LOCUS       NM_001100889            6781 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus shroom family member 3 (Shroom3), mRNA.
ACCESSION   NM_001100889 XM_001070669 XM_223229
VERSION     NM_001100889.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6781)
  AUTHORS   Yeo,N.C., O'Meara,C.C., Bonomo,J.A., Veth,K.N., Tomar,R.,
            Flister,M.J., Drummond,I.A., Bowden,D.W., Freedman,B.I., Lazar,J.,
            Link,B.A. and Jacob,H.J.
  TITLE     Shroom3 contributes to the maintenance of the glomerular filtration
            barrier integrity
  JOURNAL   Genome Res 25 (1), 57-65 (2015)
   PUBMED   25273069
  REMARK    GeneRIF: variants disrupting the actin-binding domain of SHROOM3
            may cause podocyte effacement and impairment of the glomerular
            filtration barrier
REFERENCE   2  (bases 1 to 6781)
  AUTHORS   Hildebrand,J.D.
  TITLE     Shroom regulates epithelial cell shape via the apical positioning
            of an actomyosin network
  JOURNAL   J Cell Sci 118 (Pt 22), 5191-5203 (2005)
   PUBMED   16249236
REFERENCE   3  (bases 1 to 6781)
  AUTHORS   Klezovitch,O., Fernandez,T.E., Tapscott,S.J. and Vasioukhin,V.
  TITLE     Loss of cell polarity causes severe brain dysplasia in Lgl1
            knockout mice
  JOURNAL   Genes Dev 18 (5), 559-571 (2004)
   PUBMED   15037549
REFERENCE   4  (bases 1 to 6781)
  AUTHORS   Hildebrand,J.D. and Soriano,P.
  TITLE     Shroom, a PDZ domain-containing actin-binding protein, is required
            for neural tube morphogenesis in mice
  JOURNAL   Cell 99 (5), 485-497 (1999)
   PUBMED   10589677
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Dec 20, 2009 this sequence version replaced
            XM_223229.4, XM_001070669.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760400
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000014.1  15680099-15680263   c
            166-320             JAXUCZ010000014.1  15574091-15574245   c
            321-452             JAXUCZ010000014.1  15429579-15429710   c
            453-584             JAXUCZ010000014.1  15414419-15414550   c
            585-3789            JAXUCZ010000014.1  15407033-15410237   c
            3790-3860           JAXUCZ010000014.1  15400919-15400989   c
            3861-4679           JAXUCZ010000014.1  15397312-15398130   c
            4680-5168           JAXUCZ010000014.1  15395434-15395922   c
            5169-5319           JAXUCZ010000014.1  15393474-15393624   c
            5320-5592           JAXUCZ010000014.1  15386547-15386819   c
            5593-6781           JAXUCZ010000014.1  15383769-15384957   c
FEATURES             Location/Qualifiers
     source          1..6781
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..6781
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /note="shroom family member 3"
                     /db_xref="GeneID:305230"
                     /db_xref="RGD:1310470"
     CDS             1..5961
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /codon_start=1
                     /product="protein Shroom3"
