylation at the promoter, enhancer,
            and transcribed regions of the Si and Sglt1 genes in rat jejunum in
            response to a high-starch/low-fat diet
  JOURNAL   Nutrition 31 (2), 366-372 (2015)
   PUBMED   25592016
REFERENCE   4  (bases 1 to 6021)
  AUTHORS   Sim,L., Willemsma,C., Mohan,S., Naim,H.Y., Pinto,B.M. and Rose,D.R.
  TITLE     Structural basis for substrate selectivity in human
            maltase-glucoamylase and sucrase-isomaltase N-terminal domains
  JOURNAL   J Biol Chem 285 (23), 17763-17770 (2010)
   PUBMED   20356844
REFERENCE   5  (bases 1 to 6021)
  AUTHORS   Kaur,N., Kaur,J. and Mahmood,A.
  TITLE     Effect of harmaline on rat intestinal brush border sucrase activity
  JOURNAL   Indian J Biochem Biophys 39 (2), 119-123 (2002)
   PUBMED   22896899
  REMARK    GeneRIF: harmaline has an effect on rat intestinal brush border
            sucrase activity
REFERENCE   6  (bases 1 to 6021)
  AUTHORS   Traber,P.G.
  TITLE     Regulation of sucrase-isomaltase gene expression along the
            crypt-villus axis of rat small intestine
  JOURNAL   Biochem Biophys Res Commun 173 (3), 765-773 (1990)
   PUBMED   2268340
REFERENCE   7  (bases 1 to 6021)
  AUTHORS   Broyart,J.P., Hugot,J.P., Perret,C. and Porteu,A.
  TITLE     Molecular cloning and characterization of a rat intestinal
            sucrase-isomaltase cDNA. Regulation of sucrase-isomaltase gene
            expression by sucrose feeding
  JOURNAL   Biochim Biophys Acta 1087 (1), 61-67 (1990)
   PUBMED   2400788
REFERENCE   8  (bases 1 to 6021)
  AUTHORS   Goda,T., Raul,F., Gosse,F. and Koldovsky,O.
  TITLE     Effects of a high-protein, low-carbohydrate diet on degradation of
            sucrase-isomaltase in rat jejunoileum
  JOURNAL   Am J Physiol 254 (6 Pt 1), G907-G912 (1988)
   PUBMED   3287954
REFERENCE   9  (bases 1 to 6021)
  AUTHORS   Lorenzsonn,V., Korsmo,H. and Olsen,W.A.
  TITLE     Localization of sucrase-isomaltase in the rat enterocyte
  JOURNAL   Gastroenterology 92 (1), 98-105 (1987)
   PUBMED   3536655
REFERENCE   10 (bases 1 to 6021)
  AUTHORS   Hauer-Jensen,M., Christensen,K., Wilson,H.D. and Schedl,H.P.
