LOCUS       NM_001134713            2322 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus SHQ1, H/ACA ribonucleoprotein assembly factor
            (Shq1), mRNA.
ACCESSION   NM_001134713 XM_001075316 XM_232222
VERSION     NM_001134713.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2322)
  AUTHORS   Chang,C.H., Wong,L.C., Huang,C.W., Li,Y.R., Yang,C.W., Tsai,J.W.
            and Lee,W.T.
  TITLE     Pathogenic SHQ1 variants result in disruptions to neuronal
            development and the dopaminergic pathway
  JOURNAL   Exp Neurol 382, 114968 (2024)
   PUBMED   39326821
  REMARK    GeneRIF: Pathogenic SHQ1 variants result in disruptions to neuronal
            development and the dopaminergic pathway.
REFERENCE   2  (bases 1 to 2322)
  AUTHORS   Freund,A., Zhong,F.L., Venteicher,A.S., Meng,Z., Veenstra,T.D.,
            Frydman,J. and Artandi,S.E.
  TITLE     Proteostatic control of telomerase function through TRiC-mediated
            folding of TCAB1
  JOURNAL   Cell 159 (6), 1389-1403 (2014)
   PUBMED   25467444
REFERENCE   3  (bases 1 to 2322)
  AUTHORS   Grozdanov,P.N., Roy,S., Kittur,N. and Meier,U.T.
  TITLE     SHQ1 is required prior to NAF1 for assembly of H/ACA small
            nucleolar and telomerase RNPs
  JOURNAL   RNA 15 (6), 1188-1197 (2009)
   PUBMED   19383767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC168172.1.
            
            On or before Sep 5, 2008 this sequence version replaced
            XM_001075316.1, XM_232222.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168172.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2322
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2322
                     /gene="Shq1"
                     /gene_synonym="RGD1310610"
                     /note="SHQ1, H/ACA ribonucleoprotein assembly factor"
                     /db_xref="GeneID:297483"
                     /db_xref="RGD:1310610"
     exon            1..230
                     /gene="Shq1"
                     /gene_synonym="RGD1310610"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1899
                     /gene="Shq1"
                     /gene_synonym="RGD1310610"
                     /note="SHQ1 homolog"
                     /codon_start=1
                     /product="protein SHQ1 homolog"
                     /protein_id="NP_001128185.1"
                     /db_xref="GeneID:297483"
                     /db_xref="RGD:1310610"
                     /translation="MLTPAFELTQDRDFLTVAIRVPHARASEFDVYFEGVDFKFYAKP
                     YFLRLTLPGRIVENGSEQGSYDADKGIFTIRLPKETPGQHFEGLNMLTALLAPRKSRS
                     AKPLVEEIGASGVSEEGADDEDEEFDWEIEQTPYEEVSESTLRSQCHYGFGNLRAGVV
                     QRLQDELSEVIDIKDPDFTPVTERRQKRLAAELAKFDPDHYLADFFEDEAVEQVLKYS
                     PWWNDVHTEMMASLGKSQEQGDAAALVSFSEEEKYQLRKFVNKSYLLDKTAHRQVYYS
                     LVDILLAYCYEVRVTEGEHNVESAWTIRKLSPTLCWFETWTDVHEILVSFGRRVLCYP
                     LYRHFKLVLKAYRDTLKILQLGKSAVLKCLLDVHKIFQENDPAYILNDLYISDYCVWI
                     QKAKSKKLAALTEALEAVSLSKAQLGFELLELEAAAILVQEEETAGKTAQCSPTEQVP
                     HSSPEPSDSDSTSSSDTEDSASVQEELVGTQPSLLTSLQVPLLEEDSALTIRDSGLCR
                     NMGSQKCEVRQGQPLASPRAPLIEEVGDSGLCRNMASQGCEVSQEQPLASPRAPLIEE
                     VGDELKTMLWVSTPSGVNAGSHRSVQDAKERDQVPCD"
     exon            231..295
                     /gene="Shq1"
                     /gene_synonym="RGD1310610"
                     /inference="alignment:Splign:2.1.0"
     exon            296..418
                     /gene="Shq1"
                     /gene_synonym="RGD1310610"
                     /inference="alignment:Splign:2.1.0"
     exon            419..579
                     /gene="Shq1"
                     /gene_synonym="RGD1310610"
                     /inference="alignment:Splign:2.1.0"
     exon            580..692
                     /gene="Shq1"
                     /gene_synonym="RGD1310610"
