LOCUS       XM_001062249            5890 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus Src homology 2 domain containing E
            (She), transcript variant X1, mRNA.
ACCESSION   XM_001062249
VERSION     XM_001062249.7
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051337.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_001062249.8.
            
            On Jan 21, 2021 this sequence version replaced XM_001062249.6.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5890
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..5890
                     /gene="She"
                     /note="Src homology 2 domain containing E; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 23 ESTs, 5 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     106 samples with support for all annotated introns"
                     /db_xref="GeneID:685088"
                     /db_xref="RGD:1583215"
     CDS             262..1764
                     /gene="She"
                     /codon_start=1
                     /product="SH2 domain-containing adapter protein E isoform
                     X1"
                     /protein_id="XP_001062249.1"
                     /db_xref="GeneID:685088"
                     /db_xref="RGD:1583215"
                     /translation="MRRPPAPGAPWCLGWASSLVCSAASTLPGPLMAAKWFKEFPLTL
                     KTASERARPGGAGGKPRKNSETGSAAPTPGKGRKNSAAELGGSRTGSGPPKDSRLSRD
                     SLQGLIQAAAGKGRKNSRVTTTATASASATTTEEEPHRGAVAKSAGCSTYISRLIKVD
                     TQEKNGKSIYPGGGSTSSSSSSSSSASSSPSSLGPELDKTKIMRQQDTVIILEDYADP
                     YDAKRTKGQRDAERVGENDGYMEPYDAQQMITEIRRRGSKDPLVKALQLLDGPCEPGE
                     TMKVEATAKRRSSKDLLGKPPQLYDTPYEPSEGDLRAAEVKARPADGRLPEEDDRPAA
                     EYEQPWEWKREQIARALSVQFEGSDRSPGREEAGRPQHWQKTLKPTLSDHGDGEKVDP
                     GLALEKQPWYHGSISRAEAESRLQPCKEAGYLVRNSESGNSKYSIALKTSQGCVHIIV
                     AQTKDSRYTLNQTSAVFDSIPEVVHYYSTAKLPFKGAEHMTLLHPVHKLH"
ORIGIN      
        1 gccggggcac tgcggccgcc gtcgtccctg ggagggtggg cagggctgtc gggggcttcc
       61 gtgggctcgg cctcgcccac ctcgggagga aaagcagggg aagccccggc gcccggcggc
      121 cccaagcggt agagcgcaga ggacacggcg atccggtcac cgcgcccgtc cagtttcggg
      181 ctgagcaggt cccaccctgc cgggcgcgcg cgtctagcgg ccaggagcct cgcggcggcc
      241 tccagcgccc agccccgggg aatgcggcgg cccccggccc ctggcgcccc ttggtgtctc
      301 ggctgggcct cctcgctcgt ctgctccgcg gcctcgacgc tcccgggccc cctgatggcg
      361 gcgaagtggt tcaaggagtt cccgcttact ctgaagaccg cgtcggagcg cgcccggccc
      421 gggggcgccg gcggcaagcc gcgcaagaac tcggagaccg gcagtgcggc acccaccccg
      481 ggcaagggcc gcaagaactc agcggccgaa ctggggggca gcaggacggg cagtggaccc
      541 cccaaggaca gtcggctgtc ccgggacagc ctgcagggtc tgatccaggc cgctgcaggc
      601 aaaggccgta agaactccag ggtcaccacc accgccaccg ccagtgccag cgccaccacc
      661 accgaggagg agccccaccg gggtgcggtg gccaagagcg caggctgcag cacctacatc
      721 agcaggctca tcaaggtgga cacacaggag aagaatggta agagcatcta cccgggcggt
      781 ggcagcacca gcagctccag cagctcctct tcctctgcgt cctcttctcc gtcctccctg
      841 ggcccggagc tggacaagac caagataatg agacagcaag acacggtcat cattttagaa