  TITLE     Intestinal disaccharidase activity following pancreatic duct
            occlusion in the rat
  JOURNAL   Pancreas 2 (3), 295-302 (1987)
   PUBMED   3114740
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.9711.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760393,
                                           SAMN12840105 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000002.1  159884842-159884902 c
            62-179              JAXUCZ010000002.1  159883817-159883934 c
            180-346             JAXUCZ010000002.1  159882598-159882764 c
            347-464             JAXUCZ010000002.1  159877795-159877912 c
            465-574             JAXUCZ010000002.1  159877416-159877525 c
            575-726             JAXUCZ010000002.1  159876457-159876608 c
            727-898             JAXUCZ010000002.1  159874723-159874894 c
            899-998             JAXUCZ010000002.1  159871751-159871850 c
            999-1111            JAXUCZ010000002.1  159870812-159870924 c
            1112-1237           JAXUCZ010000002.1  159869956-159870081 c
            1238-1369           JAXUCZ010000002.1  159868796-159868927 c
            1370-1489           JAXUCZ010000002.1  159868591-159868710 c
            1490-1603           JAXUCZ010000002.1  159866596-159866709 c
            1604-1688           JAXUCZ010000002.1  159865685-159865769 c
            1689-1806           JAXUCZ010000002.1  159864228-159864345 c
            1807-1978           JAXUCZ010000002.1  159862394-159862565 c
            1979-2095           JAXUCZ010000002.1  159859777-159859893 c
            2096-2250           JAXUCZ010000002.1  159856326-159856480 c
            2251-2335           JAXUCZ010000002.1  159854861-159854945 c
            2336-2392           JAXUCZ010000002.1  159854078-159854134 c
            2393-2517           JAXUCZ010000002.1  159852591-159852715 c
            2518-2606           JAXUCZ010000002.1  159846204-159846292 c
            2607-2656           JAXUCZ010000002.1  159843425-159843474 c
            2657-2827           JAXUCZ010000002.1  159842656-159842826 c
            2828-2983           JAXUCZ010000002.1  159842275-159842430 c
            2984-3190           JAXUCZ010000002.1  159839647-159839853 c
            3191-3342           JAXUCZ010000002.1  159839233-159839384 c
            3343-3511           JAXUCZ010000002.1  159837235-159837403 c
            3512-3608           JAXUCZ010000002.1  159834833-159834929 c
            3609-3721           JAXUCZ010000002.1  159834637-159834749 c
            3722-3847           JAXUCZ010000002.1  159834426-159834551 c
            3848-3976           JAXUCZ010000002.1  159833210-159833338 c
            3977-4087           JAXUCZ010000002.1  159832158-159832268 c
            4088-4150           JAXUCZ010000002.1  159830780-159830842 c
            4151-4267           JAXUCZ010000002.1  159827119-159827235 c
            4268-4355           JAXUCZ010000002.1  159825770-159825857 c
            4356-4494           JAXUCZ010000002.1  159824420-159824558 c
            4495-4628           JAXUCZ010000002.1  159822874-159823007 c
            4629-4663           JAXUCZ010000002.1  159821958-159821992 c
            4664-4780           JAXUCZ010000002.1  159821755-159821871 c
            4781-4929           JAXUCZ010000002.1  159819321-159819469 c
            4930-5014           JAXUCZ010000002.1  159816962-159817046 c
            5015-5071           JAXUCZ010000002.1  159816824-159816880 c
            5072-5196           JAXUCZ010000002.1  159816082-159816206 c
            5197-5285           JAXUCZ010000002.1  159809982-159810070 c
