LOCUS       NM_017221               1715 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus sonic hedgehog signaling molecule (Shh), mRNA.
ACCESSION   NM_017221
VERSION     NM_017221.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1715)
  AUTHORS   Wang,J., Zhan,H., Wang,M., Song,H., Sun,J. and Zhao,G.
  TITLE     Sonic hedgehog signaling promotes angiogenesis of endothelial
            progenitor cells to improve pressure ulcers healing by
            PI3K/AKT/eNOS signaling
  JOURNAL   Aging (Albany NY) 15 (19), 10540-10548 (2023)
   PUBMED   37815888
  REMARK    GeneRIF: Sonic hedgehog signaling promotes angiogenesis of
            endothelial progenitor cells to improve pressure ulcers healing by
            PI3K/AKT/eNOS signaling.
            Erratum:[Aging (Albany NY). 2023 Dec 29;15(24):15703-15704. doi:
            10.18632/aging.205458.. PMID: 38157439]
REFERENCE   2  (bases 1 to 1715)
  AUTHORS   Zhou,Y., Yang,Y., Dong,R. and Huang,Y.
  TITLE     Regulation of Shh/Bmp4 Signaling Pathway by DNA Methylation in
            Rectal Nervous System Development of Fetal Rats with Anorectal
            Malformation
  JOURNAL   J Pediatr Surg 58 (7), 1317-1321 (2023)
   PUBMED   36906487
  REMARK    GeneRIF: Regulation of Shh/Bmp4 Signaling Pathway by DNA
            Methylation in Rectal Nervous System Development of Fetal Rats with
            Anorectal Malformation.
REFERENCE   3  (bases 1 to 1715)
  AUTHORS   Wu,W., Wang,Z., Zhang,Z., Yang,W., Fan,X., Xu,J., Huang,Z. and
            Shao,Q.
  TITLE     Overexpression of sonic hedgehog enhances the osteogenesis in rat
            ectomesenchymal stem cells
  JOURNAL   Cell Tissue Bank 23 (3), 569-580 (2022)
   PUBMED   35147838
  REMARK    GeneRIF: Overexpression of sonic hedgehog enhances the osteogenesis
            in rat ectomesenchymal stem cells.
REFERENCE   4  (bases 1 to 1715)
  AUTHORS   Franchi,F., Peterson,K.M., Quandt,K., Domnick,D., Kline,T.L.,
            Olthoff,M., Parvizi,M., Tolosa,E.J., Torres,V.E., Harris,P.C.,
            Fernandez-Zapico,M.E. and Rodriguez-Porcel,M.G.
  TITLE     Impaired Hedgehog-Gli1 Pathway Activity Underlies the Vascular
            Phenotype of Polycystic Kidney Disease
  JOURNAL   Hypertension 76 (6), 1889-1897 (2020)
   PUBMED   33012205
  REMARK    GeneRIF: Impaired Hedgehog-Gli1 Pathway Activity Underlies the
            Vascular Phenotype of Polycystic Kidney Disease.
REFERENCE   5  (bases 1 to 1715)
  AUTHORS   Zhou,S.S., Ai,Z.Z., Li,W.N., Li,L., Zhu,X.Y. and Ba,Y.M.
  TITLE     Shenkang VII Recipe Attenuates Unilateral Ureteral
            Obstruction-induced Renal Fibrosis via TGF-beta/Smad, NF-kappaB and
            SHH Signaling Pathway
  JOURNAL   Curr Med Sci 40 (5), 917-930 (2020)
   PUBMED   32980902
  REMARK    GeneRIF: Shenkang VII Recipe Attenuates Unilateral Ureteral
            Obstruction-induced Renal Fibrosis via TGF-beta/Smad, NF-kappaB and
            SHH Signaling Pathway.
REFERENCE   6  (bases 1 to 1715)
  AUTHORS   Urase,K., Mukasa,T., Igarashi,H., Ishii,Y., Yasugi,S., Momoi,M.Y.
            and Momoi,T.
  TITLE     Spatial expression of Sonic hedgehog in the lung epithelium during
            branching morphogenesis
  JOURNAL   Biochem Biophys Res Commun 225 (1), 161-166 (1996)
   PUBMED   8769111
REFERENCE   7  (bases 1 to 1715)
  AUTHORS   Pringle,N.P., Yu,W.P., Guthrie,S., Roelink,H., Lumsden,A.,
            Peterson,A.C. and Richardson,W.D.
  TITLE     Determination of neuroepithelial cell fate: induction of the
            oligodendrocyte lineage by ventral midline cells and sonic hedgehog
  JOURNAL   Dev Biol 177 (1), 30-42 (1996)
   PUBMED   8660874
REFERENCE   8  (bases 1 to 1715)
  AUTHORS   Rusiniak,M.E., O'Brien,E.P., Novak,E.K., Barone,S.M., McGarry,M.P.,
            Reddington,M. and Swank,R.T.
  TITLE     Molecular markers near the mouse brachymorphic (bm) gene, which
            affects connective tissues and bleeding time
  JOURNAL   Mamm Genome 7 (2), 98-102 (1996)
   PUBMED   8835524
REFERENCE   9  (bases 1 to 1715)
  AUTHORS   Bumcrot,D.A., Takada,R. and McMahon,A.P.
  TITLE     Proteolytic processing yields two secreted forms of sonic hedgehog
  JOURNAL   Mol Cell Biol 15 (4), 2294-2303 (1995)
   PUBMED   7891723
  REMARK    Erratum:[Mol Cell Biol 1995 May;15(5):2904]
REFERENCE   10 (bases 1 to 1715)
  AUTHORS   Roelink,H., Augsburger,A., Heemskerk,J., Korzh,V., Norlin,S., Ruiz
            i Altaba,A., Tanabe,Y., Placzek,M., Edlund,T., Jessell,T.M. et al.
