LOCUS       NM_021676               7882 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus SH3 and multiple ankyrin repeat domains 3
            (Shank3), mRNA.
ACCESSION   NM_021676 NM_021675 XM_039079817 XM_346810
VERSION     NM_021676.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7882)
  AUTHORS   Yang,Q., Perfitt,T.L., Quay,J., Hu,L., Lawson-Qureshi,D. and
            Colbran,R.J.
  TITLE     Clustering of CaV 1.3 L-type calcium channels by Shank3
  JOURNAL   J Neurochem 167 (1), 16-37 (2023)
   PUBMED   37392026
  REMARK    GeneRIF: Clustering of CaV 1.3 L-type calcium channels by Shank3.
REFERENCE   2  (bases 1 to 7882)
  AUTHORS   Wu,C.H., Tatavarty,V., Jean Beltran,P.M., Guerrero,A.A.,
            Keshishian,H., Krug,K., MacMullan,M.A., Li,L., Carr,S.A.,
            Cottrell,J.R. and Turrigiano,G.G.
  TITLE     A bidirectional switch in the Shank3 phosphorylation state biases
            synapses toward up- or downscaling
  JOURNAL   Elife 11, e74277 (2022)
   PUBMED   35471151
  REMARK    GeneRIF: A bidirectional switch in the Shank3 phosphorylation state
            biases synapses toward up- or downscaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7882)
  AUTHORS   Golden,C.E.M., Wang,V.X., Harony-Nicolas,H., Hof,P.R. and
            Buxbaum,J.D.
  TITLE     Reduced brain volume and white matter alterations in
            Shank3-deficient rats
  JOURNAL   Autism Res 14 (9), 1837-1842 (2021)
   PUBMED   34313403
  REMARK    GeneRIF: Reduced brain volume and white matter alterations in
            Shank3-deficient rats.
REFERENCE   4  (bases 1 to 7882)
  AUTHORS   Bucher,M., Niebling,S., Han,Y., Molodenskiy,D., Hassani Nia,F.,
            Kreienkamp,H.J., Svergun,D., Kim,E., Kostyukova,A.S., Kreutz,M.R.
            and Mikhaylova,M.
  TITLE     Autism-associated SHANK3 missense point mutations impact
            conformational fluctuations and protein turnover at synapses
  JOURNAL   Elife 10, e66165 (2021)
   PUBMED   33945465
  REMARK    GeneRIF: Autism-associated SHANK3 missense point mutations impact
            conformational fluctuations and protein turnover at synapses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7882)
  AUTHORS   Jacot-Descombes,S., Keshav,N.U., Dickstein,D.L., Wicinski,B.,
            Janssen,W.G.M., Hiester,L.L., Sarfo,E.K., Warda,T., Fam,M.M.,
            Harony-Nicolas,H., Buxbaum,J.D., Hof,P.R. and Varghese,M.
  TITLE     Altered synaptic ultrastructure in the prefrontal cortex of
            Shank3-deficient rats
  JOURNAL   Mol Autism 11 (1), 89 (2020)
   PUBMED   33203459
  REMARK    GeneRIF: Altered synaptic ultrastructure in the prefrontal cortex
            of Shank3-deficient rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7882)
  AUTHORS   Sheng,M. and Kim,E.
  TITLE     The Shank family of scaffold proteins
  JOURNAL   J Cell Sci 113 (Pt 11), 1851-1856 (2000)
   PUBMED   10806096
  REMARK    Review article
REFERENCE   7  (bases 1 to 7882)
  AUTHORS   Boeckers,T.M., Winter,C., Smalla,K.H., Kreutz,M.R., Bockmann,J.,
            Seidenbecher,C., Garner,C.C. and Gundelfinger,E.D.
  TITLE     Proline-rich synapse-associated proteins ProSAP1 and ProSAP2
            interact with synaptic proteins of the SAPAP/GKAP family
  JOURNAL   Biochem Biophys Res Commun 264 (1), 247-252 (1999)
   PUBMED   10527873
REFERENCE   8  (bases 1 to 7882)
  AUTHORS   Boeckers,T.M., Kreutz,M.R., Winter,C., Zuschratter,W., Smalla,K.H.,
            Sanmarti-Vila,L., Wex,H., Langnaese,K., Bockmann,J., Garner,C.C.
            and Gundelfinger,E.D.
