LOCUS       NM_001191730            4741 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus shroom family member 4 (Shroom4), mRNA.
ACCESSION   NM_001191730 XM_228786
VERSION     NM_001191730.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4741)
  AUTHORS   Zapata,J., Moretto,E., Hannan,S., Murru,L., Longatti,A., Mazza,D.,
            Benedetti,L., Fossati,M., Heise,C., Ponzoni,L., Valnegri,P.,
            Braida,D., Sala,M., Francolini,M., Hildebrand,J., Kalscheuer,V.,
            Fanelli,F., Sala,C., Bettler,B., Bassani,S., Smart,T.G. and
            Passafaro,M.
  TITLE     Epilepsy and intellectual disability linked protein Shrm4
            interaction with GABABRs shapes inhibitory neurotransmission
  JOURNAL   Nat Commun 8, 14536 (2017)
   PUBMED   28262662
  REMARK    GeneRIF: Shrm4 interaction with GABA-B receptors shapes inhibitory
            neurotransmission.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4741)
  AUTHORS   Yoder,M. and Hildebrand,J.D.
  TITLE     Shroom4 (Kiaa1202) is an actin-associated protein implicated in
            cytoskeletal organization
  JOURNAL   Cell Motil Cytoskeleton 64 (1), 49-63 (2007)
   PUBMED   17009331
REFERENCE   3  (bases 1 to 4741)
  AUTHORS   Dietz,M.L., Bernaciak,T.M., Vendetti,F., Kielec,J.M. and
            Hildebrand,J.D.
  TITLE     Differential actin-dependent localization modulates the
            evolutionarily conserved activity of Shroom family proteins
  JOURNAL   J Biol Chem 281 (29), 20542-20554 (2006)
   PUBMED   16684770
REFERENCE   4  (bases 1 to 4741)
  AUTHORS   Hagens,O., Dubos,A., Abidi,F., Barbi,G., Van Zutven,L.,
            Hoeltzenbein,M., Tommerup,N., Moraine,C., Fryns,J.P., Chelly,J.,
            van Bokhoven,H., Gecz,J., Dollfus,H., Ropers,H.H., Schwartz,C.E.,
            de Cassia Stocco Dos Santos,R., Kalscheuer,V. and Hanauer,A.
  TITLE     Disruptions of the novel KIAA1202 gene are associated with X-linked
            mental retardation
  JOURNAL   Hum Genet 118 (5), 578-590 (2006)
   PUBMED   16249884
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Jul 17, 2010 this sequence version replaced XM_228786.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.1437942.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000021.1  18748399-18748515   c
            118-269             JAXUCZ010000021.1  18638250-18638401   c
            270-404             JAXUCZ010000021.1  18585195-18585329   c
            405-2889            JAXUCZ010000021.1  18580491-18582975   c
            2890-2951           JAXUCZ010000021.1  18575334-18575395   c
            2952-3743           JAXUCZ010000021.1  18550094-18550885   c
            3744-3924           JAXUCZ010000021.1  18545441-18545621   c
            3925-4194           JAXUCZ010000021.1  18542513-18542782   c
            4195-4741           JAXUCZ010000021.1  18540913-18541459   c
FEATURES             Location/Qualifiers
     source          1..4741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..4741
                     /gene="Shroom4"
                     /gene_synonym="RGD1563434"
                     /note="shroom family member 4"
                     /db_xref="GeneID:317391"
                     /db_xref="RGD:1563434"
     CDS             1..4464
