LOCUS       NM_001191065            3972 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SHC adaptor protein 4 (Shc4), mRNA.
ACCESSION   NM_001191065 XM_001054695
VERSION     NM_001191065.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3972)
  AUTHORS   Robeson,H.N., Lau,H.R., New,L.A., Lalonde,J., Armstrong,J.N. and
            Jones,N.
  TITLE     Localization of phosphotyrosine adaptor protein ShcD/SHC4 in the
            adult rat central nervous system
  JOURNAL   BMC Neurosci 20 (1), 57 (2019)
   PUBMED   31823725
  REMARK    GeneRIF: ShcD shows relatively widespread distribution in the adult
            brain and spinal cord, with prominent levels of staining throughout
            the olfactory bulb, as well as in sub-structures of the cerebellum
            and hippocampus, including the subgranular zone. Co-localization
            studies confirm the expression of ShcD in mature neurons and
            progenitor cells. ShcD immunoreactivity is primarily localized to
            axons and somata.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3972)
  AUTHORS   Turco,M.Y., Furia,L., Dietze,A., Fernandez Diaz,L., Ronzoni,S.,
            Sciullo,A., Simeone,A., Constam,D., Faretta,M. and Lanfrancone,L.
  TITLE     Cellular heterogeneity during embryonic stem cell differentiation
            to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein
  JOURNAL   Stem Cells 30 (11), 2423-2436 (2012)
   PUBMED   22948967
REFERENCE   3  (bases 1 to 3972)
  AUTHORS   Jones,N., Hardy,W.R., Friese,M.B., Jorgensen,C., Smith,M.J.,
            Woody,N.M., Burden,S.J. and Pawson,T.
  TITLE     Analysis of a Shc family adaptor protein, ShcD/Shc4, that
            associates with muscle-specific kinase
  JOURNAL   Mol Cell Biol 27 (13), 4759-4773 (2007)
   PUBMED   17452444
REFERENCE   4  (bases 1 to 3972)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 8, 2022 this sequence version replaced NM_001191065.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1168070.1,
                                           SRR26360176.405900.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-585               JAXUCZ010000003.1  133427043-133427627 c
            586-656             JAXUCZ010000003.1  133398089-133398159 c
            657-720             JAXUCZ010000003.1  133383622-133383685 c
            721-840             JAXUCZ010000003.1  133381913-133382032 c
            841-894             JAXUCZ010000003.1  133371941-133371994 c
            895-946             JAXUCZ010000003.1  133367926-133367977 c
            947-1067            JAXUCZ010000003.1  133361064-133361184 c
            1068-1233           JAXUCZ010000003.1  133358999-133359164 c
            1234-1294           JAXUCZ010000003.1  133355752-133355812 c
            1295-1459           JAXUCZ010000003.1  133351914-133352078 c
            1460-1713           JAXUCZ010000003.1  133342679-133342932 c
            1714-3972           JAXUCZ010000003.1  133334034-133336292 c
FEATURES             Location/Qualifiers
     source          1..3972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..3972
                     /gene="Shc4"
                     /gene_synonym="RGD1309182"
                     /note="SHC adaptor protein 4"
                     /db_xref="GeneID:679845"
                     /db_xref="RGD:1583644"
     CDS             1..1869
                     /gene="Shc4"
                     /gene_synonym="RGD1309182"
                     /note="SHC (Src homology 2 domain containing) family,
                     member 4"
                     /codon_start=1
                     /product="SHC-transforming protein 4"
                     /protein_id="NP_001177994.1"
                     /db_xref="GeneID:679845"
                     /db_xref="RGD:1583644"
                     /translation="MRERSQDSQAGLTLYVGLFGHLGMLHRTKYSRFRNESITSLDEG
