LOCUS       NM_012650               1396 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus sex hormone binding globulin (Shbg), mRNA.
ACCESSION   NM_012650
VERSION     NM_012650.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1396)
  AUTHORS   Xu,P., Zeng,R., Wan,Q., Xie,Y., Liu,X., An,S., Jiang,J., Yang,J.,
            Zhou,Y. and Shen,X.
  TITLE     Aging-related increases in serum sex hormone-binding globulin
            levels in men might be related to increased synthesis
  JOURNAL   Exp Gerontol 179, 112249 (2023)
   PUBMED   37392803
  REMARK    GeneRIF: Aging-related increases in serum sex hormone-binding
            globulin levels in men might be related to increased synthesis.
REFERENCE   2  (bases 1 to 1396)
  AUTHORS   Ploss,V., Gebhart,V.M., Dolz,W. and Jirikowski,G.F.
  TITLE     Sex hormone binding globulin in the rat olfactory system
  JOURNAL   J Chem Neuroanat 57-58, 10-14 (2014)
   PUBMED   24681170
  REMARK    GeneRIF: SHBG may be of functional importance for rapid effects of
            olfactory steroids on limbic functions including the control of
            reproductive behaviours through pheromones
REFERENCE   3  (bases 1 to 1396)
  AUTHORS   Wood,M.A., Mukherjee,P., Toocheck,C.A. and Walker,W.H.
  TITLE     Upstream stimulatory factor induces Nr5a1 and Shbg gene expression
            during the onset of rat Sertoli cell differentiation
  JOURNAL   Biol Reprod 85 (5), 965-976 (2011)
   PUBMED   21734262
  REMARK    GeneRIF: Upstream stimulatory factors (USF1 and USF2) induce Nr5a1
            and Shbg gene expression during the onset of rat Sertoli cell
            differentiation.
REFERENCE   4  (bases 1 to 1396)
  AUTHORS   Pinos,T., Barbosa-Desongles,A., Hurtado,A., Santamaria-Martinez,A.,
            de Torres,I., Reventos,J. and Munell,F.
  TITLE     Human SHBG mRNA translation is modulated by alternative
            5'-non-coding exons 1A and 1B
  JOURNAL   PLoS One 5 (11), e13844 (2010)
   PUBMED   21079794
  REMARK    GeneRIF: Data show that the use of alternative SHBG first exons 1A
            and 1B differentially inhibits translation from the ATG situated in
            exon 2, which codes for methionine 30 of transcripts that begin
            with the exon 1 sequence.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1396)
  AUTHORS   Xu,R., Shang,W., Liu,J., Duan,L., Ba,Y., Zhang,H., Cheng,X. and
            Cui,L.
  TITLE     [Influence of fluorine on expression of androgen-binding protein
            and inhibin B mRNA in rat testis sertoli cells]
  JOURNAL   Wei Sheng Yan Jiu 39 (5), 615-617 (2010)
   PUBMED   21033444
  REMARK    GeneRIF: Fluorine had no effect on the expression of androgen
            binding protein and inhibin B mRNA in testis sertoli cells of
            Sprague Dawley rats.
REFERENCE   6  (bases 1 to 1396)
  AUTHORS   Danzo,B.J., Parrott,J.A. and Skinner,M.K.
  TITLE     Analysis of the steroid binding domain of rat androgen-binding
            protein
  JOURNAL   Endocrinology 129 (2), 690-696 (1991)
   PUBMED   1855466
REFERENCE   7  (bases 1 to 1396)
  AUTHORS   Sullivan,P.M., Petrusz,P., Szpirer,C. and Joseph,D.R.
  TITLE     Alternative processing of androgen-binding protein RNA transcripts
            in fetal rat liver. Identification of a transcript formed by trans
            splicing
  JOURNAL   J Biol Chem 266 (1), 143-154 (1991)
   PUBMED   1702422
REFERENCE   8  (bases 1 to 1396)
  AUTHORS   Wang,Y.M., Bayliss,D.A., Millhorn,D.E., Petrusz,P. and Joseph,D.R.
  TITLE     The androgen-binding protein gene is expressed in male and female
            rat brain
  JOURNAL   Endocrinology 127 (6), 3124-3130 (1990)
   PUBMED   1701136
REFERENCE   9  (bases 1 to 1396)
  AUTHORS   Joseph,D.R., Hall,S.H., Conti,M. and French,F.S.
  TITLE     The gene structure of rat androgen-binding protein: identification
            of potential regulatory deoxyribonucleic acid elements of a
            follicle-stimulating hormone-regulated protein
  JOURNAL   Mol Endocrinol 2 (1), 3-13 (1988)
   PUBMED   2840566
REFERENCE   10 (bases 1 to 1396)
  AUTHORS   Joseph,D.R., Hall,S.H. and French,F.S.
  TITLE     Rat androgen-binding protein: evidence for identical subunits and
            amino acid sequence homology with human sex hormone-binding
            globulin
  JOURNAL   Proc Natl Acad Sci U S A 84 (2), 339-343 (1987)
   PUBMED   2432609
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_012650.3.