                     /inference="alignment:Splign:2.1.0"
     exon            693..820
                     /gene="Shq1"
                     /gene_synonym="RGD1310610"
                     /inference="alignment:Splign:2.1.0"
     exon            821..975
                     /gene="Shq1"
                     /gene_synonym="RGD1310610"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1029
                     /gene="Shq1"
                     /gene_synonym="RGD1310610"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1153
                     /gene="Shq1"
                     /gene_synonym="RGD1310610"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1274
                     /gene="Shq1"
                     /gene_synonym="RGD1310610"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..2239
                     /gene="Shq1"
                     /gene_synonym="RGD1310610"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggaagcgc tgtggcagac ggcttgggtc tgtcgcgtgg gtacttgtcg cgtgtctagc
       61 cggtggtggc ttcaggcgcg cgcaacgatg ctaactcctg cgttcgaact gacccaggac
      121 cgcgacttcc ttaccgtcgc catccgcgtg ccccacgcgc gcgcctccga gttcgacgtg
      181 tacttcgagg gggtggactt caagttctac gccaagccgt actttctgag gttaacactt
      241 cctggaagga ttgtagaaaa tggatctgag cagggatcct atgatgcaga taaaggaatt
      301 tttaccattc gattgcccaa ggaaactcct ggccagcatt ttgaggggct gaacatgtta
      361 actgcgcttc tggcaccaag aaaatccagg tctgccaaac cgcttgtgga agaaataggt
      421 gcttccgggg tttctgagga aggagctgat gatgaggatg aagagtttga ctgggaaatt
      481 gagcagactc cctatgaaga ggtctcagaa agtactctgc gatcgcagtg tcactatgga
      541 tttggaaacc tgcgagcagg tgtggttcag cggttacagg atgaactgag tgaggttatc
      601 gatattaagg atccagattt cactcctgtg actgaacgga ggcagaaacg cctggccgct
      661 gaattggcca aatttgatcc agatcattat ctagctgact tctttgaaga tgaggcagtt
      721 gaacaggttt tgaagtacag tccttggtgg aacgatgtgc acacagaaat gatggcctct
      781 ttgggaaaga gccaagagca aggggatgct gctgccttag tatctttttc agaagaggaa
      841 aaataccagc tacgaaagtt tgtgaataaa tcttacctgc tggacaagac agctcaccgt
      901 caagtgtact atagtttagt tgacatcctt ctggcctatt gctatgaagt acgtgtgact
      961 gaaggagagc acaacgtgga gtctgcgtgg accatcagga agctgagccc tacactctgc
     1021 tggtttgaga catggacaga cgttcatgaa atcctggtgt cttttggacg gagagttttg
     1081 tgctatccgc tctatcgcca tttcaagctg gtgctgaaag cctacagaga tactctaaag
     1141 atactgcaac tcggtaagag tgcagttttg aagtgtctcc tggatgttca caaaatcttc
     1201 caggaaaacg acccagcata tattttgaat gatctctaca tctcagacta ctgtgtatgg
     1261 attcagaagg ccaagtccaa aaagttggct gccctaacag aagctttgga agcagtctca
     1321 ctcagtaagg cccagctggg attcgagctg ctagaactgg aagctgctgc aattcttgtc
     1381 caggaggaag aaactgccgg aaagacagcc cagtgcagtc ctacagagca ggttccacac
     1441 tccagccctg agcccagtga ctcagacagc acctcatcat ctgacacaga agactcagcg
     1501 tcagtgcaag aggagcttgt cgggacccag ccctccctgc tcacttctct gcaagtcccc
     1561 cttttggaag aggacagtgc cctgaccatc agagatagtg ggctctgcag aaacatgggc
     1621 agtcagaaat gtgaagttcg tcaaggtcag ccactggcct ctccccgggc tcctctgata
     1681 gaggaggttg gagatagtgg actctgcaga aacatggcca gccagggatg tgaagtcagt
     1741 caagagcagc cactggcctc tccccgggct cctctgatag aggaggttgg agatgaactg
     1801 aagaccatgc tttgggtttc cacacccagt ggtgtcaatg ctgggagcca caggagtgta
     1861 caggatgcaa aggagaggga tcaggtgccc tgtgattgac ttaagtggta ggctcattat
     1921 ggggcactag gtcaactatg atctcataca gaagtggaat ttctgatttt gattgtgtac
     1981 attttctgtg tggatacagg acattgtttt tcagtgagct aacatttgta cttttcaaag
     2041 tttttatttt gcaacttgaa aaatatactt ctaaagtatt ctttataagg tataaataat
     2101 taaaaatgaa gaccatagtt ctactaggaa aatctctaga ccagtgattc tcaaccttcc
     2161 taatgctgtg accttttaat acagttcctc atgttgtggt gaccaccaac tataaaatta
     2221 ttttgttgct acttcataaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2281 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