            5286-5335           JAXUCZ010000002.1  159807827-159807876 c
            5336-5503           JAXUCZ010000002.1  159807454-159807621 c
            5504-6021           JAXUCZ010000002.1  159804568-159805085 c
FEATURES             Location/Qualifiers
     source          1..6021
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q32"
     gene            1..6021
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /note="sucrase-isomaltase"
                     /db_xref="GeneID:497756"
                     /db_xref="RGD:3675"
     exon            1..61
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..5572
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /EC_number="3.2.1.10"
                     /EC_number="3.2.1.48"
                     /note="sucrase-isomaltase (alpha-glucosidase)"
                     /codon_start=1
                     /product="sucrase-isomaltase, intestinal"
                     /protein_id="NP_001376155.1"
                     /db_xref="GeneID:497756"
                     /db_xref="RGD:3675"
                     /translation="MAKKKFSALEISLIVLFIIVTAIAIALVAVLATKVPAVEEIKSP
                     TPTSNSTPTSTPTSTSIPTSTSTPSPGKCPPEQGEPINERINCIPEQHPTKAICEERG
                     CCWRPWNNTVIPWCFFADNHGYNAESITNENAGLKATLNRIPSPTLFGEDIKSVILTT
                     QTQTGNRFRFKITDPNNKRYEVPHQFVKEETGIPAADTLYDVQVSENPFSIKVIRKSN
                     NKVLFDTSVGPLVYSNQYLQISTRLPSEYIYGFGEHIHKRFRHDLYWKTWPIFTRDEI
                     PGDNNHNLYGHQTFFMGIEDTSGKSYGVFLMNSNAMEVFIQPTPIITYRVTGGILDFY
                     IFLGDTPEQVVQQYQEFIGRPAMPAYWNLGFQLSRWNYGSLDTVKEVVRRNREAGIPY
                     DAQVTDIDYMEDKKDFTYDEVKFNGLPEFAQDLHNHGQKYIIILDPAISINKRANGAE
                     YQTYVRGNEKNVWVNESDGTTPLIGEVWPGLTVYPDFTNPQTIEWWANECNLFHQQVE
                     YDGLWIDMNEVSSFIQGSLKGCTSNLLNYPPFTPGILDKVMYSKTLCMDAVQHWGKQY
                     DVHSLYGYSMAIATEQAVERVFPNKRSFILTRSTFAGSGRHANHWLGDNTASWEQMEW
                     SITGMLEFGIFGMPLVGADICGFLADTTEELCRRWMQLGAFYPFSRNHNAEGYMEQDP
                     AYFGQDSLLVNTSRHYLTIRYTLLPFLYTLFYRAHMFGETVARPFLYEFYDDTNSWIE
                     DTQFLWGPALLITPVLRPGVENVSAYIPNATWYDYETGIKRPWRKERINMYLPGDKIG
                     LHLRGGYIIPTQEPDVTTTASRKNPLGLIVALDDNQAAKGELFWDDGESKDSIEKKMY
                     ILYTFSVSNNELVLNCTHSSYAEGTSLAFKTIKVLGLGEDVRSITVGENDQQMATHTN
                     FTFDSTNKILSITALNFNLGKSFIVRWSQTFSDNEKFTCYPDVGTVTEETCKQRGCLW
                     QPVSGLSNVPPCYFPPEHNPYTLTSIQPLPTGITAELQLNPANARIKLPSNPISTLRV
                     EVKYHKNDMLQFKIYDAQHKRYEVPVPLNIPDTPTSSNERLYDVEIKENPFGIQVRRR
                     SSGKLIWDSSLPGFAFNDQFIQISTRLPSNYLYGFGEVEHTAFKRDLNWHTWGMFTRD
                     QPPGYKLNSYGFHPYYMALENEGNAHGVLLLNSNGMDVTFQPTPALTYRTIGGILDFY
                     MFLGPTPEIATRQYHEVIGFPVMPPYWALGFQLCRYGYRNTSEIEQLYNDMVAANIPY
                     DVQYTDINYMERQLDFTIGERFKTLPEFVDRIRKDGMKYIVILDPAISGNETQPYPAF
                     ERGIQKDVFVKWPNTNDICWAKVWPDLPNVTIDETITEDEAVNASRAHVAFPDFFRNS
                     TLEWWAREIYDFYNEKMKFDGLWIDMNEPSSFVNGTVTNKCRNDTLNYPPYFPELTKR
                     GEGLHFRTMCMETEHILSDGSSVLHYDVHNLYGWSQVKPTLDALQNTTGLRGIVISRS
                     TYPTAGRWGGHWLGDNYANWDNLEKSLIGMLEFNLFGIPYIGADICGFFNDSEYHLCT
                     RWMQVGAFYPYSRNHNIQFTRRQDPVSWNETFAQMSKKVLEIRYTLLPYFYTQMHEAH
                     AQGGTVIRPLMHEFFDDKETWEIYKQFLWGPAFMVTPVVEPFRTSVTGYVPKARWFDY
                     HTGEDIKLKGILHTFSAPFDTINLHVRGGYILPCQEPARNTHLSRQNYMKLIVAADDN
                     QMAQGTLFWDDGESIDTYERGQYTSIQFNLNQTTLTSTVLANGYKNKQEMRLGSIHIW
                     GKGTLRISNANLIYGGSKHQPPFTQEEAKETLIFDLKNMNVTLDEPIQITWS"
