LOCUS       NM_001013155            2145 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus SHOC2 leucine-rich repeat scaffold protein
            (Shoc2), mRNA.
ACCESSION   NM_001013155 XM_220082
VERSION     NM_001013155.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2145)
  AUTHORS   Motta,M., Solman,M., Bonnard,A.A., Kuechler,A., Pantaleoni,F.,
            Priolo,M., Chandramouli,B., Coppola,S., Pizzi,S., Zara,E.,
            Ferilli,M., Kayserili,H., Onesimo,R., Leoni,C., Brinkmann,J.,
            Vial,Y., Kamphausen,S.B., Thomas-Teinturier,C., Guimier,A.,
            Cordeddu,V., Mazzanti,L., Zampino,G., Chillemi,G., Zenker,M.,
            Cave,H., den Hertog,J. and Tartaglia,M.
  TITLE     Expanding the molecular spectrum of pathogenic SHOC2 variants
            underlying Mazzanti syndrome
  JOURNAL   Hum Mol Genet 31 (16), 2766-2778 (2022)
   PUBMED   35348676
REFERENCE   2  (bases 1 to 2145)
  AUTHORS   Wang,J., Chen,Y., Liang,J., Cao,M., Shen,J. and Ke,K.
  TITLE     Study of the pathology and the underlying molecular mechanism of
            tissue injury around hematoma following intracerebral hemorrhage
  JOURNAL   Mol Med Rep 24 (4) (2021)
   PUBMED   34368865
REFERENCE   3  (bases 1 to 2145)
  AUTHORS   Leon,G., Sanchez-Ruiloba,L., Perez-Rodriguez,A., Gragera,T.,
            Martinez,N., Hernandez,S., Anta,B., Calero,O.,
            Garcia-Dominguez,C.A., Dura,L.M., Pena-Jimenez,D., Castro,J.,
            Zarich,N., Sanchez-Gomez,P., Calero,M., Iglesias,T., Oliva,J.L. and
            Rojas,J.M.
  TITLE     Shoc2/Sur8 protein regulates neurite outgrowth
  JOURNAL   PLoS One 9 (12), e114837 (2014)
   PUBMED   25514808
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2145)
  AUTHORS   Hannig,V., Jeoung,M., Jang,E.R., Phillips,J.A. 3rd and Galperin,E.
  TITLE     A Novel SHOC2 Variant in Rasopathy
  JOURNAL   Hum Mutat 35 (11), 1290-1294 (2014)
   PUBMED   25137548
REFERENCE   5  (bases 1 to 2145)
  AUTHORS   Gripp,K.W., Zand,D.J., Demmer,L., Anderson,C.E., Dobyns,W.B.,
            Zackai,E.H., Denenberg,E., Jenny,K., Stabley,D.L. and Sol-Church,K.
  TITLE     Expanding the SHOC2 mutation associated phenotype of Noonan
            syndrome with loose anagen hair: structural brain anomalies and
            myelofibrosis
  JOURNAL   Am J Med Genet A 161A (10), 2420-2430 (2013)
   PUBMED   23918763
REFERENCE   6  (bases 1 to 2145)
  AUTHORS   Moon,B.S., Kim,H.Y., Kim,M.Y., Yang,D.H., Lee,J.M., Cho,K.W.,
            Jung,H.S. and Choi,K.Y.
  TITLE     Sur8/Shoc2 involves both inhibition of differentiation and
            maintenance of self-renewal of neural progenitor cells via
            modulation of extracellular signal-regulated kinase signaling
  JOURNAL   Stem Cells 29 (2), 320-331 (2011)
   PUBMED   21732489
  REMARK    GeneRIF: Sur8 is an antidifferentiation factor that stimulates
            proliferation for maintenance of self-renewal in NPCs via
            modulation of the Ras-ERK pathway.
REFERENCE   7  (bases 1 to 2145)
  AUTHORS   Komatsuzaki,S., Aoki,Y., Niihori,T., Okamoto,N., Hennekam,R.C.,
            Hopman,S., Ohashi,H., Mizuno,S., Watanabe,Y., Kamasaki,H.,
            Kondo,I., Moriyama,N., Kurosawa,K., Kawame,H., Okuyama,R.,
            Imaizumi,M., Rikiishi,T., Tsuchiya,S., Kure,S. and Matsubara,Y.
