LOCUS       NP_001101535             573 aa            linear   ROD 02-JUN-2024
DEFINITION  SHC-transforming protein 2 [Rattus norvegicus].
ACCESSION   NP_001101535 XP_001077415 XP_234904
VERSION     NP_001101535.1
DBSOURCE    REFSEQ: accession NM_001108065.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 573)
  AUTHORS   Jiang,X., Edstrom,E., Altun,M. and Ulfhake,B.
  TITLE     Differential regulation of Shc adaptor proteins in skeletal muscle,
            spinal cord and forebrain of aged rats with sensorimotor impairment
  JOURNAL   Aging Cell 2 (1), 47-57 (2003)
   PUBMED   12882334
  REMARK    GeneRIF: data show that the regulation of Shc mRNAs in senescence
            is region as well as isoform specific
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474029.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_234904.4, XP_001077415.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     Protein         1..573
                     /product="SHC-transforming protein 2"
                     /note="src homology 2 domain-containing transforming
                     protein C2; protein Sck; SH2 domain protein C2; SHC (Src
                     homology 2 domain containing) transforming protein 2"
                     /calculated_mol_wt=61639
     Region          116..285
                     /region_name="PTB_Shc"
                     /note="Shc-like phosphotyrosine-binding (PTB) domain;
                     cd01209"
                     /db_xref="CDD:269920"
     Site            order(145..148,153,227..235,247,253,266,269..270,272..273,
                     276..277,280..283,285)
                     /site_type="other"
                     /note="phosphopeptide binding site [polypeptide binding]"
                     /db_xref="CDD:269920"
     Site            order(190,194,217)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269920"
     Region          470..573
                     /region_name="SH2_SHC"
                     /note="Src homology 2 (SH2) domain found in SH2 adaptor
                     protein C (SHC); cd09925"
                     /db_xref="CDD:198179"
     Site            order(485,501,503,508,513,522..524)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198179"
     Site            order(512,523,525,527,532..534,539,545,556..558)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198179"
     CDS             1..573
                     /gene="Shc2"
                     /coded_by="NM_001108065.1:70..1791"
                     /db_xref="GeneID:314612"
                     /db_xref="RGD:1307137"
ORIGIN      
        1 mtqgpggraa pepeapttfc allprmpqwk faapgsflgr gpaaarvaga aeaqpepgvp
       61 alaavlgace prcaapcplp algrcrgsgs rgargtpdva dewvrkggfi hkpahgwlhp
      121 darvlgpgvs yivrymgcie vlrsmrsldf ntrtqvtrea inrlheavpg vrgswkkkap
      181 nkalasilgk snlrfagmsi svnisvdgln lsvpatrqii anhhmqsisf asggdtdmtd
      241 yvayvakdpi nqrachilec ceglaqsvis tvgqafelrf kqylhsppka vvpperltgl
      301 eesawgdgev tadhdyynsi pgkepplggl vdsrlavtqp calttlgglg qglspawrdv
      361 rglpwdmgps gavppgdgyv qadargphdy eehlyvntqg ldaleledts etplqpedsp
      421 kkdlfdmrpf edalklhecs vaagitaasl pledqwpspp trrapiapte eqlrqepwyh
      481 grmsrraaek llradgdflv rdsitnpgqy vltgmhagqp khlllvdpeg vvrtkdvlfe
      541 sishlidyhl knglpivaae selhlrgvvs rep
//
