LOCUS       NM_001415765            8182 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus shisa family member 6 (Shisa6), transcript
            variant 1, mRNA.
ACCESSION   NM_001415765 XM_017597452
VERSION     NM_001415765.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8182)
  AUTHORS   Tokue,M., Ikami,K., Mizuno,S., Takagi,C., Miyagi,A., Takada,R.,
            Noda,C., Kitadate,Y., Hara,K., Mizuguchi,H., Sato,T., Taketo,M.M.,
            Sugiyama,F., Ogawa,T., Kobayashi,S., Ueno,N., Takahashi,S.,
            Takada,S. and Yoshida,S.
  TITLE     SHISA6 Confers Resistance to Differentiation-Promoting
            Wnt/beta-Catenin Signaling in Mouse Spermatogenic Stem Cells
  JOURNAL   Stem Cell Reports 8 (3), 561-575 (2017)
   PUBMED   28196692
REFERENCE   2  (bases 1 to 8182)
  AUTHORS   Klaassen,R.V., Stroeder,J., Coussen,F., Hafner,A.S., Petersen,J.D.,
            Renancio,C., Schmitz,L.J., Normand,E., Lodder,J.C., Rotaru,D.C.,
            Rao-Ruiz,P., Spijker,S., Mansvelder,H.D., Choquet,D. and Smit,A.B.
  TITLE     Shisa6 traps AMPA receptors at postsynaptic sites and prevents
            their desensitization during synaptic activity
  JOURNAL   Nat Commun 7, 10682 (2016)
   PUBMED   26931375
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8182)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 29, 2022 this sequence version replaced XM_017597452.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.61219.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1382              JAXUCZ010000010.1  51689775-51691156   c
            1383-1543           JAXUCZ010000010.1  51667698-51667858   c
            1544-1639           JAXUCZ010000010.1  51554357-51554452   c
            1640-1696           JAXUCZ010000010.1  51409553-51409609   c
            1697-1849           JAXUCZ010000010.1  51405168-51405320   c
            1850-8182           JAXUCZ010000010.1  51396806-51403138   c
FEATURES             Location/Qualifiers
     source          1..8182
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..8182
                     /gene="Shisa6"
                     /gene_synonym="RGD1564618"
                     /note="shisa family member 6"
                     /db_xref="GeneID:497926"
                     /db_xref="RGD:1564618"
     exon            1..1382
                     /gene="Shisa6"
                     /gene_synonym="RGD1564618"
                     /inference="alignment:Splign:2.1.0"
     CDS             739..2400
                     /gene="Shisa6"
                     /gene_synonym="RGD1564618"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein shisa-6 homolog; shisa homolog 6"
                     /codon_start=1
                     /product="protein shisa-6 isoform 1 precursor"
                     /protein_id="NP_001402694.1"
                     /db_xref="GeneID:497926"
                     /db_xref="RGD:1564618"
                     /translation="MALRRLLLSPLLLSLLLSLASLHLPPGADAARGRSANRTLSAGA
