LOCUS       NM_031751               7577 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus SH3 and multiple ankyrin repeat domains 1
            (Shank1), mRNA.
ACCESSION   NM_031751
VERSION     NM_031751.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7577)
  AUTHORS   Alo,R., Olivito,I., Fazzari,G., Zizza,M., Di Vito,A., Avolio,E.,
            Mandala,M., Bruno,R., Barni,T., Canonaco,M. and Facciolo,R.M.
  TITLE     Correlation of distinct behaviors to the modified expression of
            cerebral Shank1,3 and BDNF in two autistic animal models
  JOURNAL   Behav Brain Res 404, 113165 (2021)
   PUBMED   33577886
  REMARK    GeneRIF: Correlation of distinct behaviors to the modified
            expression of cerebral Shank1,3 and BDNF in two autistic animal
            models.
REFERENCE   2  (bases 1 to 7577)
  AUTHORS   Fu,Y., Liu,D., Guo,J., Long,H., Xiao,W., Xiao,W., Feng,L., Luo,Z.
            and Xiao,B.
  TITLE     Dynamic Change of Shanks Gene mRNA Expression and DNA Methylation
            in Epileptic Rat Model and Human Patients
  JOURNAL   Mol Neurobiol 57 (9), 3712-3726 (2020)
   PUBMED   32564287
  REMARK    GeneRIF: Dynamic Change of Shanks Gene mRNA Expression and DNA
            Methylation in Epileptic Rat Model and Human Patients.
REFERENCE   3  (bases 1 to 7577)
  AUTHORS   Shi,R., Redman,P., Ghose,D., Hwang,H., Liu,Y., Ren,X., Ding,L.J.,
            Liu,M., Jones,K.J. and Xu,W.
  TITLE     Shank Proteins Differentially Regulate Synaptic Transmission
  JOURNAL   eNeuro 4 (6) (2017)
   PUBMED   29250591
  REMARK    GeneRIF: Loss of scaffold proteins via knockdown of Shank1 or
            Shank2, but not Shank3, led to a reduction of the number but not
            the unitary response of AMPAR-containing synapses. Only when both
            Shank1 and Shank2 were knocked down, were both the number and the
            unitary response of active synapses reduced. This reduction was
            accompanied by a decrease in NMDAR-mediated synaptic response.
            Erratum:[eNeuro. 2018 Mar 19;5(1):ENEURO.0073-18.2018. doi:
            10.1523/ENEURO.0073-18.2018.. PMID: 29569864]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7577)
  AUTHORS   Lilja,J., Zacharchenko,T., Georgiadou,M., Jacquemet,G., De
            Franceschi,N., Peuhu,E., Hamidi,H., Pouwels,J., Martens,V.,
            Nia,F.H., Beifuss,M., Boeckers,T., Kreienkamp,H.J., Barsukov,I.L.
            and Ivaska,J.
  TITLE     SHANK proteins limit integrin activation by directly interacting
            with Rap1 and R-Ras
  JOURNAL   Nat Cell Biol 19 (4), 292-305 (2017)
   PUBMED   28263956
  REMARK    GeneRIF: SHANK1 and SHANK3 act as integrin activation inhibitors by
            sequestering active Rap1 and R-Ras via the SPN domain and thus
            limiting their bioavailability at the plasma membrane.
REFERENCE   5  (bases 1 to 7577)
  AUTHORS   Tao-Cheng,J.H., Yang,Y., Reese,T.S. and Dosemeci,A.
  TITLE     Differential distribution of Shank and GKAP at the postsynaptic
            density
  JOURNAL   PLoS One 10 (3), e0118750 (2015)
   PUBMED   25775468
  REMARK    GeneRIF: Upon depolarization with high K+, neither the intensity
            nor distribution of label for GKAP changed, but labeling intensity
            for Shank at the postsynaptic density increased to ~150% of
            controls.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7577)
  AUTHORS   Zitzer,H., Honck,H.H., Bachner,D., Richter,D. and Kreienkamp,H.J.
  TITLE     Somatostatin receptor interacting protein defines a novel family of
            multidomain proteins present in human and rodent brain
  JOURNAL   J Biol Chem 274 (46), 32997-33001 (1999)
   PUBMED   10551867
REFERENCE   7  (bases 1 to 7577)
  AUTHORS   Lim,S., Naisbitt,S., Yoon,J., Hwang,J.I., Suh,P.G., Sheng,M. and
            Kim,E.
