LOCUS       NM_001107470            7005 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SNF2 histone linker PHD RING helicase (Shprh),
            mRNA.
ACCESSION   NM_001107470 XM_001069964 XM_218084
VERSION     NM_001107470.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7005)
  AUTHORS   Zeman,M.K., Lin,J.R., Freire,R. and Cimprich,K.A.
  TITLE     DNA damage-specific deubiquitination regulates Rad18 functions to
            suppress mutagenesis
  JOURNAL   J Cell Biol 206 (2), 183-197 (2014)
   PUBMED   25023518
REFERENCE   2  (bases 1 to 7005)
  AUTHORS   Motegi,A., Liaw,H.J., Lee,K.Y., Roest,H.P., Maas,A., Wu,X.,
            Moinova,H., Markowitz,S.D., Ding,H., Hoeijmakers,J.H. and Myung,K.
  TITLE     Polyubiquitination of proliferating cell nuclear antigen by HLTF
            and SHPRH prevents genomic instability from stalled replication
            forks
  JOURNAL   Proc Natl Acad Sci U S A 105 (34), 12411-12416 (2008)
   PUBMED   18719106
REFERENCE   3  (bases 1 to 7005)
  AUTHORS   Motegi,A., Sood,R., Moinova,H., Markowitz,S.D., Liu,P.P. and
            Myung,K.
  TITLE     Human SHPRH suppresses genomic instability through proliferating
            cell nuclear antigen polyubiquitination
  JOURNAL   J Cell Biol 175 (5), 703-708 (2006)
   PUBMED   17130289
REFERENCE   4  (bases 1 to 7005)
  AUTHORS   Unk,I., Hajdu,I., Fatyol,K., Szakal,B., Blastyak,A., Bermudez,V.,
            Hurwitz,J., Prakash,L., Prakash,S. and Haracska,L.
  TITLE     Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent
            polyubiquitylation of proliferating cell nuclear antigen
  JOURNAL   Proc Natl Acad Sci U S A 103 (48), 18107-18112 (2006)
   PUBMED   17108083
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473994.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218084.4, XM_001069964.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..7005
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..7005
                     /gene="Shprh"
                     /note="SNF2 histone linker PHD RING helicase"
                     /db_xref="GeneID:308282"
                     /db_xref="RGD:1310342"
     exon            1..157
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            158..810
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..5301
                     /gene="Shprh"
                     /EC_number="2.3.2.27"
                     /note="SNF2 histone linker PHD RING helicase, E3 ubiquitin
                     protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SHPRH"
                     /protein_id="NP_001100940.1"
                     /db_xref="GeneID:308282"
                     /db_xref="RGD:1310342"
                     /translation="MSSRRKRAPPMKVDEERQQQLRWNMHEDLRNEPLSLTEEERACW
                     DADSSDCIIIDDDPPEGAAHRDKKRCTESVSILNSTEKETPLSVALNVTISPHPSDDS
                     WKAFLGDFVLQLLPEESLVEHFSERTFTLMSSESSSQLLIYVHSECNNVEKEENVLKG
                     PASIYGKGIRVESSFSSDMLQDLAWLQKRRGIKLYQRPEGTHTIKVRIYLLEAGLTRL
                     DFMSDAGSRMKKFNQLLKRVMGKLYSLSIPDVLEEDEEESESEPEGQDIDELYQFVKR
                     THQQEAKSVQVDVQHPALIPVLRPYQREAVNWMLQQEQFRSTPADNSLHFLWREIVTP
