LOCUS       NM_031153               1733 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SHANK-associated RH domain interactor (Sharpin),
            mRNA.
ACCESSION   NM_031153
VERSION     NM_031153.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1733)
  AUTHORS   Damgaard,R.B., Walker,J.A., Marco-Casanova,P., Morgan,N.V.,
            Titheradge,H.L., Elliott,P.R., McHale,D., Maher,E.R.,
            McKenzie,A.N.J. and Komander,D.
  TITLE     The Deubiquitinase OTULIN Is an Essential Negative Regulator of
            Inflammation and Autoimmunity
  JOURNAL   Cell 166 (5), 1215-1230 (2016)
   PUBMED   27523608
REFERENCE   2  (bases 1 to 1733)
  AUTHORS   Elliott,P.R., Nielsen,S.V., Marco-Casanova,P., Fiil,B.K.,
            Keusekotten,K., Mailand,N., Freund,S.M., Gyrd-Hansen,M. and
            Komander,D.
  TITLE     Molecular basis and regulation of OTULIN-LUBAC interaction
  JOURNAL   Mol Cell 54 (3), 335-348 (2014)
   PUBMED   24726323
REFERENCE   3  (bases 1 to 1733)
  AUTHORS   Calderwood,D.A., Campbell,I.D. and Critchley,D.R.
  TITLE     Talins and kindlins: partners in integrin-mediated adhesion
  JOURNAL   Nat Rev Mol Cell Biol 14 (8), 503-517 (2013)
   PUBMED   23860236
  REMARK    Review article
REFERENCE   4  (bases 1 to 1733)
  AUTHORS   Bouvard,D., Pouwels,J., De Franceschi,N. and Ivaska,J.
  TITLE     Integrin inactivators: balancing cellular functions in vitro and in
            vivo
  JOURNAL   Nat Rev Mol Cell Biol 14 (7), 430-442 (2013)
   PUBMED   23719537
  REMARK    Review article
REFERENCE   5  (bases 1 to 1733)
  AUTHORS   Chu,W.M.
  TITLE     Tumor necrosis factor
  JOURNAL   Cancer Lett 328 (2), 222-225 (2013)
   PUBMED   23085193
  REMARK    Review article
REFERENCE   6  (bases 1 to 1733)
  AUTHORS   Gerlach,B., Cordier,S.M., Schmukle,A.C., Emmerich,C.H., Rieser,E.,
            Haas,T.L., Webb,A.I., Rickard,J.A., Anderton,H., Wong,W.W.,
            Nachbur,U., Gangoda,L., Warnken,U., Purcell,A.W., Silke,J. and
            Walczak,H.
  TITLE     Linear ubiquitination prevents inflammation and regulates immune
            signalling
  JOURNAL   Nature 471 (7340), 591-596 (2011)
   PUBMED   21455173
REFERENCE   7  (bases 1 to 1733)
  AUTHORS   Jung,J., Kim,J.M., Park,B., Cheon,Y., Lee,B., Choo,S.H., Koh,S.S.
            and Lee,S.
  TITLE     Newly identified tumor-associated role of human Sharpin
  JOURNAL   Mol Cell Biochem 340 (1-2), 161-167 (2010)
   PUBMED   20179993
REFERENCE   8  (bases 1 to 1733)
  AUTHORS   Daigo,Y., Takayama,I., Ward,S.M., Sanders,K.M. and Fujino,M.A.
  TITLE     Novel human and mouse genes encoding a shank-interacting protein
            and its upregulation in gastric fundus of W/WV mouse
  JOURNAL   J Gastroenterol Hepatol 18 (6), 712-718 (2003)
   PUBMED   12753155
  REMARK    GeneRIF: The upregulation of Shank-interacting protein-like 1
            (SIPL1) in the fundus of W/WV mice, and expression in the upper
            gastrointestinal tract suggest that the SIPL1 gene could be
            associated with interstitial cells of Cajal (ICC) function in mice
            and humans.
REFERENCE   9  (bases 1 to 1733)
  AUTHORS   Lim,S., Sala,C., Yoon,J., Park,S., Kuroda,S., Sheng,M. and Kim,E.
  TITLE     Sharpin, a novel postsynaptic density protein that directly
            interacts with the shank family of proteins
  JOURNAL   Mol Cell Neurosci 17 (2), 385-397 (2001)
   PUBMED   11178875
REFERENCE   10 (bases 1 to 1733)
  AUTHORS   Gijbels,M.J., HogenEsch,H., Blauw,B., Roholl,P. and Zurcher,C.
  TITLE     Ultrastructure of epidermis of mice with chronic proliferative
            dermatitis
  JOURNAL   Ultrastruct Pathol 19 (2), 107-111 (1995)
   PUBMED   7792947
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083553.1.
