LOCUS       NM_001047893            6987 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus shroom family member 2 (Shroom2), mRNA.
ACCESSION   NM_001047893 XM_001064752 XM_228847
VERSION     NM_001047893.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6987)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 6987)
  AUTHORS   Etournay,R., Zwaenepoel,I., Perfettini,I., Legrain,P., Petit,C. and
            El-Amraoui,A.
  TITLE     Shroom2, a myosin-VIIa- and actin-binding protein, directly
            interacts with ZO-1 at tight junctions
  JOURNAL   J Cell Sci 120 (Pt 16), 2838-2850 (2007)
   PUBMED   17666436
  REMARK    GeneRIF: Characterization and functional analysis of the mouse
            Shroom2 ortholog.
REFERENCE   3  (bases 1 to 6987)
  AUTHORS   Fairbank,P.D., Lee,C., Ellis,A., Hildebrand,J.D., Gross,J.M. and
            Wallingford,J.B.
  TITLE     Shroom2 (APXL) regulates melanosome biogenesis and localization in
            the retinal pigment epithelium
  JOURNAL   Development 133 (20), 4109-4118 (2006)
   PUBMED   16987870
REFERENCE   4  (bases 1 to 6987)
  AUTHORS   Dietz,M.L., Bernaciak,T.M., Vendetti,F., Kielec,J.M. and
            Hildebrand,J.D.
  TITLE     Differential actin-dependent localization modulates the
            evolutionarily conserved activity of Shroom family proteins
  JOURNAL   J Biol Chem 281 (29), 20542-20554 (2006)
   PUBMED   16684770
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            [WARNING] On Oct 22, 2024 this sequence was replaced by
            NM_001047893.4.
            
            On Nov 26, 2008 this sequence version replaced NM_001047893.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000021.1  25479022-25479186   c
            166-317             JAXUCZ010000021.1  25402892-25403043   c
            318-449             JAXUCZ010000021.1  25371282-25371413   c
            450-2916            JAXUCZ010000021.1  25351298-25353764   c
            2917-3017           JAXUCZ010000021.1  25349229-25349329   c
            3018-3227           JAXUCZ010000021.1  25322099-25322308   c
            3228-3773           JAXUCZ010000021.1  25318906-25319451   c
            3774-3936           JAXUCZ010000021.1  25317179-25317341   c
            3937-4209           JAXUCZ010000021.1  25312446-25312718   c
            4210-6987           JAXUCZ010000021.1  25308163-25310940   c
FEATURES             Location/Qualifiers
     source          1..6987
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..6987
                     /gene="Shroom2"
                     /gene_synonym="Ab2-404; Apxl"
                     /note="shroom family member 2"
                     /db_xref="GeneID:317435"
                     /db_xref="RGD:1565163"
     CDS             1..4476
                     /gene="Shroom2"
                     /gene_synonym="Ab2-404; Apxl"
                     /note="protein Apxl; liver regeneration-related protein
                     LRRG167; apical protein-like"
                     /codon_start=1
                     /product="protein Shroom2"
                     /protein_id="NP_001041358.2"
                     /db_xref="GeneID:317435"