  TITLE     Mutation analysis of the SHOC2 gene in Noonan-like syndrome and in
            hematologic malignancies
  JOURNAL   J Hum Genet 55 (12), 801-809 (2010)
   PUBMED   20882035
REFERENCE   8  (bases 1 to 2145)
  AUTHORS   Cordeddu,V., Di Schiavi,E., Pennacchio,L.A., Ma'ayan,A.,
            Sarkozy,A., Fodale,V., Cecchetti,S., Cardinale,A., Martin,J.,
            Schackwitz,W., Lipzen,A., Zampino,G., Mazzanti,L., Digilio,M.C.,
            Martinelli,S., Flex,E., Lepri,F., Bartholdi,D., Kutsche,K.,
            Ferrero,G.B., Anichini,C., Selicorni,A., Rossi,C., Tenconi,R.,
            Zenker,M., Merlo,D., Dallapiccola,B., Iyengar,R., Bazzicalupo,P.,
            Gelb,B.D. and Tartaglia,M.
  TITLE     Mutation of SHOC2 promotes aberrant protein N-myristoylation and
            causes Noonan-like syndrome with loose anagen hair
  JOURNAL   Nat Genet 41 (9), 1022-1026 (2009)
   PUBMED   19684605
REFERENCE   9  (bases 1 to 2145)
  AUTHORS   Rodriguez-Viciana,P., Oses-Prieto,J., Burlingame,A., Fried,M. and
            McCormick,F.
  TITLE     A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic
            subunit of PP1 functions as an M-Ras effector to modulate Raf
            activity
  JOURNAL   Mol Cell 22 (2), 217-230 (2006)
   PUBMED   16630891
REFERENCE   10 (bases 1 to 2145)
  AUTHORS   Miller,M.E., Michaylira,C.Z., Simmons,J.G., Ney,D.M., Dahly,E.M.,
            Heath,J.K. and Lund,P.K.
  TITLE     Suppressor of cytokine signaling-2: a growth hormone-inducible
            inhibitor of intestinal epithelial cell proliferation
  JOURNAL   Gastroenterology 127 (2), 570-581 (2004)
   PUBMED   15300589
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 25, 2020 this sequence version replaced NM_001013155.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079032.1, SRR26643288.7581.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-914               JAXUCZ010000001.1  263001305-263002218
            915-1052            JAXUCZ010000001.1  263019085-263019222
            1053-1183           JAXUCZ010000001.1  263032250-263032380
            1184-1372           JAXUCZ010000001.1  263044996-263045184
            1373-1495           JAXUCZ010000001.1  263047358-263047480
            1496-1633           JAXUCZ010000001.1  263049169-263049306
            1634-1751           JAXUCZ010000001.1  263049589-263049706
            1752-2145           JAXUCZ010000001.1  263050878-263051271
FEATURES             Location/Qualifiers
     source          1..2145
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..2145
                     /gene="Shoc2"
                     /note="SHOC2 leucine-rich repeat scaffold protein"
                     /db_xref="GeneID:309548"
                     /db_xref="RGD:1308146"
     exon            1..914
                     /gene="Shoc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1960
                     /gene="Shoc2"
                     /note="protein soc-2 homolog; protein sur-8 homolog; soc-2
                     (suppressor of clear) homolog"
                     /codon_start=1
                     /product="leucine-rich repeat protein SHOC-2"
                     /protein_id="NP_001013173.1"
                     /db_xref="GeneID:309548"
                     /db_xref="RGD:1308146"
                     /translation="MSSSLGKEKDSKEKDPKVPSAKEREKEAKASGGFGKESKEKEPK
                     TKGKDAKDGKKESSAAQPGVAFSVDNTIKRPNPALGTRKKSSNAEVTKELNKCREENS
                     MRLDLSKRSIHILPPSVKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS
                     LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITAVEKDVRNLPRLS
                     TLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDL
                     PDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLN
