LOCUS       NM_001394375            1647 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus shiftless antiviral inhibitor of ribosomal
            frameshifting (Shfl), mRNA.
ACCESSION   NM_001394375 XM_006242662
VERSION     NM_001394375.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1647)
  AUTHORS   Wang,X., Xuan,Y., Han,Y., Ding,X., Ye,K., Yang,F., Gao,P.,
            Goff,S.P. and Gao,G.
  TITLE     Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor
            of Programmed -1 Ribosomal Frameshifting
  JOURNAL   Cell 176 (3), 625-635 (2019)
   PUBMED   30682371
REFERENCE   2  (bases 1 to 1647)
  AUTHORS   Balinsky,C.A., Schmeisser,H., Wells,A.I., Ganesan,S., Jin,T.,
            Singh,K. and Zoon,K.C.
  TITLE     IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral
            Activity against Dengue Virus, Interacts with MOV10
  JOURNAL   J Virol 91 (5), e01606-16 (2017)
   PUBMED   27974568
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1647)
  AUTHORS   Suzuki,Y., Chin,W.X., Han,Q., Ichiyama,K., Lee,C.H., Eyo,Z.W.,
            Ebina,H., Takahashi,H., Takahashi,C., Tan,B.H., Hishiki,T.,
            Ohba,K., Matsuyama,T., Koyanagi,Y., Tan,Y.J., Sawasaki,T.,
            Chu,J.J., Vasudevan,S.G., Sano,K. and Yamamoto,N.
  TITLE     Characterization of RyDEN (C19orf66) as an Interferon-Stimulated
            Cellular Inhibitor against Dengue Virus Replication
  JOURNAL   PLoS Pathog 12 (1), e1005357 (2016)
   PUBMED   26735137
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Apr 16, 2021 this sequence version replaced XM_006242662.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1606658.1,
                                           SRR22399481.1713128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               JAXUCZ010000008.1  27684510-27684810
            302-425             JAXUCZ010000008.1  27685226-27685349
            426-475             JAXUCZ010000008.1  27685478-27685527
            476-514             JAXUCZ010000008.1  27687139-27687177
            515-664             JAXUCZ010000008.1  27687308-27687457
            665-768             JAXUCZ010000008.1  27688805-27688908
            769-923             JAXUCZ010000008.1  27689047-27689201
            924-1647            JAXUCZ010000008.1  27689546-27690269
FEATURES             Location/Qualifiers
     source          1..1647
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..1647
                     /gene="Shfl"
                     /gene_synonym="RyDEN"
                     /note="shiftless antiviral inhibitor of ribosomal
                     frameshifting"
                     /db_xref="GeneID:500956"
                     /db_xref="RGD:1565995"
     exon            1..301
                     /gene="Shfl"
                     /gene_synonym="RyDEN"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..1147
                     /gene="Shfl"
                     /gene_synonym="RyDEN"
                     /note="UPF0515 protein C19orf66 homolog; repressor of
                     yield of DENV protein homolog"
                     /codon_start=1
                     /product="shiftless antiviral inhibitor of ribosomal
                     frameshifting protein homolog"
                     /protein_id="NP_001381304.1"
                     /db_xref="GeneID:500956"
                     /db_xref="RGD:1565995"
                     /translation="MAQDGVELEKSVRRLREKFHGKVSPKKAGALMRKFGSDHTGVGR
                     SIVYGVKQKDGQELSNDLDAQDPPEDMKQDQDIQAVATSLLPLTQANLRMFQRAQDDL
