LOCUS       NM_013028               2549 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SHOX homeobox 2 (Shox2), mRNA.
ACCESSION   NM_013028
VERSION     NM_013028.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2549)
  AUTHORS   Ye,F., Wang,H., Zheng,Z., He,P., Sribastav,S.S., Wang,H., Wang,J.,
            Liu,H. and Leung,V.Y.L.
  TITLE     Role of SHOX2 in the development of intervertebral disc
            degeneration
  JOURNAL   J Orthop Res 35 (5), 1047-1057 (2017)
   PUBMED   26697824
  REMARK    GeneRIF: important role in the process of intervertebral disc
            degeneration
REFERENCE   2  (bases 1 to 2549)
  AUTHORS   Ilse,P., Biesterfeld,S., Pomjanski,N., Wrobel,C. and Schramm,M.
  TITLE     Analysis of SHOX2 methylation as an aid to cytology in lung cancer
            diagnosis
  JOURNAL   Cancer Genomics Proteomics 11 (5), 251-258 (2014)
   PUBMED   25331797
REFERENCE   3  (bases 1 to 2549)
  AUTHORS   Jolma,A., Yan,J., Whitington,T., Toivonen,J., Nitta,K.R.,
            Rastas,P., Morgunova,E., Enge,M., Taipale,M., Wei,G., Palin,K.,
            Vaquerizas,J.M., Vincentelli,R., Luscombe,N.M., Hughes,T.R.,
            Lemaire,P., Ukkonen,E., Kivioja,T. and Taipale,J.
  TITLE     DNA-binding specificities of human transcription factors
  JOURNAL   Cell 152 (1-2), 327-339 (2013)
   PUBMED   23332764
REFERENCE   4  (bases 1 to 2549)
  AUTHORS   Gross,S., Krause,Y., Wuelling,M. and Vortkamp,A.
  TITLE     Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of
            Runx2 and Shox2 in mice
  JOURNAL   PLoS One 7 (8), e43553 (2012)
   PUBMED   22916278
REFERENCE   5  (bases 1 to 2549)
  AUTHORS   Vickerman,L., Neufeld,S. and Cobb,J.
  TITLE     Shox2 function couples neural, muscular and skeletal development in
            the proximal forelimb
  JOURNAL   Dev Biol 350 (2), 323-336 (2011)
   PUBMED   21156168
REFERENCE   6  (bases 1 to 2549)
  AUTHORS   Yu,L., Liu,H., Yan,M., Yang,J., Long,F., Muneoka,K. and Chen,Y.
  TITLE     Shox2 is required for chondrocyte proliferation and maturation in
            proximal limb skeleton
  JOURNAL   Dev Biol 306 (2), 549-559 (2007)
   PUBMED   17481601
REFERENCE   7  (bases 1 to 2549)
  AUTHORS   Blaschke,R.J., Hahurij,N.D., Kuijper,S., Just,S., Wisse,L.J.,
            Deissler,K., Maxelon,T., Anastassiadis,K., Spitzer,J., Hardt,S.E.,
            Scholer,H., Feitsma,H., Rottbauer,W., Blum,M., Meijlink,F.,
            Rappold,G. and Gittenberger-de Groot,A.C.
  TITLE     Targeted mutation reveals essential functions of the homeodomain
            transcription factor Shox2 in sinoatrial and pacemaking development
  JOURNAL   Circulation 115 (14), 1830-1838 (2007)
   PUBMED   17372176
REFERENCE   8  (bases 1 to 2549)
  AUTHORS   Cobb,J., Dierich,A., Huss-Garcia,Y. and Duboule,D.
  TITLE     A mouse model for human short-stature syndromes identifies Shox2 as
            an upstream regulator of Runx2 during long-bone development
  JOURNAL   Proc Natl Acad Sci U S A 103 (12), 4511-4515 (2006)
   PUBMED   16537395
REFERENCE   9  (bases 1 to 2549)
  AUTHORS   Yu,L., Gu,S., Alappat,S., Song,Y., Yan,M., Zhang,X., Zhang,G.,
            Jiang,Y., Zhang,Z., Zhang,Y. and Chen,Y.