  TITLE     Proline-rich synapse-associated protein-1/cortactin binding protein
            1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the
            postsynaptic density
  JOURNAL   J Neurosci 19 (15), 6506-6518 (1999)
   PUBMED   10414979
REFERENCE   9  (bases 1 to 7882)
  AUTHORS   Tu,J.C., Xiao,B., Naisbitt,S., Yuan,J.P., Petralia,R.S.,
            Brakeman,P., Doan,A., Aakalu,V.K., Lanahan,A.A., Sheng,M. and
            Worley,P.F.
  TITLE     Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of
            postsynaptic density proteins
  JOURNAL   Neuron 23 (3), 583-592 (1999)
   PUBMED   10433269
REFERENCE   10 (bases 1 to 7882)
  AUTHORS   Naisbitt,S., Kim,E., Tu,J.C., Xiao,B., Sala,C., Valtschanoff,J.,
            Weinberg,R.J., Worley,P.F. and Sheng,M.
  TITLE     Shank, a novel family of postsynaptic density proteins that binds
            to the NMDA receptor/PSD-95/GKAP complex and cortactin
  JOURNAL   Neuron 23 (3), 569-582 (1999)
   PUBMED   10433268
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000187.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_021676.4.
            
            On or before Jun 3, 2021 this sequence version replaced
            XM_039079817.1, NM_021676.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AJ133120.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760393, SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               JACYVU010000187.1  7303206-7303373
            169-828             JACYVU010000187.1  7304538-7305197
            829-1032            JACYVU010000187.1  7305494-7305697
            1033-1104           JACYVU010000187.1  7306728-7306799
            1105-1213           JACYVU010000187.1  7308393-7308501
            1214-1365           JACYVU010000187.1  7308576-7308727
            1366-1533           JACYVU010000187.1  7308812-7308979
            1534-1650           JACYVU010000187.1  7309073-7309189
            1651-1728           JACYVU010000187.1  7309587-7309664
            1729-1795           JACYVU010000187.1  7310661-7310727
            1796-2066           JACYVU010000187.1  7326098-7326368
            2067-2260           JACYVU010000187.1  7329096-7329289
            2261-2374           JACYVU010000187.1  7330247-7330360
            2375-2450           JACYVU010000187.1  7336098-7336173
            2451-2533           JACYVU010000187.1  7336397-7336479
            2534-2658           JACYVU010000187.1  7336817-7336941
            2659-2791           JACYVU010000187.1  7337024-7337156
            2792-2872           JACYVU010000187.1  7338072-7338152
            2873-2896           JACYVU010000187.1  7342813-7342836
            2897-3027           JACYVU010000187.1  7348248-7348378
            3028-3112           JACYVU010000187.1  7348927-7349011
            3113-5372           JACYVU010000187.1  7352663-7354922
            5373-7882           JACYVU010000187.1  7362786-7365295
FEATURES             Location/Qualifiers
     source          1..7882
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..7882
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /note="SH3 and multiple ankyrin repeat domains 3"
                     /db_xref="GeneID:59312"
                     /db_xref="RGD:69264"
     exon            1..168
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            169..828
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             541..5961
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /note="proline-rich synapse-associated protein 2; Shank
                     postsynaptic density protein 3a; SH3/ankyrin domain gene