                     /db_xref="RGD:1565163"
                     /translation="MEGAEPRARPERLAEAEARATDGVRLVEVQLSGGAPWGFTLKGG
                     REHGEPLVITKIEEGSKAASVDKLLAGDEIVAINDVTLSGFRQEAICLVKGSHKTLKL
                     VVKRKSDPSWRPHSWHATKYFDVHPEPPVSLFLNSSSSPSWKSQHQASSSSHDLSGSW
                     EHTSLQRTSDHFSSMGSIDSLDHSSQLYPSGHLSSAKSNSSIDHLGGHSKRDSAYGSF
                     STCSSTPDHTLPKADASSTENILYKVGLWEASRPGSSRQSQSTGDPQGLQDRPSSFLP
                     RVPGNSSKSPRPEDNIEPKIATSGRSNFGPVWYVPDKKKAPSPPPLGLPLRSDSFAVA
                     ARGHEKARGPPFSDLASMQHFTTLPHVQPRGDRRMETTDRQWKLAHPSSGKEIGNVGY
                     QPEGHLDCRWLCSDDRAGRPSGAPGRHQFSLSSTDVHFLKSYHGSQHPQPCSDESPRF
                     PSSPRELLRITPSGCLQEPPELSQDDNPAQVRWPGSVNQKLDDRGRSHYFSVPHRQPV
                     HGSAHVLIPRSDYWHSDTTPVDLECPLLRPDQRGYPQQYEETPASHERGGYQQLNAGI
                     EGCCSGIHEPPRASHTVRAGLQCPGNDFKLVDAESGRISRQRTPMLHSLTQDGAWRPG
                     NSKDCGNEKPPLLDAQVGKPTRRSDRFATTLRNEIQMRRAKLQKSKSTVTLAGDSEAE
                     DCAGDWRVDVGAVPEGSFPSTYKEHLKEAQTRVLKATSFQRRDLDPTPADQYPGPPEH
                     RTCDHSASSSLSSFPGEPDSAPRLCEAGLAKPPSSAGGVPHILRIGGRKRFTAEQKLK
                     SYSEPEKINEVGLSGDHSPHPTIRTSEDSVGTFADRWKFFEETSKSLLQKPGHRQAFC
                     GIPREKAERPQTQGHECESTEPWFQKRSRATSCGEILSEDRKVEKASEKLNPPRRLGT
                     FAEYQASWKEQKKSLEARSSGRYHSADDILDAGLDQQQRPQYIHERSRSSPSTDHYSQ
                     EVPVEPNRQAEDSGGQKEALLCTLQAEEGCSAPSSSVLSSAQPQDSQHVNEDPTSPQP
                     EAQLSSKCQHLQTSTMETSRSPSPQFAPQKLTDKPPLLIHEDNSARIERVMDNNTTVK
                     MVPIKIVHSESQPEKESRQSLACPAELPALPSGLEKDQIKTLSTSEQCYSRFCVYTRQ
                     EVETPHRARPPEPQPPSTPAPPVRDSCSSPPSLNYGKAKEKTVDDLKSEELAREIVGK
                     DKSLADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPSPRVTEDKKQDP
                     GMPGVVSLATNSTYYSTSAPKAELLIKMKDLQEPEEYSAGDLDHDLSIKKQELIDSIS
                     RKLQVLREARESLLEDIQANNALGDEVEAIVKDVCKPNEFDKFRMFIGDLDKVVNLLL
                     SLSGRLARVENALNNLDDSPSPGDRQSLLEKQRVLTQQHEDAKELKENLDRRERIVFD
                     ILATYLSEENLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLFDSLQPERSK"
     exon            1..165
                     /gene="Shroom2"
                     /gene_synonym="Ab2-404; Apxl"
                     /inference="alignment:Splign:2.1.0"
     exon            166..317
                     /gene="Shroom2"
                     /gene_synonym="Ab2-404; Apxl"
                     /inference="alignment:Splign:2.1.0"
     exon            318..449
                     /gene="Shroom2"
                     /gene_synonym="Ab2-404; Apxl"
                     /inference="alignment:Splign:2.1.0"
     exon            450..2916
                     /gene="Shroom2"
                     /gene_synonym="Ab2-404; Apxl"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3017
                     /gene="Shroom2"
                     /gene_synonym="Ab2-404; Apxl"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3227
                     /gene="Shroom2"
                     /gene_synonym="Ab2-404; Apxl"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3773