  TITLE     Characterization of the Shank family of synaptic proteins. Multiple
            genes, alternative splicing, and differential expression in brain
            and development
  JOURNAL   J Biol Chem 274 (41), 29510-29518 (1999)
   PUBMED   10506216
REFERENCE   8  (bases 1 to 7577)
  AUTHORS   Yao,I., Hata,Y., Hirao,K., Deguchi,M., Ide,N., Takeuchi,M. and
            Takai,Y.
  TITLE     Synamon, a novel neuronal protein interacting with
            synapse-associated protein 90/postsynaptic density-95-associated
            protein
  JOURNAL   J Biol Chem 274 (39), 27463-27466 (1999)
   PUBMED   10488079
REFERENCE   9  (bases 1 to 7577)
  AUTHORS   Tu,J.C., Xiao,B., Naisbitt,S., Yuan,J.P., Petralia,R.S.,
            Brakeman,P., Doan,A., Aakalu,V.K., Lanahan,A.A., Sheng,M. and
            Worley,P.F.
  TITLE     Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of
            postsynaptic density proteins
  JOURNAL   Neuron 23 (3), 583-592 (1999)
   PUBMED   10433269
REFERENCE   10 (bases 1 to 7577)
  AUTHORS   Naisbitt,S., Kim,E., Tu,J.C., Xiao,B., Sala,C., Valtschanoff,J.,
            Weinberg,R.J., Worley,P.F. and Sheng,M.
  TITLE     Shank, a novel family of postsynaptic density proteins that binds
            to the NMDA receptor/PSD-95/GKAP complex and cortactin
  JOURNAL   Neuron 23 (3), 569-582 (1999)
   PUBMED   10433268
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031751.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF159046.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000001.1  103944819-103944856
            39-336              JAXUCZ010000001.1  103947255-103947552
            337-540             JAXUCZ010000001.1  103947714-103947917
            541-612             JAXUCZ010000001.1  103948329-103948400
            613-721             JAXUCZ010000001.1  103950772-103950880
            722-873             JAXUCZ010000001.1  103951097-103951248
            874-1041            JAXUCZ010000001.1  103953915-103954082
            1042-1158           JAXUCZ010000001.1  103954462-103954578
            1159-1236           JAXUCZ010000001.1  103960140-103960217
            1237-1303           JAXUCZ010000001.1  103960459-103960525
            1304-1634           JAXUCZ010000001.1  103960785-103961115
            1635-1828           JAXUCZ010000001.1  103961865-103962058
            1829-1942           JAXUCZ010000001.1  103967120-103967233
            1943-2018           JAXUCZ010000001.1  103967377-103967452
            2019-2045           JAXUCZ010000001.1  103967867-103967893
            2046-2128           JAXUCZ010000001.1  103975982-103976064
            2129-2253           JAXUCZ010000001.1  103976308-103976432
            2254-2389           JAXUCZ010000001.1  103976942-103977077
            2390-2470           JAXUCZ010000001.1  103977573-103977653
            2471-2494           JAXUCZ010000001.1  103978208-103978231
            2495-2563           JAXUCZ010000001.1  103978415-103978483
            2564-2682           JAXUCZ010000001.1  103978834-103978952
            2683-2779           JAXUCZ010000001.1  103984803-103984899
            2780-5867           JAXUCZ010000001.1  103985423-103988510
            5868-7577           JAXUCZ010000001.1  103990647-103992356
FEATURES             Location/Qualifiers
     source          1..7577
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..7577
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /note="SH3 and multiple ankyrin repeat domains 1"
                     /db_xref="GeneID:78957"
                     /db_xref="RGD:621011"
     exon            1..38
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            39..336
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..6585
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /note="SPANK-1; synamon; SSTR-interacting protein;
                     GKAP/SAPAP-interacting protein; somatostatin
                     receptor-interacting protein; SH3/ankyrin domain gene 1;
                     SAPAP-interacting protein synamon"
                     /codon_start=1
                     /product="SH3 and multiple ankyrin repeat domains protein
                     1"
                     /protein_id="NP_113939.2"
                     /db_xref="GeneID:78957"
                     /db_xref="RGD:621011"
                     /translation="MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPQGTRGRG
                     SGAPGNLASTRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQ
                     VLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRV
                     YKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLT
                     LAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLGGSPNYK
                     DRRGLTPLFHTAMVGGDPRCCELLLYNRAQLGIADENGWQEIHQACQRGHSQHLEHLL
                     FYGAEPGAQNASGNTALHICALYNKETCARILLYRGANKDVKNNNGQTPFQVAVIAGN