                     /gene="Shroom4"
                     /gene_synonym="RGD1563434"
                     /codon_start=1
                     /product="protein Shroom4"
                     /protein_id="NP_001178659.1"
                     /db_xref="GeneID:317391"
                     /db_xref="RGD:1563434"
                     /translation="MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGG
                     KAALSQKMRTGDELVNINGTPLYGSRQEALILIKGSFRILKLIVRRRNTPVSRPHSWH
                     VAKLLEGCPDVATTMHFPSEAFSLSWHSGCNTSDVSVQWCPLSRHCSTEKSSSIGSME
                     SLEQPGQATYEGHLLPIEQNMYPSQRDSAYSSFSASSNASDCALSLKPEEPPSTDCVM
                     SGPGPTKVTDDQANVSETSGSSHSTSGGHMTSTSHASSCSEEGHHSGPAKMVRGPPEP
                     PVRRDSLQASRAQLLNGEQHRASEPVDSLQQKEKPALETMLPPRSSNQFCCISGQDQV
                     TGEDHQNCELSKPSESSQDDCDHLLIEGSSKALDSPKAHDKGSNKEFGLLKEASADLA
                     NTLSFGAIPHLRGSIEHRHSAPEQLLASHLQQMHLDSRGNKGMELPTGQDGHQWTMSP
                     LHNNPKGKKSPGLPTGGTQDQTSKERKIKPTDDKLMVSANQSQSDALLGEVDGHPSER
                     TYLDSNRASRASSDLTGQQPSATCSPVQQTRDFFSANKVVGHTEATEEGDNEPKEGGR
                     LGGRRSGGPRGRSIQNRRKSERFATNLRNEIQRRKAQLQKSKGPLSQLCDTKEDVEET
                     QEPPESPPLPASNSSLLPSYKNVPSHGDQLFNKSMILRARSSECLSQASESSKARVGL
                     EGRMSPGQRSGQSSLALNTWWKASDSSTLDTEKANAHHGVCRGHWRWSPEHNAQPQVA
                     LSTEGPSNPDDNKELKIPTPQAGDEAILMPFADRRKFFEESSKSLSTSHLPGLTTHNK
                     PFIQRPKPIDQNFQSVSYRELRCHPMDQSYHSADQPYHAADQSYHSLSPLQSEAPTYP
                     DCFAPKGVDNSLYCKPVHHGDCDYHRTCSHPCSAQGTVMHDPCICCSGEICPALLKRN
                     LLPKCHNCRCHHHQCIRCTGCCHSPQHGAHEDSSMASGNAWKSRKAAIQEFPVDKWKP
                     ITGNRKTSHSGREMAHSKANLSLSAPFRPHIENSALDLSNYRAVSSLDLLGDFKHASN
                     TPEESSVYEDESSVASMPRPLRSRAFSESHISLEPQNTRAWGKQQRESFSKGSETQPD
                     TLGARKKAFPPPRPPPPNWEKYRLFRAAQQQQQQQQQQQQQQQQQQQQCEKEEEEEKE
                     QEEKGEKEEDLPPQYFSSETTGSCAPITEEQPQSLKMGHQEASRQSSQSLQEQEAYAV
                     HPSNFVPAVRSYPVTQPEKAQPPCYYGAHGLWRTTEQEATVTPKQEFQHFSPPTGASG
                     IPTSYSAYYNISVAKAELLNKLKQQPEMAEAGLGEEGVDYELAQKKIQLIESISRKLS
                     VLREAQRGLLDDINANAALGEEVEVNLKAVCKSNELEKYHLFIGDLDKVVNLLLSLSG
                     RLARVENALNSIDAESNQEKLVLREKKQQLTNQLADAKELKEHVDRREKLVFSMVSRY
                     LPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQLKCLKESLHLGPSNF"
     exon            1..117
                     /gene="Shroom4"
                     /gene_synonym="RGD1563434"
                     /inference="alignment:Splign:2.1.0"
     exon            118..269
                     /gene="Shroom4"
                     /gene_synonym="RGD1563434"
                     /inference="alignment:Splign:2.1.0"
     exon            270..404
                     /gene="Shroom4"
                     /gene_synonym="RGD1563434"
                     /inference="alignment:Splign:2.1.0"
     exon            405..2889
                     /gene="Shroom4"
                     /gene_synonym="RGD1563434"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..2951
                     /gene="Shroom4"
                     /gene_synonym="RGD1563434"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3743
                     /gene="Shroom4"