     exon            62..179
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            180..346
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            347..464
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            465..574
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            575..726
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            727..898
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            899..998
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1111
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1237
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1369
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1489
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1603
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1688
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1806
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1978
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2095
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2250
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2335
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2392
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2517
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2606
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2656
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2827
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2983
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3190
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3342
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3511
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3608
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3721
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3847
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3848..3976
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3977..4087
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            4088..4150
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            4151..4267
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            4268..4355
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            4356..4494
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4628
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            4629..4663
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            4664..4780
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            4781..4929
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            4930..5014
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            5015..5071
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            5072..5196
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            5197..5285
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            5286..5335
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            5336..5503
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
     exon            5504..6021
                     /gene="Si"
                     /gene_synonym="SUCIMAL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actttaatag ccttgctcaa ctccagcaaa gaactgcaaa taggacaggc tatgagctaa
       61 gatggcaaag aagaagttca gtgcactaga gatctctctg attgtcctct tcatcatagt
      121 aacagcaata gctattgctc ttgtcgctgt tttagcaacc aaggtgccag ctgtggaaga
      181 aataaaaagt ccaactccaa cttcaaattc aactccaact tcaactccaa cttcaacttc
      241 aatcccaact tcaacttcaa cccctagtcc tgggaagtgt cctcctgaac aaggtgaacc