                     VGGRRAGSALARGDRELNSTARGSGVSEAGSRRGQSAAAAAAASATVTYETCWGYYDV
                     SGQYDKEFECNNSESGYLYCCGTCYYRFCCKKRHEKLDQRQCTNYQSPVWVQTPSTKV
                     VSPGPENKYDPEKDKTNFTVYITCGVIAFVIVAGVFAKVSYDKAHRPPREMNIHRALA
                     DILRQQGPIPIAHCERETISAIDTSPKENTPVRSTSKNHYTPVRTAKQTPGHYGKDAY
                     RSGGPDLHNFISSGFVTLGRGHTKGDRQYNHPILSSATQTPTHEKPRMNNILTSATEP
                     YDLSFSRSYQNLAHLPPSYESAVKTNPSKYSSLKRLTDKEADEYYMRRRHLPDLAARG
                     TLPLNVIQMSQQKPLPRERPRRPIRAMSQDRVLSPRRGLPDEFGMPYDRILSDEQLLS
                     TERLHSQDPLLSPERTAFPEQSLSRAISHTDVFVSTPVLDRYRMTKMHSHPSASNNSY
                     ATLGQSQTAAKRHAFASRRHNTVEQLHYIPGHHTCYTASKTEVTV"
     exon            1383..1543
                     /gene="Shisa6"
                     /gene_synonym="RGD1564618"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1639
                     /gene="Shisa6"
                     /gene_synonym="RGD1564618"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1696
                     /gene="Shisa6"
                     /gene_synonym="RGD1564618"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1849
                     /gene="Shisa6"
                     /gene_synonym="RGD1564618"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..8182
                     /gene="Shisa6"
                     /gene_synonym="RGD1564618"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgcgtgt gtctccctct ccctatcgca cacgctccgg cactagtgca ggcggttccc
       61 ggctctgctc actcgctccg gccgctgcgc tcccgcctag ccgctgccgc cgccgctgca
      121 gtcgcagccg ggcatggtga gtgactgagg tgcagccgcg gagcacccgg gctgcccttc
      181 cgaccccagc ctcagccggc agcaccgccc ccgggccagg cggcggggtg gcttccccag
      241 gggctctacg tgcgccctcg ggccaccgtc ccagccggga ctcactcctc gagggctgag
      301 cgctccttct ccgctcggct gccggctgct ccccgtaccc cgtgaccgct gccccgtctc
      361 gtcccgcagg acctgcccgg acgggaccac accgccgccg ccgccgcctc cgcctcccgg
      421 agccgcgctt cggggccggc ctgagccgag tcgcgcgggg ccgccgctgc cgcgggcggg
      481 ggatggggct gcccgcctgg cgcgcggagc ccgcaggggg agcgcggagc cggcgcgcag
      541 cctgaaagcc ccgcgcagcc cgcgcccggc cgctctgtgc gctcccactg ccgcctgcgc
      601 ctcgatggcg ccatctcccc gccgctgact ggtccgcctc gccctcccag cccgcgcggc
      661 ggccctcgga gcccggccag cctcccgggc agcggcctgc agcccgcgtc cgcccgcgcc
      721 ctcccgcccg gccccgccat ggcgctgcgc cgcctcctgc tgtcgcctct gctgctgtcg
      781 ctgctgctgt cgctcgcgtc cctgcacctg ccgcccggcg cagacgccgc ccgtggccgc
      841 tccgctaacc ggaccctgag cgcgggagcc gtcggaggtc ggcgagcggg gagcgccctg
      901 gcccgaggcg accgcgagct caacagcacc gcccgtgggt ccggcgtctc ggaggcgggc
      961 agccggcggg gacagtccgc agcggcggcg gcggcggcca gcgcgactgt tacttacgag
     1021 acgtgctggg gctactacga cgtgagcggc cagtacgaca aggagttcga gtgcaacaac
     1081 agcgagagcg gctacctgta ctgctgcggc acctgctact atcgcttctg ctgcaagaag
     1141 cgccacgaga agctggacca gcgccagtgc accaactacc aaagcccggt atgggtgcag