            
            On Oct 10, 2004 this sequence version replaced NM_031153.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083553.1, AF203906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1733
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1733
                     /gene="Sharpin"
                     /gene_synonym="Conneck1"
                     /note="SHANK-associated RH domain interactor"
                     /db_xref="GeneID:81859"
                     /db_xref="RGD:631353"
     exon            1..543
                     /gene="Sharpin"
                     /gene_synonym="Conneck1"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..1491
                     /gene="Sharpin"
                     /gene_synonym="Conneck1"
                     /note="shank-associated RH domain-interacting protein;
                     shank-interacting protein; SHANK-associated RH domain
                     interacting protein"
                     /codon_start=1
                     /product="sharpin"
                     /protein_id="NP_112415.1"
                     /db_xref="GeneID:81859"
                     /db_xref="RGD:631353"
                     /translation="MSPPAGGAAAAADPASPVVLLAVQAAVRLLGAGHEDEAQLRKLQ
                     LKADPERPGRFRLGLLGIEPGAVSLEWPLESICYTIRGPNQHELQPPPGGPGTFSVHF
                     LNSEEAQQWAALVRDATAEGQNGNDSTAPVPTPAMCPTSPPCSSVTPTPKATQPEMDL
                     PQGSGNLKKEELATHLAQAIAGGDEKAAAQVAAILAQHHVALNVQLLEAWFPRGPIRL
                     QVTVEDATSVLSSSSSAHVSLQIHPHCSIAALQEQVFSEFGFPPAVQRWVIGRCLCMP
                     ERSLASYGVSQDGDPAFLYLLSAPREVSGHSPQHSKMDRKLGCLFPQSLELPHNLQAS
                     SSSLPSPPQPGWSCPSCTFINASNRPGCEMCSTQRPCAWDPLTATST"
     exon            544..718
                     /gene="Sharpin"
                     /gene_synonym="Conneck1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..853
                     /gene="Sharpin"
                     /gene_synonym="Conneck1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..995
                     /gene="Sharpin"
                     /gene_synonym="Conneck1"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1104
                     /gene="Sharpin"
                     /gene_synonym="Conneck1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1258
                     /gene="Sharpin"
                     /gene_synonym="Conneck1"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1374
                     /gene="Sharpin"
                     /gene_synonym="Conneck1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1503
                     /gene="Sharpin"
                     /gene_synonym="Conneck1"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1641
                     /gene="Sharpin"
                     /gene_synonym="Conneck1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggttttgg cttatgtcgg gcagcagcta tcgttcgttc gaacttttaa gaaaagtcca
       61 tccttgcctc ctttttgtga acggtgatcg gtctgtgaca ctgtccccag gtcctgcaga
      121 aacgtgacta gcgtggacgg actgtacctg gagatccttg gaccatctct atcccttaat
      181 gagctatcag gctctggtag tgcgcagcac tgtgtccttc ttgttctcca cgctctgcca
      241 catccggaac ctagcctcac agtccaagtt tctgtcggcg gaagtactcg acagttctgt
      301 atcacggaag cgctctcgga gagtcaggac tccgccggac cagaaatgtc gccgcccgcc
      361 ggcggtgcgg cagcggctgc agaccctgct tcacctgtgg tgctcctggc agtgcaagcc
      421 gcggtgagac tcctgggcgc cggacatgaa gacgaagcgc agctgcgaaa gctgcagttg
      481 aaagccgacc ctgagcggcc tggacgcttc cggctgggac tgttaggcat tgagccaggg
      541 gcggtcagtt tagaatggcc cttggagtct atttgctata ccattcgtgg tcctaaccaa
      601 cacgagctgc agcctccacc tggaggtcct ggaaccttca gtgtgcactt cctcaactct
      661 gaggaagcac agcagtgggc agcactggtg cgagatgcca ccgcagaagg acaaaatggc
      721 aatgacagca cagccccagt cccaacccca gccatgtgcc ccacttctcc accatgttct
      781 tctgtgactc caacacctaa agcaacccaa ccagagatgg accttcctca aggttctgga
      841 aacttgaaaa aagaagagct ggctacacac ctggcccagg ccattgcagg tggggatgag
      901 aaagcagcag cccaagtggc ggcaatcctg gcacagcatc atgtggctct caatgtccag
      961 ctcttagagg cctggttccc acggggtccc ataaggctgc aagtcacagt tgaagatgcc
     1021 acatcggttt tatcctcttc gtcgtctgcc catgtctcac tgcagatcca cccacactgt
     1081 tccattgcag ccctccagga acaggtgttc tcagagttcg gtttcccacc agctgtgcag
     1141 cgctgggtca ttggccggtg cctgtgtatg cctgaacgaa gccttgcttc ctatggggtc
     1201 tctcaagatg gggaccctgc ttttctttac ttgctctcag ccccccgaga agtttcagga
     1261 cacagccctc aacactccaa gatggatagg aaattaggat gcttgtttcc tcagtcattg
     1321 gagctgcctc ataacctcca ggcatccagt tccagtctcc caagtccccc tcagcctggc
     1381 tggtcttgcc cttcctgcac cttcatcaat gcttcaaacc gccctggctg tgagatgtgt
     1441 agcacccaaa ggccctgtgc ttgggatccc cttactgcaa cttccaccta gaagccacca
     1501 aaggttacag agaatatgcc ctcttgtcac aggcccaacc accacctgaa ctttggaggg
     1561 gaccgctgct tgttggggac agagatgcca gtgttagaga acaggggcca caagccagta
     1621 attaaagaca cataagagcc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1681 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