  TITLE     Floor plate and motor neuron induction by vhh-1, a vertebrate
            homolog of hedgehog expressed by the notochord
  JOURNAL   Cell 76 (4), 761-775 (1994)
   PUBMED   8124714
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L27340.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L27340.1, EV771078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1715
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..1715
                     /gene="Shh"
                     /gene_synonym="ShhNC"
                     /note="sonic hedgehog signaling molecule"
                     /db_xref="GeneID:29499"
                     /db_xref="RGD:3673"
     exon            1..617
                     /gene="Shh"
                     /gene_synonym="ShhNC"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..1628
                     /gene="Shh"
                     /gene_synonym="ShhNC"
                     /note="sonic hedgehog protein; sonic hedgehog homolog; shh
                     unprocessed N-terminal signaling and C-terminal
                     autoprocessing domains"
                     /codon_start=1
                     /product="sonic hedgehog protein precursor"
                     /protein_id="NP_058917.1"
                     /db_xref="GeneID:29499"
                     /db_xref="RGD:3673"
                     /translation="MLLLLARCFLVALASSLLVCPGLACGPGRGFGKRQHPKKLTPLA
                     YKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQR
                     CKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYG
                     MLARLAVEAGFDWVYYESKARIHCSVKAENSVAAKSDGCFPGSATVHLEQGGTKLVKD
                     LSPGDRVLAADDQGRLLYSDFLTFLDRDEGAKKVFYVIETREPRERLLLTAAHLLFVA
                     PHNDSGPTPGPSPLFASRVRPGQRVYVVAERGGDRRLLPAAVHSVTLREEAAGAYAPL
                     TADGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDGGGGGSIPAP
                     QSVAEARGAGPPAGIHWYSQLLYHIGTWLLDSETLHPLGMAVKSS"
     exon            618..879
                     /gene="Shh"
                     /gene_synonym="ShhNC"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1715
                     /gene="Shh"
                     /gene_synonym="ShhNC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttaaaatcag gctctttttg tcttttaatt gccgtctcga gacccaactc cgatgtgttc
       61 cgttaccagc gaccggcagc ctgccatcgc agcccctgtc tgggtgggga tcggagacaa
      121 gtcccctgca gcaacagcag gcaaggttat ataggaagag aaagagccag gcagcgccag
      181 agggaacgaa cgagccgagc gaggaaggga gagccgagcg caaggaggag cgcacacgca
      241 cacacccgcg cgtaccagct cgcgcacaga ccggcgcggg gacggctcgc aagtcctcag
      301 gttccgcgga cgagatgctg ctgctgctgg ccagatgttt tctggtggcc cttgcttcct
      361 cgctgctggt gtgccccgga ctggcctgtg ggcccggcag ggggtttgga aagaggcagc
      421 accccaaaaa gctgacccct ttagcctaca agcagtttat ccccaacgta gccgagaaga
      481 ccctaggggc cagcggccga tatgaaggga agatcacaag aaactccgaa cgatttaagg
      541 aactcacccc caattacaac cccgacatca tatttaagga tgaggaaaac actggagcag
      601 accggctgat gactcagagg tgcaaagaca agttaaatgc cttggccatc tccgtgatga
      661 accagtggcc tggagtgaag cttcgagtga ctgagggctg ggatgaggac ggccatcatt
      721 cagaggagtc tctacactat gagggtcgag cagtggacat caccacgtct gacagggacc
      781 gcagcaagta tggcatgctg gctcgcctgg ctgtggaggc tggattcgac tgggtctact
      841 atgaatccaa agctcgcatc cactgctctg tgaaagcaga gaactccgtg gcggccaaat
      901 ctgacggctg cttcccggga tcagccacag tgcacctgga gcagggtggc accaagttag
      961 tgaaggatct aagtcccggg gaccgcgtgc tggcggctga cgaccagggc cggctgctgt
     1021 acagcgactt cctcaccttc ctggaccgcg acgaaggtgc caagaaggtc ttctacgtga
     1081 tcgagacgcg ggagccgcgg gagcgtctgc tgctcactgc cgcgcacctg ctcttcgtgg
     1141 cgccgcacaa cgactccggg cccactccgg gaccgagccc actcttcgcc agccgcgtgc
     1201 gtccggggca gcgcgtgtac gtggtggctg aacgcggcgg ggaccgccgg ctgctgcccg
     1261 ccgcggtgca cagcgtaacg ctacgagagg aggcggcggg tgcgtacgcg ccgctcacgg
     1321 cggacggcac cattctcatc aaccgggtgc tcgcctcgtg ctacgcagtc atcgaggagc
     1381 acagctgggc acaccgggcc ttcgcgccct tccgcctggc gcacgcgctg ctggccgcgc
     1441 tggcacccgc ccgcacggac ggcgggggcg ggggcagcat ccctgccccg caatctgtag
     1501 cggaagcgag gggcgcaggg ccgcctgcgg gcatccactg gtactcgcag ctgctgtacc
     1561 acattggcac ctggctgttg gacagcgaga ccctgcatcc cttgggaatg gcagtcaagt
     1621 ccagctgaag tccgacggga ccgggcaggg ggcgtggggg cgggcggggc gggaagcgac
     1681 tgccagataa gcaaccggga aagcgcacgg aagga
//
