LOCUS       NM_001413151            1908 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus serine hydroxymethyltransferase 1 (Shmt1), mRNA.
ACCESSION   NM_001413151 XM_006246469
VERSION     NM_001413151.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1908)
  AUTHORS   Wei,J., Zhang,J., Wei,J., Hu,M., Chen,X., Qin,X., Chen,J., Lei,F.
            and Qin,Y.
  TITLE     Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of
            acute kidney injury by WGCNA
  JOURNAL   PLoS One 18 (2), e0281439 (2023)
   PUBMED   36735737
  REMARK    GeneRIF: Identification of AGXT2, SHMT1, and ACO2 as important
            biomarkers of acute kidney injury by WGCNA.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1908)
  AUTHORS   Pinthong,C., Maenpuen,S., Amornwatcharapong,W., Yuthavong,Y.,
            Leartsakulpanich,U. and Chaiyen,P.
  TITLE     Distinct biochemical properties of human serine
            hydroxymethyltransferase compared with the Plasmodium enzyme:
            implications for selective inhibition
  JOURNAL   FEBS J 281 (11), 2570-2583 (2014)
   PUBMED   24698160
REFERENCE   3  (bases 1 to 1908)
  AUTHORS   Watkins,D. and Rosenblatt,D.S.
  TITLE     Update and new concepts in vitamin responsive disorders of folate
            transport and metabolism
  JOURNAL   J Inherit Metab Dis 35 (4), 665-670 (2012)
   PUBMED   22108709
  REMARK    Review article
REFERENCE   4  (bases 1 to 1908)
  AUTHORS   Stover,P.J. and Field,M.S.
  TITLE     Trafficking of intracellular folates
  JOURNAL   Adv Nutr 2 (4), 325-331 (2011)
   PUBMED   22332074
  REMARK    Review article
REFERENCE   5  (bases 1 to 1908)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   6  (bases 1 to 1908)
  AUTHORS   Liu,X., Reig,B., Nasrallah,I.M. and Stover,P.J.
  TITLE     Human cytoplasmic serine hydroxymethyltransferase is an mRNA
            binding protein
  JOURNAL   Biochemistry 39 (38), 11523-11531 (2000)
   PUBMED   10995219
REFERENCE   7  (bases 1 to 1908)
  AUTHORS   Renwick,S.B., Snell,K. and Baumann,U.
  TITLE     The crystal structure of human cytosolic serine
            hydroxymethyltransferase: a target for cancer chemotherapy
  JOURNAL   Structure 6 (9), 1105-1116 (1998)
   PUBMED   9753690
REFERENCE   8  (bases 1 to 1908)
  AUTHORS   Garrow,T.A., Brenner,A.A., Whitehead,V.M., Chen,X.N., Duncan,R.G.,
            Korenberg,J.R. and Shane,B.
  TITLE     Cloning of human cDNAs encoding mitochondrial and cytosolic serine
            hydroxymethyltransferases and chromosomal localization
  JOURNAL   J Biol Chem 268 (16), 11910-11916 (1993)
   PUBMED   8505317
REFERENCE   9  (bases 1 to 1908)
  AUTHORS   Masuda,T., Sakamoto,M., Nishizaki,I., Hayashi,H., Yamamoto,M. and
            Wada,H.
  TITLE     Affinity purification and characterization of serine
            hydroxymethyltransferases from rat liver
  JOURNAL   J Biochem 101 (3), 643-652 (1987)
   PUBMED   3110140
REFERENCE   10 (bases 1 to 1908)
  AUTHORS   Hulse,J.D., Ellis,S.R. and Henderson,L.M.
  TITLE     Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an
            alpha-ketoglutarate-dependent mitochondrial dioxygenase
  JOURNAL   J Biol Chem 253 (5), 1654-1659 (1978)
   PUBMED   627563
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 27, 2022 this sequence version replaced XM_006246469.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.758093.1,
                                           SRR26643429.36959.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JAXUCZ010000010.1  45990128-45990341   c
            215-311             JAXUCZ010000010.1  45985286-45985382   c
            312-457             JAXUCZ010000010.1  45983058-45983203   c
            458-573             JAXUCZ010000010.1  45980083-45980198   c
            574-734             JAXUCZ010000010.1  45979598-45979758   c
            735-816             JAXUCZ010000010.1  45977190-45977271   c
            817-1029            JAXUCZ010000010.1  45976063-45976275   c
            1030-1146           JAXUCZ010000010.1  45974942-45975058   c
            1147-1269           JAXUCZ010000010.1  45973362-45973484   c
            1270-1386           JAXUCZ010000010.1  45970648-45970764   c
            1387-1497           JAXUCZ010000010.1  45969638-45969748   c
            1498-1908           JAXUCZ010000010.1  45968959-45969369   c
FEATURES             Location/Qualifiers
     source          1..1908
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1908
                     /gene="Shmt1"
                     /gene_synonym="LRRGT00032; mShmt; Shmt"
                     /note="serine hydroxymethyltransferase 1"
                     /db_xref="GeneID:287379"
                     /db_xref="RGD:1312011"
     exon            1..214
                     /gene="Shmt1"
                     /gene_synonym="LRRGT00032; mShmt; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            215..311
                     /gene="Shmt1"
                     /gene_synonym="LRRGT00032; mShmt; Shmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1670
                     /gene="Shmt1"