      301 tatcaatgag agaattaact gcattccaga acaacatcca acaaaggcaa tatgtgaaga
      361 gcgtggctgt tgctggcgtc cgtggaacaa cactgtcatt ccttggtgct tctttgcaga
      421 caaccatggc tataatgctg agtccatcac aaatgaaaac gcgggactta aagccacact
      481 gaacaggatc ccttctccca ctctatttgg agaagacatt aaaagcgtca tcctcacaac
      541 tcagactcaa acaggcaatc gtttccggtt caagatcaca gatccaaata acaagagata
      601 tgaagtgccg caccagtttg taaaagagga aactggaatc ccagcagctg acacactcta
      661 tgatgtccag gtctcagaaa atccgttcag catcaaagtg atcaggaaaa gcaacaacaa
      721 agtcttgttt gataccagtg ttggtccact ggtgtactca aaccaatatt tgcagatttc
      781 gacaagactt ccaagtgaat atatttatgg ctttggggaa catattcata agagatttcg
      841 tcatgactta tactggaaga catggccaat ctttactcga gatgaaatcc ctggtgataa
      901 taatcataat ctctatgggc atcagacatt cttcatgggc attgaagata cctctgggaa
      961 gtcatatggt gttttcctta tgaacagcaa tgcaatggag gttttcatcc agccaactcc
     1021 aataattact tacagagtta ctggtggcat actagacttt tatatatttc ttggagacac
     1081 accagaacaa gtagttcaac aataccaaga gttcattgga cgaccggcaa tgccagcata
     1141 ttggaacctt ggctttcaac tgagtcgctg gaattacggg tcattagaca ctgtgaaaga
     1201 agtagtaaga agaaaccggg aagctggcat cccatatgat gcacaagtca ctgatattga
     1261 ctatatggaa gacaaaaagg actttactta tgatgaagtc aaatttaatg gacttcctga
     1321 atttgcccag gatttacata accatggaca aaaatatatt atcatcctgg accctgccat
     1381 ctccataaat aagcgagcca acggtgcaga atatcaaaca tatgtgagag ggaatgagaa
     1441 aaatgtttgg gtgaatgagt cagatgggac tacaccactt attggagagg tatggccagg
     1501 attaacagtg tacccagatt ttactaatcc ccaaaccatc gagtggtggg caaatgaatg
     1561 caatcttttc catcagcagg tcgaatatga tggactatgg attgacatga atgaagtttc
     1621 cagctttatt caagggtctc tgaaagggtg tacttctaat ctgctgaact accctccttt
     1681 tactcctggt attcttgaca aagtcatgta ttccaaaact ctttgcatgg atgctgtgca
     1741 gcactggggg aagcagtatg atgtacatag cctgtatggg tacagcatgg ctatagccac
     1801 agagcaagct gtggaaagag tttttcctaa taagagaagc ttcatcctca cccggtcaac
     1861 ctttgctggc tctggaaggc atgctaatca ttggctcgga gacaacacag cctcgtggga
     1921 gcagatggaa tggtccatca caggaatgct ggaatttggc atatttggca tgcctttggt
     1981 aggggccgac atctgtggat ttttggctga caccacagaa gaactctgca gaagatggat
     2041 gcaactggga gccttttacc cattttctag aaaccacaat gcagaaggct acatggaaca
     2101 ggatcctgct tatttcggac aagactctct tttggtaaac acatcaaggc actacctaac
     2161 catccgctat actttactcc ctttcctcta cactctgttc tatagagccc acatgtttgg
     2221 tgagacagtc gcaaggccat ttctttatga gttttacgat gacactaaca gctggattga
     2281 ggacacccag tttctgtggg gccctgcact acttatcact cctgttttga gaccgggagt
     2341 agaaaacgtg agtgcatata ttcctaatgc tacctggtat gattatgaaa caggtataaa
     2401 aaggccatgg aggaaagaaa ggattaacat gtacctgcca ggagataaaa taggattaca
     2461 tcttagagga ggttatatca tccctaccca ggaacctgat gtaacaacaa cagcaagccg
     2521 aaagaatcct ctaggcctca ttgttgcatt agatgataat caggcagcaa aaggagaatt
     2581 attctgggat gatggcgaat ctaaagattc catagaaaag aaaatgtata tattatacac
     2641 gttttcagtc tcaaataatg aattggttct aaactgcacg cattcatcat atgcagaggg
     2701 aacttccctt gcatttaaaa caatcaaagt ccttgggctg ggagaggatg tcaggagcat
     2761 tacagtgggt gaaaatgacc agcaaatggc tactcatact aacttcactt ttgattctac
     2821 caataagatt ctgtcaatta cagctctcaa cttcaacctt ggcaaaagct tcatagttag
     2881 atggtcccaa accttctcag acaacgagaa attcacctgt tacccagatg taggcacagt
     2941 gacagaggaa acatgcaaac agagaggctg cttatggcaa ccggttagtg gactctccaa
     3001 tgtgcctcca tgctactttc ctccagaaca caatccctat acgttaactt caattcaacc
     3061 tttgcccacg ggcataacag cagaactcca gttgaatcct gcaaatgcta gaatcaagct
     3121 tccatctaat cccatctcca ctctccgtgt ggaagtaaaa tatcacaaaa atgacatgct