                     /gene="Shroom2"
                     /gene_synonym="Ab2-404; Apxl"
                     /inference="alignment:Splign:2.1.0"
     exon            3774..3936
                     /gene="Shroom2"
                     /gene_synonym="Ab2-404; Apxl"
                     /inference="alignment:Splign:2.1.0"
     exon            3937..4209
                     /gene="Shroom2"
                     /gene_synonym="Ab2-404; Apxl"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..6987
                     /gene="Shroom2"
                     /gene_synonym="Ab2-404; Apxl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagggcg ccgagccccg tgcacggccc gagcgcttgg ctgaagctga ggcgcgggcg
       61 accgacggcg tccgtctggt ggaggtgcag ctgagcggcg gtgccccttg gggcttcacc
      121 ttgaagggcg gccgcgagca tggtgagcct ctggtcatca ccaagatcga agaaggaagc
      181 aaagctgcat cagtggacaa gcttcttgct ggagatgaga tagtggccat caatgatgtc
      241 actctctcag ggttcagaca agaagcaatt tgcctggtga aaggctccca caagaccctc
      301 aagcttgtgg tcaaaaggaa aagtgatcca agttggaggc ctcactcctg gcatgctacc
      361 aagtacttcg atgtccaccc tgagccacca gtctcactgt ttctgaactc cagcagttcc
      421 ccttcctgga agagccagca ccaggctagt tcttcctccc atgatttatc tggctcatgg
      481 gagcacacca gcctacagcg cacttctgac cacttcagct ccatgggcag catagacagc
      541 ctggaccaca gctcccagct ctacccatct ggtcacctct catctgccaa gtccaacagc
      601 agcattgacc acctgggtgg ccatagcaag cgagactcgg cttatggctc cttttccacc
      661 tgttccagca cccctgacca caccttgccc aaggctgacg cctcatccac tgagaacatt
      721 ctctacaaag ttggcctttg ggaggcttcc aggccaggca gcagccgaca aagccagtct
      781 acaggtgatc ctcagggact acaggacagg ccatcgtctt tcttacctag ggttcctggt
      841 aacagtagta aaagcccaag gccggaggat aatattgagc ccaaaatagc aacttctggg
      901 agatccaatt ttgggcctgt ctggtatgtt cctgataaga aaaaagcccc ttctccccca
      961 cctcttggac ttcctttgcg cagtgatagc tttgctgtgg cagccagggg ccatgaaaag
     1021 gctcggggcc ctccattctc agacttggcc agcatgcagc actttaccac cctgcctcat
     1081 gtacaacccc ggggagaccg cagaatggaa actactgatc gacagtggaa gcttgcacac
     1141 ccaagcagtg gcaaagaaat aggtaatgtg ggttaccagc cagaaggcca cctggattgc
     1201 cgttggctgt gctctgatga tagggcaggt aggccctcag gagctccagg aagacaccag
     1261 ttctccctgt ccagcacaga tgtgcacttt ctgaagtctt accatgggag ccaacaccca
     1321 cagccgtgca gtgatgagag cccaagattc ccctcatcac caagggaatt gcttcgtata
     1381 actcctagtg gatgtctgca ggagcctcct gaactgtctc aggatgacaa ccctgctcag
     1441 gtgaggtggc ccggttctgt taaccagaag ctagatgaca gagggcggag ccactatttt
     1501 tctgtgcccc acaggcagcc agtgcacggg agtgcccacg ttttgatacc ccgaagtgac
     1561 tattggcatt cagacacaac tcctgtggac cttgagtgtc ctctcttacg cccagaccag
     1621 aggggctacc cacagcagta tgaggagacc ccagcctctc atgagagagg cgggtatcaa
     1681 cagctaaatg cagggattga aggctgctgc tcaggaatcc atgagcctcc tagagccagc
     1741 cacactgtga gagctggtct gcagtgtcct ggcaatgact tcaagttagt ggatgcagag
     1801 agtggaagaa tttctcgtca gagaacaccc atgctgcact ctctgaccca agatggtgca
     1861 tggaggcctg ggaacagcaa ggattgtgga aatgagaagc caccactgct tgatgcccag
     1921 gtgggtaaac ccacacggag gagtgaccgt tttgccacaa cactaaggaa tgagattcag