     1201 acgcccagca ccaaggtagt gtcgccgggg cccgagaaca agtacgaccc agagaaggac
     1261 aagaccaact ttaccgtcta catcacttgc ggggtgatag ccttcgtcat cgtggcgggt
     1321 gtcttcgcca aggtctccta tgacaaggcc caccgccctc cgcgagagat gaacatccac
     1381 agggctctgg ctgacatcct aagacaacag ggaccaatcc ccatagcaca ctgtgaaaga
     1441 gaaaccatct cggccatcga tacctctccc aaagagaaca cgccggtccg atcaacctcc
     1501 aaaaaccact acacccctgt gcgcacagcc aagcagactc cagggcatta tgggaaggat
     1561 gcttaccgaa gtggaggacc agatctccat aacttcatct catctggatt tgtcacatta
     1621 ggaagaggac acacgaaggg tgatcgtcag tataatcatc ctatattaag cagcgctacc
     1681 cagaccccta cgcatgagaa gccacggatg aataacatcc tgacatcagc cacagagccc
     1741 tatgacctct ccttctcgcg ctcttaccag aacttagccc atttgcctcc atcatatgaa
     1801 tctgcagtga agacaaatcc gagcaagtac tcatctctga agaggctaac ggacaaggaa
     1861 gctgatgagt attacatgag aaggaggcac ctgccagatc ttgcagcccg tggtactctc
     1921 cccctcaacg tcatccagat gtctcaacag aagcctcttc ctcgagaacg gccacgcagg
     1981 cccattaggg ccatgtccca ggacagggtc ttgtctccac gtcggggatt gccagatgaa
     2041 ttcggcatgc cctatgaccg catcttgtct gatgaacagc tgctctccac agagcgcctg
     2101 cactcccagg acccgttgct gtccccagag aggacagctt tcccggagca gtcgctgtcg
     2161 cgggccatct cgcacacgga cgtctttgtg tccacaccag tgctggaccg ttaccgcatg
     2221 accaagatgc actcccatcc cagtgcctcc aataactcct atgccaccct gggccagagc
     2281 cagacggcag ccaagcgcca tgcctttgcc tctcgcagac ataacacggt ggaacagctg
     2341 cactatatcc cgggccatca cacctgctac acagccagca agaccgaagt gacagtgtga
     2401 cccgcagtgt ggccagggct gcttggcaga gtcagggcag gacagagcag agtagggcag
     2461 gggtgaggag cagagtatcc agtcaggctc tcctcccctc cctggttccc cccattgaag
     2521 ttggaggtgg gctgcctctg tccagaaagc cataccccca gggagatggc gccaaatgcc
     2581 tggtacaaca agcacagacc caggctcttt aaagctcttt ctctcccagt agactccccc
     2641 tgcagatgag aagtgtggtg aggcccaaat ctctccctca gtccctgccc cgccccttcc
     2701 tggggactca gctgcaggtt ctgccagcca gtggaccctc tcctgaaggt gatgtgaagc
     2761 tgcctgagtt tgatcagcca gctggctaga gggtgcagcg agtgggctaa ccaaataggc
     2821 tactcggtct tcttccttta tctacaactg caccgcagat atctcttagt gcctaaaaac
     2881 tgcctgctcg ctctcagcca gagagctgct gtgtccataa gcacaatatg attctcttcc
     2941 gcctgctgga actctggtct ataccgagtg gccctcccct cactgagccc tgcagcccga
     3001 cgacagggag gatccccttc cttcagctgc ttggttgtct ctgcctctgt gctgtgaggg
     3061 ctgtgctctt gcagccttca ctgtttctcc tcaaagctct ctggggcttt agcttttgcc
     3121 cacaggaggg ggcattagcc cttgtcctcc agagaggagt agcgacaggt tgccaggact
     3181 ttagaggtgc ctgggcaact gcctgattgt ctcccctact tcctccaggc ctcgggtctt
     3241 aactaggacc tcctctcagg cctgccttct gcacctgagc tctgctccca ggaggcacct
     3301 gcggtgggca gagagctagg gtgtggagga ccactgtgat gcccagggtc tcaggggctc
     3361 accattctca ttttctaggg ctctgcctgt cctccattca tgagcctcag gcagaagttt
     3421 ccagacacag acagaagaag cttagctctc aaaagagcag gagctctctg aggtggtcat
     3481 gctggaccct gcccagtctt ttccatcatc tttgcccacc accccaccac cccgtttctg
