LOCUS       NM_001164060            3543 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus SHC adaptor protein 1 (Shc1), transcript variant
            1, mRNA.
ACCESSION   NM_001164060
VERSION     NM_001164060.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3543)
  AUTHORS   Miller,B., Regner,K. and Sorokin,A.
  TITLE     p66Shc signaling does not contribute to tubular damage induced by
            renal ischemia-reperfusion injury in rat
  JOURNAL   Biochem Biophys Res Commun 603, 69-74 (2022)
   PUBMED   35278882
  REMARK    GeneRIF: p66Shc signaling does not contribute to tubular damage
            induced by renal ischemia-reperfusion injury in rat.
REFERENCE   2  (bases 1 to 3543)
  AUTHORS   Hughes,W.E., Hockenberry,J., Miller,B., Sorokin,A. and Beyer,A.M.
  TITLE     Modulation of p66Shc impairs cerebrovascular myogenic tone in low
            renin but not low nitric oxide models of systemic hypertension
  JOURNAL   Am J Physiol Heart Circ Physiol 321 (6), H1096-H1102 (2021)
   PUBMED   34714691
  REMARK    GeneRIF: Modulation of p66Shc impairs cerebrovascular myogenic tone
            in low renin but not low nitric oxide models of systemic
            hypertension.
REFERENCE   3  (bases 1 to 3543)
  AUTHORS   Miller,B., Palygin,O., El-Meanawy,A., Mattson,D.L., Geurts,A.M.,
            Staruschenko,A. and Sorokin,A.
  TITLE     p66Shc-mediated hydrogen peroxide production impairs nephrogenesis
            causing reduction of number of glomeruli
  JOURNAL   Life Sci 279, 119661 (2021)
   PUBMED   34087282
  REMARK    GeneRIF: p66Shc-mediated hydrogen peroxide production impairs
            nephrogenesis causing reduction of number of glomeruli.
REFERENCE   4  (bases 1 to 3543)
  AUTHORS   Miller,B., Kostrominova,T.Y., Geurts,A.M. and Sorokin,A.
  TITLE     Double p52Shc/p46Shc Rat Knockout Demonstrates Severe Gait
            Abnormalities Accompanied by Dilated Cardiomyopathy
  JOURNAL   Int J Mol Sci 22 (10), 5237 (2021)
   PUBMED   34063460
  REMARK    GeneRIF: Double p52Shc/p46Shc Rat Knockout Demonstrates Severe Gait
            Abnormalities Accompanied by Dilated Cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3543)
  AUTHORS   Yu,P., Yang,K. and Jiang,M.
  TITLE     RXRalpha Blocks Nerve Regeneration after Spinal Cord Injury by
            Targeting p66shc
  JOURNAL   Oxid Med Cell Longev 2021, 8253742 (2021)
   PUBMED   33628383
  REMARK    GeneRIF: RXRalpha Blocks Nerve Regeneration after Spinal Cord
            Injury by Targeting p66shc.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3543)
  AUTHORS   Craparo,A., O'Neill,T.J. and Gustafson,T.A.
  TITLE     Non-SH2 domains within insulin receptor substrate-1 and SHC mediate
            their phosphotyrosine-dependent interaction with the NPEY motif of
            the insulin-like growth factor I receptor
  JOURNAL   J Biol Chem 270 (26), 15639-15643 (1995)
   PUBMED   7541045
REFERENCE   7  (bases 1 to 3543)
  AUTHORS   Gustafson,T.A., He,W., Craparo,A., Schaub,C.D. and O'Neill,T.J.
  TITLE     Phosphotyrosine-dependent interaction of SHC and insulin receptor
            substrate 1 with the NPEY motif of the insulin receptor via a novel
            non-SH2 domain
  JOURNAL   Mol Cell Biol 15 (5), 2500-2508 (1995)
   PUBMED   7537849
REFERENCE   8  (bases 1 to 3543)
  AUTHORS   Blaikie,P., Immanuel,D., Wu,J., Li,N., Yajnik,V. and Margolis,B.
  TITLE     A region in Shc distinct from the SH2 domain can bind
            tyrosine-phosphorylated growth factor receptors
  JOURNAL   J Biol Chem 269 (51), 32031-32034 (1994)
   PUBMED   7798194
REFERENCE   9  (bases 1 to 3543)
  AUTHORS   Sasaoka,T., Rose,D.W., Jhun,B.H., Saltiel,A.R., Draznin,B. and
            Olefsky,J.M.
  TITLE     Evidence for a functional role of Shc proteins in mitogenic
            signaling induced by insulin, insulin-like growth factor-1, and
            epidermal growth factor
  JOURNAL   J Biol Chem 269 (18), 13689-13694 (1994)
   PUBMED   7513704
REFERENCE   10 (bases 1 to 3543)
  AUTHORS   McGlade,J., Cheng,A., Pelicci,G., Pelicci,P.G. and Pawson,T.