  TITLE     Shox2-deficient mice exhibit a rare type of incomplete clefting of
            the secondary palate
  JOURNAL   Development 132 (19), 4397-4406 (2005)
   PUBMED   16141225
REFERENCE   10 (bases 1 to 2549)
  AUTHORS   van Schaick,H.S., Smidt,M.P., Rovescalli,A.C., Luijten,M., van der
            Kleij,A.A., Asoh,S., Kozak,C.A., Nirenberg,M. and Burbach,J.P.
  TITLE     Homeobox gene Prx3 expression in rodent brain and extraneural
            tissues
  JOURNAL   Proc Natl Acad Sci U S A 94 (24), 12993-12998 (1997)
   PUBMED   9371788
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 25, 2020 this sequence version replaced NM_013028.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ002259.1, SRR22582424.697804.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984016 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               JAXUCZ010000002.1  153536660-153537161 c
            503-711             JAXUCZ010000002.1  153533616-153533824 c
            712-769             JAXUCZ010000002.1  153531295-153531352 c
            770-858             JAXUCZ010000002.1  153530906-153530994 c
            859-2549            JAXUCZ010000002.1  153527571-153529261 c
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..2549
                     /gene="Shox2"
                     /note="SHOX homeobox 2"
                     /db_xref="GeneID:25546"
                     /db_xref="RGD:3674"
     exon            1..502
                     /gene="Shox2"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1152
                     /gene="Shox2"
                     /note="paired family homeodomain protein Prx3; short
                     stature homeobox 2"
                     /codon_start=1
                     /product="short stature homeobox protein 2"
                     /protein_id="NP_037160.2"
                     /db_xref="GeneID:25546"
                     /db_xref="RGD:3674"
                     /translation="MEELTAFVSKSFDQKVKEKKEAITYREVLESGPLRGAKEPGCVE
                     PGRDDRSSPAVRAAGGGGGAGGGGGGGGGGGGGAGGGGAGGGAGGGRSPVRELDMGAA
                     ERSREPGSPRLTEVSPELKDRKEDAKGMEDEGQTKIKQRRSRTNFTLEQLNELERLFD
                     ETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVLIGAASQFEACR
                     VAPYVNVGALRMPFQQDSHCNVTPLSFQVQAQLQLDSAVAHAHHHLHPHLAAHAPYMM
                     FPAPPFGLPLATLAADSASAASVVAAAAAAKTTSKNSSIADLRLKAKKHAAALGL"
     exon            503..711
                     /gene="Shox2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..769
                     /gene="Shox2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..858
                     /gene="Shox2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..2549
                     /gene="Shox2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcttcctcct cctccctctc ctcccccatc cccctgcccc attgatgtgt tattattggg
       61 ggggctggag cagtaaaaaa agaaggagga aaaaaagagc ggggctcggc agggagagct
      121 tgagcgcgag gctgaccggc agcggcagcg gccgcgatgg aagaacttac ggcgttcgtc
