LOCUS       NM_001105743            1968 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SHC adaptor protein 3 (Shc3), mRNA.
ACCESSION   NM_001105743 XM_001054242 XM_341498
VERSION     NM_001105743.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1968)
  AUTHORS   Tang,N., Lyu,D., Liu,T., Chen,F., Jing,S., Hao,T. and Liu,S.
  TITLE     Different Effects of p52SHC1 and p52SHC3 on the Cell Cycle of
            Neurons and Neural Stem Cells
  JOURNAL   J Cell Physiol 231 (1), 172-180 (2016)
   PUBMED   26058566
  REMARK    GeneRIF: that p52SHC3 plays an important role in maintaining the
            mitotic quiescence of neurons, while p52SHC1 regulates the
            proliferation of neural stem cells
REFERENCE   2  (bases 1 to 1968)
  AUTHORS   Mehlitz,A., Banhart,S., Maurer,A.P., Kaushansky,A., Gordus,A.G.,
            Zielecki,J., Macbeath,G. and Meyer,T.F.
  TITLE     Tarp regulates early Chlamydia-induced host cell survival through
            interactions with the human adaptor protein SHC1
  JOURNAL   J Cell Biol 190 (1), 143-157 (2010)
   PUBMED   20624904
REFERENCE   3  (bases 1 to 1968)
  AUTHORS   Magrassi,L., Marziliano,N., Inzani,F., Cassini,P., Chiaranda,I.,
            Skrap,M., Pizzolito,S., Arienta,C. and Arbustini,E.
  TITLE     EDG3 and SHC3 on chromosome 9q22 are co-amplified in human
            ependymomas
  JOURNAL   Cancer Lett 290 (1), 36-42 (2010)
   PUBMED   19748727
REFERENCE   4  (bases 1 to 1968)
  AUTHORS   Miyamoto,Y., Chen,L., Sato,M., Sokabe,M., Nabeshima,T., Pawson,T.,
            Sakai,R. and Mori,N.
  TITLE     Hippocampal synaptic modulation by the phosphotyrosine adapter
            protein ShcC/N-Shc via interaction with the NMDA receptor
  JOURNAL   J Neurosci 25 (7), 1826-1835 (2005)
   PUBMED   15716419
REFERENCE   5  (bases 1 to 1968)
  AUTHORS   Jiang,X., Edstrom,E., Altun,M. and Ulfhake,B.
  TITLE     Differential regulation of Shc adaptor proteins in skeletal muscle,
            spinal cord and forebrain of aged rats with sensorimotor impairment
  JOURNAL   Aging Cell 2 (1), 47-57 (2003)
   PUBMED   12882334
  REMARK    GeneRIF: data show that the regulation of Shc mRNAs in senescence
            is region as well as isoform specific
REFERENCE   6  (bases 1 to 1968)
  AUTHORS   Nakazawa,T., Nakano,I., Sato,M., Nakamura,T., Tamai,M. and Mori,N.
  TITLE     Comparative expression profiles of Trk receptors and Shc-related
            phosphotyrosine adapters during retinal development: potential
            roles of N-Shc/ShcC in brain-derived neurotrophic factor signal
            transduction and modulation
  JOURNAL   J Neurosci Res 68 (6), 668-680 (2002)
   PUBMED   12111828
  REMARK    GeneRIF: ShcC could be a potential phosphotyrosine adapter among
            the Shc family members for BDNF signaling and function during
            retinal development.
REFERENCE   7  (bases 1 to 1968)
  AUTHORS   Cook,K.K. and Fadool,D.A.
  TITLE     Two adaptor proteins differentially modulate the phosphorylation
            and biophysics of Kv1.3 ion channel by SRC kinase
  JOURNAL   J Biol Chem 277 (15), 13268-13280 (2002)
   PUBMED   11812778
  REMARK    GeneRIF: modulation of phosphorylation and biophysics by combined
            effect of src kinase, Grb10 and n-Shc adaptor proteins (Kv1.3)
REFERENCE   8  (bases 1 to 1968)
  AUTHORS   Nakamura,T., Muraoka,S., Sanokawa,R. and Mori,N.
  TITLE     N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their
            differential regional expression in the brain and roles in
            neurotrophin and Src signaling
  JOURNAL   J Biol Chem 273 (12), 6960-6967 (1998)
   PUBMED   9507002
REFERENCE   9  (bases 1 to 1968)
  AUTHORS   Basu,T., Warne,P.H. and Downward,J.