                     3"
                     /codon_start=1
                     /product="SH3 and multiple ankyrin repeat domains protein
                     3"
                     /protein_id="NP_067708.2"
                     /db_xref="GeneID:59312"
                     /db_xref="RGD:69264"
                     /translation="MQLNRAAVAAAAAPAEPPEPLSPALAPAPAPPGPLPRSAVGGTL
                     AGGQGGPGRRAESPCAPLSAGNSQGPGASTGMDGPGASAVVVRVGIPDLQQTKCLRLD
                     PTAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQDYPPNLDTPL
                     PYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNF
                     HDPDSGECPLSLAAQLDNATDLLKVLRNGGAHLDFRTRDGLTAVHCATRQRNAGALTT
                     LLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGTTDENGWQEIHQACR
                     FGHVQHLEHLLFYGANMGAQNASGNTALHICALYNQESCARVLLFRGANKDVRNYNSQ
                     TAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGPSGLASPRPLQRSAS
                     DINLKGDQPAASPGPTLRSLPHQLLLQRLQEEKDRDRDGEQENDISGPSAGRGGHSKI
                     SPSGPGGSGPAPGPGPASPAPPAPPPRGPKRKLYSAVPGRKFIAVKAHSPQGEGEIPL
                     HRGEAVKVLSIGEGGFWEGTVKGRTGWFPADCVEEVQMRQYDTRHETREDRTKRLFRH
                     YTVGSYDSLTSHSDYVIDDKVAILQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQ
                     YLESVDVEGVAWKAGLRTGDFLIEVNGVNVVKVGHKQVVGLIRQGGNRLVMKVVSVTR
                     KPEEDSARRRAPPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEILAVAAEP
                     TLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKS
                     VGEDEKLASLLEGRFPRSTSMQDTVREGRGIPPPPQTAPPPPPAPYYFDSGPPPTFSP
                     PPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYDSGTPLGPLPYPERQKRARSMIILQD
                     SAPEVGDVPRPAPAATPPERPKRRPRPSGPDSPYANLGAFSASLFAPSKPQRRKSPLV
                     KQLQVEDAQERAALAVGSPGPVGGSFAREPSPTHRGPRPGGLDYSSGEGLGLTFGGPS
                     PGPVKERRLEERRRSTVFLSVGAIEGSPPSADLPSLQPSRSIDERLLGTGATTGRDLL
                     LPSPVSALKPLVGGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQTPSRS
                     PTPVHSPDADRPGPLFVDVQTRDSERGPLASPAFSPRSPAWIPVPARREAEKPTREER
                     KSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPNRLGAEEERPGTPELAPTPMQA
                     AAVAEPMPSPRAQPPGSIPADPGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELA
                     RIGLVPPPEEFANGILLATPPPGPGPLPTTVPSPASGKPSSELPPAPESAADSGVEEA
                     DTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKL
                     KSPLGKGPVTFRDPLLKQSSDSELMAQQHHATSTGLTSAAGPARPRYLFQRRSKLWGD
                     PVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAA
                     RLFSSLGELSTISAQRSPGGPGGGASYSVRPSGRYPVARRAPSPVKPASLERVEGLGA
                     GVGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPSPGSG
                     PSAGPRRPFQQKPLQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKEDFVE
                     LGVTRVGHRMNIERALRQLDGS"
     exon            829..1032
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1104
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1213
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1365
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1533
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1650
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1728
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1795
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..2066
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2260