     3181 acagtttaaa atttatgatg ctcagcataa gagatatgaa gttcctgtac cactaaatat
     3241 tccagacacc cctaccagtt ctaatgaaag actctatgat gtagaaatca aggaaaatcc
     3301 ttttggcatc caggttcgaa gaagaagcag tggaaagctt atctgggatt ctagtctgcc
     3361 tggatttgcc ttcaatgatc agtttatcca gatatctaca cgtctgccat caaattattt
     3421 atatggtttc ggggaagtgg aacacacggc attcaagcgc gatttgaatt ggcacacttg
     3481 gggaatgttc acaagagatc aacctcctgg atataaactt aattcctatg gatttcatcc
     3541 ctattatatg gctttggaga atgagggcaa tgctcatgga gttctgttac tgaacagcaa
     3601 tggaatggat gttacattcc agccaactcc tgctctaaca taccgcacaa ttggtggaat
     3661 cttggatttt tacatgtttt tgggaccaac accagaaatt gcaacaagac aatatcatga
     3721 agtaattggc tttccagtca tgccacctta ctgggctcta ggattccaat tatgtcgtta
     3781 tggatacaga aatacttcag agattgaaca actatataac gacatggtgg ctgctaatat
     3841 cccctatgat gttcagtata cagacatcaa ttatatggaa aggcaactag acttcacaat
     3901 tggtgaacga ttcaagactc ttcctgaatt tgttgaccga ataagaaaag atggaatgaa
     3961 atatattgtt atactggatc cagcaatttc aggaaatgaa acacagcctt accctgcctt
     4021 tgaacgggga atacagaaag atgtttttgt caaatggcct aacacaaatg acatttgttg
     4081 ggcaaaggtc tggccagatt tacctaatgt tacaatagat gagactataa ccgaagatga
     4141 agctgttaac gcttccagag cacatgtagc atttccagac ttctttagga attccacatt
     4201 ggagtggtgg gcaagagaaa tttatgattt ctacaatgaa aaaatgaagt ttgatggctt
     4261 gtggattgat atgaatgagc cttctagttt tgtaaatgga acagttacta ataaatgcag
     4321 aaatgataca ctaaattatc caccgtattt cccagaactc acgaaaagag gtgaggggct
     4381 acatttccga accatgtgta tggagactga acatatactt agcgatggct catcagtttt
     4441 gcattatgat gttcacaatt tatatgggtg gtctcaagta aaacccactc tggatgcatt
     4501 acagaacacc actggtctga gagggatagt catctctcgg tccacatatc ccacagctgg
     4561 tcgatggggt ggacactggc ttggagacaa ttatgcaaac tgggataatt tggaaaaatc
     4621 actcattggc atgctggaat ttaatctttt tgggatacca tacattggag cagatatctg
     4681 cggctttttt aatgattcag aataccatct ctgtactcgt tggatgcaag ttggagcctt
     4741 ttatccatat tcaaggaatc acaacattca atttactaga aggcaagatc ctgtttcctg
     4801 gaatgaaact tttgctcaaa tgtcaaagaa agttctagaa atcagataca ctttgctgcc
     4861 ctatttctac acacagatgc atgaagccca tgctcaaggt ggaactgtca tcagacccct
     4921 catgcatgag ttctttgatg ataaagaaac ctgggaaata tacaagcagt tcctatgggg
     4981 tccagctttt atggtgactc ctgtcgttga acctttcagg accagtgtga ctggctatgt
     5041 tcctaaggct cgatggtttg actaccatac aggggaagat ataaagctca aaggaatact
     5101 tcacacattt tcagctccct ttgatacaat aaatctacac gtccgaggag gttacattct
     5161 accatgtcaa gagccagcac ggaacacaca tctaagtcga cagaattaca tgaagctcat
     5221 tgttgctgca gatgacaacc aaatggcaca agggactcta ttttgggatg atggagagtc
     5281 tatagacact tatgaaagag gtcaatacac ctcgatacaa ttcaatttaa atcagacaac
     5341 tttaacaagc actgtattgg caaatgggta taaaaacaaa caggagatga gacttggaag
     5401 catccacata tgggggaaag gaacactccg tatcagcaat gctaatttga tttatggagg
     5461 aagtaaacat cagcctcctt ttactcaaga ggaagctaag gagacactaa tatttgacct
     5521 gaaaaatatg aatgttactc ttgatgaacc aatacaaatc acctggtcat gaagatcaac
     5581 atcagtttga gttcctgagg aggaattgat atcaggtcca tggttctatt tccatttttc
     5641 ctgactacat acgttctttg aaacacaatt atcatgctcc ttatccaaat atttctccat
     5701 tgtttgcatc aaaagaaatg ctagcttgtg ctacaaatgc atcctggatg ccactgctca
     5761 gcaggttgaa aaggatttga atgattatga taccttgcaa gtcacagcta aacagctaaa
     5821 cctgtaaact tgtatgcata caactaggtt atgattaatg gaagtgattt ttaaattaaa
     5881 atttttgtat ctataaatta tatatactaa tacattcaat tgtgtaggct aaacttattt
     5941 aacatatcac aatatttaat cattttgtac tatgtatatt tcattttaaa acagaaaata
     6001 aaagttgtat aaatacatta a
//