            
            On Nov 26, 2020 this sequence version replaced NM_012650.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M15034.1, BC097336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               JAXUCZ010000010.1  54834754-54834901   c
            149-240             JAXUCZ010000010.1  54834489-54834580   c
            241-430             JAXUCZ010000010.1  54834145-54834334   c
            431-592             JAXUCZ010000010.1  54833704-54833865   c
            593-752             JAXUCZ010000010.1  54833355-54833514   c
            753-889             JAXUCZ010000010.1  54832841-54832977   c
            890-1097            JAXUCZ010000010.1  54832322-54832529   c
            1098-1396           JAXUCZ010000010.1  54831721-54832019   c
FEATURES             Location/Qualifiers
     source          1..1396
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1396
                     /gene="Shbg"
                     /gene_synonym="Abpa"
                     /note="sex hormone binding globulin"
                     /db_xref="GeneID:24775"
                     /db_xref="RGD:3671"
     exon            1..148
                     /gene="Shbg"
                     /gene_synonym="Abpa"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1246
                     /gene="Shbg"
                     /gene_synonym="Abpa"
                     /note="ABP; SBP; sex steroid-binding protein;
                     testis-specific androgen-binding protein; androgen binding
                     protein; Sex hormone binding globulin or androgen-binding
                     protein (other gene product from ABP gene)"
                     /codon_start=1
                     /product="sex hormone-binding globulin precursor"
                     /protein_id="NP_036782.1"
                     /db_xref="GeneID:24775"
                     /db_xref="RGD:3671"
                     /translation="MEKGEVASLRCRLLLLLLLLTLPPTHQGRTLRHIDPIQSAQDSP
                     AKYLSNGPGQEPVTVLTIDLTKISKPSSSFEFRTWDPEGVIFYGDTNTEDDWFMLGLR
                     DGQLEIQLHNLWARLTVGFGPRLNDGRWHPVELKMNGDSLLLWVDGKEMLCLRQVSAS
                     LADHPQLSMRIALGGLLLPTSKLRFPLVPALDGCIRRDIWLGHQAQLSTSARTSLGNC
                     DVDLQPGLFFPPGTHAEFSLQDIPQPHTDPWTFSLELGFKLVDGAGRLLTLGTGTNSS
                     WLTLHLQDQTVVLSSEAEPKLALPLAVGLPLQLKLDVFKVALSQGPKMEVLSTSLLRL
                     ASLWRLWSHPQGHLSLGALPGEDSSASFCLSDLWVQGQRLDIDKALSRSQDIWTHSCP
                     QSPSNDTHTSH"
     exon            149..240
                     /gene="Shbg"
                     /gene_synonym="Abpa"
                     /inference="alignment:Splign:2.1.0"
     exon            241..430
                     /gene="Shbg"
                     /gene_synonym="Abpa"
                     /inference="alignment:Splign:2.1.0"
     exon            431..592
                     /gene="Shbg"
                     /gene_synonym="Abpa"
                     /inference="alignment:Splign:2.1.0"
     exon            593..752
                     /gene="Shbg"
                     /gene_synonym="Abpa"
                     /inference="alignment:Splign:2.1.0"
     exon            753..889
                     /gene="Shbg"
                     /gene_synonym="Abpa"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1097
                     /gene="Shbg"
                     /gene_synonym="Abpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1396
                     /gene="Shbg"
                     /gene_synonym="Abpa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atattctgag ccactgggtg gacagctgct aactatggag aagggagagg tggcctcctt
       61 gcgttgccga ctgcttctgt tgttgctact attgacgctg cctcccaccc accagggacg
      121 gaccctgaga cacattgacc ctatccagag tgctcaggac tctcctgcta aatacctcag
      181 caatggccca ggacaagagc ccgtcactgt tctgaccatt gacctcacca aaatcagcaa
      241 accctcttcc tcctttgagt ttcgaacctg ggatccagag ggagtgattt tttatgggga
      301 caccaacact gaagatgact ggttcatgct gggactgcgg gatggccagc ttgaaatcca
      361 gctgcacaat ctctgggctc ggcttacagt aggctttggc cctcggctga atgatgggag
      421 atggcacccg gtggagctaa agatgaacgg ggattcactg ctgctatggg tggatggaaa
      481 agagatgcta tgcctgagac aagtttctgc atccctggct gaccatcccc agctcagcat
      541 gaggattgca ctaggggggc tcctcctccc cacttccaaa cttcggtttc cgctcgttcc
      601 tgccctggat ggctgtatac gccgagatat ctggctgggc caccaggccc agctctcaac
      661 ctctgcccga actagccttg ggaactgtga tgtggacctg caacctggac tgttcttccc
      721 tccagggacc catgcagaat tcagtctcca agacattccc cagcctcaca cagacccctg
      781 gaccttttct ctggagctgg gatttaagct ggtggatgga gcaggacgac tccttactct
      841 tgggacaggg acaaattctt cttggctcac ccttcacctc caagaccaaa cggtggttct
      901 gtcttctgaa gcagaaccta aactagcttt acccttggcg gtgggactcc ctcttcaact
      961 gaagctggat gtattcaaag tagccttgag ccaaggacca aagatggagg tcctttctac
     1021 atctctttta agacttgcct ccctctggag actctggtcc caccctcagg gccatctctc
     1081 ccttggggct ttaccaggag aggactcttc tgcttccttt tgcctgagtg acctttgggt
     1141 acaaggacag agactggaca tagacaaagc cctgagcaga agccaggaca tctggactca
     1201 tagttgccct cagagcccta gcaatgatac ccacacctcc cactaaaccc ctttgagaag
     1261 caggcacggc tgtgcacatc cttaaatccc ggagaggtga attgggacct caaggttatc
     1321 cttggctata tgacatgttt gaggccagcc tgggctacat gaaaccctgc cttcaaaaat
     1381 aaaaaagaac tttgga
//