     3541 tttagaaccc tttatctctc cctctgttct ctcccaggcc tatctttcca ccttgctgcc
     3601 tgcagcccca ttagtttcct cagaccagtg gatccaaggg accaagatcc attggtagat
     3661 gcaaataaat aatggtgtcc caggatgctc tggggaccgt ttcaagcttt cttccttgca
     3721 ggagtgcttg ggcatgtggc agaggcacca tgagctctgc caaaggctcc attgtcaatc
     3781 catctcagcc ccatctttgc ctccaatctg atggtggaca agatgtaacc agctactggg
     3841 aatgagagca atcctgctcc cccaagatca gaaggaggac gacaacaaga ccccacacat
     3901 cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca cacccttctt
     3961 agggccagag catctctctg agactgggga gaatcagccc cagaatgtct tgtgaaatga
     4021 cataagagtt aaaaccacca cttaccagac tccagcagca atgcccttac atcaggtttt
     4081 atacccccac ccccagttct gcatggatag cctttaaaaa agtgaggtga tgagaagctt
     4141 gcatctgtcc tggtcatttt tagtccagcc aagggaagtc agaggattgc ttcccctttc
     4201 tgctttcaag agctgtaggc tctcctggcc cctctccaga atccctactc tgagaagcta
     4261 tgttctgcat aacccagaag gatgaaagtt gagacttcca aaggtagtct ttagcctccc
     4321 cagtgagggg ttgtccctgg caacatgggg ccgggaagcc tcggaccatt ctgatttgct
     4381 ccctgcaaac atataaagct tcttaagggc tggtccccat gggtctttga gcacttgttg
     4441 cagaaggtaa ggatcacagg aagaaaggaa ctcaatccaa atagagaaca gctcacttct
     4501 agaagcaaag gaatgtctca cagctggacc ccagcctagc accctgtaaa ctctctttaa
     4561 ccctaagctg gtcccttgtg ctggtgatgt gctggtggga aggggaaagg acaagactgt
     4621 ggtgggcgag aaacccctcc catttgtttg tacatcccat ggagactctt ccagatacca
     4681 agttttccag cctttgggga acaagacttt atcccaggct cttcccccaa ccttggctct
     4741 gacaaggtgt ctgtcatctg tctatcttct gtctgtctgt ctgtctgtct gtctgtctgt
     4801 ctcaggggtt gtttgataag ttgttttcca aactatttgt catccctgcc ttaccaccat
     4861 ttggtataaa gtacctggca tcagttacat cagacaattc taatggaatg cttgcttctc
     4921 ctgaaggctt ttcttcagct tcatcattgg aaggaaagaa ataataacag agacataact
     4981 ctacaaacta cactaaccta gttccctgct ccaaactccg gaaaactgtg tcttaactgg
     5041 gacatggaaa tacagtaatc aacccccatc ttcagttctg catgactcca tttcaattac
     5101 ctgtagacaa ccatgatcca gaaatattta tatttgtctt aactcttttg agagagtcca
     5161 caattacata gcttttatta cactatattc ttataacttg ccctacttta ttattgtcaa
     5221 tctctttctg tgcctaattt acaaattaaa ctttattgta tgtgtatgta gatgaagaaa
     5281 aattcaatac ctatatagag ggtgtggtac tctgtgtggt ttcaggcacc caatgggatt
     5341 gttggagctt atccctcagt gataagggaa aaccactaga tcgcatcaac tcatccatca
     5401 ctccagaacc agctagctct gttgctatat gaagtcactt gagagtgtct ggggctggaa
     5461 ccccagtcac cgcttctaac ccgagcaggc tgtgtccttt gtcacataga agggccatgg
     5521 ccccttcatg ataaacactc atatcccaag caaacccaag atttccctct gcatgtctcc
     5581 actgccctgg acttgggtat gtacagatct cacttacccc aagtgttctt cctgaagacc
     5641 tcttaccacc cacattcttt accacatctt tcttacttcc tccagtgaac tcttggctcc
     5701 atatattcat gaaccacaca agcttgccaa taattcctta acctcctaag tggactttga
     5761 ccatcagaat tccccagtgt cttaggcaat gtgtttccct tgagaaggtc cagtccttcc
     5821 cccactgaaa tctctcccct tctttacatt cttattcctg tcttaacctc ctatgccagt