                     SPGGSVGNKGSSPPPYAALTPHLPAEDATVPNQESPTALCTLIPRMASMKLANPVTFL
                     SLKTFCLGSKQVPRLKLQENQDQTPSSPASPETSLNSTGPAPTPLPDQVGCRPTSLRP
                     DTCPLPGPGEPNPRSKQDGPPLQHLLGNGLNYCVRYMGCIEVLQSMRSLDFGMRTQVT
                     REAISRLCEAVPGVHGAIKKRKAPVKFLTTVLGKSNLQFSGMNIKLTVSTSSLTLMNL
                     DNQQIIANHQMQSISFASGGDPDTTDYVAYVAKDPVNQRACHILECRSGTAQDIISTI
                     GQAFELRFKQYLKNPSLNTWEREEVLVDGTSEDRGHDYYNSIPGKQPPAGGIADVRIQ
                     VQADPVAYCPIRCEKLCYLPGTSTCSGVYKNCMGRSRPIGIPHERAMQSDAASLRHFW
                     RVDLFDDPCYVNTQNMRGCAGNQSSTLPQGSPWHLGKAPETVQPGATAKPGSSHALPH
                     IKQQLWSEECFHGRLSRGAAERLLVKDGDFLVRESVTSPGQFVLSGLQGGQAKHLLLV
                     DPEGKVRTKDHVFDNVGHLIKYHMDNSLPIISSGSEVSLKQPVKKHNNPGLSHSKK"
     exon            1..585
                     /gene="Shc4"
                     /gene_synonym="RGD1309182"
                     /inference="alignment:Splign:2.1.0"
     exon            586..656
                     /gene="Shc4"
                     /gene_synonym="RGD1309182"
                     /inference="alignment:Splign:2.1.0"
     exon            657..720
                     /gene="Shc4"
                     /gene_synonym="RGD1309182"
                     /inference="alignment:Splign:2.1.0"
     exon            721..840
                     /gene="Shc4"
                     /gene_synonym="RGD1309182"
                     /inference="alignment:Splign:2.1.0"
     exon            841..894
                     /gene="Shc4"
                     /gene_synonym="RGD1309182"
                     /inference="alignment:Splign:2.1.0"
     exon            895..946
                     /gene="Shc4"
                     /gene_synonym="RGD1309182"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1067
                     /gene="Shc4"
                     /gene_synonym="RGD1309182"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1233
                     /gene="Shc4"
                     /gene_synonym="RGD1309182"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1294
                     /gene="Shc4"
                     /gene_synonym="RGD1309182"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1459
                     /gene="Shc4"
                     /gene_synonym="RGD1309182"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1713
                     /gene="Shc4"
                     /gene_synonym="RGD1309182"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..3972
                     /gene="Shc4"
                     /gene_synonym="RGD1309182"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcgagaac gcagccagga cagccaggca ggactcacgc tgtatgtagg actctttggg
       61 cacctgggga tgcttcacag gaccaagtac agccgctttc ggaacgagtc catcacgtct
      121 ttggacgaag ggagccccgg aggctcggtt ggaaacaagg gctcatcgcc acctccttac
      181 gcagccctga cccctcacct gcctgctgaa gatgccactg tgcccaacca ggagagcccc
      241 accgcgctgt gcaccttgat tccccgtatg gcaagcatga agctggccaa ccccgtcact
      301 tttctgagtc tgaaaacctt ctgcctgggt tcgaaacagg tgcccaggct gaagctccaa
      361 gagaaccagg atcagactcc aagcagccca gcgtccccag aaaccagtct gaatagtact
      421 gggcctgcac ctacacctct tccggaccag gtgggatgca ggcccacctc cttgcgtcct
      481 gatacttgcc cactgcctgg gcctggagaa ccaaacccta ggagcaagca ggatggacct
      541 cctctgcagc acctgttggg gaacggtctc aactactgtg tgaggtacat gggctgcatt
      601 gaagtgctgc agtcaatgag gtcactggat tttggaatga gaacccaagt tacaagggaa
      661 gcaataagtc gcctgtgtga agctgtccct ggggtccatg gagccattaa aaaacgaaag
      721 gctcccgtta agttcctgac aacggttctt ggcaaaagca atcttcagtt ttcaggaatg
      781 aatataaaac tgactgtttc aacaagcagc ctcacgctga tgaaccttga caaccaacag
      841 attattgcaa atcatcaaat gcaatcgatt tcctttgcct ctggagggga tcctgatacc
      901 acagactatg ttgcctatgt agctaaagat ccagtcaacc aacgagcgtg ccacatcctg
