LOCUS       NM_001108065            3904 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus SHC adaptor protein 2 (Shc2), mRNA.
ACCESSION   NM_001108065 XM_001077415 XM_234904
VERSION     NM_001108065.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3904)
  AUTHORS   Jiang,X., Edstrom,E., Altun,M. and Ulfhake,B.
  TITLE     Differential regulation of Shc adaptor proteins in skeletal muscle,
            spinal cord and forebrain of aged rats with sensorimotor impairment
  JOURNAL   Aging Cell 2 (1), 47-57 (2003)
   PUBMED   12882334
  REMARK    GeneRIF: data show that the regulation of Shc mRNAs in senescence
            is region as well as isoform specific
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474029.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_234904.4, XM_001077415.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3904
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3904
                     /gene="Shc2"
                     /note="SHC adaptor protein 2"
                     /db_xref="GeneID:314612"
                     /db_xref="RGD:1307137"
     exon            1..471
                     /gene="Shc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1791
                     /gene="Shc2"
                     /note="src homology 2 domain-containing transforming
                     protein C2; protein Sck; SH2 domain protein C2; SHC (Src
                     homology 2 domain containing) transforming protein 2"
                     /codon_start=1
                     /product="SHC-transforming protein 2"
                     /protein_id="NP_001101535.1"
                     /db_xref="GeneID:314612"
                     /db_xref="RGD:1307137"
                     /translation="MTQGPGGRAAPEPEAPTTFCALLPRMPQWKFAAPGSFLGRGPAA
                     ARVAGAAEAQPEPGVPALAAVLGACEPRCAAPCPLPALGRCRGSGSRGARGTPDVADE
                     WVRKGGFIHKPAHGWLHPDARVLGPGVSYIVRYMGCIEVLRSMRSLDFNTRTQVTREA
                     INRLHEAVPGVRGSWKKKAPNKALASILGKSNLRFAGMSISVNISVDGLNLSVPATRQ
                     IIANHHMQSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSVISTVGQAF
                     ELRFKQYLHSPPKAVVPPERLTGLEESAWGDGEVTADHDYYNSIPGKEPPLGGLVDSR
                     LAVTQPCALTTLGGLGQGLSPAWRDVRGLPWDMGPSGAVPPGDGYVQADARGPHDYEE
                     HLYVNTQGLDALELEDTSETPLQPEDSPKKDLFDMRPFEDALKLHECSVAAGITAASL
                     PLEDQWPSPPTRRAPIAPTEEQLRQEPWYHGRMSRRAAEKLLRADGDFLVRDSITNPG
                     QYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDYHLKNGLPIVAAESELHLR
                     GVVSREP"
     exon            472..542
                     /gene="Shc2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..603
                     /gene="Shc2"
                     /inference="alignment:Splign:2.1.0"
     exon            604..723
                     /gene="Shc2"
                     /inference="alignment:Splign:2.1.0"
     exon            724..777
                     /gene="Shc2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..829
                     /gene="Shc2"
                     /inference="alignment:Splign:2.1.0"
     exon            830..956
                     /gene="Shc2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1122
                     /gene="Shc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1186
                     /gene="Shc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1351
                     /gene="Shc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1662
                     /gene="Shc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1796
                     /gene="Shc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..3904
                     /gene="Shc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catcactcgg cggggaggag cgcacggctc ccggccaggc tcagccgggg ttcctcggcg
       61 gccgcggcca tgacgcaggg tcccggtggc cgcgcggccc ccgagcccga ggcgcccacc
      121 accttctgcg cgctgctacc gcgcatgccg cagtggaagt tcgcggcgcc cggtagcttc
      181 ctgggccgcg gtccggcggc tgcgcgcgtg gcgggggcgg cagaggcgca gcccgagcct
      241 ggggtccccg cgctggccgc cgtgctgggt gcctgcgaac cgcgctgtgc cgcgccctgt
      301 ccgctaccag ctctcggccg ctgccggggc tcggggtcgc ggggcgcgcg gggaactccc
      361 gacgtcgccg acgagtgggt gcgcaagggc ggcttcattc acaagcccgc gcacggctgg
      421 ctgcaccccg atgcgagggt cctggggccc ggggtctctt acatcgttcg gtacatgggc