     1981 atgcgcagag caaagctaca gaagagcaaa agcacagtga cattagctgg agatagtgaa
     2041 gctgaagact gtgctggaga ctggagagtt gatgtggggg ctgttccaga aggttccttc
     2101 cccagcacct ataaagagca cctgaaggag gcccagacac gtgttctaaa ggccacctct
     2161 ttccaacgcc gagatttaga tcccacccca gcagatcagt atccaggacc accagaacat
     2221 aggacttgtg accacagtgc ctcatcttct ttatcttctt tccctgggga gccagactct
     2281 gcccctcgcc tctgtgaagc aggtctggcc aagccaccct cttctgcagg tggtgttccc
     2341 cacattcttc gaattggagg ccggaaacgg ttcacagcag agcagaaact aaagtcctat
     2401 tctgagccag aaaaaattaa tgaagtgggg ctttcagggg accacagtcc tcatcctact
     2461 attaggacat ctgaggattc tgtgggtaca tttgctgata ggtggaagtt ttttgaggaa
     2521 acaagcaaat ctcttctcca gaagccaggc cataggcaag ctttctgtgg gatcccaaga
     2581 gaaaaggctg agaggcctca aacacagggc catgagtgtg agagtacaga gccctggttt
     2641 cagaagaggt cacgggccac ctcttgtgga gagatcctca gtgaagacag aaaagtagaa
     2701 aaggcctcag agaaattgaa cccacccaga aggcttggaa cctttgcaga atatcaagca
     2761 tcttggaagg agcagaagaa atctctagaa gccaggagtt ctggacgata ccattcagca
     2821 gatgatattc tggatgctgg cctagatcag cagcagaggc cacagtacat tcatgaacgg
     2881 tctcgttcat caccgtccac agatcactat tcacaggaag tgcctgttga accaaacagg
     2941 caggcagagg actctggtgg ccagaaagaa gcacttcttt gtacactgca agctgaagag
     3001 ggatgctctg ctccaagctc ctctgtgctc agcagtgccc agccgcaaga cagccagcat
     3061 gtgaatgagg acccaacttc ccctcaacca gaagcccagc tctcctccaa gtgtcaacac
     3121 ttacagacat caaccatgga aacttctcgc tccccttcac ctcagtttgc cccacagaag
     3181 ctgacagaca agcctcccct gcttatccat gaagacaatt cagcaagaat tgagcgggtg
     3241 atggacaaca acaccactgt gaagatggtg cccataaaaa ttgtgcactc agaaagccag
     3301 cctgagaagg aaagccgcca gagtctcgct tgcccagccg agctgcccgc actgcccagt
     3361 gggctggaga aggaccagat caagacactg agtacatcag agcagtgcta ctcgcgcttt
     3421 tgtgtgtaca cacgacagga ggtggaaacc cctcatagag cccgccctcc agagccccag
     3481 ccacctagca cccctgcacc tcctgtcaga gatagctgtt cctctcctcc ctcactcaac
     3541 tatgggaagg ccaaggagaa gaccgtggac gacttgaagt ctgaagaatt agccagagag
     3601 attgtgggaa aggacaagtc tttggctgac atcctggacc ccagcgtgaa aatcaaaact
     3661 accatggatc tgatggaggg aattttcccc aaagatgagt acctcctaga ggaagctcag
     3721 caacggagga agctgctccc caaagtcccc tcacccagag tcacagagga caagaaacag
     3781 gacccaggta tgccaggggt tgtgtccttg gccacaaatt ctacctatta tagcacatca
     3841 gcccccaagg cagaactgct tatcaagatg aaggacctac aggagcctga ggagtattca
     3901 gcaggtgact tggatcatga cctttccatt aagaagcaag agctcatcga cagtatcagc
     3961 cgcaagctgc aggtgctccg agaagcacgt gagagtctgc tggaggacat ccaagccaac
     4021 aatgctctcg gggatgaagt ggaagccatt gtgaaagatg tctgcaagcc caatgagttt
     4081 gacaagttcc ggatgttcat tggagacctg gacaaagtgg tgaacctcct gctgtcactg
     4141 tcaggacgcc tggcccgtgt ggaaaatgcc cttaataatt tagatgacag tccttctcct
     4201 ggagatcggc agtcactgtt ggagaaacag agagtcctaa ctcagcagca tgaggatgcg
     4261 aaggagctta aagagaacct ggaccgtcgt gagcgcattg tgttcgacat cctggccacc
     4321 tacctcagcg aggagaacct ggctgactat gagcacttcg tgaagatgaa gtcagccctc
     4381 atcattgagc agcgagagct ggaagataaa atccacctgg gtgaagaaca gctcaagtgt
     4441 ttgtttgaca gcctgcagcc tgagagaagc aaatgagcga cccattcctg cagaaggcag