                     IPAVDRQFACSSCDHVWWRRVPQRKEVSRCRKCRKRYEPVPNDKMWGLAEFHCPKCRH
                     NFRGWAQMGSPSPCYGCGFPVYPTRILPPRWDRDLDRRSTHTHSCSAADCYNRREPHV
                     PGTSCAHPKSRKQNHLPKVLHPSNPHISSGSTVATCLSQGGLLDDLDHLILEDLKEEE
                     EEEEEEDGGPRE"
     exon            302..425
                     /gene="Shfl"
                     /gene_synonym="RyDEN"
                     /inference="alignment:Splign:2.1.0"
     exon            426..475
                     /gene="Shfl"
                     /gene_synonym="RyDEN"
                     /inference="alignment:Splign:2.1.0"
     exon            476..514
                     /gene="Shfl"
                     /gene_synonym="RyDEN"
                     /inference="alignment:Splign:2.1.0"
     exon            515..664
                     /gene="Shfl"
                     /gene_synonym="RyDEN"
                     /inference="alignment:Splign:2.1.0"
     exon            665..768
                     /gene="Shfl"
                     /gene_synonym="RyDEN"
                     /inference="alignment:Splign:2.1.0"
     exon            769..923
                     /gene="Shfl"
                     /gene_synonym="RyDEN"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1647
                     /gene="Shfl"
                     /gene_synonym="RyDEN"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtgaccga ctgcagaggc cgcgcgctgc atccccggcc ccgccgcgct gctgcgcagg
       61 acgcggtgag gcgcgcgccg aggcccggga gcaccagccg ggagcactac agggcgcgcg
      121 agcagacgcg tggacaaggc ctgggcgggg tctcctcagg gtccccagct tcggtcagaa
      181 acgaaactga aagaggggcc cgagggaggc ggagctgcgc cgacgccacc caggcttgcg
      241 aggcccggac ccaggcgcgg ccaggtgtgc ttcagccacc atggctcagg atggcgtgga
      301 gttggagaag agcgtcaggc gcctccggga gaagtttcat ggaaaagtgt cccccaagaa
      361 ggcaggggct cttatgagga agtttggcag cgaccacact ggagttgggc gctctatcgt
      421 gtacggtgtc aagcagaaag atggacagga gctgagcaac gatttggacg ctcaggaccc
      481 accagaggac atgaagcagg accaagatat ccaggcagta gccacctctc tgttgcccct
      541 gacgcaagcc aatcttcgaa tgttccaaag agcccaagat gacctcatcc ctgccgtgga
      601 ccgacagttt gcctgctcct cctgtgacca tgtctggtgg cgccgtgtgc ctcagaggaa
      661 ggaggtgtcc cggtgtcgaa aatgtcggaa gcgttatgaa ccagtgccaa acgacaagat
      721 gtggggtctg gcagagttcc actgcccaaa gtgtcgccac aacttccggg gctgggcaca
      781 gatggggtcc ccatcaccct gctatgggtg cggcttccct gtgtatccca ctcggatcct
      841 gcctccacgc tgggaccgtg acctggatcg ccgcagcaca cacacccact cctgctcagc
      901 cgcagattgc tacaaccgga gagagcccca cgtgcctggg acctcctgtg cccatcccaa
      961 gagccggaag cagaatcacc tccccaaagt cctgcaccct agcaaccccc acatcagcag
     1021 cggctccaca gtggccacat gcctgagcca aggaggcctc ctggacgacc tggaccacct
     1081 catcctggag gacctgaagg aggaggaaga ggaggaagaa gaggaggatg gtgggccccg
     1141 agagtgaccc tggccaggtg cacgaaggaa tgacagacac agtgaatgga cacctcctgt
     1201 tgctataaga taccagctca aggagatagg agcacccttg ggggggtact catgggacag
     1261 tcacaaccga acaagccggg tcagcatagc agccttcttc agagagtacg ccccaccacg
     1321 gaactcggcc cagtagaccc cgtcctggta tcggctccgg taatgacctc cgtgatacca
     1381 tacaccattg aggttggagt gggcgcaggc atggtaccac cagcccccac gatggtagag
     1441 ggcacagttg cctgaggggg gagagagagg agagagaaag agacagcatt cgttttccca
     1501 ccaaaataaa agtatctacc agcacttctt tgtgcaaagc ttttgcaagc aagcattcct
     1561 caaccttcca tatcttattg aatagaagcc ctgatactcc atttcttcac caaaataaaa
     1621 ggctgtggct tctcactttc ttcttca
//