                     SLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLT
                     SLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKL
                     RELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTH
                     LPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPS
                     FIIQFLKMQGPYRAMV"
     exon            915..1052
                     /gene="Shoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1183
                     /gene="Shoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1372
                     /gene="Shoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1495
                     /gene="Shoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1633
                     /gene="Shoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1751
                     /gene="Shoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..2145
                     /gene="Shoc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaatccta atgaactgac cagcagcatt ttcacaagtt gaaatgaaca gagagctttt
       61 agagccaaca tgtaacagat ggatgtgagc ccaaggccat catcttcatg ccgacactct
      121 tgactgggta ggatctgtct cttcatcttt gatctggatt gctggcaaat aaaaggagtt
      181 catgtagtgt tttagttaag cttgagtcac catgagtagt agtttaggaa aagaaaaaga
      241 ctcgaaagag aaagatccca aagtaccatc tgccaaggaa agagaaaagg aggcaaaagc
      301 ctctggaggt tttgggaaag aaagcaaaga aaaagaacct aaaaccaaag ggaaagatgc
      361 caaagatgga aagaaggagt ccagtgctgc ccaacctggt gtggcttttt cagtcgacaa
      421 taccatcaaa cggcctaatc cagcacttgg gactagaaag aaatccagca atgccgaggt
      481 aactaaggag cttaacaaat gccgggagga gaactcaatg cgcttggact tatccaagcg
      541 gtctatacat atactgccgc cgtcagtcaa agagttgaca caactcacgg aactttattt
      601 atacagtaac aaattgcagt ccctcccagc agaggtgggc tgtctagtca atcttatgac
      661 gctggctctc agtgagaatt cactcaccag tttgcctgac tctctcgata acttgaagaa
      721 gctgcggatg cttgatttac ggcataataa actgagagaa atcccttcgg tggtgtacag
      781 gctagactcc ctgactactc tctaccttcg ctttaaccgc ataaccgctg tggagaagga
      841 cgtcagaaac ctgccgaggc tcagcacgct tagcatccga gagaacaaaa tcaagcagct
      901 ccctgccgag atcggtgaac tgtgtaacct cattaccctg gatgtagctc acaatcaact
      961 tgaacacctt ccgaaggaga ttgggaactg cacccagata accaacctgg acctgcagca
     1021 caatgagctg ctagacctcc cagacacaat aggaaacctg tccagtttaa atcgccttgg
     1081 cctgaggtac aatagattgt cagcaatacc cagatcatta gcaaaatgca gcgcacttga
     1141 ggagctaaat ctagagaaca ataacatttc tactctgcca gagagtcttt tatccagtct
     1201 tgtaaaattg aatagcttga ccttagctag aaattgcttc cagttgtacc cagtgggagg
     1261 cccatctcag ttttccacca tttattccct caacatggaa cacaatcgaa tcaacaaaat
     1321 cccatttgga attttttcca gagctaaagt gctgagtaag ctgaatatga aggacaatca
     1381 gttaacatca cttcctttgg attttggaac ttggaccagt atggtagaat tgaatttagc
     1441 gaccaatcag ctcacaaaga tcccggagga cgtgtctggt cttgtttctc ttgaggttct
     1501 aatattatcg aacaatcttc taaagaagct tccccatggt cttggaaacc ttagaaagtt
     1561 acgagaatta gacctggagg agaacaagct ggagtccttg cccaatgaga ttgcttatct
     1621 taaggattta cagaaattag tcttgacaaa caaccagttg accactctcc ccagaggcat
     1681 cggtcacctt accaacctca cacaccttgg tctcggagag aaccttctca ctcaccttcc
     1741 tgaggaaatt ggtacactgg aaaacctaga ggagctgtac ttgaatgaca accccaacct
     1801 tcacagcctc cccttcgagc ttgccctctg cagcaagctg tcaatcatga gtattgagaa
     1861 ctgtccactc agtcacctcc cacctcaaat tgttgctgga gggccttcat tcattattca
     1921 gttcttaaag atgcagggtc cgtatcgtgc catggtctga tacaaactgc tggtcccata
     1981 cactgttcaa aatagactgc cattactctt tggtatctgt atctgtgtct gtgtggatat
     2041 cgatctatgg cagacttata aagactgcat tatgtgtttc tgctaataga ggaatcatag
     2101 ccatttagat ttttttaatt ctgtaaaaaa aaaaaggctt aataa
//