                     /protein_id="NP_001094359.1"
                     /db_xref="GeneID:305230"
                     /db_xref="RGD:1310470"
                     /translation="MRTPENLEEPSATPNSSRTPKERYVYLEALLEGGAPWGFTLKGG
                     LEHGEPLIISKIEEGGKADSVSSGLQTGDEVIHINEVVLSSSRREAVSLVKGSYKTLR
                     LVVRRDVCAAPGHADPGTSNSISSELLTCSPQHRKATWSGGVKLRLKQRCSEPAARPH
                     SWHTTKFGETQADVSMMRISQGTVGPPWHQSCHSSSSTSDLSNYDHAYLRRSPDRCSS
                     QGSMESLGPRGGSPPCHLLSPAKSTSSIDQLGHLHNKRDSAYSSFSTSSSIFEYPPPG
                     GSARERSGSLDMIPARGGLLEGMRQADIRYVKTVYDTRRGVSSEYEVNPSALLLQGRD
                     AHTSADSQGCAKWHSIPRGKGTPPLPWSQQCSGSPETADNPPHKAGAPMPPTRSDSYV
                     ALRHRERPSSWSSLDQKRFCRPQTNSLGSQKTPFVEEQLHTVPERSPENSPPVKPKHN
                     YTQKTQPGQPLLPTGIYPVPSPEPHFAQVPQPSVSGNGTVYPALVKESGYTAAQGTCS
                     KMAALDENGNQKEVSRPGFAFCQPPEHDSMTPVEKKPEPRAKYIPYKVHFSSVPENED
                     SSLKRHVTPPHGNSLYPSERKNVHGGGSRPCSNHHSLPSAQAQAPHAGDDDRRPSRLF
                     QPWEGDFQEDHNANLRQKVEREGQGQGLPGNSGGTKSTFSPLQNIPENLRRQSSVDLG
                     EGLEVYPGGRSTCATTTTKVEDPGRKAGPDNRGYLDRSVSYPRPEGKMNAAESFHSAD
                     SRYEEPLAAPPQQTSGMSQRRLSASSTPALQYKKPHCSVLEKVSKIEEREQGRHRPTS
                     VGSSAYALSYRPGRTGPTPSTSSSDLDDPKASSSHFSESAAEHLRNGEQNPPNGEPKL
                     EEASRQQCNQLLRRTTADGRGPPARGSEPSRPEARLLRSQSTFQLFSEAEREASWSED
                     RPSTPESPLLDAPFSRAYRNSIKDAQSRVLGATSFRRRDLEPGTPATSRPWRPRPASA
                     HVGMRSPEASAPLSSPHTPRERHSVTPATGTPPAPQAARRGARRRLTAEQKKRSYSEP
                     EKMNEVGVSEEAESVHCVPQRPAQLRFSESTVADRRRLFERDGKACSTLSLSGPELKQ
                     FQQSALADYIQRKTGKRPTGAACTPEPGLRERAQSVYFQAVPAAPEGPGLASACSLSS
                     LREPEVLPCKEHPHQSAADGPQTPRDRSSSFASGRLVGERRRWDPQAPRQLLSGANCG
                     PRGVQRMDRTSRGPPSWDMVVGKSGKSKSAEDLLERSDTLTVPVHVRSRSSPTSDKKG
                     QDVLLREDSGFGFVKDPYLAGPGSRPLSYSDRGQKEQALPLHHPATCWNGSGYKATVV
                     SSTESSGAPDHLKQLRAPCPRPLSAGMHGHFPDARASSVAPLSSPLPSPVPSGYRSQL
                     DMDQQMGHQPLPSPASAVTQPPSPRSHELEEGMWKRASLPQRPPRPWKWAHAVREDGL
                     AEDASSAPEFATLKHYKNQLSLPSSCSTSDPDTPGRISLRISESALQASPPPRGDYDD
                     EVFVKDLHPKVPSSPTFEALPPPPPPPSPLSQEPLTCGSDDFPSPPPQAMCEAPLDGE
                     VSEEPGSGSCGLPRVTATREGQVPGAGHAEGSQIMVAIPPQTSAEGSAAESSTAARVS
                     AQPPLHSFPGKQPCPSQARNLTYEPADRTQDLGKKIHAEPQKTSEDIRTEALAKEIVH
                     QDKSLADILDPDSRMKTTMDLMEGLFPRDAGVLKENAERRAVDSTTRRAGWEVETSDH
                     KEAAGVLVNCPAYYSVSAAKAELLNKIKDMPEELREEEEQEDVNEKKAELIGSLTHKL
                     ETLQEAKGSLLTDIRLNNALGEEVEALISELCKPNEFDKYKMFIGDLDKVVNLLLSLS
                     GRLARVENVLSGLGEDASKEERSSLNEKRKVLAGQHEDARELKENLDRRERVVLDILA
                     NYLSAEQLQDYQHFVKMKSTLLIEQRKLDDKIKLGQEQVRCLLESLPSDFRPKAGAIS
                     LPPALASHVTPGGGPAFGGVFPTLTSPL"
     exon            1..165
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            166..320
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            321..452