     5881 tttctcttgc cttcctctca tttctctctt cactcatcca gattcctcca gccctgattt
     5941 cttttacctg ggcccactga aatctctagt tttaagaatt agagctcttg gtgtaaactg
     6001 tgaagactct ggcattctgc gttcaagttc tttgttggcc tcgttggttt gttatacttc
     6061 ctcatgtggg aaatgatgcc ccaaggtgta aggtcattgg gctccctaca tccctatgat
     6121 ctctaaaagg gaagggagag agctggctga ttagaggtgc catggccaaa agatcagctt
     6181 tggttcctgt ggctaccgga ctcaagaagc tcttgactaa gactgctact agcccagagt
     6241 cttctgctct ggccaaagat tcatcccctt tgatgcttgt agctcttgct tctactccaa
     6301 cactcttctt cttgtagaca tcacagcttt tccttcatcc caaagacatg aggaccttgt
     6361 atgtcttcaa ctatgagtag tcatcccaat atctctgcca ccaaactcaa cccattgcct
     6421 ttggaaagtt cttgactgcc acctgcttca tccttcattc cttccacaga tgtctgtgga
     6481 ctgaacccaa ggtttgaaag ggctgcctat cacttgaacc ctagaaggta cctgctctga
     6541 gaggagcagg cacatcggcc acacattcct ctgccatcct ctctgaatct ggggaacttc
     6601 tgaatagctt caaggggctt gctctgcttt aatgaagtat tatcagggct taagtgttat
     6661 ttttataagc agtgcatttt aatggtaggt taaatatgaa agataagtcc ttctagtccc
     6721 tctctttgtt tttagaagat ggtatatcaa agagaaaaaa aaaacagcac tgaagctcta
     6781 gacacatggc ttccaatttt gacgtttgtc tccaccttgc tatgtgaata tgggcaagtc
     6841 acattccagt gcctcagttt cctcacttat aaaatgaggg gctttggcta gatgagcccc
     6901 ctaagtttca ttcagctctt atgctatagg gttttcagtc tccactctcc cctctctaca
     6961 ttcatcccca tttcaactga gctgtgccca tcatactctg cctgccctat ggcaacatca
     7021 ccagactcct cgacagattt ttggatggaa ccaatgggtt tggcattgta cctgaaagtt
     7081 aaggcctgac tactcaacag gtcaccaact gtgtctcaga agcctctcat ataaacatac
     7141 atctgggtgt ctgtcgctgt gaaattctga gtttggagtt ttcatttttg atgttgtcct
     7201 tatagctgga gggaggtaac tctgctttta gagaggggac agactgaaag atggtccaga
     7261 agtctgacca tgacatttgg gcatggaatt tttattgaag gtcagatggg aattttgttc
     7321 tgtgtctcaa aggagcatgc gtggcagagg ttctgtgtgg caagggatgc cattgtatcc
     7381 caggtcacag catgcatccc aaagaccaca tctggaagca gaagcttcat cctggctgga
     7441 gagaacaagg tactaccacc agggctgctg ggaggtgtgt cttcacccca tcccagtatg
     7501 tttgtggccc ctcttcatgc tattatcacc ctccccatga aggcttgcga agcaccaatg
     7561 gaaattccaa gtctctgtca tcaagaccat cttgtaaatc gcaaacacat taacccttcc
     7621 atcattcagg aaaaaaaatg atgctgtgtg tttgcttaac aacctccctc aggtagggga
     7681 ggagaagacc ctgctcaaca ctgctgccaa cccttcaatg accctccaat gcctctccac
     7741 aggaggactc attcatttgc ttcatagtgg caaatacgtc tctatcctgt aaactcaact
     7801 agatattttg tagtaaagaa ttcttgaaat tctgtaataa aaggcaattc ttactgtaac
     7861 atttttagtt tggggacaca atttcctaag ggggggttaa ggaacatttt tactcattag
     7921 ctggatttat ggattctatg tttattatat ggtagtatta tgaaaagtac ctttctatcc
     7981 ataccgctgc agtttcgcca tcactcacat gcccccatta ctgcttctgt ataaattcat
     8041 cattctccta ccctgtcaaa gcacacccta tatgtactgt aaacagagac tgctttagta
     8101 agatttagtc ttaaggattt tccacttttg tcagtaacat atatttatgg atcaaaaaaa
     8161 aaataaagct gtttcaacat aa
//
