LOCUS       NM_201350               5625 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus SH3 and multiple ankyrin repeat domains 2
            (Shank2), transcript variant 1, mRNA.
ACCESSION   NM_201350
VERSION     NM_201350.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5625)
  AUTHORS   Li,N., Ren,C., Li,S., Yu,W., Jin,K. and Ji,X.
  TITLE     Remote ischemic conditioning alleviates chronic cerebral
            hypoperfusion-induced cognitive decline and synaptic dysfunction
            via the miR-218a-5p/SHANK2 pathway
  JOURNAL   Prog Neurobiol 230, 102514 (2023)
   PUBMED   37574039
  REMARK    GeneRIF: Remote ischemic conditioning alleviates chronic cerebral
            hypoperfusion-induced cognitive decline and synaptic dysfunction
            via the miR-218a-5p/SHANK2 pathway.
REFERENCE   2  (bases 1 to 5625)
  AUTHORS   Fu,Y., Liu,D., Guo,J., Long,H., Xiao,W., Xiao,W., Feng,L., Luo,Z.
            and Xiao,B.
  TITLE     Dynamic Change of Shanks Gene mRNA Expression and DNA Methylation
            in Epileptic Rat Model and Human Patients
  JOURNAL   Mol Neurobiol 57 (9), 3712-3726 (2020)
   PUBMED   32564287
  REMARK    GeneRIF: Dynamic Change of Shanks Gene mRNA Expression and DNA
            Methylation in Epileptic Rat Model and Human Patients.
REFERENCE   3  (bases 1 to 5625)
  AUTHORS   Ishida,H., Skorobogatov,A., Yamniuk,A.P. and Vogel,H.J.
  TITLE     Solution structures of the SH3 domains from Shank scaffold proteins
            and their interactions with Cav1.3 calcium channels
  JOURNAL   FEBS Lett 592 (16), 2786-2797 (2018)
   PUBMED   30058071
REFERENCE   4  (bases 1 to 5625)
  AUTHORS   Modi,M.E., Brooks,J.M., Guilmette,E.R., Beyna,M., Graf,R., Reim,D.,
            Schmeisser,M.J., Boeckers,T.M., O'Donnell,P. and Buhl,D.L.
  TITLE     Hyperactivity and Hypermotivation Associated With Increased
            Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism
  JOURNAL   Front Mol Neurosci 11, 107 (2018)
   PUBMED   29970986
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5625)
  AUTHORS   Shi,R., Redman,P., Ghose,D., Hwang,H., Liu,Y., Ren,X., Ding,L.J.,
            Liu,M., Jones,K.J. and Xu,W.
  TITLE     Shank Proteins Differentially Regulate Synaptic Transmission
  JOURNAL   eNeuro 4 (6) (2017)
   PUBMED   29250591
  REMARK    GeneRIF: Loss of scaffold proteins via knockdown of Shank1 or
            Shank2, but not Shank3, led to a reduction of the number but not
            the unitary response of AMPAR-containing synapses. Only when both
            Shank1 and Shank2 were knocked down, were both the number and the
            unitary response of active synapses reduced. This reduction was
            accompanied by a decrease in NMDAR-mediated synaptic response.
            Erratum:[eNeuro. 2018 Mar 19;5(1):ENEURO.0073-18.2018. doi:
            10.1523/ENEURO.0073-18.2018.. PMID: 29569864]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5625)
  AUTHORS   Boeckers,T.M., Winter,C., Smalla,K.H., Kreutz,M.R., Bockmann,J.,
            Seidenbecher,C., Garner,C.C. and Gundelfinger,E.D.
  TITLE     Proline-rich synapse-associated proteins ProSAP1 and ProSAP2
            interact with synaptic proteins of the SAPAP/GKAP family
  JOURNAL   Biochem Biophys Res Commun 264 (1), 247-252 (1999)
   PUBMED   10527873
REFERENCE   7  (bases 1 to 5625)
  AUTHORS   Lim,S., Naisbitt,S., Yoon,J., Hwang,J.I., Suh,P.G., Sheng,M. and
            Kim,E.