  TITLE     Shc proteins are phosphorylated and regulated by the v-Src and
            v-Fps protein-tyrosine kinases
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8869-8873 (1992)
   PUBMED   1409579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001164060.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.3147666.1,
                                           SRR26360190.3229814.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-703               JAXUCZ010000002.1  177138548-177139250
            704-774             JAXUCZ010000002.1  177139810-177139880
            775-838             JAXUCZ010000002.1  177140365-177140428
            839-958             JAXUCZ010000002.1  177140558-177140677
            959-1012            JAXUCZ010000002.1  177141054-177141107
            1013-1064           JAXUCZ010000002.1  177141393-177141444
            1065-1191           JAXUCZ010000002.1  177141608-177141734
            1192-1378           JAXUCZ010000002.1  177143510-177143696
            1379-1448           JAXUCZ010000002.1  177143785-177143854
            1449-1580           JAXUCZ010000002.1  177143935-177144066
            1581-1819           JAXUCZ010000002.1  177144206-177144444
            1820-3543           JAXUCZ010000002.1  177145534-177147257
FEATURES             Location/Qualifiers
     source          1..3543
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3543
                     /gene="Shc1"
                     /gene_synonym="P66shc"
                     /note="SHC adaptor protein 1"
                     /db_xref="GeneID:85385"
                     /db_xref="RGD:620446"
     exon            1..703
                     /gene="Shc1"
                     /gene_synonym="P66shc"
                     /inference="alignment:Splign:2.1.0"
     exon            704..774
                     /gene="Shc1"
                     /gene_synonym="P66shc"
                     /inference="alignment:Splign:2.1.0"
     exon            775..838
                     /gene="Shc1"
                     /gene_synonym="P66shc"
                     /inference="alignment:Splign:2.1.0"
     exon            839..958
                     /gene="Shc1"
                     /gene_synonym="P66shc"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1012
                     /gene="Shc1"
                     /gene_synonym="P66shc"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1064
                     /gene="Shc1"
                     /gene_synonym="P66shc"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1191
                     /gene="Shc1"
                     /gene_synonym="P66shc"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1378
                     /gene="Shc1"
                     /gene_synonym="P66shc"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1448
                     /gene="Shc1"
                     /gene_synonym="P66shc"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1580
                     /gene="Shc1"
                     /gene_synonym="P66shc"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1819
                     /gene="Shc1"
                     /gene_synonym="P66shc"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..3543
                     /gene="Shc1"
                     /gene_synonym="P66shc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctgggcc aggatgtggt ttgaaactgt ctaggtctga gttgggagag cagaggtcac
       61 ttgtccttcg cctccccagg tcctctgtta tcacccggct gccgaggtca gactaggcta
      121 agggtctggg gatgccccct gcctggcccc cttgcctgaa ttggcagggg ggccgggccg
      181 ggcagcagcc ccccttctca ccccagccat ggatcttcta ccccccaagc cgaagtacaa
      241 cccacttcgg aatgagtctc tgtcatcgct ggaggagggg gcttcagggt ctactccacc
      301 ggaggagctg ccttccccat cagcctcatc cctgggaccc attctgcctc ctctgccggg
      361 ggacgatagc ccgactaccc tgtgttcctt ctttccccgg atgagcaact tgaagctggc
      421 caatcctgct ggggggcgcc tgggacctaa aggggagcca ggaaaagctg cagaagatgg