      961 gagtgtcgca gtggaacggc ccaagatatc ataagcacca tagggcaggc ctttgagctc
     1021 cggttcaaac agtacttgaa gaatccttcc ttgaacactt gggaaaggga ggaggtcctt
     1081 gttgatggca cctctgaaga cagaggccac gactattaca actccatccc agggaagcag
     1141 ccccctgcag gcggcattgc agatgtgcgg atccaggttc aagcagatcc agtggcttac
     1201 tgccctatcc ggtgtgagaa gttgtgctat ttgcccggga cctccacgtg cagcggcgtg
     1261 tacaagaact gcatgggacg gagcaggcca atcggtattc cccacgagag agcgatgcag
     1321 agtgacgctg catcgctgag gcacttctgg cgagtggatc tctttgatga cccctgctat
     1381 gtcaatacac agaatatgcg cggctgtgct ggaaatcaaa gctcaactct gccacaaggg
     1441 agcccatggc accttggaaa ggcaccagag accgtgcagc caggagccac cgccaagcct
     1501 gggagctcac acgctttgcc acacattaag cagcaactgt ggagtgagga atgcttccac
     1561 ggcaggctga gcaggggggc agcggagaga cttttggtga aggatgggga ctttttggtt
     1621 cgagagagtg tgacatctcc tggccagttt gtactgagcg gactgcaagg cggccaggcc
     1681 aagcatcttc tcttggtgga tcctgaaggc aaggtgagga ccaaggacca tgtgtttgat
     1741 aatgttggcc acctgatcaa ataccacatg gataatagtt tgccaatcat ctcttctgga
     1801 agtgaagtaa gccttaaaca accagtaaaa aaacataata acccaggact ttcgcactcg
     1861 aagaaatgat gactctgggc actgtgtcag agcgatcaga agcatatccc ttttgtgtca
     1921 ggaggagtga ccattcagac cttttcaaca catgaagtag aacacaaact ctgaaacatg
     1981 tctttcttag accaccatgg acccaggtct tttataaaac agagaagtaa tagattatct
     2041 tctgaatatg aaaatctgag aagaggaatt ttgggccatt tgacccatat gcacggaggt
     2101 cactttttaa aggtcacatg gcattgagga aaagctgaaa agcacaacta caatttcaca
     2161 tgctaaagac aacttgaact gcctaggcag tggtacgtgc cttcaccctg acaatccggg
     2221 gacattttcc tgtggggaga ttagtcccaa gtgtcttcat gttctatagc tacagaacca
     2281 gttgccaaaa agttcttcct tgctagaaac agcaagaaga agcattttga ctaatagcat
     2341 tgactttatt acattttgtt tagtagcact ttttgctgcc atcttaaata tgacactgac
     2401 atcaaacttg gactatgtcg tggttgtgga atgaaagcaa aagtcaccga aggtttccta
     2461 attctgtctc atttgctggt taaaaggttg gaggccaaat tcactggcta gcattccttg
     2521 acctttgcta tctgagctgt tcgtgtgcag catgggacac attcagaaag ccaaattcct
     2581 tggttatttc tgatttggag tgtatggata taaaagacag caaacgaagc cagttttctt
     2641 cacgctcagc ccacactggt gccattgttg agagtacaga aggtaattta aagcatagca
     2701 aaatttcctt ttgactggcg gccactgtat cctggtgtca cctcggtatg tgtcccatca
     2761 ccttctctac atgtgatcta catgtgatca gacaagatgc agaagggctt ggaaaggcct
     2821 gccacacagt ggacaagggt tcagccagtg gtgagattaa gaatgctcag agaagccctg
     2881 ggctcagact actcatcacc tccagccttg gcagtccgtt aaacctgtcc ggattccact
     2941 tttcttgttt ataagatgag ggagctcgag gtacactcag aggtccattg ctgtcctaac
     3001 atgatagttt ttttcttcat tagaagttaa cactaataag cagactatgc agttgggggt
     3061 aaacattcag gacttctcct ttattctgtg tccatgctct gcagatgaaa ggtttagtca
     3121 aattacactc acatggtctg accccgagtg tttcagcata gagcaggtga tgttggtacc
     3181 atggatctgg ttggttttag ttatagtcct tacttacctg tgcatataaa gatacagtca
     3241 ttactgaaga gaaagagaga gagagagaga gagagagaga gagagagaga gaggagagag
     3301 agagaggaga gagatcggtc atgagctttc tggatggtca tctcaacatc tcaacatttt
     3361 ggctaagtag acacacctta acctttgtga ttatgatgta tttggtaagt tttaagtcta
     3421 atatgagtag ttcttttggg tagaaatcat cagaaatcaa gtacattgaa gtctggcatt
     3481 tttatgtaac agctcaccat tttatttctg tcaccactgg cttcttaggt aggtttgttt
     3541 ccttcccaca ggtagaaaac aatatatact tcattgattt tcctccatat atcttaggtc
     3601 ttagtcattt ctcttcgtaa aagggatcag catagtgact tgtaggcaac ctgcagcaga
     3661 gacagggcgg gtctctcgtc tccttccagc agaggaacac agactgggtg gccagtggga
     3721 gttccagaag caagatgctg tgagcagcgc acatgggcag tcgacgatgg gccggtgctg
     3781 tcgtaaccag ggaagcaaat gctgcactat cagatgccac acaactgtca actgttcaca
     3841 caaccctaag agatataaga atgactgcat gcgatttcaa gctcatattc tcaacctcta
     3901 ggttaaaatg gctcatttgc ctacacatat ctgtaaatgg attttcttta aaaataaatg
     3961 actattgctt ta
//