                     /gene_synonym="RGD1563434"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..3924
                     /gene="Shroom4"
                     /gene_synonym="RGD1563434"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..4194
                     /gene="Shroom4"
                     /gene_synonym="RGD1563434"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..4741
                     /gene="Shroom4"
                     /gene_synonym="RGD1563434"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagaacc ggccggggtc cttccagtac gtcccggtgc agctgcaagg gggggcgccc
       61 tggggcttca ccctgaaggg gggcttggag cactgcgagc cgctcacggt gtcgaagatt
      121 gaagatggag gcaaggcagc cttgtcccag aagatgcgga ctggtgatga actggtaaat
      181 atcaatggca ctccattgta tggctcccgc caagaggccc tcatcctcat caaaggctcc
      241 ttcaggatcc tcaagctgat tgtcaggagg agaaacaccc ctgtgagtag gccgcactca
      301 tggcatgtgg ccaagctatt ggaggggtgc cctgacgtgg ccaccaccat gcatttccct
      361 tctgaagcct tcagcttgtc ctggcattct ggttgcaaca caagtgacgt gagtgtacag
      421 tggtgcccac tctcccggca ttgtagcact gagaaaagca gctctattgg cagcatggag
      481 agcctggaac agccaggcca agctacctac gagggccacc tcttacccat tgagcagaac
      541 atgtacccca gccagcgtga ctcagcctac agctccttct cagccagctc aaatgcctct
      601 gactgtgccc tttcccttaa gccagaggaa ccaccctcta cagactgtgt catgtcaggc
      661 ccagggccga ctaaagtcac tgatgaccaa gctaatgtat ctgagacctc aggaagtagc
      721 catagtacca gtgggggcca catgacctcc acttcccatg catcatcctg ctcagaagaa
      781 gggcaccact caggacctgc caagatggtg cggggtccac cagagcctcc agtgaggcgg
      841 gacagccttc aggcctctag agcccaactt ctcaatggag agcagcatcg tgcatctgaa
      901 cctgtggact ccttacagca aaaggaaaaa ccagccttag agacaatgct gcccccaagg
      961 agctctaacc agttctgctg cattagtggg caagaccagg tgacaggtga ggaccaccag
     1021 aactgtgagc tcagcaagcc ttctgaatcc agccaggatg actgtgacca tctactgata
     1081 gagggctcct ccaaagctct tgattctcca aaggcccatg acaaaggttc caacaaagag
     1141 tttggcctgc ttaaggaggc ttcagcagat ctggctaaca ctttgtcttt tggtgccatc
     1201 ccgcacctcc gaggaagcat agaacatcgc catagtgctc ctgaacagct gttggcatcc
     1261 cacttgcagc agatgcacct tgattccaga ggcaacaagg ggatggagtt gccaactggg
     1321 caggatggac accagtggac catgtcccct ttgcacaaca accctaaagg gaagaaaagt
     1381 ccaggtctcc ccacaggagg tacccaggac cagaccagca aagaaaggaa gatcaagccc
     1441 acagatgata agctgatggt ttctgcaaac cagagccaaa gtgatgccct acttggagag
     1501 gtcgatggac acccatcaga acgaacttac ctagactcaa accgagcaag cagagcaagc
     1561 agtgacttga ctggccagca gccctctgcc acttgctccc ctgttcaaca aaccagagac
     1621 ttcttttcag ccaataaagt agttggtcac actgaagcaa ctgaagaagg tgacaatgag
     1681 cctaaggaag gtggccgatt gggtggcaga agaagtggag gcccccgagg tcgctccatc
     1741 caaaaccgac ggaagagtga gaggttcgct accaatctac ggaatgaaat tcagaggagg
     1801 aaagcccagc tccagaaaag taagggcccc ttgtcacaat tgtgtgacac taaggaagat
     1861 gtggaagaga cccaagagcc tccagaaagc cctccactcc ctgcttctaa ctcatccctt
     1921 ctgccttcat ataaaaacgt ccctagccat ggagatcagc tctttaacaa aagcatgatt
     1981 ctcagggcta ggtcttcaga atgcctcagc caagcctcag agagctctaa agctagggta
     2041 ggcttagagg gaagaatgag ccctggccag aggtctggcc agtcttcttt ggccctgaac
     2101 acatggtgga aggcatctga ctcatccacc ttagacactg agaaagcaaa tgctcaccac