      181 tccaagtctt ttgaccagaa agtgaaggag aagaaggagg ccatcacgta ccgggaggtg
      241 ctggagagcg ggccgctgcg cggggccaaa gagcccggct gcgtcgagcc gggccgcgac
      301 gaccgcagca gcccggcagt ccgggcggcc ggcggaggcg gcggcgcggg aggaggcgga
      361 ggcggaggcg gaggaggcgg aggaggtgct ggaggaggag gagcaggcgg aggagctgga
      421 ggagggcgct ctcccgtccg ggagctggac atgggagccg cggagcggag cagggagccc
      481 ggcagcccgc ggctgacgga ggtgtcccct gaactgaagg atcgcaaaga ggatgcgaaa
      541 gggatggagg acgaaggcca gaccaaaatc aagcagcggc gaagtcggac caattttacc
      601 ctggaacaac tcaacgagct ggagaggctt ttcgatgaga cccactatcc agacgctttt
      661 atgcgcgagg aactgagcca gcgactgggg ctatctgagg cccgagtaca ggtttggttt
      721 caaaatcgaa gagctaagtg tagaaaacag gaaaatcaac ttcataaagg tgtccttata
      781 ggggctgcta gccagtttga agcttgtaga gttgcaccct atgtcaacgt aggtgcttta
      841 aggatgccat ttcagcagga tagtcattgc aacgtgacgc ccttgtcctt tcaggttcag
      901 gcgcagctgc agctggacag cgccgtggcg cacgcgcacc accacctgca tccgcacctg
      961 gccgcgcacg cgccttacat gatgttcccg gcaccgccct tcggactgcc gctggccacg
     1021 ctggccgcgg actcggcctc cgccgcctcg gtggtggctg ccgccgccgc cgccaagacc
     1081 accagcaaga actccagcat cgcggatctc agactgaaag ctaaaaagca cgcggccgcc
     1141 ctgggtctgt gacgccggcg ccagcgccac ggtcggtgga gccttctatg cggcgcgacc
     1201 ccgcacgctc tccgcgaccg gctgcttctc ccgcacccgc ttcggaccga ctaagcctgt
     1261 cccttccccg ctgactgccg ccttttcttt ctgcaccctg gatccctagg gcgggactct
     1321 gcgctggacc cgggatccca cgaggaccac cagcccggag ctcctgccca cccgcccttg
     1381 ggactaaaat tcggctttgt aggagcgggt ttggggaagt ctggatagag actggacaaa
     1441 ggagtgtggc aacagtgacc acagctgcgg cgacggactc gttcatagga ataaaatctt
     1501 gctaacaaca aatgagcaaa aacaaaaaag gatagagaac aaactaaaaa aagaaaatga
     1561 gaaagggggc ttgtttctta ttgctatttg gctggaatta gagagagaac gacgaagcaa
     1621 aacaattctt aaaattattt tgtacataaa aatacggaaa aataacctgg atgaatcttg
     1681 agagaaaggg gggagggatt taccaactaa aatgtatgtt tttttaaaaa tggtccaagg
     1741 aaacaaaaca gaaggaagag gtatacttat ttaaagaatt aagatgaaaa aaaaaaagcg
     1801 cagctgggaa gttcacaggt tttgaagctg acctttttct gcgaagttca ctttaatacg
     1861 agacatttga taagagaggc gggcctcctt ttacgttgaa tctgatgctt tgagttttaa
     1921 aacaccatgt ttggaagagc aagaagaggg aagacagtgt ggaaacgagg agggaaaaaa
     1981 ggacgttcat acaaaaaaaa aaaaaagcga taccacagac aatgattctt ctgagaaatt
     2041 attaaggcag aactgtccag actgctgaca gtaaattctg gtttgcatgt tacttgtatt
     2101 ccattgatgg tgtcccctcc cctcccactc tcacgtgcac tcactacact ttcattctcc
     2161 gtatgaaaag cgtctggaaa ttgatgtgaa tccatatata atttgtccgg cccttgatcc
     2221 caaggggcaa aggaaaaaaa aagtcgtaag ggagtaaaat acactctgag tcttccaaga
     2281 agatggaggc tgttagaaaa tatgggcaaa gaaaagagac gagcaaatga agtcacgaag
     2341 gtatacagcc gcgcatcgtg ataggcgctt gatctgttta gtccctttcc gtgaattccc
     2401 tcttgctagt ttaagtccta tttgaggaca acgctttatt cccacctccc tctctatccc
     2461 gaaaattcac cttaaacgac acccaactag gtacagacac taggtttgtg tataatatgt
     2521 tgataaacac gaacaaagtt tattttggc
//
