LOCUS       NM_001399552            1325 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus shieldin complex subunit 1 (Shld1), mRNA.
ACCESSION   NM_001399552 XM_008762240
VERSION     NM_001399552.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1325)
  AUTHORS   Gupta,R., Somyajit,K., Narita,T., Maskey,E., Stanlie,A., Kremer,M.,
            Typas,D., Lammers,M., Mailand,N., Nussenzweig,A., Lukas,J. and
            Choudhary,C.
  TITLE     DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of
            NHEJ and PARP Inhibitor Sensitivity
  JOURNAL   Cell 173 (4), 972-988 (2018)
   PUBMED   29656893
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 12, 2022 this sequence version replaced XM_008762240.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.798642.1,
                                           SRR26643288.15775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                JAXUCZ010000003.1  140391719-140391750
            33-217              JAXUCZ010000003.1  140394967-140395151
            218-1325            JAXUCZ010000003.1  140461166-140462273
FEATURES             Location/Qualifiers
     source          1..1325
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1325
                     /gene="Shld1"
                     /note="shieldin complex subunit 1"
                     /db_xref="GeneID:681292"
                     /db_xref="RGD:1597982"
     exon            1..32
                     /gene="Shld1"
                     /inference="alignment:Splign:2.1.0"
     exon            33..217
                     /gene="Shld1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..660
                     /gene="Shld1"
                     /note="uncharacterized protein C20orf196 homolog"
                     /codon_start=1
                     /product="shieldin complex subunit 1"
                     /protein_id="NP_001386481.1"
                     /db_xref="GeneID:681292"
                     /db_xref="RGD:1597982"
                     /translation="MDSQAATPSSLSEESCTLDLPMVCDSMGYEASQGASQGSDSTSL
                     SSLEPHPFPSSSTADSDSNSLTTEQKGSWDSENFWLDPSSKGQVETNEEEDGLRKSLD
                     RFYEAFAQPLPGSGDPLSAPVCQCLSQTISELEGQESQKYALRSFQMARVIFSRDGCS
                     TLQRHSRETRFYPLEQEGSSVDDEEPTPGLSREVIRFLLEQTIMKDS"
     exon            218..1325
                     /gene="Shld1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttccggtt ccgggctctt gcggtcaggc cggcctatgg actcccaggc agccacgccc
       61 agcagcctgt ccgaagagag ctgtaccttg gatctaccta tggtgtgtga ctccatgggt
      121 tatgaagcat cccagggagc cagccaggga agcgacagca cctctctgag ttctctggaa
      181 ccccatcctt tcccttcttc ttcaactgcc gattcagata gcaattctct aactactgag
      241 caaaaaggct cctgggactc tgagaacttc tggcttgatc cttcttcaaa aggccaggtg
      301 gagaccaacg aagaggagga tggacttcgg aaatccctgg atagattcta tgaagcattt
      361 gcccaaccac tgccaggctc tggggatccg ctctctgcac ctgtgtgtca gtgcctgtct
      421 cagaccatct ctgagctcga gggccaggag agccaaaagt atgctctccg cagtttccag
      481 atggcccggg tcatcttcag ccgggatggc tgctctacct tacagcggca ttccagggaa
      541 acccgcttct acccactaga gcaagaaggc agctctgtgg atgatgaaga gcccacccca
      601 ggactgtcaa gagaggtcat tcgttttctc ttggaacaga ccataatgaa agactcatag
      661 ctggtgctga tgttgtgaaa gtgctgtcac ctgctcccca gagtccatgg atgtgtgtag
      721 cacatctttc tgtttccacc attagccgta agctttgcag ggagaagctt tgatggagcc
      781 agtaagcacc ttggtgtgct acctcctact caccttggcc aaggctgcta ctgattcaac
      841 tagggtcgag tcctagccga gcttcttgcc ttagtcagtg ctcctgagtg ctgtcctggt
      901 gacctggcca gagctgggac tttggcagga aatcacttcc ctgattgagt tcatcccttc
      961 ccccactcac ctactggtat ctctagggcc ttttcttttc ttcgtttttt ttttaattta
     1021 tttttcttga atattttatg tattcacatt tcaaatgtta tctcttttcc cctctcccat
     1081 acctcatccc cctcctcctg cttctatgag actgctccca tccacccact ccaacctcaa
     1141 caccctggca ttcccctaca ttggggaaat agccttcaca ggaccaacgg ctttccctcc
     1201 tattgatgct ggataatgcc atcctctgct acatatgtgg ctagagtcat gggtccgttc
     1261 atgtgtactt gttggttgtt ggtttagttc tagggccttt tttaaataaa cttcttgtat
     1321 ctgca
//