     4501 acacagagcc ttggagatta atgcctagga ctacaagagt gaacccaagc ctatttgccc
     4561 atctctggag actcacactc tggagccaca aggctagtaa aaaagcaata atgtcctgct
     4621 agtatgtgat gctttattta tgattttcat ttctgttggt ttgctgaaca tagtttctcg
     4681 tatcacatgt gatgtcagaa aatgccaggt tttgctagtc aacaagggtt ccctagcact
     4741 ccttcacagc agtggcacca ttgttccttc cttgtataga tgccaaatac atccctatgg
     4801 tgcatgagag gaaagaccct tgtcatttag ccaggcatgg gctgctgtgt tttctgtcct
     4861 tattcattta acaatgtgag cattcatcat tctgtcatca tgacattctc tgacccagta
     4921 aaaatcagtg atgataattt attgatgtgt gaaaaacatg aacagtttcc tagtagttaa
     4981 aaactaactt taaaatgaac aacctacata ttgaattcat tcattccaag attaaaatga
     5041 tcacataaat tgtgtgcata ttttgaaaca ccccatatag ctagtatcct tcttgccaca
     5101 tcttaaataa tttctaccca agtgatatta attggtcaaa agtgtgtcta ctaacagtgt
     5161 tattgcttgc tctttatttc ctgagaccaa tgaaatattt tgaagtttcc ttccccagaa
     5221 cactaatttg tgtacatgat cattaataat gcatgatctt taatgataat cagtggttta
     5281 tctctttttt tatctgttac catgggccac atgccacgta ccttaagact taagattcca
     5341 tccaatggtc agaggtcctg tgcagtgact agtgcttaca tttgaaacag agttttgtcc
     5401 ttgacaaata gagtgttact cattaaagct acaatgccat cctgttggtt tccagttgac
     5461 aggacagaga tcgggaaaag acatttgtaa atggtgtctg acttgttgct ccttttgtgt
     5521 ttgctatttg ttttagaaga gtctaaccca gattggcttc aaactcccta tgtagtccag
     5581 tgaccttgaa ctcctggtcc tcttgcctct acttcctaat ttctgggttt agcagcatat
     5641 cctacttcat ggcttcatac atctgataaa ggatctgtat aaagaacttc caacacccaa
     5701 tagtaggaat ggtttgaaaa aaaagtgggc aaaagacttg actagacact tcaccaaaga
     5761 ggatatatgt atggcagata aacacatgaa aaatgttcag ttaccagtgg cgtgtatagc
     5821 ttatgttaag tgtttgtaga tttggtgtag ttcaaatgct gtttatgtaa ctaaatgcat
     5881 ggtgagtgat gagcaagtcc tcctggtgac ttgatatgta ggcatcacta gtctttgttc
     5941 tatcaaggga tcatttaatt catattttcc ccagagattg cagcagatac aaagatttcc
     6001 ctctctaagc agtagccaca ccttttccaa aatacacatg catacttaca tccatgtgta
     6061 tgtgcatgtg ttcacactcc cacacagagt tgtcttaaag gaccagaatc catgcttctt
     6121 gagccagagg aacagatatt gacagcataa gctctggtga agatgacagt gtcctccaaa
     6181 cagctgagtc aagatgggcg agcttctgta ctgcagacca tggatggcat ggttgaatgc
     6241 gtatcactgt tagtcaaaag gagatcttgc aaaagtgtcg attcctatta attcctatta
     6301 aatgaagcta cgtctacctt ttgaagtccc tgatctgcca ctgcagcctc ttcctccttc
     6361 cagttcgtca tcccttgctg tgaatgtgga tcatgtcaga aaacatgatg ctggctctcc
     6421 acaaactttc caaggaattg cagactattt tgtttttaat ttacaccaag ctatttacct
     6481 gtggttcttt atccccaaat acagtgttgt ggacatttta atgatgtgta taacatgtga
     6541 gtaatggaac tttgtttgtc tgtaacctgc cttttcatgt tgcttcaaga ttgttatggg
     6601 aaacagtacg tagtgctcaa gcatgcttgt aatgaaacac ataacaatta tgaccttcct
     6661 atccattccc tgcttgcctg ttccatgtct gattagcagg gatccaagaa ttccagagag
     6721 tccatataca tatgtctatg aattgtgata ttactgcata agaaacaatc tggtgctaat
     6781 ggttggtcct tggcatgcaa aggcgtgggc atgggcacag ctatggaact ctctgtacat
     6841 atactgacct tgcctgtggt cagcttttgt gactttaccc tgaactctac cctggcaaat
     6901 atgcacattg atgcttgatg cttaccactt atcaacagat cctcttgctt gaccttaaca
     6961 aaataaatag tgtctcttca aatgaaa
//