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2374
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2450
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2533
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2658
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2791
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2872
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2896
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3027
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3112
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..5372
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            5373..7882
                     /gene="Shank3"
                     /gene_synonym="Prosap2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgccctagcc cctagggtac cctaagtccc accactcaag tcacaccttg ggaggggctt
       61 ggaggtcaga gcttactggg gcttcactcc ccaagcacgg aggggcccac ccaggcttga
      121 gggtagcagg gaacggacgc acagacgctg gagacttagc tctgtcggtc ggcctgtggg
      181 tcctcttgcc ccgacgcgtc cccacccagc tccagaaccc tccgtcaccc tagtacggtg
      241 gtctgcgacg ctcgcctgca gcggaagcgc ggcgtgccac cccccccccc ccgctgtgtc
      301 agccactccc cctcgacagc caaccccccc tccccggcgc gggcccccgg cccccgccct
      361 ctgcaccaca cgcccacgcc gccccgaccc cgcgggggac cccattttcc cggccgcggg
      421 cttcccatcc ccgcctccgg cgcggccccc tccccgcctc cgctccgctc cgggctcggg
      481 ccccctcccc ccgccgcccc cgcccccggg gaaggcaggc gccgctcgaa gccggggccg
      541 atgcagctaa accgtgccgc cgtcgccgcc gccgctgcgc ctgcggagcc cccggagccg
      601 ctgtcccccg cgctggcccc ggccccggcc ccccccggcc ccctcccgcg tagcgcggtc
      661 ggcgggactc tggcgggggg tcaggggggg ccagggcgcc gcgcggagtc cccgtgcgct
      721 cctctctccg ccgggaacag tcagggcccc ggcgctagca ccgggatgga cggccccggg
      781 gccagcgccg tggtcgtgcg cgtcggcatc ccggacctgc aacaaacgaa gtgcctgcgt
      841 ctggatccaa ccgcgcccgt gtgggccgcc aagcagcgtg tgctctgcgc cctcaaccac
      901 agccttcagg acgcgctcaa ctacgggcta ttccagcctc cctcccgggg tcgcgccggc
      961 aagttcctgg atgaagagcg gctcttacag gactacccgc ctaacctgga cacgcccctg
     1021 ccctatctgg agtttcgata caagcggaga gtttatgccc agaacctcat agatgacaag
     1081 cagtttgcaa agctgcacac aaaggcaaac ctgaagaagt tcatggacta tgtccagcta
     1141 cacagcacag acaaggtggc ccgcctgctg gacaaggggc tggaccccaa tttccatgac
     1201 cctgactcag gagagtgccc tctgagcctt gcagcacagt tggacaacgc cactgacctc
     1261 ctgaaggttc ttcgcaatgg cggtgctcat ctggacttcc gaacccgaga tgggctaacc
     1321 gctgtccact gcgccacccg acagcggaat gcgggagcat tgacgaccct gctggacctg
     1381 ggggcttcac ctgactacaa ggacagccgc ggcctgacgc ccctgtacca tagtgcccta
     1441 gggggcgggg atgccctctg ctgtgagctg cttctccatg atcacgcaca gttggggacc
     1501 actgacgaga atggctggca ggagatccat caggcctgtc gctttgggca tgtacagcac
     1561 ttggagcacc tgctgttcta tggggccaac atgggtgccc agaacgcctc gggaaacaca
     1621 gccttgcaca tctgtgccct ctataaccag gagagctgtg cccgcgtcct gcttttccgt
     1681 ggtgccaaca aggacgtccg caattacaac agccagacag ccttccaggt ggccattatt
     1741 gcagggaact ttgagcttgc cgaggtaatc aagacccaca aagactcgga tgtcgtacca
     1801 ttcagggaaa cccccagcta tgcaaagcga cgacgtctgg ctggcccgag tggcttggca
     1861 tcccctcggc ccttacagcg ctcagccagt gatatcaacc tgaagggtga ccagcccgca
     1921 gcttctcccg ggcccactct ccgaagcctc cctcaccaac tgctgctcca gaggcttcag
     1981 gaggagaaag accgggacag ggatggtgag caggagaacg acatcagcgg tccctcagca
     2041 ggcaggggcg gccacagcaa gatcagcccc agcgggcccg gcggatccgg ccccgcgccc
     2101 ggccccggcc cggcgtctcc cgcgcccccc gcgccgccgc cccggggccc gaagcggaaa
     2161 ctttacagtg ccgtccccgg ccgcaagttc atcgctgtga aggcgcacag cccgcagggc
