LOCUS       NM_001033682            2794 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus sedoheptulokinase (Shpk), mRNA.
ACCESSION   NM_001033682 XM_220650
VERSION     NM_001033682.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2794)
  AUTHORS   Haschemi A, Kosma P, Gille L, Evans CR, Burant CF, Starkl P, Knapp
            B, Haas R, Schmid JA, Jandl C, Amir S, Lubec G, Park J, Esterbauer
            H, Bilban M, Brizuela L, Pospisilik JA, Otterbein LE and Wagner O.
  TITLE     The sedoheptulose kinase CARKL directs macrophage polarization
            through control of glucose metabolism
  JOURNAL   Cell Metab 15 (6), 813-826 (2012)
   PUBMED   22682222
REFERENCE   2  (bases 1 to 2794)
  AUTHORS   Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ and Mohammed
            S.
  TITLE     Lys-N and trypsin cover complementary parts of the phosphoproteome
            in a refined SCX-based approach
  JOURNAL   Anal Chem 81 (11), 4493-4501 (2009)
   PUBMED   19413330
REFERENCE   3  (bases 1 to 2794)
  AUTHORS   Kardon T, Stroobant V, Veiga-da-Cunha M and Schaftingen EV.
  TITLE     Characterization of mammalian sedoheptulokinase and mechanism of
            formation of erythritol in sedoheptulokinase deficiency
  JOURNAL   FEBS Lett 582 (23-24), 3330-3334 (2008)
   PUBMED   18775706
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC101914.1.
            
            On Sep 25, 2005 this sequence version replaced XM_220650.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132293
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2794
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2794
                     /gene="Shpk"
                     /gene_synonym="Carkl"
                     /note="sedoheptulokinase"
                     /db_xref="GeneID:287479"
                     /db_xref="RGD:1308004"
     exon            1..191
                     /gene="Shpk"
                     /gene_synonym="Carkl"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1448
                     /gene="Shpk"
                     /gene_synonym="Carkl"
                     /EC_number="2.7.1.14"
                     /codon_start=1
                     /product="sedoheptulokinase"
                     /protein_id="NP_001028854.1"
                     /db_xref="GeneID:287479"
                     /db_xref="RGD:1308004"
                     /translation="MTSRPVTLGIDLGTTSVKAALLEAAPGHPSGFVVLASCARAAGA
                     ETESAAAGPQGREQDVTRIIQALNECLDALPPRQLQRVGAIGVSGQMHGILFWKTGQG
                     CEWTERGSAPVFEPRAVSHLVTWQDNRCNSGFLASLPKPASHLSVATGFGCATIFWLL
                     KNSPEFLKSYDVAGTIQDYVVAMLCGLPRPLMSDQNAASWGYFNTQSQSWNSDILQMA
                     GFPTHLLPDIAEPGSLAGRTSHTWFEIPAGTEVGVALGDLQASVYSCMGQRTDAVLNI
                     STSVQLAASMPVGFQPPQTPDPAAPVAFFPYFDRTYLGVAASLNGGNVLATFVHMLVQ
                     WMTDLGLEVEESTVYSRMIQAAAQQKDTHLTITPTVLGERHLPDQLASVTRISSSDLS
                     LGHVTRALCRGIVQNLHSMLPFQQLQEWGVERVVGSGSALSRNEVLKQEVQRAFPFPV
                     CFGQDVDAAFGAALVMLRRDIS"
     exon            192..333
                     /gene="Shpk"
                     /gene_synonym="Carkl"
                     /inference="alignment:Splign:2.1.0"
     exon            334..517
                     /gene="Shpk"
                     /gene_synonym="Carkl"
                     /inference="alignment:Splign:2.1.0"
     exon            518..670
                     /gene="Shpk"
                     /gene_synonym="Carkl"
                     /inference="alignment:Splign:2.1.0"
     exon            671..846
                     /gene="Shpk"
                     /gene_synonym="Carkl"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1047
                     /gene="Shpk"