                     DGLNLYYNPYTGCIIRDFPHAGPQLLGGILADEMGLGKTVEVLALILTHTRQDVRQDA
                     LTLPEGKVVNYFIPTHCPRGKVKSREIQNTECEPKEKVHCPPTRVMILTAVKEMNGKK
                     GVSILSIYKYVSSTFRYDVQRNRSLLKRMLKCLIFEGLVKQIKGRGFSGTFTLGKNYK
                     EDVFDKTKKQAVGSPQKIEKELRKSVNKDTDSEYMPSDIYDDDNDNDDDDDDDPYYYY
                     CKARKSRKLKKKPVLLTKKEKGQPVNLDSQVEAPAAGDCASADAHVSESTCVSENRQI
                     QDAEDCVESPSPAAMELAQSNTASFCETPDYRFECICGEFDQIGRKPRVQCLKCHLWQ
                     HAKCVNYEEKNLKVKPFYCPHCLVAMEPVSTRATLIISPSSICHQWVDEINRHVRSSS
                     LRVLVYQGVKKDGFLQPHFLAEQDIVIITYDVLRSELNYVDIPHSNSEDGRRLRNQKR
                     YMAIPSPLVAVEWWRICLDEAQMVECPTVKAAEMAQRLSGINRWCVSGTPVQRGLEDL
                     FGLVVFLGIEPYCVKHWWIRLLYHPYCKKNPQHLYSFIAKIMWRSAKKDVIDQIQIPP
                     QTEEMHWLHFSPVERHFYHRQHEVCCQDAVVKLRKISDWALKLSSLDRRTVSSILYPL
                     LRLRQACCHPQAVRGEFLPLQKSTMTMEELLTSLQKKCGTECEEAHRQLVCALNGLAG
                     IHIIKGRRAQYRAALALPPPECVILSEYALAAELYREVLRSSEEHKGKLKTDSLQRLH
                     ATHNLMELLVAKHPGIPPTLRDGRLEEEAKQLREHYMSKCNTEVAEAQQALQPVQQSI
                     RELQRKVHSGSPWWLNVVHRAMEYAVDEELVQRVRNEISSNYKHQTDKLSMSEKFRDC
                     RGLQFLLTTQMEELHKFQKLVREAVKKLEKPPSRDVIESATVCHLRPARLPLNCCVFC
                     KADELFTEYESKLFSNTVKGQTAIFEEMIEDEEGLVDDRVPTTTRGLWAVSETERSMK
                     AILSFARSHRFDVEYIDEGSVSMDLFEAWKKEYKLLHEYWMTLRNRVSAVDELAMATE
                     RLRVRHPKEPKPNPPVHHIIEPHEVEQNRIKLVNDKAVATSQLQKKLGQLLYLTNLEK
                     SQDKTSGGINPEPCPICARQLGKQWAVLTCGHCFCNECTSIIIEQYSVGSHRSSIKCA
                     ICRQTTSHKEVSYVFTSEKANQEDDIPVKGSHSTKVEAVVRTLMKIQLKDPGAKALVF
                     STWQDVLDIISKALTDNNMGFTQISRIKTFQENLSAFKYDPQINILLLPLHTGSNGLT
                     IIEATHVLLVEPILNPAHELQAIGRVHRIGQTKPTIVHRFLIKATIEERMQAMLKTAE
                     RSHTSSSGKHSEASALTVADLADLFTKESEELE"
     exon            811..940
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1156
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1235
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1386
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1495
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1749
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..2427
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2679
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2758
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2922
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3179
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3308
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..3361
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3450
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3451..3543
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3544..3651
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3652..3794
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3968
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3969..4031
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4032..4257
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4258..4401