      901 gactatgctg acccatacga tgccaaacgg acaaaaggtc aaagggatgc ggagagagtg
      961 ggtgagaacg acggctacat ggaaccatat gatgcacagc agatgataac agaaatcaga
     1021 cgccgaggtt ccaaagaccc tctcgtgaag gccctccagc tgctcgacgg cccgtgtgaa
     1081 ccaggggaga ccatgaaggt agaggccaca gccaagagac gcagctccaa ggacctactg
     1141 gggaagccac cacagctcta cgacaccccg tacgagcctt cggagggtga cctgcgtgcg
     1201 gcagaggtga aggcacggcc agcagacggc aggctacctg aggaggatga ccggcctgct
     1261 gccgagtatg agcagccctg ggagtggaag agggagcaga tcgcacgagc cctgtcagtc
     1321 cagtttgagg gatctgatcg atctccgggc agagaggagg cagggagacc gcagcactgg
     1381 cagaagacct tgaagccgac cctgtcagac cacggagacg gggagaaggt ggacccaggc
     1441 ctggctttgg aaaagcagcc ttggtatcat ggctccatta gccgagccga ggctgagagc
     1501 agactacagc cctgcaaaga agctggctac ctggtccgga acagtgagtc ggggaacagc
     1561 aagtattcca tcgcactcaa gactagtcaa gggtgtgtcc acatcatagt ggctcagaca
     1621 aaagacagca gatacacact gaaccagacg agcgccgtgt ttgacagcat ccccgaagtg
     1681 gtacactact actccactgc aaagctgcct ttcaaagggg cagagcacat gacccttctc
     1741 caccccgtgc acaagttgca ctaaggtcca gccagcacgc ccgggcacct gcgaggacat
     1801 cagcacctac caccatcgtg gacaggacct tctgctgctg ctgcggacca gagtcagcac
     1861 ccgtggtcct aaatccagga cacagtgttt tctgatctgt tccttctctc cctgccaaat
     1921 agctgtccta taagataata ttgcttgcct gccgccttct cccttggagt aggagttctg
     1981 tttggagtgt gacccttagg aaaggtagat ctagagctca ggagcactga acttgtccct
     2041 tggtgcagtt ctctggagtg cctgtcttct ggacaacaga gagcccctag gccttcatga
     2101 gcgaccacgt gggctggaga tcctgcagtg taggcccctc atgaggaggg gacggacagt
     2161 gggaaatagg aacaatggac aggaaaggtg tctttcccca cgtcctgatg cagctgtggc
     2221 cttcacacaa cattcacaac ctgaggtctt cacaagagtg ttatttgatt gaccagctct
     2281 cctaagaaaa gtacgtgctt tctcgattcc tctgggcgtt cccgtccttc agcagtaact
     2341 cagtactatg agcaagactt ggatggagga ccccagatta aagtgttacc aatataatca
     2401 agcggtagca tcccctgtat aaactctgat tgctattaag tgtactccaa agagttggtt
     2461 tctgattttt tttttaattc tacagagctc aacacctgtt ttgttattgg atatttacaa
     2521 agcatttcag acagcttttc tttttgtgta tttttgttgc atgaagtcat ctttaagatt
     2581 tctttctgaa agtagatttg ctttttattt ttggcaaaaa aaaaatttga caacaaaatt
     2641 gggatctgat tgtatgaact gagccactgg tctgaaaaga tcgcctctga catacagaac
     2701 acaccaacat acgcctgaca gaaacatttt gaaaaatatt gtagttgggg ctgtcttggc
     2761 tgctctctga gacactaaat cattgtatgt ttagcctgtg accggtgaac tgtggaaaat
     2821 cccgcaggag gagcttgctg cgtgcaggtg ccatggagaa tgggctcggt cagaacggca
     2881 ggaacatttc ttgctcgtgt ttgtaaactg gatctcaaga ctgttcccaa ggcgatgtgc
     2941 tgaccaccgt cagtggaaag tggatgtggg tggcttctca gatacacaaa aaaatattaa
     3001 ccgtaagtca ggtgtgatgg cacacacgtt taatcccagc actcaggagt cagaggcagg
     3061 tgagtctttg cgagttcgag atcagtctgg tctacagagt gagttccagg acagccaagg
     3121 ctacacacag aaacactgtc ttgaaaaatc caaaacaaca aaaacctggc cagatttctt
     3181 aggagaaagc acagcctagt ccttaactcc ctcgcttggc tgccctgaca gaatggtagg
     3241 aagacgtttg ctcctggttc aggacgtctt agctaaaggg ttgtgtgagg ttttgttgga
     3301 ggttaaaagg gccttttcct cagtggagca cagcagtcct cacaaaggct gccctcgcag
     3361 tgctgacaat cattctggct cctgtatgca gggcactcgg tttaagtttt cggcagccgc