     2161 ggggtctgta gaggtcactg gagatggtct ccagaacata acgcacagcc acaggtggca
     2221 ctctccacag agggtccttc caacccagat gacaacaaag aattgaagat acctactcct
     2281 caggctgggg atgaagccat cctcatgcca tttgcagaca gaagaaagtt ctttgaagag
     2341 agcagcaaat ctttatctac atctcatttg ccaggcttaa ccactcacaa caagccattt
     2401 atccagagac caaaacctat agatcaaaac ttccagtcag tgagctatag ggaattacga
     2461 tgccatccta tggaccaatc atatcattct gcagaccaac cataccatgc tgctgaccaa
     2521 tcatatcatt ccttgtcacc acttcagtca gaagctccca cttacccaga ctgctttgct
     2581 cccaaaggcg tagataattc cctgtactgt aagccagtgc accatgggga ttgtgattac
     2641 cacaggacct gttctcatcc ctgcagtgct cagggaactg taatgcatga tccttgcatt
     2701 tgctgttctg gagaaatttg ccctgccttg ctaaagagaa atttgttgcc aaaatgccac
     2761 aactgtaggt gtcaccatca ccaatgcatc cggtgtacag gttgctgtca cagtcctcag
     2821 catggtgccc atgaggacag cagtatggca tctggcaatg cttggaaatc caggaaggca
     2881 gccatacagg aatttcctgt ggacaagtgg aagccaataa caggaaacag gaaaactagt
     2941 cattccggga gggaaatggc tcattctaag gccaacttgt cattgtctgc tcccttccgg
     3001 cctcacattg agaactcagc actggacttg tcaaactacc gagcagtctc ttcgcttgac
     3061 ctccttggag acttcaaaca tgcctcgaac actccagagg aatcttcagt ttatgaggat
     3121 gagagctccg ttgcctccat gccccgccca ctgcggagcc gagccttctc tgagagtcac
     3181 atcagtttag agccacaaaa cacccgggcc tgggggaaac agcaaaggga atcatttagt
     3241 aaaggcagtg agactcagcc agatactctt ggggcccgaa agaaggcctt tcctccccct
     3301 cgccctcctc ctcccaattg ggaaaaatat aggctctttc gtgcagcgca gcagcagcag
     3361 cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcaatg tgaaaaggaa
     3421 gaagaggagg agaaggagca agaggagaag ggagagaaag aagaggacct accgccccag
     3481 tattttagtt cagaaaccac tggatcatgt gcccctatta cagaggagca gccacagtcc
     3541 ctgaagatgg gccaccagga agcctcaagg cagagttcac agagcctcca agagcaagag
     3601 gcctatgctg tgcatcccag caattttgtg cctgcagtaa ggagctaccc tgtaacccag
     3661 cccgagaaag ctcaacctcc ttgctattac ggcgctcatg gactgtggag gacaactgag
     3721 caagaagcta ctgtgacccc aaaacaagag tttcagcact tctcacctcc tacaggggcc
     3781 tcaggaatcc ctacctctta ctcagcttat tataatatct ctgtggccaa ggcagaactg
     3841 ctgaacaagt taaaacagca gcctgagatg gctgaggcag gcctgggaga ggagggagtt
     3901 gactatgaac tggctcaaaa aaagattcag ctcattgaaa gcattagtag aaaactttct
     3961 gtcctgcggg aggcccagcg tgggctactg gatgacatca atgccaacgc tgcccttgga
     4021 gaggaggtgg aggtcaactt aaaagctgtc tgcaagtcca atgagttgga aaagtatcat
     4081 ttgtttattg gagacctgga caaagtggtc aacctgttgt tgtcactctc tggacgactg
     4141 gcccgggtag agaatgctct caacagcatc gatgctgagt ccaaccagga gaagttggtg
     4201 ctgagagaga agaagcagca gctgacgaac cagttggcag atgccaaaga gctgaaggag
     4261 catgtggacc gcagggagaa gctggtgttc agcatggtct cccgctacct gccgcaggac
     4321 cagctccaag attaccagca ctttgtgaag atgaaatctg ctctcatcat tgagcagaga
     4381 gagctggagg agaagatcaa acttggagaa gaacagctta aatgcctcaa agagagcctg
     4441 cacttggggc ccagcaattt ctaattacag cagaagtgtg ccattgcacc agtggaaaag
     4501 ggctctgtct ttaggagcag tttgttagcc aagtatatcg aaattactta gcagatgagt
     4561 ccagccatct accttggcca gccatcaagg agagcctggg aaggccccat gcttctctcc
     4621 tatggagctg cagcgaggta tggctacact gccatgctct ttctcagtaa atgagactta
     4681 aaaagtgcct tcatctctgt accagaatac caaagacttc acaaactcaa tgctctccct
     4741 t
//