                     /gene_synonym="LRRGT00032; mShmt; Shmt"
                     /EC_number="2.1.2.1"
                     /note="serine hydroxymethyltransferase 1 (soluble)"
                     /codon_start=1
                     /product="serine hydroxymethyltransferase, cytosolic"
                     /protein_id="NP_001400080.1"
                     /db_xref="GeneID:287379"
                     /db_xref="RGD:1312011"
                     /translation="MAERDATVWASHEKMLTQPLKESDAEVYSIIKKESNRQRVGLEL
                     IASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYHLDP
                     QCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIF
                     FESMPYKVYPDTGYINYDQLEENASLFHPKLIIAGTSCYSRNLDYARLRKIADDNGAY
                     LMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVRSVDPKTGE
                     ETYYELESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTTEFKIYQLQVLANCRALSD
                     ALTELGYKIVTGGSDNHLILMDLRPKGTDGGRAEKVLEACSIACNKNTCPGDKSALRP
                     SGLRLGTPALTSRGLLEEDFQKIAHFIHRGIELTLQIQSHMTMRATLKEFKEKLTGDE
                     KFQSAVAALREEVENFASNFSLPGLPDF"
     exon            312..457
                     /gene="Shmt1"
                     /gene_synonym="LRRGT00032; mShmt; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            458..573
                     /gene="Shmt1"
                     /gene_synonym="LRRGT00032; mShmt; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            574..734
                     /gene="Shmt1"
                     /gene_synonym="LRRGT00032; mShmt; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            735..816
                     /gene="Shmt1"
                     /gene_synonym="LRRGT00032; mShmt; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1029
                     /gene="Shmt1"
                     /gene_synonym="LRRGT00032; mShmt; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1146
                     /gene="Shmt1"
                     /gene_synonym="LRRGT00032; mShmt; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1269
                     /gene="Shmt1"
                     /gene_synonym="LRRGT00032; mShmt; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1386
                     /gene="Shmt1"
                     /gene_synonym="LRRGT00032; mShmt; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1497
                     /gene="Shmt1"
                     /gene_synonym="LRRGT00032; mShmt; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1908
                     /gene="Shmt1"
                     /gene_synonym="LRRGT00032; mShmt; Shmt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttttgcc tgctctacag gaactcggcg gtccacctgc ctctgcctct ctagtgctgg
       61 gattaaaggc gtccgccatc acgacgtgtt tagttccttt cgtaaaggct agaggaccag
      121 gcatttaagg ccagttccgg ctaccaagtg aattggaggc caccctgcac caagggttga
      181 gaccttctca caaaacccac gctcctaata cttggcaact ctgaaccagt gcaatggcag
      241 agagggatgc caccgtgtgg gcctctcatg agaagatgtt gacacagccc ctgaaggaga
      301 gcgatgctga ggtttacagc atcattaaaa aggagagcaa ccggcagagg gtcggattgg
      361 agctgattgc ctcggagaac tttgccagca gagctgtgtt ggaggcccta ggatcttgct
      421 taaataacaa atactctgag gggtacccag gccaaaggta ttatggtggg actgagttca
      481 tcgatgagct ggagacgctg tgtcagaagc gtgcattaca ggcctaccat ctggatcctc
      541 agtgctgggg cgtcaatgtc cagccttatt caggctcccc tgcaaacttt gctgtgtata
      601 ctgccctagt agagccccat gggcgaatca tgggtttgga cctgccagat ggtggccatc
      661 tgactcatgg cttcatgaca gacaagaaga aaatctctgc cacctctatc ttctttgaat
      721 ccatgcctta taaggtatac ccagacactg ggtacatcaa ctatgaccag ctagaggaga
      781 atgccagcct cttccacccg aagctgatca ttgcagggac cagctgctac tcccggaacc
      841 tggactatgc gcggctgcga aagattgcgg atgataatgg ggcatatctc atggcagaca
      901 tggcacacat cagtgggctc gtggcagctg gtgtggtgcc ctcacccttt gaacactgtc
      961 atgtagtaac cactacaacc cacaagaccc tgagaggctg ccgtgctggt atgatattct
     1021 acagaaaggg tgtgcgcagt gttgatccca agactggcga agagacttac tatgaactgg
     1081 agtccctcat caactcggcc gtgttcccag gcctgcaggg cggccctcac aaccatgcca
     1141 ttgctggtgt tgctgtggcc ctgaagcaag ccatgactac agaattcaaa atctaccagc
     1201 tccaggtgtt ggccaactgc agggctctgt ctgatgcact cacagagcta ggctacaaaa
     1261 tagtcacagg tggctctgat aatcacttga tcctaatgga tctgcgtcct aagggtactg
     1321 atggcggaag ggctgagaag gtactggaag cctgttctat cgcctgcaac aagaatacct
     1381 gcccaggtga caagagtgcg ttacggccca gtggcctgcg actgggaact ccagcattga
     1441 catcccgagg acttttggaa gaagacttcc aaaaaatagc acactttatc cacagaggga
     1501 tagagttgac tctgcagatt cagagccaca tgaccatgag ggccacactg aaagagttca
     1561 aggagaagct gacaggggat gagaagttcc agagtgctgt ggcagctctc cgggaagaag
     1621 tggagaattt tgcttccaac ttctcactac ctggacttcc tgacttctga cagcacagcc
     1681 tgtgtctgcc aagagggtag gactgttcca ggacactgtg aaccctgtgc cctcctgagg
     1741 ctgtgaggtg gaccaccgag ctgcaccatg cttgggtggg tgtttctgtt tacctgtttt
     1801 caaatatttt gggacaggtc attgaggact tgaaatttga aatgttctgt agccatttga
     1861 cctcattgaa gcatatgagg caaagctatt aaagattcca gaatatcc
//