      481 ggaagggagt gcaggagcag cccttcggga ctcaggcctc ttgcccctcc tccaggacat
      541 gaacaagctg agtggaggcg gcgggcgcag gactcgggta gaagggggcc agctgggggg
      601 cgaggagtgg accagacacg ggagctttgt caataagccc acacgaggct ggctgcatcc
      661 caacgacaaa gtcatgggac ctggggtttc ctacttggtt cggtacatgg gttgcgtgga
      721 ggtcttacag tcaatgcgag cccttgactt caatacccgg actcaggtca ccagggaggc
      781 tatcagtttg gtgtgtgaag ctgtgcctgg tgccaaaggg gcgatgagga ggagaaagcc
      841 ctgcagccgc ccactcagct ctatcctggg aaggagtaac ctgaagtttg ctggaatgcc
      901 gatcactctc actgtgtcta ccagcagcct taacctcatg gcagcagact gcaaacagat
      961 cattgccaac catcacatgc aatctatctc attcgcgtct ggtggggatc cggacacagc
     1021 tgagtacgtt gcctatgttg ccaaagaccc tgtgaatcag agagcctgcc atatcctgga
     1081 gtgtcctgaa ggacttgctc aggacgtcat cagcaccatc gggcaggcct ttgagttgcg
     1141 cttcaaacag tatctcagga atccacccaa gctggtcacc ccccatgaca ggatggctgg
     1201 ctttgatggc tcagcttggg atgaggagga agaagagccc cctgaccatc agtactacaa
     1261 tgacttccca gggaaggaac cccctcttgg tggagtggta gatatgaggc ttcgggaagg
     1321 ggctgctcga cccactctgc ccagtaccca gatgcccagc cacttgggag ctacactgcc
     1381 aatagggcag catgttacag gagaccatga agtccgtaaa cagatgctgc ctccaccacc
     1441 gtgcccaggc agagaactct tcgatgatcc ttcctatgtc aacatccaga atctagacaa
     1501 ggcccggcaa gctggtggtg gggctggacc cccaaatcct tctgttaatg gcagtgcacc
     1561 ccgagacctc tttgacatga agcccttcga agatgcactc cgggtgccgc cagctcccca
     1621 gtccatgtcc atggctgagc agctccaagg ggagtcctgg tttcatggga aactcagccg
     1681 gcgggaggct gaggcgctgc tgcagctcaa cggtgacttc ttggtgcgag agagtacaac
     1741 cacacctggc cagtacgtgc tcactggtct gcagagtggg cagcccaagc acttgcttct
     1801 ggtggaccct gaaggtgtgg ttcggacaaa ggatcaccgc tttgagagtg tcagtcacct
     1861 gatcagctac cacatggaca atcacttacc catcatctct gcaggcagtg agctgtgtct
     1921 acagcaacct gtggatcgaa aagtgtgatc cttcttagcc tctcctggag gacgctctcc
     1981 actcccttct accgtgtact cgtggggccg ctgcttggtg ggaactgagc ggcaaggaca
     2041 cggctttagt gcccacttga gagaggattt ttaggagcct gggaaagcat ccttcttctg
     2101 cccaaacctc accaaagtat taatgtgcag agtggtccct tgtctgggcc ttgcctgtgc
     2161 caacctgatg cccttccccc aaaagggtgg gttttataat ggaaaatacc ctgtggtgtt
     2221 agacccagtg gagtaattgc cctttggggg aagggaaata atcatacctc tggtttactc
     2281 ctggtcttca gggtacccca gacccctttt aacatatcct actccctatg catctcctta
     2341 aaactttgtg ccttcgacta tcataggtct gcagatactt tatgcagagt tctcaggctc
     2401 ttcagatgtg gacaggggtt actgacacct tgacttctgg aaccctgttc tgctcagcat
     2461 cccttcctgt gtctggggag aatagggcag gagtggccac catctcctct gcttttggat
     2521 gtacagccct ttaaaggttg ccccaggcca ggatgtggtg acacatgcct ttaatcactg
     2581 cactcaggag gcagaggcag gaggatttgt gaagctaccc tggcctacaa cagtgagttc
     2641 cagtacagcc agggctatgg agagaggacc tgtttccaaa aaaccaaaaa gaacaattac
     2701 ccccagagcc ttggggaggg gcaggattgg actcatcttg ctcagtgcct cctgacctca
     2761 atgccttcct tccaaggggt ctgtatacat ttcttaagcc cacccctccc atgtttgcat
     2821 gtgtgttata gtctacagcc aaagtgtagc cgttactgta accccatcag tctccctctt
     2881 ttgggacagg tgtgtgtggc tcacttgggc ctccagtatg tgtgcagtcc aagtgggttt
     2941 tatggaggcc tggagactga agcagtagac aatccccaat accatttgca ggtctggaac
     3001 tgctcgctcg ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct
     3061 ctctcttttt tatagaaaaa aaaaagtata cattttaggg ctgtagattt attttcctag
     3121 ttttgttttt cgttgctgac ttttgagcac agaattatga taatcaatta catttataca
     3181 tcacctcgtt gacgtttcca aacttttttt tttaaaacat cttgttggaa ttttactccc
     3241 tggcctaact aggacagggt cccgtacctc cccctacccc ccgcccccgc ctccttcttc
     3301 ctcaagacac ctgagcagaa atttggctga acagtgttgt ggaattatgt gatagcttta
     3361 gatcctccct tctgcttgag ggcagatgcg gccaggccag cacagaaacc ttgcaagctt
     3421 actctgaagg ctttctggac aaggagtggt cgactggatt tcagtcttgg ctgtcgccta
     3481 tttttggttt ggatgtctta taccaaaggg aaatagtctt cattaaagtc cgtatttctt
     3541 cta
//