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4402..4503
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4504..4575
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4576..4764
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4765..4857
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4858..4944
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4945..5123
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            5124..5204
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            5205..7005
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctggtgct gtggcttccg gccccgggcg cgcaactcca cccagagtgc agcgcgcgtg
       61 cgcaactccg gcaggtgtgt gaagcgactg tccgcccggg atctgcaggc tccgaggagg
      121 gccggtcctc gcgactggtg ctcgtatagc ggttgagaat tcacgtttac caaccaagaa
      181 agggaaagct cgaggatgag tagccgaagg aaacgtgctc ccccgatgaa ggtggatgaa
      241 gaaaggcagc agcagcttcg ctggaacatg cacgaggacc tgaggaatga gccgctcagc
      301 ttgactgagg aagagcgggc ctgctgggat gcagactcct ccgattgcat catcatagat
      361 gatgaccctc ccgaaggtgc agctcacaga gataagaaga ggtgtacaga gtctgtgagc
      421 atcttaaact ccactgaaaa agagacccct ctgtccgtgg ccttgaatgt taccatttct
      481 ccccatcctt ccgatgattc ttggaaagcg tttctgggag attttgtgct tcagcttctc
      541 cctgaagaga gtttagttga acatttttct gaaaggactt ttacgttgat gagttcagag
      601 tcaagcagtc agctcctgat ctatgttcat tcagaatgta acaatgtgga gaaagaagaa
      661 aacgtactta aaggaccagc aagtatctat ggcaagggta ttcgagtgga atcctccttc
      721 agtagtgaca tgttacagga tttggcctgg ctacagaaga gaagaggaat aaaactctac
      781 cagcgaccag aaggaactca tacgatcaag gttagaattt acctcttgga agctggcctg
      841 acaagactag acttcatgag tgatgcaggc tccagaatga aaaagttcaa tcagctcctg
      901 aagagagtga tgggaaagtt atacagtctc agtattccag atgtgttgga agaagatgag
      961 gaggaatcag agagtgagcc agagggccag gacattgatg agctctatca gtttgtgaag
     1021 cgaacacacc agcaagaggc aaagtcagtc caagtggatg tccagcaccc tgcactgatt
     1081 ccggtgctga ggccgtacca gagagaggca gtcaactgga tgctacagca ggagcagttc
     1141 aggagcactc ctgctgataa ctccctgcac ttcttgtggc gagaaattgt tacacctgat
     1201 ggcttgaacc tctactataa tccgtacaca ggctgcatca ttcgggactt cccacatgct
     1261 gggccacagt tgctcggtgg aatcttagca gatgagatgg gcctcgggaa gacagtggag
     1321 gttctggctc tgattctgac tcatacccga caagatgtca gacaggatgc cctcaccctg
     1381 cctgagggaa aagtggtaaa ttatttcatc ccaactcatt gtcctagagg aaaagtgaaa
     1441 agtagagaaa tccagaatac agagtgtgaa ccaaaagaga aagttcactg ccctcccaca
     1501 cgtgtgatga ttctgacagc tgtgaaagaa atgaatggga aaaaaggcgt ttctattctt
     1561 tctatctata agtatgtcag ctccacattc agatacgacg ttcagcggaa ccggagtctt
     1621 ctgaagcgga tgttgaaatg tttaatcttt gaaggtcttg tgaaacagat taaaggccgt
     1681 ggtttctctg ggacttttac actgggaaag aattacaaag aagatgtatt tgataaaacg
     1741 aaaaagcagg cagtagggag tccacaaaaa attgagaaag agttaaggaa atcagtgaac
     1801 aaggatacag attctgaata catgccatca gacatttatg atgacgataa tgacaacgac
     1861 gatgacgacg acgatgatcc ttattattat tactgcaagg caagaaaaag ccgtaagttg
     1921 aagaagaagc ctgtgttact cactaaaaag gaaaagggtc agcctgtcaa tctggattcc
     1981 caagttgagg ctccagctgc tggtgactgt gcaagcgccg atgctcatgt gtcagaaagt