      481 tgcattgagg tgctccgatc tatgcgctcc ctggatttca acacccggac acaggtgacg
      541 agggaagcca tcaatcggct ccacgaggct gtgccaggtg tccgaggctc ctggaagaag
      601 aaggccccca acaaggcgct ggcctccatc ttggggaaaa gcaacctgcg cttcgccggc
      661 atgagcatct cagtcaacat ctctgtggac ggccttaact tgtcagttcc cgctacccgt
      721 cagatcatcg ccaaccatca catgcagtct atttccttcg cctccggtgg cgacacggac
      781 atgaccgatt acgtggccta tgtggccaag gaccccatca accagagagc ctgccacatc
      841 ttggaatgct gtgagggtct cgcccagagt gtcatcagca ccgtggggca agcctttgag
      901 ctgcgcttca agcaatacct gcacagtccg cccaaggctg tcgtgccccc tgaaaggctg
      961 accgggctgg aggagtcggc ctggggtgat ggtgaggtta ctgcagacca cgattactac
     1021 aacagcattc caggaaagga gccacccctg ggcgggctgg tggactccag actggctgtc
     1081 acacagccct gtgcgctgac aacacttggg ggccttggac agggattgtc acctgcctgg
     1141 agagatgtcc gtggcttgcc ttgggacatg ggcccctctg gagcagtccc acctggggat
     1201 ggctacgtgc aggcagatgc ccgagggcca catgactacg aggaacacct gtatgtcaac
     1261 acccagggcc tggacgcttt ggagcttgag gacacctccg agacacctct gcagcctgag
     1321 gacagcccca agaaggacct gtttgacatg cgaccctttg aagatgccct gaagttgcac
     1381 gagtgctccg tggcagcagg cattactgca gcctcactcc ctctggagga tcagtggccc
     1441 agccccccta cccgcagggc ccccattgca cccacagagg agcaactgag gcaggagccc
     1501 tggtaccatg gacgaatgag ccgtcgggct gcagagaagc tgcttcgtgc cgatggggac
     1561 ttccttgtga gagacagcat caccaacccg gggcagtatg tcctcacagg catgcacgcg
     1621 gggcagccca agcacctgct gctggtggac cccgagggtg tggtacggac aaaagatgtg
     1681 ctgtttgaga gcatcagcca cctcatagac tatcacctga agaacgggtt gcccatcgtg
     1741 gctgccgaga gtgaactgca tctgcgggga gtggtctctc gggagccatg agccaggtga
     1801 cagtcgtcag cccttgctgt ggccccgagg gctcagcctt tctctcagac cctgaagcca
     1861 cgagaaccag aatggttacc acctctcctt ccgcatgagc ctcaggaagc cgcctatttc
     1921 cagctgcact tgctcagctg gctgggccag tgagacagag tcagggttca agcccctcgt
     1981 cccacctgag ccccaaccct gaacttgggt gaggccatat aaaccaaaga cagaccgagt
     2041 cgcctttaac aaagacatcc aaatgcaggt cccatgcctc tggtgcccgg cgcgggtaga
     2101 gacatcgggc tgtgtccaca gagtgacgtg gacggctctg tgtgggcagg agtaacatcc
     2161 tgccttagca gggctctgag gacctagatg cactgttgct tttgggggtg attaaggtgc
     2221 ttttgagtct cagatgcctg ctaggggagt agcctggggc tcgcctggcg tgtagggcat
     2281 ccaggtgagt aggaggcgga ggatcctcag tgaggtctgg tgtccagtca gcacctcgca
     2341 gctgtcgcct gcctggacct tcaactgtca ttagacacag ggttgagcgt gagcccgctg
     2401 tgcctgctag ggactcccag gtggacagct gaggctgggg aaagccgtgt ggagaccctg
     2461 ggctgcagca cagtgggcta gatgggtctg tggggggtct gatctccccc agcaccccag
     2521 cccctgtatc ccaacagtga acaaggctct ggttttactc caagataaat gggcctctct
     2581 ctttgtttgg tgtttcccca gccccttctt ggaaatactg tggcttacct cctaggggcc
     2641 ccacctaggg attcctgaac acgggcccct ggggagggct gggctcctct gtgtggttct
     2701 agagaaacat gtcagggatg gcatgggagc aaaagcttcc agctgctcca aacatgagac
     2761 accattaaag tcagagttac aggtcacttt gatgccctct tcttccgaac acagaaaggc
     2821 ccagagtccc atccccatga tccccacggc ccacccttcc atcccccgtg gaaacttaca
     2881 cggtttcttt ggaaagtcag ttgtgtcagg tggtgtttta gcgggacaga cgcataaagg
     2941 agtgttttcc tgaagcagac acaggtcaaa ggatgttttc cttagcatag acgtgtgaag
     3001 aaatgtttcg acgaagctga cacagattaa aaaaagtgtt tttgttagag caaacatgta
     3061 aaaggatgta tgatgttaaa aaggacccaa cagacggtgg acaatgttag atgatattgt
     3121 cgttattcga tggtcactgc ttgtcgtgac tttataaaac acacacacta aaaatcttct
     3181 ggtggtgatc tggccgcttt cgcagaccca gtgccattgg cagagtggtg tcagctgatt
     3241 caaactcatg gaggacacgt gatgcttggg gagagtataa ataggaccca atggacggtg
     3301 acaggcttac gtagccagct ttgtaatcca tcccagggat ccagtcttaa gtctttgctg
     3361 atcttaactt cattgagagg cacagcagaa gactttctgt ggggtccctg ctggtcctgt
     3421 cactctggct gactcgtgct gatatgtctg aggcctgatt gttaggtcac accaccgctg
     3481 ctgattcctg tttgctatcc tggcactgct gaactggact gctggtgcat atcctgacaa
     3541 cacagatggg agttgctcta aagaactctt tctaaacatg tctccttccc cggtacccta
     3601 ataacatttc ttttccactt cttctggtgg ttagtgggca agaagagagg ttaaaacatt
     3661 tagaaacact tattaaaagt aggttttaaa ggggctggag ggatggctca gcggtgaaga
     3721 gcactgactg ctcttccaga ggtcctgagt tcaaacccca gcaaccacat ggtggctcac
     3781 aaccatctgt aatgggatct gacagtcctt ctggtgtgtc tgaagacagc cacagtgtat
     3841 tcatatacat taaataaata aatcaatctt taagaaagtt ttttttaaat cagtctaccc
     3901 tacc
//