  TITLE     Characterization of the Shank family of synaptic proteins. Multiple
            genes, alternative splicing, and differential expression in brain
            and development
  JOURNAL   J Biol Chem 274 (41), 29510-29518 (1999)
   PUBMED   10506216
REFERENCE   8  (bases 1 to 5625)
  AUTHORS   Boeckers,T.M., Kreutz,M.R., Winter,C., Zuschratter,W., Smalla,K.H.,
            Sanmarti-Vila,L., Wex,H., Langnaese,K., Bockmann,J., Garner,C.C.
            and Gundelfinger,E.D.
  TITLE     Proline-rich synapse-associated protein-1/cortactin binding protein
            1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the
            postsynaptic density
  JOURNAL   J Neurosci 19 (15), 6506-6518 (1999)
   PUBMED   10414979
REFERENCE   9  (bases 1 to 5625)
  AUTHORS   Zitzer,H., Richter,D. and Kreienkamp,H.J.
  TITLE     Agonist-dependent interaction of the rat somatostatin receptor
            subtype 2 with cortactin-binding protein 1
  JOURNAL   J Biol Chem 274 (26), 18153-18156 (1999)
   PUBMED   10373412
REFERENCE   10 (bases 1 to 5625)
  AUTHORS   Du,Y., Weed,S.A., Xiong,W.C., Marshall,T.D. and Parsons,J.T.
  TITLE     Identification of a novel cortactin SH3 domain-binding protein and
            its localization to growth cones of cultured neurons
  JOURNAL   Mol Cell Biol 18 (10), 5838-5851 (1998)
   PUBMED   9742101
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY298755.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY298755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5625
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..5625
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /note="SH3 and multiple ankyrin repeat domains 2"
                     /db_xref="GeneID:171093"
                     /db_xref="RGD:628772"
     exon            1..90
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            91..310
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..5623
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /note="isoform a is encoded by transcript variant 1; SH3
                     and multiple ankyrin repeat domains protein 2;
                     GKAP/SAPAP-interacting protein; proline-rich
                     synapse-associated protein 1; cortactin-binding protein 1;
                     SH3 and multiple ankyrin repeat domains protein 2-like;
                     SH3/ankyrin domain gene 2"
                     /codon_start=1
                     /product="SH3 and multiple ankyrin repeat domains protein
                     2 isoform a"
                     /protein_id="NP_958738.1"
                     /db_xref="GeneID:171093"
                     /db_xref="RGD:628772"
                     /translation="MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATTEKP
                     GGVKMEDLQGNTLVIRVVIQDLQQTKCIRFNPDATVWVAKQRILCTLNQGLKDVLNYG
                     LFQPASNGRDGKFLDEERLLREYPQPMGQGVPSLEFRYKKRVYKQSNLDEKQLARLHT
                     KTNLKKFMDHTQHRSVEKLVKLLDRGLDPNFHDLETGETPLTLAAQLDGSMEVIKALR
                     NGGAHLDFRSRDGMTALHKAARMRNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGG
                     DPYCCELLLHEHASVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTA
                     LHICALYNQDSCARVLLFRGGDKELKNYNSQTPFQVAIIAGNFELAEYIKNHKETDIV
                     PFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNAGAPEWAVCSAATSHRSLSPQLL
                     QQTPSKPDGATKSLGSYAPGPRSRSPSLNRLGGAGEDGKRPQPPHWHVGSPFTPGANK