                     /gene_synonym="Carkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..2780
                     /gene="Shpk"
                     /gene_synonym="Carkl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcctgag ttgtgctgtc accgctgcca tgacttcgcg acccgtcact ctcggtatcg
       61 acttgggcac cacgtccgta aaggccgccc tcttggaggc tgcacccggc cacccatccg
      121 ggttcgtggt gctggcgagc tgcgcccggg ctgcgggggc agagaccgag agcgcggctg
      181 ccggacccca ggggcgggag caggatgtga ctagaatcat ccaagctcta aatgaatgcc
      241 ttgatgccct tcccccgagg cagctccaga gagtcggggc catcggagtg tcaggacaga
      301 tgcatggcat cctattttgg aaaacaggcc aaggctgtga atggacagag agagggtctg
      361 cccctgtatt tgaacccaga gccgtgagcc atttggtcac atggcaggat aaccgttgta
      421 acagtggttt cctggcttct ctgcccaagc cagcatccca tctcagcgtg gccacaggat
      481 tcggctgtgc aaccatcttc tggcttttga aaaacagccc ggagtttctg aagtcctatg
      541 acgtggctgg caccattcaa gactatgtgg ttgctatgct gtgtggcttg ccaagacccc
      601 tgatgtctga ccagaacgct gctagctggg gctattttaa cacccagagc cagagctgga
      661 actcggacat actgcaaatg gcaggttttc ctacccacct tctccccgac attgcagagc
      721 caggcagctt ggcaggcaga acttctcaca cgtggtttga aatcccagca gggacggagg
      781 tgggcgtagc cctgggtgac ttacaagcct ctgtctattc ctgcatgggc caaaggactg
      841 atgcagttct caacatcagc acctcggtcc agctggcagc ctccatgccc gtggggttcc
      901 agccaccgca gactccggat cctgcagccc cagtcgcctt cttcccttac ttcgacagga
      961 cctacctagg cgtggcagcg tcactcaacg gaggcaatgt gctggccacg tttgtccaca
     1021 tgcttgttca gtggatgaca gacctaggtc tggaggttga agaatccact gtctattcac
     1081 gcatgatcca ggcggctgca cagcagaaag atacccatct caccatcacc ccaacagtgc
     1141 tgggggagag gcacctgcca gaccagctgg cctctgtgac tagaatctcc tcctctgacc
     1201 tttccctggg ccatgtgacc cgggccctat gcagaggcat tgttcagaac ctgcactcca
     1261 tgcttccttt tcaacagctc caagagtggg gtgtggaacg ggtggtgggg agtggaagtg
     1321 cattgtccag gaatgaggtc ctgaagcagg aggtccagag ggcatttcct ttcccagtgt
     1381 gctttgggca ggatgtagat gcagccttcg gggcagcttt ggtcatgctc cggagagaca
     1441 tcagctagaa ggagccttag ttcttcaagc tcgttgcctt aaggaaatgc tgggaatctt
     1501 acctaattga caatgtcatc atgatctctg ggttgtcctt ttctgggatg gttctgtggg
     1561 cagactgtaa attatacttg atcttgaggt gctatctaga ctgataaaga tcttcccttc
     1621 agggcatatg gtaatcatac agccaggaag ctctaaccag accccaagct agtgccttcc
     1681 aagaatagga tcttccgaga gctgattgca attgcagatg tggggggagg agagcaaggg
     1741 agggaagaaa atgggatgag ggagaggaag aaagaaacaa acagcttcct ggtcactagg
     1801 ctcggctgtg attcagtcat agacagaagg aaaagaaaga tgacttatgc agccatggct
     1861 ccagctaagc aaagaagacc tggtttatgc ccagcgtttg gactggtcca gttttgtgtc
     1921 aaatgcatta ctggaaaaat cctccctgcc ctgttgtagc aggtggctgg agtctcctct
     1981 cctagtcttg ggaaatagaa ggatccttac ttagttcagc aagttccttg tctaaaggaa
     2041 tgctgggaac ctcatctaac cagtcagctt gatagccctg tcagttgaag ggaccagcta
     2101 tagcatgttc tccagtcaga gagagatcga agacatgaag caacacgcat tggaggagga
     2161 agccaaggtc tgtgtgcttg ccttgctgtg tgcttcagga aacgtgctgc accatggtta
     2221 cctcgagtcc tctcaacaca accggcttaa aggcacgtcc cagagaaggg aaggcaggtg
     2281 gcacgaacag ctaaagggac cacagagcac tgtgaccaac accgtctgac agactgtttt
     2341 caagatggca gcaaggcacc ctagcccctt tctatgacta tgtatggcca cctgtctccc
     2401 taacccctgc tacaagaggt gaccagtttc atgagagaac ccttaaccca caggtcccac
     2461 ccctttctcc atggtgaaga tcttgctggc ctctggtggt tctggcccag cagaaatgtc
     2521 ctgttcagat gggcatgcat ctagggtcag agaaccacca gtctttccac attacagtac
     2581 ctccgaggag agggtcacca tcactgtgtc tactcctaga ctcctaaagt acccaaggct
     2641 cggaggcacc tgtgactttt ggggagaaac catgttgtct ctttgtaaga gtcattttat
     2701 aaggaatatt attgtggtaa cccctttgat gaatttacct cccactgctg gctatctgaa
     2761 taaatttcat tttttttcca aaaaaaaaaa aaaa
//