     2221 gagggcgaga tcccgctgca ccgcggcgag gccgtgaagg tgctcagcat tggggagggc
     2281 ggtttctggg agggaaccgt gaagggccgt acaggctggt tcccagctga ctgtgtggag
     2341 gaagtgcaga tgcgacagta tgacacacgg catgaaactc gagaggaccg gacgaagcgt
     2401 cttttccgcc actacactgt gggttcctat gacagcctca cttcacacag tgattatgtc
     2461 attgatgata aggtggctat cctgcaaaaa cgggaccatg agggttttgg ctttgttctc
     2521 cggggagcca aagcagagac ccccattgag gagtttacac ccacacctgc cttccctgcg
     2581 ctccagtacc ttgagtctgt agatgtggaa ggtgtggcct ggaaggctgg gcttcgcact
     2641 ggggacttcc tcattgaggt aaacggagtg aacgtcgtga aggttggaca caagcaagtg
     2701 gtgggtctca tccgtcaggg tggcaaccgt ctggtcatga aggttgtgtc tgttaccagg
     2761 aagccagagg aggatagtgc tcggcgcaga gccccaccac ctcccaagag ggcccccagc
     2821 accacgctga ccctgcggtc caagtccatg acggctgagc tcgaggaact cgcttccatt
     2881 cggagaagga aaggggagaa gttggatgag atcctggcgg ttgctgcgga accaacgctg
     2941 aggccagaca ttgcagacgc tgattccagg gcagccactg tcaagcagcg gcccaccagc
     3001 cggaggatta cccctgccga gatcagctca ttgtttgagc gacagggcct cccgggccca
     3061 gagaagctgc cgggctctct gcggaagggg attccacgga ccaaatctgt aggggaggat
     3121 gagaagctgg catccctact ggaagggcgt ttcccacgca gcacatcaat gcaagacaca
     3181 gtgcgtgaag gccgaggcat tccgccccca ccgcagaccg ccccgccacc cccacccgcg
     3241 ccctactact tcgactccgg gccacccccc accttctcac caccgccacc accaccgggc
     3301 cgggcctatg acactgtgcg ctccagcttc aagccaggcc tggaggctcg tctgggtgca
     3361 ggggcagctg gcctgtatga ttctggcaca cctctgggcc cgctgcccta ccctgagcgc
     3421 cagaagcgtg cacgctccat gatcatattg caggactctg cgccagaagt gggcgatgta
     3481 ccccggcctg cgcctgcagc cacaccgcct gagcgcccca agcgccggcc tcggccgtca
     3541 ggccctgata gtccctatgc caacctgggc gccttcagtg ccagcctctt tgctccgtcg
     3601 aaaccgcagc gccgcaagag tccgctggtg aagcagcttc aggtggagga cgctcaggag
     3661 cgcgcggcgt tggccgtggg tagcccggga ccagtgggtg gaagctttgc acgagaaccc
     3721 tccccaacgc accgcgggcc ccgaccgggc ggccttgact acagctctgg agaaggcctg
     3781 gggctcacct ttggcggccc tagccctggc ccagtcaagg agcggcgcct ggaggagcga
     3841 cgccgttcca ctgtgttcct gtctgtgggt gccatcgagg gcagccctcc cagcgcggat
     3901 ctgccatccc tacagccctc ccgctccatt gatgagcgcc tcctggggac aggcgccacc
     3961 actggccgcg atttgctgct cccctcccct gtctctgctc tgaagccatt ggtcggtggt
     4021 cccagccttg ggccctcagg ctccaccttc atccatcctc ttactggcaa acccttggat
     4081 cctagctcac ccctagctct tgctctggct gcccgagagc gggctctggc ctcgcaaaca
     4141 ccttcccggt cccccacacc cgtgcacagt cctgatgctg accgccctgg acccctcttt
     4201 gtggatgtgc aaacccgaga ctccgagaga ggacccttgg cctccccagc cttctcccct
     4261 cggagtccag cctggattcc agtgcctgct cgcagagagg cagagaagcc cactcgggaa
     4321 gagcggaagt caccagagga caagaaatcc atgatcctca gcgtcttgga cacgtccttg
     4381 caacggccag ctggtctcat tgttgtgcat gccaccagca atggacagga gcccaacagg
     4441 ctgggggctg aagaggagcg cccgggtact ccggagctgg ccccaacccc catgcaggca
     4501 gcagctgtgg cagagcccat gccaagccca cgagcccagc cccctggcag catcccagca
     4561 gatcccgggc caggccaagg cagctcagag gaggagccag agctggtatt cgctgtgaac
     4621 ctgccacctg ctcagctgtc ctccagcgat gaggagacca gagaggagct ggcccgcatt
     4681 gggctagtgc caccccctga agagtttgcc aatgggatcc tgctggccac cccaccccca
     4741 ggaccgggcc ccctgcccac cacggtaccc agcccggcct cagggaagcc cagcagcgag
     4801 ctgccccctg cccctgagtc tgcagctgac tctggagtag aggaggccga cactcgaagc
     4861 tccagtgacc cccacctgga gaccacaagc accatttcca cagtgtccag catgtccacc
     4921 ctgagctcgg agagtggaga actcactgac acccacacct cctttgccga tggacacact
     4981 tttctactcg agaagccacc agtgcctccc aagcccaaac tcaagtcccc gctggggaag