                     DSLSTFEYPGPRRKLYSAVPGRLFVAIKPYQPQVDGEIPLHRGDRVKVLSIGEGGFWE
                     GSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDAASDCIIE
                     DKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRT
                     GDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPPKR
                     APTTALTLRSKSMTAELEELDKPEEIVPASKPSRTAENVAIESRVATIKQRPTSRCFP
                     AASDVNSVYERQGIAVMTPTVPGSPKGPFLGLPRGTMRRQKSIDSRIFLSGITEEERQ
                     FLAPPMLKFTRSLSMPDTSEDIPPPPQSVPPSPPPPSPTTYNCPRSPTPRVYGTIKPA
                     FNQNPVAKVPPATRSDTVATMMREKGMFYRRELDRFSLDSEDVYSRSPAPQAAFRTKR
                     GQMPENPYSEVGKIASKAVYVPAKPARRKGMLVKQSNVEDSPEKTCSIPIPTIIVKEP
                     STSSSGKSSQGSSMEIDPQATEPGQLRPDDSLTVSSPFAAAIAGAVRDREKRLEARRN
                     SPAFLSTDLGDEDVGLGPPAPRMQPSKFPEEGGFGDEDETEQPLLPTPGAAPRELENH
                     FLGGGEAGAQGEAGGPLSSTSKAKGPESGPAAALKSSSPASPENYVHPLTGRLLDPSS
                     PLALALSARDRAMQESQQGHKGEAPKADLNKPLYIDTKMRPSVESGFPPVTRQNTRGP
                     LRRQETENKYETDLSKDRRADDKKNMLINIVDTAQQKSAGLLMVHTVDIPVAGPPLEE
                     EEDREDGDTKPDHSPSTVPEGVPKTEGALQISAAPEPAAAPGRTIVAAGSVEEAVILP
                     FRIPPPPLASVDLDEDFLFTEPLPPPLEFANSFDIPDDRAASVPALADLVKQKKSDTP
                     QPPSLNSSQPANSTDSKKPAGISNCLPSSFLPPPESFDAVTDSGIEEVDSRSSSDHHL
                     ETTSTISTVSSISTLSSEGGESMDTCTVYADGQAFVVDKPPVPPKPKMKPIVHKSNAL
                     YQDTLPEEDTDGFVIPPPAPPPPPGSAQAGVAKVIQPRTSKLWGDVTEVKSPILSGPK
                     ANVISELNSILQQMNRGKSVKPGEGLELPVGAKSANLAPRSPEVMSTVSGTRSTTVTF
                     TVRPGTSQPITLQSRPPDYESRTSGPRRAPSPVVSPTELSKEILPTPPSAAAASPSPT
                     LSDVFSLPSQSPAGDLFGLNPAGRSRSPSPSILQQPISNKPFTTKPVHLWTKPDVADW
                     LESLNLGEHKETFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIERALKQLLDR"
     exon            311..514
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            515..586
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            587..695
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            696..847
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1015
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1132
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1210
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1277
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1599
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1769
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1883
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1959
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2042
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2167
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2303
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2384
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2515
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2627
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2648
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..5052
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
     exon            5053..5625
                     /gene="Shank2"
                     /gene_synonym="CortBP1; ProSAP1; Shank2E; Spank-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcttctc cactctctcc accatccaga gtgaaggctg tggctgctga agggagcctt
       61 cctgtgggac ctggtgtgct gacacctctg agatccaggc accatgccac gcagccccac
      121 atccagtgag gacgagatgg cccagagttt ctctgactat tctgtgggct cagagtcaga