  TITLE     Role of Shc in the activation of Ras in response to epidermal
            growth factor and nerve growth factor
  JOURNAL   Oncogene 9 (12), 3483-3491 (1994)
   PUBMED   7970708
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473977.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_341498.3, XM_001054242.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1968
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1968
                     /gene="Shc3"
                     /gene_synonym="ShcC"
                     /note="SHC adaptor protein 3"
                     /db_xref="GeneID:114858"
                     /db_xref="RGD:69348"
     CDS             1..1785
                     /gene="Shc3"
                     /gene_synonym="ShcC"
                     /note="N-Shc; neuronal Shc; SH2 domain protein C3; SHC
                     (Src homology 2 domain containing) transforming protein 3;
                     SHC-transforming protein C; src homology 2
                     domain-containing transforming protein C3"
                     /codon_start=1
                     /product="SHC-transforming protein 3"
                     /protein_id="NP_001099213.1"
                     /db_xref="GeneID:114858"
                     /db_xref="RGD:69348"
                     /translation="MLPRTKYNRFRNDSVTSVDDLLHSLSVSGSGGKVSAEPAASPYL
                     VSGEALRKAPDDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSL
                     AAPDGGSATPGSRAPAASMSATRKSRASDEPLPRPPRGAPHASDQVLGSGVTYVVKYL
                     GCIEVLRSMRSLDFSTRTQVTREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNL
                     QFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVN
                     RRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPSKIPALQDRMQSLDEPWTEEEG
                     DGPDHPYYNSVPNKMPPPGGFLDARLKARPHAPDAAQFSGKEQTYYQGRHLGDAFGED
                     WQRAPTRQGSLDIYSTPEGKAHMVPVGETPTYVNTQPVPPQVWPAATSSTESSPRKDL
                     FDMKPFEDALRNQPLGPVLSKAASVECISPVTPRAPDAKMLEELNAEPWYQGEMSRKE
                     AEALLQEDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTVRTKDRVFDSISHL
                     ITYHLESSLPIVSAGSELCLRQPVERKP"
     exon            1..474
                     /gene="Shc3"
                     /gene_synonym="ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            475..545
                     /gene="Shc3"
                     /gene_synonym="ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            546..609
                     /gene="Shc3"
                     /gene_synonym="ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            610..729
                     /gene="Shc3"
                     /gene_synonym="ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            730..783
                     /gene="Shc3"
                     /gene_synonym="ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            784..835
                     /gene="Shc3"
                     /gene_synonym="ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            836..962
                     /gene="Shc3"
                     /gene_synonym="ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1113
                     /gene="Shc3"
                     /gene_synonym="ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1201
                     /gene="Shc3"
                     /gene_synonym="ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1360
                     /gene="Shc3"
                     /gene_synonym="ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1656
                     /gene="Shc3"
                     /gene_synonym="ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1968
                     /gene="Shc3"
                     /gene_synonym="ShcC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcttccac gcaccaagta caaccgcttc aggaatgact cggtgacatc ggtcgatgac
       61 cttctccaca gcctgtcggt gagcggcagc ggcggcaagg tctcggcgga gcccgcggcg
      121 agcccctacc tggtgtcggg cgaggcgctg cgcaaggcgc cggacgatgg gcccggcagc
      181 ctgggccacc tgctccacaa ggtgtcccac ttgaaactct ccagctccgg cctgcgtggc
      241 ctgtcgtcgg ccgcccggga gcgggcagga gcgcggctct cgggcagctg cagcgcgccc
      301 agcctggcgg ccccggacgg tggcagcgcg acccccgggt cccgtgcccc ggccgccagc
      361 atgagcgcca ccaggaagag ccgggccagc gacgagccgt tgcccaggcc cccgcggggc
      421 gcgccgcacg ccagcgacca ggtgctgggg tcgggagtca cctatgtggt caagtacttg
      481 ggatgcatcg aagttctgcg ctcaatgagg tctcttgact tcagtacaag aactcaggtt
      541 accagggaag ccatcagccg tgtctgcgaa gctgtgccag gcgccaaagg agccttcaag
      601 aagagaaagc ctccgagtaa aatgctgtcc agcatcctgg ggaagagcaa cctccagttc
      661 gcagggatga gcatctccct gaccatctcc accgccagcc tgaacctgcg cactcctgac
      721 tccaaacaga tcatagcgaa ccatcacatg cggtccatct ccttcgcctc agggggagac
      781 ccggacacaa cagactatgt tgcctacgtc gctaaggacc ctgtgaatcg cagagcttgc
      841 cacattctgg aatgctgtga cgggctagcc caagatgtca tcggctccat cggacaagcc
      901 tttgaactcc ggttcaagca gtatttgcag tgtccttcca agattcctgc tctccaggac
      961 cgaatgcaga gtctggacga gccgtggact gaagaagagg gagatggccc cgatcacccg
     1021 tactacaaca gcgttcccaa caagatgcct cctccaggag ggtttctcga tgctcgattg
     1081 aaagccagac cccacgctcc tgatgcagcc cagttttcag gaaaagagca aacttattac
     1141 cagggaagac acttaggaga tgcattcggt gaagactggc agagagcacc caccaggcaa
     1201 ggctccttgg acatctatag cacaccagaa gggaaagctc acatggttcc tgtaggagaa
     1261 acaccaacct atgtcaacac ccagccagtc ccaccacagg tttggccagc agcaaccagc
     1321 agcactgaga gcagcccacg gaaggacctc tttgacatga agccttttga agatgccctc
     1381 agaaaccaac ccctgggccc tgtgttgagc aaagctgcgt ctgtggagtg tatcagcccc
     1441 gttacaccca gagccccgga cgccaagatg ctggaggagc ttaatgctga gccctggtac
     1501 caaggcgaga tgagcaggaa ggaggcagag gctctactac aggaagatgg agacttccta
     1561 gtcaggaaga gtaccaccaa ccccggctcc tttgtcctca caggcatgca caatggccag
     1621 gccaagcacc tgctgctggt ggacccggaa ggcacggtcc ggacgaagga cagggtcttt
     1681 gacagcatca gtcacctcat tacttaccac ctggagagca gcctgcccat tgtctctgcc
     1741 gggagtgagc tttgtctccg gcaaccagtg gagaggaaac cctgagcttg ccctgcgccc
     1801 aggtcaggag gacctgggct ccgctgctct tagcctatgg aatctggggc aactgtctgt
     1861 gggcccatca ccttcttcaa aagccccgtg agagaggttt ccttcaaatt caaatttcat
     1921 aaatatgttc acatgactca gatgcatagt agaaatgtat atacccac
//