     5041 gggccggtga ccttcaggga cccgctgctg aagcaatcct cggacagtga gctcatggcc
     5101 cagcagcacc atgccacctc tactgggttg acttctgctg cggggcctgc ccgccctcgc
     5161 tacctcttcc agagaaggtc caagctgtgg ggggaccccg tggagagtcg ggggctccct
     5221 gggcctgagg atgacaaacc aactgtgatc agtgagctca gctcccgtct gcagcagctg
     5281 aataaagaca ctcgctcctt gggggaggaa ccagttggtg gcctgggcag cctgctggac
     5341 cctgctaaga agtcgcccat tgcagcagct cggctcttca gcagcctcgg tgagctgagc
     5401 accatctcag cgcagcgcag ccccgggggc ccgggcggag gggcctccta ctcggtgcgg
     5461 cccagcggcc ggtaccccgt ggcgagacga gccccgagcc cagtgaaacc cgcatcgctg
     5521 gagcgggtgg aggggctggg ggcgggcgtg ggaggcgcgg ggcggccctt cggcctcacg
     5581 cctcccacca tcctcaagtc gtccagcctc tccatcccgc acgaacccaa ggaagtgcgc
     5641 ttcgtggtgc gaagtgtgag tgcgcgcagc cgctccccct caccatctcc gctgccctcg
     5701 ccttctcctg gctctggccc cagtgccggc ccgcgtcggc catttcaaca gaagcccctg
     5761 cagctttgga gcaagttcga tgtgggcgac tggctggaga gcatccactt aggcgagcac
     5821 cgagaccgct tcgaggacca tgagatcgaa ggcgcacacc tgcctgcgct caccaaggaa
     5881 gacttcgtgg agctgggagt cacacgcgtt ggccaccgca tgaacatcga gcgtgcgctc
     5941 aggcagctgg atggcagctg acgcccctct ccctctcctg ttcctgctgc gccctgccgg
     6001 cagggccccc acccctactc caggccgcag gctcggctcg ccccctacca cggcgcccgg
     6061 gccaggaatg ttgcatgaat cgtcctgttt gctgttgctt ggagacttgc cctgtacatt
     6121 gcttagtgcc ctcccctgcc gctgaacccc acccagcaca cagtaagggc gcggaccagg
     6181 ggggctgggt ggaagggggt tggggcaggg tgctctggcc tgaccacctc ctccacagct
     6241 cctggtggcc attcttccag agggggaacc tagtccagca tgcgaggtca ggacacgcct
     6301 tggtgactcg gggggagggg ggagacattg gggttctcga taggggccaa ggagccccct
     6361 gttttacata ttttaatcca ctctatattt ggaaagagaa aaggaacaaa tatctctgtc
     6421 cgtaacagtt cccgccctct tcccctcaag tcctctcgct ggtcccgcca cagctaccca
     6481 gtcttccatc tccggcccct cactgccacc ccatataggg caggggacac tccagctggc
     6541 ctggggttag ccagggtcct ggcagcccac cctggggacc ccggctcagc ccccttccct
     6601 cgctgagcta tagtatgccc cacccaccct ttaggtgctg ctcaggggga cgggtggcag
     6661 gcattgcctg ctgggcacta gcagggccag gtggcctggg agattattgc cctggggctg
     6721 ggccccggta acccaacccc agccatcatc ttcacagggt ctctcccaaa ggaggggtct
     6781 aacctttccc cacttcttgg gcaactacag cagagaagcc tccctgcctc gcgccccaaa
     6841 gactccccaa ttcctgccct gtgtgtgtgc accacatgtg tgtgtgcacg cctgcgtgct
     6901 tgtgaaaatt gggtgtggct gagcgcatgg gtgccctgta tgtgcttgat tgtggagtgg
     6961 tccccagggg ctgttctgga tgggtgggag gttgaggaag cttgcacagg ggtgcatgca
     7021 tgggtgtgtg cctgtgaaag ggccctgtct tctccaaaga aaggctgtcc tgctcttggg
     7081 tcctgctgtt ttctcagcct gttctccctg aacctcaccc agcttaagca ggggttcttg
     7141 gtgaatcctt tcagctttgg gaggcctcaa gggctcccgt gcaggcagca cccctttggg
     7201 cttctaaggg aattgtgggg accactaaaa tcaggccaca acagcccttg gagagaggca
     7261 aagactcctg agggtaccct ggcccccctt actgtgactc ctcacaactc agcaatgacc
     7321 tgtggggcgg ggggccctgg ggcattttta aacatagggt ttggagtctg gactaagctc
     7381 catccacgtc actcacaagt ttctgtttct atttctagct ttttttaata aaatatatat
     7441 atatatatat aaaaaagaca gaaaacaggt gttttcatgg cccaggggct tggcacgccg
     7501 gtctgtgccc acccgccccg ccccaccctg gcccaccggc cccattcctt agacacagag
     7561 tcacgcccac taaccctctt accaacagag caggtcacac acacagcagc ggtcactgta
     7621 acagactgcc acatacacag tctcacattt acctgtgggt ttttggttct gttcagtttg
     7681 ggtttttaac tttacagggt cagttccgct tcatccccct tttgtatgga gttccatctc
     7741 ggggctttca accccctgct ccagtcctga ggcctcctga ccctgacgtt gtgatacacc
     7801 ccacagagat ctatgtttct tatattatta ttattaataa taattattat aatattatgt
     7861 aataaattta taagaaatga aa
//