     2041 acatgtgtct ctgaaaacag gcagatccaa gacgcagagg actgtgttga gtctccaagc
     2101 ccggccgcca tggagctggc acagtctaac actgcaagtt tctgtgagac ccctgactac
     2161 cgctttgagt gtatatgtgg tgaatttgac cagatcggcc gcaagccaag agttcagtgt
     2221 ctgaagtgtc acctgtggca gcatgcaaag tgtgtgaatt acgaggagaa gaatctgaag
     2281 gttaagcctt tttactgccc tcattgcctg gttgcaatgg agccagtgtc aaccagagcg
     2341 actctcatca tctccccaag ctccatttgc caccagtggg tagatgaaat caaccggcac
     2401 gtgagatcgt catcccttcg agttttggta tatcaaggag tgaagaaaga tgggttctta
     2461 cagcctcatt ttttggcaga acaagatata gttatcatta cctatgatgt tctccgttca
     2521 gaattaaact atgtcgatat cccacatagc aatagtgaag atgggcgtcg cctgaggaac
     2581 cagaagcgct acatggccat tcccagcccc ctggtagcgg tggagtggtg gcggatctgt
     2641 ctggatgaag cgcagatggt cgagtgtcct acagtaaaag ctgcagaaat ggcccagcgt
     2701 ttgagtggca ttaatcggtg gtgtgtcagt ggcactccag tgcagagagg attggaagat
     2761 ctttttgggc tggtggtctt tcttgggatt gaaccttatt gtgtcaaaca ctggtggatt
     2821 cgacttctct atcatccata ctgcaagaaa aatcctcaac acctgtacag ttttattgct
     2881 aagataatgt ggaggtccgc aaagaaagat gtcattgacc aaatccagat cccacctcag
     2941 actgaagaaa tgcactggct ccatttttcc cctgtggaga ggcatttcta ccaccgccag
     3001 catgaggtgt gctgccagga tgctgtggta aagctcagga agatctcgga ctgggccctg
     3061 aagctgagca gcttggacag aaggacggtc tcctccatcc tgtaccccct gctgagactc
     3121 aggcaggcct gctgccaccc acaggctgtg cgtggggagt tcctgccact ccagaagagc
     3181 accatgacga tggaggagtt gctgacatct ttgcagaaga agtgtggaac agagtgtgaa
     3241 gaggcccacc ggcagctagt ttgtgccctt aacggcttag caggcatcca catcattaaa
     3301 ggtagaagag cacagtacag agcagccctt gctttgcctc ccccagaatg tgtcattctt
     3361 agtgaatacg ccttggcagc ggaactctac agagaagttt taaggtcgtc tgaggagcac
     3421 aaaggaaaac tcaaaactga ttcacttcaa agacttcacg ccacacataa cctgatggag
     3481 ctcctggtag ccaaacaccc agggataccg cccaccctga gagatggcag acttgaagaa
     3541 gaggccaagc agctccgaga gcactacatg agcaagtgta acacagaggt ggccgaagcc
     3601 cagcaagctt tgcagcctgt gcagcagtcc attcgggagc tccaaaggaa ggttcattct
     3661 ggttctcctt ggtggctgaa tgtagttcac agagcaatgg agtatgctgt tgacgaggag
     3721 cttgttcagc gcgtgcgaaa tgagataagc agtaactaca agcaccaaac ggacaaactc
     3781 tccatgtcag agaagttccg tgactgtaga ggtcttcagt tcttacttac aacacaaatg
     3841 gaagagctgc acaagttcca gaagctagtg agggaggctg tgaagaagct ggagaaacct
     3901 ccgtcccggg atgtgattga gtctgcaaca gtttgccacc tgcggccagc tagactccct
     3961 ctcaactgct gtgtcttttg taaagctgat gaattgttca cagagtatga gtcaaagcta
     4021 ttttctaaca ctgtcaaagg ccagaccgcc atctttgaag aaatgataga agatgaagaa
     4081 ggactcgtgg atgatagagt ccctaccact accagaggcc tgtgggccgt gagcgagacg
     4141 gagcgatcta tgaaagcaat actatcattt gcaagatcac ataggtttga cgttgaatat
     4201 atagatgaag gaagtgtttc aatggatctc ttcgaggcat ggaagaagga gtataagtta
     4261 cttcatgaat actggatgac tctgagaaac cgcgtatccg ctgttgatga acttgcaatg
     4321 gctacagagc gactaagagt gcgccatccc aaggagccaa agccaaaccc acccgtccac
     4381 cacatcattg aaccacacga ggttgaacag aatcgtataa aactagtaaa tgataaagct
     4441 gttgctactt cccagcttca gaagaaactt ggacagcttc tttacctgac aaatttggag