     3421 aattccatcc agcaaatgtt aattatcatt tattatcttg tatctgtgca ctgtccgcta
     3481 tgtcaaacct atattagctc atcttgtagc catgaagcct taatttttgc ttaaccctcc
     3541 ttactcttca aaagaaatgg agttgttgtc tctaatggtc agcgttaaat attaaaacgt
     3601 ttctgggtgg ggaaggatgt gggcacacac ctggcgactc tgatgaacgc cggcctgaca
     3661 ggtcagagtc acctggcctc tgctgcacac ccaggcatgc tccctccata tttgctctac
     3721 attcttgaag gcggaggaga tggagtttat atatagtcca gtcttcatgg taaggggagg
     3781 ggggctataa aaagcaaaaa tactgtagat tagcagaagg ccagtgaggg aggatgttaa
     3841 agctgctatt ttcttcttag gttgtgacac acgctgacag aagccagggg actcacagct
     3901 gggtggtggc atatagtacc ctaccctacg ttctaaaaac aattaggccc agcagggtgc
     3961 cctaaccgct tgctagtgag cctgggccgg ctgatctgaa gctctggggc ttgtcctccg
     4021 agctccaaac gattgggctt cttacccttt ttctcctgat aaaagtattt tcctatttat
     4081 tcctttgaat caattccgtc tcccaggggg aaagttattt ttttttccta caaagattgt
     4141 cttttggtga accctccaga tgccttgaac atctgtagag ctcctcacct ttttctcctt
     4201 cagcaaaact tatttgtaaa aactgctttg ttcgagggca tcgacttaga cagggacccc
     4261 tgagaacgga cggcatctgt aatccagcta gctatccagg aggtagagcc aagagtccaa
     4321 aactagcctg ggcaacagag caagggcgtc tccaagaaga acacagaaag gcaaaggaca
     4381 tttctacttc ctgtgattgc ccagcggttt ctgtccagat atattccaat caccacccca
     4441 ggtgtctccg gccagtatga tgcgctgagg caaaggcagg aggagttgaa ttcagtgcta
     4501 ttcttgggtt acacctgggg acaaagaact gtctcagagg tgggaaatac ttgctgcact
     4561 tgtagaagac cctggttagt tcccaggatc caccttgccc agttctaggg gatctggtgt
     4621 cctcttctgg cttctgaagg tactgggcaa catggtacac acacatctat acaagcaaaa
     4681 catccatgca cacgaacctt ttaaaacact gagtaacgga ataaagcaat ggggaaattt
     4741 agtgagtatg cacaaaggca ggagatggca aaggcaccag agtcccttcc ggttaccgag
     4801 agtgctttaa taggcaccgt aagaacagcc ttcattcttg gccgcttagt gtgtgctgtg
     4861 ctggagttca gtcactgctc tctgccacag gaaggggagc tgggcagaga accaggaggg
     4921 aaagtgggct gttctccatg caggtcctac cttaatcatc cttgtttggt gttgggagtc
     4981 tttgccagtg ttacccctgc tgggtagatt aatgtttaat tcaagaacaa ctgtgagact
     5041 tctttagtcg cctgttggac gagtctgtta gcattttagt tacaagctca tgacttactt
     5101 ttccttgcct cagtcaaaaa gccagtgtac tcttgagtca tccctcctgt ctgatactta
     5161 gggtttcact gctcccctcc ctgggcctca cagccttctg tcttcctcct gtcttctgta
     5221 gccagcgccc gcttaacctt aaactccctt aggactgatc ttttttcttc tctttgccac
     5281 ctacatccta ctaacttggc cttggagaaa ctcggtcagt atgaaccttc cctctaatta
     5341 gctttccttc ttggcggaac ccatgccatg aaagatggtg ttctcctgcc atctactggg
     5401 gcaaaggaaa actgcagttg agaaacaagc tgtccattta gggtggtttg tctaaaggat
     5461 ttctcataca gtccataact caaaataaac gatgacacag cagttgccat cttgaaatgt
     5521 acccttccct atagaaagag ttctttgact cctactatgt ccctggaccc aggctgagtc
     5581 atgtatttca taatctttat tctatttttg aagactgtgc tgtcaataga tcactgaggc
     5641 gggaatcatt tcgttaaagt cttagctgtt ccaaatgctg tcaggaggat ttgacatgta
     5701 aacattaatt gatacattgt tctaactttt taaaatattt aacagattgt aatacaggag
     5761 ccttggcaat tggtattata ctggaatctt ataaatcatt ggctctcttg cacggaccag
     5821 tgtagctgtg tgccttctgg aaggtggttt actctgaaat gctactatca ataaatgctt
     5881 gccaggaaaa
//