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            453..584
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            585..3789
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            3790..3860
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..4679
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            4680..5168
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            5169..5319
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            5320..5592
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            5593..6781
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaggaccc ccgagaactt ggaggagcct agcgccactc caaactccag caggaccccc
       61 aaggagagat acgtttatct ggaagcgctc ctagagggag gggctccctg gggcttcacc
      121 ctgaaaggtg gcctggagca tggagaacca ttaattattt ccaagatcga agaaggcggg
      181 aaggctgact ccgtgagctc cggactgcaa actggagatg aagtcataca catcaatgag
      241 gtggtgctga gcagctccag gagagaggct gtctccctgg tgaaaggatc ctacaagacc
      301 ctccggctgg tggtacgcag agacgtgtgt gcagccccgg gccatgcaga tcctggtacc
      361 tcgaattcca tcagctcaga gctgctcacc tgcagtcccc agcaccggaa agcaacatgg
      421 tcaggagggg tgaaacttcg gctaaagcag aggtgcagtg aacctgccgc tcgcccacac
      481 tcgtggcata ccaccaaatt tggagagacc caggctgacg tcagcatgat gcggatatct
      541 cagggcacag tgggccctcc ttggcaccag agctgccatt ccagctcttc tacgagtgac
      601 ctctccaact acgaccatgc ttatctgagg cggagccctg accggtgcag ctcccagggg
      661 agcatggaaa gcctgggtcc ccgtggcggg tccccacctt gccatcttct ttcccctgcc
      721 aagtccacga gcagcatcga ccagctaggc caccttcata acaaaagaga ctcggcctac
      781 agctccttct ccaccagttc cagcatcttc gagtacccgc ccccgggtgg ctctgcccga
      841 gaacgttcag gctccctgga catgattcct gcccggggcg gcctcctaga agggatgagg
      901 caggcagaca ttcgctatgt caagacagtt tacgataccc ggaggggagt atcttcagag
      961 tatgaggtga acccttcagc cttgcttctt caaggtaggg atgcccacac ctcagcagac
     1021 agtcagggct gtgctaaatg gcacagcatt cctcggggca agggaacacc tcccctgcct
     1081 tggagccagc agtgttctgg ttccccggag actgcggaca acccacccca taaggctggc
     1141 gcacccatgc ccccaactcg cagtgacagt tatgtggccc tccggcatcg tgagcgtccc
     1201 agctcctggt ccagccttga tcagaaaagg ttctgccgtc ctcagacgaa ctctttgggc
     1261 tcccagaaaa ccccattcgt cgaggaacag ctacataccg tcccagagag gagcccggag
     1321 aacagccccc cagtgaaacc taagcataat tatacccaga agacgcagcc tggccaacct
     1381 ctactgccca cgggcatcta tccggtacct tctccagagc ctcactttgc ccaggtgccc
     1441 cagccctctg tgagtggtaa tggtacagtc taccctgcac tggtcaaaga gagtggatac
     1501 acagctgctc agggaacttg tagcaagatg gctgccttag acgagaacgg gaatcaaaaa
     1561 gaagtgagca ggcctgggtt tgccttctgt cagcccccag aacacgactc gatgactcca
     1621 gtggagaaaa agccagaacc cagggccaaa tacatcccct acaaagtcca tttttcttca
     1681 gtgcctgaaa atgaagactc ctccctcaag agacacgtca cacctcccca cggcaatagc
     1741 ctatacccca gcgagagaaa gaacgttcac ggtggtggca gcagaccgtg ttctaatcac
     1801 cacagtctcc cgtccgctca agcccaggcc ccgcacgcgg gtgatgatga caggaggcct
     1861 tccaggctct tccagccctg ggagggtgac tttcaggaag atcacaatgc caacctcagg