     4501 aagtctcagg acaaaacatc aggaggtatt aatccagagc cttgtccgat ctgtgctcgg
     4561 cagttgggaa aacagtgggc agtgctgacc tgcggacact gcttctgtaa tgaatgcact
     4621 tcaattataa ttgaacaata cagtgtggga tcccatcgaa gctccattaa gtgtgctatc
     4681 tgccgccaga ccacatcaca caaagaagtc tcctatgtct tcacttcaga gaaggcaaac
     4741 caagaggatg atatccctgt gaagggtagc cattctacaa aagtggaagc tgtggtcaga
     4801 actctgatga aaatacaact taaagatccg ggggccaaag cgctcgtttt ctcaacgtgg
     4861 caagatgtgt tagatattat ttcaaaagct ctcacggaca acaacatggg attcacacaa
     4921 atcagtcgca ttaagacatt ccaggagaac ctttcagcat ttaaatatga tccccagatc
     4981 aatattttgc tgctgcccct gcatacaggc tctaatggat taactatcat tgaagccact
     5041 catgtcctcc tggtggaacc gatactgaat cctgcccatg agcttcaggc cattgggaga
     5101 gtgcaccgaa ttggacagac aaaacctact attgtacata gattcttaat taaagcaaca
     5161 atagaagagc ggatgcaggc aatgctaaag actgctgaga ggagccacac cagctcgtct
     5221 gggaagcatt ctgaagcctc tgcactgacc gtggctgacc tggcagacct gttcaccaaa
     5281 gagagtgagg agcttgaatg aagcgccatc gcgtcattgc acggatgttc agacttagct
     5341 ctcacagatg taaagcaagc ttacaaagtt aagatcagta accattagta gatactattt
     5401 taatgaattg attttgttat acaccagcct agtaataatt ggcaattggt tccttttcag
     5461 taaacctatt tcacaccatt tacaatgaat tttaatttta cattcctact gaaacattta
     5521 ctttttgttc tacatgtata tctataactg ataaggcagg agaatttaaa aaagaaggta
     5581 ttaaataatt tttcattagt agatagatgt ttgttataac aagacagaat acataagaaa
     5641 gaaggtaaat tagtctagtt ttgtatgacc tgacctacac agccagtgta aatgacattt
     5701 ttgaaagggc ctttggcatc tttagcttat gattcatcat tctcttctcg gtagtgtttt
     5761 aagaagacgc taaactatga tacctagttg tttgcatgag tttaaactgt aacactctct
     5821 ttggaacttt aagtagtaca gctcctgatc ataaattctt aggtggttat tttgtgtctt
     5881 gttactagcc gtcaaaatac tgaaaagctc atttttctat tatgtttaag ccgtgtcatt
     5941 gttagtgttt ttaagtgtat taacatttac ctacaatgat ctctttaatc tttgtagtga
     6001 gttctttttg tgttttaaga tgatgtatct gtaaataggg cttttttaaa atcatcattg
     6061 tactgaattc tttccctgtg ttcctgtaac taatcatttt agccggtaat tatctaagtt
     6121 tacagtagag tttattcatt tcagttactc tgtcattaag tattttatct tactgcaaga
     6181 gaatgctgtg ttcacacatg catagaacta taagtggtta aactgtctct tctgtgaaga
     6241 cttcatagat gactttgaaa tcacaaaata agaagtagct tgtatcctaa ccctgtgttg
     6301 aaatataaat gttcttgttt tccttccttt agctgttgaa gttttaagtg actctcgaga
     6361 ttcattagct cctacctaac tgcccaggaa gctgtactag aaatagtccc tggagctcct
     6421 tcatccattg agcttggtgc ttaagctaag gtgcattttc ctatccgggt ttataggtga
     6481 cagctcagct gaggaagaca cattctgggt gcttattcct tagtgaaggg agatatgcat
     6541 tggttctttt atatgagatt aaacataata tttttacagc tctttgacat ccatgaagag
     6601 cttttctgtg tattaatgta gttaattttc ccaaccgtcc tgtgaagtgg acataattaa
     6661 agtcattcct gttgtgaagg taaggagcga atgctcagga ggaatcttgg ctatgatatg
     6721 tagcaaatag acagaggagt ccaggccctg gcttcatgtc tgcttttctt ccaccaaatc
     6781 gtgtcatgct gaggtccaga agcctcagag gtgtaattta ggggtgcgat tgttgaggtt
     6841 tttctttttc ctaatatttc atgtgctatg ttctaggaaa agcaatctga tatgcttcaa
     6901 ttaaaaaaat aacataaata gatatctgta cttattagta ttagaaaaac tactcttatt
     6961 tatttcagta agatacctca aataaatatt ttagtgaaaa atgaa
//