      181 cagctccaaa gaagagacca tctatgacac gatcagagcc accacagaga agccaggcgg
      241 ggtgaagatg gaggacctcc agggtaatac cctggtgatt cgagtggtca tccaggatct
      301 gcagcagacg aagtgcattc gatttaaccc ggacgccacc gtgtgggtgg ccaagcagcg
      361 gatactgtgc acgctgaacc aaggcctgaa ggatgtactc aactatgggc tctttcagcc
      421 cgccagcaac gggcgtgacg gcaagttcct ggatgaggaa cggctcctgc gggaataccc
      481 acagcccatg ggccagggtg tgccttcctt ggagtttcgc tacaagaagc gtgtgtacaa
      541 gcagtccaac ctggatgaga agcagctggc caggctccac acaaagacca atctgaagaa
      601 gtttatggac cacactcagc atcgctcagt ggagaaactg gtcaagctcc tggacagagg
      661 cctggatccc aatttccatg acctggagac tggagagacg cccctgaccc tggctgccca
      721 gctcgatggc tccatggagg tcatcaaagc tctcagaaat gggggtgcac atttggactt
      781 ccgctccagg gatgggatga ctgcccttca caaggctgcc cggatgagga accaggttgc
      841 cctgaagacc ctcctggagc ttggcgcctc cccagattac aaagacagct acgggctcac
      901 accgctgtat cacacggcca ttgtgggggg tgacccttac tgctgcgagc tccttctcca
      961 cgagcatgcc tccgtgtgct gcaaggatga aaatggctgg cacgagattc accaggcctg
     1021 caggtacggc catgtccagc atctggaaca tctgcttttc tatggcgcag acatgagcgc
     1081 acagaatgcc tcagggaaca cagccctgca tatctgcgcc ctctacaatc aggacagctg
     1141 tgccagagtc ctactgtttc ggggtggaga caaggagttg aaaaactaca acagccagac
     1201 accgttccag gtggctataa tagcggggaa ctttgaactt gccgagtaca tcaagaacca
     1261 caaggaaaca gacattgtgc ccttccgaga ggccccagct tattccaacc gcaggcggcg
     1321 gccccccaac acattggctg cccccagagt tcttctgcgt tccaatagcg acaacaacct
     1381 caatgccggt gcgcctgaat gggctgtctg ctctgcagcc acctcccacc gaagcctctc
     1441 accccagctg ctgcagcaga cacccagcaa acctgatgga gccacaaaga gccttggaag
     1501 ctacgcccct gggccccgca gccgctctcc ctcactcaac aggctgggtg gcgctggtga
     1561 ggatggcaag aggccacagc cgccacattg gcatgtgggg tcgcccttca ctcctggtgc
     1621 caacaaggac tccctctcga cctttgagta cccagggccc cggaggaagc tgtatagtgc
     1681 ggtgcctggg agactcttcg tcgccatcaa gccataccaa ccccaagtcg acggcgagat
     1741 cccccttcac cgaggcgaca gggtcaaagt tctgagcatc ggcgagggcg gcttctggga
     1801 aggcagcgcc cgtggccaca tcgggtggtt cccagctgag tgtgtggagg aggtacaatg
     1861 taagccccgg gacagccaag cagaaacccg tgcggaccgc agcaagaagc tctttcggca
     1921 ttacacagtg ggctcctatg acagctttga tgctgccagt gactgcatta ttgaggacaa
     1981 gacggtggtc ctgcagaaga aagacaacga gggctttgga tttgtgctcc gaggggcaaa
     2041 agctgatacc cccattgagg aattcacacc cacgccggca tttccagccc tgcagtacct
     2101 ggagtccgtg gatgaaggag gggtggcatg gcaagccgga ctaaggaccg gggacttctt
     2161 gattgaggtt aacaatgaaa atgtcgtcaa ggtgggccac aggcaggtgg tgaacatgat
     2221 ccgccaggga gggaatcacc tcgtccttaa ggtcgtcacg gtgaccagga atctagaccc
     2281 tgatgataca gccagaaaga aagctccccc acctccaaag cgggctccga ccacggccct
     2341 caccctgcgt tccaagtcca tgacagcgga attggaggaa ctcgataaac cggaagagat
     2401 agtcccagcc tccaagccct ccaggactgc agagaacgtg gccatagaat ccagggtggc
     2461 aaccatcaag cagcggccca caagccggtg ctttccagct gcctctgatg tgaactccgt
     2521 gtacgagcgc caagggattg ctgtaatgac gcccacggtc cctgggagcc cgaaaggccc
     2581 atttctgggc ctccctcgag gtacgatgcg aaggcagaaa tcgatagaca gcagaatctt
     2641 tctatcaggg ataacagagg aagagcggca gtttctggct cccccaatgc tgaagttcac
     2701 ccgaagcttg tccatgccag acacttctga ggacatcccc cctccgccac agtctgtgcc
     2761 cccctctccc cctccacctt cccccaccac atacaactgt cccaggtccc cgactccaag
     2821 agtctatggg acaattaagc ctgcgttcaa ccagaacccc gtcgccaagg tgcccccagc