     1921 cagaaagtgg agagggaagg ccaaggccag ggcctgccag gcaactctgg tgggaccaaa
     1981 tcgaccttct cacctctcca gaatattcca gaaaatctaa gaagacaaag cagcgtggac
     2041 ctaggagaag gcctggaggt ttaccccggt ggcagatcca cctgtgccac caccaccacc
     2101 aaggtggagg accctgggag gaaagcaggg cccgacaaca ggggctacct ggacaggtct
     2161 gtttcctatc caaggcccga ggggaaaatg aacgctgcag aatccttcca cagtgcagac
     2221 tccaggtatg aagagcccct ggccgcgcca ccgcagcaga catccggtat gagccagagg
     2281 aggctcagtg ccagcagtac ccctgccctg cagtacaaga agccccactg ctccgtgctg
     2341 gagaaggttt ctaagataga ggagcgagag caagggcgcc acagacccac gagtgtgggc
     2401 agctccgctt acgccctcag ctacaggcct ggtaggactg gccccactcc tagtacttcc
     2461 agcagtgacc ttgatgatcc aaaagccagc agctcccatt tctctgagtc cgccgccgaa
     2521 cacctgcgaa atggggagca gaacccccca aacggggagc ccaaactgga agaggcttcc
     2581 aggcagcagt gcaaccagct gctgaggagg accactgcag atggccgtgg acctcctgcc
     2641 cgaggcagcg agccctcaag gcccgaggcc cgcctgctcc gcagccagag cacctttcag
     2701 ctcttcagtg aggcggagag agaagcctcg tggtcggagg ataggcccag cacccccgag
     2761 tcacccctcc tagacgcacc cttcagccgc gcctacagga acagcatcaa ggatgcccag
     2821 tcccgtgtcc tgggggccac atcatttcgt cgccgggacc tggaaccggg cacccccgcg
     2881 acttcgaggc cttggcgccc gcgacccgcc tctgcccacg tgggcatgcg gagccccgag
     2941 gcctcggcac ccttgtcctc cccgcacacc cctcgggaga gacacagcgt gaccccggcc
     3001 acagggaccc cgcctgcacc ccaggctgcc cgcagagggg cacgccggcg cctcacagcc
     3061 gagcagaaga agcgttccta ctcggagccg gagaagatga acgaggtcgg ggtctcggag
     3121 gaggctgagt ccgtgcactg cgtcccacag aggccagcgc agctgcgctt ctcggagagc
     3181 accgtggccg accggcgacg cctcttcgag cgcgacggca aggcctgctc cacgctcagc
     3241 ctgtctggcc ctgaactgaa gcagttccag cagagcgccc tggccgacta catccagcgc
     3301 aagaccggca agcggcccac tggagctgcc tgcacgccgg aacccgggct gcgcgagcgc
     3361 gcacagagcg tctactttca ggcggtcccc gcggcgcccg aaggccccgg cctggcctcc
     3421 gcctgcagcc tgagttcgct acgggagccc gaggtgctgc cctgcaagga gcacccccat
     3481 cagtccgccg cagatggtcc acagacgccc cgagatcgca gcagctcctt tgccagcgga
     3541 cgcctagtcg gggagcgacg acgctgggac cctcaggccc ccaggcagct gctcagtgga
     3601 gctaactgcg gacccagggg cgtccagagg atggacagga cctccagagg gccgccttcc
     3661 tgggacatgg tggtcgggaa gtcagggaag tccaagtcag ccgaggatct gctggagcgc
     3721 tcggacacac tgaccgttcc tgtgcatgtg aggtccaggt cgtctcccac ctcggacaag
     3781 aaaggtcagg atgtgctcct cagagaagac agtggctttg gttttgtgaa ggatccatat
     3841 ttggctggcc ctggatctag gcctctcagc tactcggaca gaggccaaaa ggagcaggca
     3901 ttgcccctgc accatcctgc cacttgctgg aatggctcag gctacaaagc cactgtggtt
     3961 tcctctactg aatcttccgg agccccagat catctgaagc aacttagagc accttgccct
     4021 aggccacttt cagcaggaat gcacggccac ttcccagatg ccagagcctc ctccgtggcc
     4081 cccctcagct cccctctgcc atcacctgtc ccctccggtt accgctcaca gcttgacatg
     4141 gatcagcaga tgggacatca gcctctcccc tcccctgcct ctgcagtgac gcagcctccc
     4201 agcccaagaa gccatgagct agaggaggga atgtggaaga gggcgtccct gcctcagcga
     4261 ccccctcgac cttggaagtg ggcccacgca gtccgagagg acggccttgc tgaggacgcc
     4321 tcatcggcgc ctgagtttgc aaccctgaag cactataaaa accagctgag tcttccgagt