     2881 caccaggtct gacactgtgg ccaccatgat gcgggaaaag gggatgttct acaggagaga
     2941 gctggaccgc ttttccctgg actcagaaga cgtctacagc cgcagccccg ccccacaggc
     3001 tgccttccgc accaagcggg gacagatgcc tgagaacccg tactcggagg tgggaaagat
     3061 agccagcaag gccgtctatg tccctgccaa gccagccagg cggaagggca tgctggtaaa
     3121 gcagtccaac gtggaggaca gccctgagaa gacgtgctcc atccccatcc caaccatcat
     3181 agtcaaggaa ccctccacca gcagcagcgg caagagcagc caggggagca gcatggagat
     3241 cgacccccag gccactgagc ccggccagct gcggccagat gacagcctca ccgtcagcag
     3301 ccccttcgcg gcagccatcg ctggggccgt gcgtgaccgg gagaagcgtc tggaagccag
     3361 gaggaattcc ccggccttcc tctccaccga cctgggagat gaggacgtgg gtctggggcc
     3421 tcctgctccc cggatgcagc cctccaagtt tcccgaggag ggtgggtttg gtgatgagga
     3481 tgaaacggaa cagccgctat tgcctacccc tggagcagcg cccagggagc tggagaacca
     3541 cttcctaggt ggtggtgagg ctggtgctca gggggaggct gggggacccc tgagttccac
     3601 atccaaagcc aaggggcctg aaagtggccc agcagccgcc ctcaagagca gcagcccagc
     3661 cagccctgag aattacgtgc acccactcac ggggcggctg ctcgacccca gctccccgct
     3721 ggccctggca ctgtccgcca gggaccgagc catgcaggag tcccagcaag gacacaaggg
     3781 ggaggccccc aaggccgacc ttaacaagcc tctctacatc gataccaaaa tgcggcccag
     3841 tgtggagtcc ggctttccac cggtcaccag acagaacacc aggggtcccc tgcgaaggca
     3901 ggagacagag aacaagtatg agacggacct gagcaaggac cggagggctg acgacaagaa
     3961 gaacatgctg atcaacatcg tggacactgc ccagcagaag tcagccggcc tactgatggt
     4021 gcacacagtg gacattcccg tggcggggcc acccctggag gaagaggagg acagagagga
     4081 tggggataca aagccagacc actcaccctc cacagtgcca gaaggcgttc ccaaaaccga
     4141 aggtgcttta cagatctccg ctgccccgga gcccgccgct gcgcccggca ggaccatcgt
     4201 ggcagcgggc tccgtggaag aggcggtaat tctgccattc cgcatccccc ctccccctct
     4261 ggcgtccgtg gacttggatg aggactttct tttcacagaa ccattgcctc ctcccctgga
     4321 attcgccaat agttttgata tccccgacga ccgggcagct tcagttcccg ctctggctga
     4381 cctggtcaag cagaagaaaa gtgacacccc tcagccccct tcgttgaact ccagccaacc
     4441 agccaactct acagacagta agaagccagc cggcatctca aactgtctgc cctcctcatt
     4501 cctgccaccc cccgaaagct ttgacgcggt caccgactcg gggatcgagg aggtggacag
     4561 ccggagtagc agcgaccacc acctggagac aaccagcacc atctccacag tgtccagcat
     4621 ctccacgctg tcttcagagg gcggggagag catggatact tgcacagtct atgcagacgg
     4681 gcaagccttt gtggttgaca agcccccagt acctccaaag ccaaaaatga agcccatcgt
     4741 tcacaaaagc aacgcacttt accaagacac gctcccagaa gaggacacag atggctttgt
     4801 gatcccccca cctgcacccc cgcccccgcc cggcagtgcc caggccggtg tggcgaaggt
     4861 catccagcca aggacctcca agttgtgggg tgatgttaca gaggtcaaaa gcccaattct
     4921 ctcaggccca aaggcaaatg tcattagtga gttaaactcc attctgcagc agatgaacag
     4981 ggggaaatcg gtcaagcctg gggaagggct ggagctgccc gtgggagcca agtcagctaa
     5041 cctcgctcca agaagcccgg aggtcatgag cactgtctca ggtacacgga gcacgacggt
     5101 caccttcact gtccgccccg gaacctccca gcccatcacc ctacagagcc ggccccctga
     5161 ctatgaaagc aggacctcag gaccgagacg tgccccaagc cctgtggttt cgccaacgga
     5221 attgagcaaa gagattctgc ccacccctcc gtctgctgca gcagcctctc cctcccccac
     5281 actctcagat gtctttagcc ttccaagcca gtcccctgca ggggacctct ttggcttgaa
     5341 cccagcagga cgcagcaggt caccatctcc ttcaatattg caacagccaa tctcaaataa
     5401 gccttttaca actaagcctg tccacctgtg gacgaaacca gatgtggcag actggctgga
     5461 aagtctgaac ttgggtgaac acaaggagac gttcatggac aatgagattg acggcagcca
     5521 tctgccaaac ctccagaagg aagacttgat agatcttggg gtgactcgag ttgggcacag
     5581 gatgaacata gaaagggctt tgaaacagct gctggacaga taagg
//