     4381 tcgtgcagca cttctgaccc agacactcca gggaggatct ctctccgaat atccgagtca
     4441 gccctacaag cttccccgcc accccggggg gactatgatg atgaggtgtt cgtgaaggac
     4501 ttgcacccca aggttccttc aagccccaca tttgaagctc tccccccgcc cccaccacca
     4561 ccttctccac tgagccagga gcctctaacg tgtggctcag atgactttcc ttcacctcct
     4621 ccccaagcca tgtgtgaggc accgctggat ggcgaagtat cggaggagcc cggcagcggt
     4681 tcctgcggac ttcccagggt gacagccacg agggaaggac aggtgcccgg ggcaggccat
     4741 gcagaaggaa gtcagataat ggttgccatc ccaccccaaa cttcggccga aggctcagca
     4801 gccgagtcca gcactgctgc ccgagtgagc gcccagcctc cgctccacag ttttcctggc
     4861 aagcagccct gtcccagcca ggcccgaaac ctcacttacg aacctgctga cagaactcag
     4921 gatctaggga agaaaatcca tgctgagccc cagaagactt cagaagatat ccgaacggag
     4981 gctctcgcca aggaaattgt ccaccaagac aagtctctgg cggacatttt ggacccggac
     5041 tccagaatga agaccacgat ggatctgatg gagggtctgt tccccaggga tgctggtgtg
     5101 ctgaaggaga acgctgagag gagagccgta gacagcacca ccaggcgtgc tgggtgggaa
     5161 gtcgagacga gcgaccacaa ggaggcagcg ggtgtgctgg tcaactgccc tgcgtactac
     5221 agtgtctctg ctgccaaggc ggaactgctg aacaaaatca aagacatgcc ggaggagctg
     5281 cgggaggagg aggagcagga ggacgtcaat gagaaaaagg ctgagctcat tggaagcctc
     5341 acccacaagc tggagaccct gcaggaagcg aaggggagtc tgctcacgga catcagactg
     5401 aacaatgccc tgggggagga ggtggaggcc ctgatcagtg agctctgcaa acccaacgag
     5461 ttcgacaagt acaagatgtt cataggcgac ttggacaagg tggtcaacct gctgctctcc
     5521 ctgtctggac gcctcgcccg agtagagaac gtcctcagtg gccttggtga agacgccagt
     5581 aaagaagaaa ggagttctct gaatgagaaa aggaaggttc tggctggcca gcatgaggat
     5641 gcccgggagc tcaaggagaa cctggaccgg agggagcgcg tggtgctgga tatcctggcc
     5701 aattacctgt ccgccgagca gctccaggac taccagcact tcgtgaaaat gaagtccaca
     5761 ctcctcatcg agcagcggaa gctggatgac aaaataaagc tgggccagga gcaggtcagg
     5821 tgtctgctgg agtcgctgcc ctcagacttc aggcccaagg caggggccat ctccctgccc
     5881 ccagccctcg ccagtcatgt gactcctggg gggggccctg cattcggtgg cgttttccca
     5941 acgttgacct ctcctcttta acctctcctg aaagacccga gcaaaagatg ccactctcaa
     6001 cactgttgaa tctgaaagat atttcaccac caaccacggt ttgagttgtg ggttattggg
     6061 ggcttcctga ggaaacggaa gagactatcc aggagtcttt gtgcctttca cagttggtct
     6121 tctacgagct tgcacacagc gggagccttt ccactctgtg ggaggaaagc cggtgacact
     6181 gagagagacc cgatgaaggg tgtctgatgt gcaggtttcc tcaggccaag gtgtcgtaga
     6241 ggaaggtgtg gcgccctcag gaatgtatcg gtggccttcc ttgctggcgg gcagtgcacc
     6301 ctgacacaaa gccttaaaaa gacatgcgcg cgcacacaca cacacacaca cacacacaca
     6361 cacacacaca cacacacaca caaagaagac tgttaacccc tgaacatttt tgttatttat
     6421 atttttaaaa atgaaaaaga tcattgtttg tgtgctaacc acttagttga ttctgttttg
     6481 cggtggatgt agacaattat gtttgagcgt tgtatttcgc gaaaacctta atgaagaatt
     6541 ccaaagatag tcaagttgaa tatggagatt tttgtggggt ttttcttctc atttgctctt
     6601 tgaaaaatct atttggtgtg tatgtatttg atactgggtg gctgtgagtg ccgcaggtta
     6661 cgtgcagaat tagacaactt tatgtgggtt ctgaggcttg gacctcggcc atcagtcttt
     6721 tcatccactc agccatcgtc agatggtaat aaagaccagt ggccattcta cacttgtgtt
     6781 a
//