                     FELGELIRNHREQDVVPFQESPKYAARRRGPPGAGLTVPPALLRANSDTSMALPDWMV
                     FSAPGASSSGTPGPTSGPQGQSQPSAPSTKLSSGTLRSASSPRGARARSPSRGRHPED
                     AKRQPRGRPSSSGTPRDGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQ
                     AQGEGEISLSKGEKIKVLSIGEGGFWEGQVKGRVGWFPSDCLEEVANRSQEGRQESRS
                     DKAKRLFRHYTVGSYDSFDAPSLIDGIDSGSDYIIKEKTVLLQKKDSEGFGFVLRGAK
                     AQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVN
                     MIRQGGNTLMVKVVMVTRHPDMDEAVHKKASQQAKRLPPPAISLRSKSMTSELEEMVS
                     PWKKKIEYEQQPAAVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPGPGGLASLG
                     KHRPKGFFATESSFDPHHRSQPSYDRPSFLPPGPGLMLRQKSIGAAEDDRPYLAPPAM
                     KFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPAPSSSGRLTPSPRGGPFNPSSGGPLPA
                     SSPSSFDGPSPPDTRGGGREKSLYHSAALPPAHHHPPHHHHHHAPPPQPHHHHAHPPH
                     PPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTSGAPSPSHHSSSGGSSGPTQAP
                     ALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGSIPSASSPTSPALPR
                     SEPPPAGPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPDGAGGGGSSPSP
                     APATSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFL
                     STDAGDEDGGDSGLGPGGPPGPRLRHSKSIDEGMFSAEPYLRLESGGSSGGYGAYAAG
                     SRAYGGSGSSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGTP
                     QPPPRPPSPRYDAPPPTLHHHSPHSPHSPHARHEPVLRLWGDPARRELGYRAGLGSQE
                     KALTASPPAARRSLLHRLPPTAPGVGPLLLQLGPEPPTPHPGVSKAWRTAAPEEPERL
                     PLHVRFLENCQARPPPAGTRGSSTEDGPGVPPPSPRRVLPTSPTSPRGNEENGLPLLV
                     LPPPAPSVDVDDGEFLFAEPLPPPLEFSNSFEKPESPLTPGPPHPLPDPPSPATPLPA
                     APPPAVAAAPPTLDSTASSLTSYDSEVATLTQGAPAAPGDPPAPGPPAPAAPAPPAPQ
                     PGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLSAEGGGNTGGVAGGGAGVAS
                     GTELLDTYVAYLDGQAFGGSGTPGPPYPPQLMTPSKLRGRALGTSGNLRPGPSGGLRD
                     PVTPTSPTVSVTGAGTDGLLALSACPGPSTAGVAGGPVAVEPEVPPVPLPAASSLPRK
                     LLPWEEGPGPPPPPLPGPLSQPQASALATVKASIISELSSKLQQFGGSSTAGGALPWA
                     RGGSGGSTDSHHGGASYIPERTSSLQRQRLSEDSQTSLLSKPSSSIFQNWPKPPLPPL
                     PTGSGVSSSTAAAPGATSPSASSASASTRHLQGVEFEMRPPLLRRAPSPSLLPASDHK
                     VSPAPRPSSLPILPSGPIYPGLFDIRSSPTGGAGGSTDPFAPVFVPPHPGISGGLGGA
                     LSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLSEHRAQFLDHEIDG
                     SHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLER"
     exon            337..540
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            541..612
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            613..721
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            722..873
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1041
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1158
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1236
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1303
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1634
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1828
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1942
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2018
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2045
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2128
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2253
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2389
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2470
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2494
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2563
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2682
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2779
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..5867
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
     exon            5868..7577
                     /gene="Shank1"
                     /gene_synonym="Shank1a; Spank1; Sstrip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgccgccg accgggactc agcagccccg ccaggcagct gcctgtgatg ctgctgtccc
       61 ccgtcgcccc gtggccccac gatgacccac agccccgcga caagcgagga cgaggaacgc
      121 cacagtgcca gcgagtgtcc cgaggggggc tcagaatcgg acagctcccc agacggacca
      181 ggaagaggcc cccagggtac tcggggccgg ggcagcggag cacctggtaa cctggcctct
      241 acccgaggcc tccagggacg ctccatgtct gtccctgacg acgcccactt cagcatgatg
      301 gttttcagga ttggcatccc tgacttgcac cagacgaaat gcctacgctt caacccggat
      361 gctaccatct ggacagccaa acagcaagta ctctgtgccc tgagcgagag tctacaggat
      421 gtgctaaact atggactgtt ccagccagcc acctcaggcc gggatgccaa cttcctggag
      481 gaagagaggc ttctaagaga gtaccctcag tcctttgaga aaggggtacc ctacctggag
      541 ttccgctaca agacccgagt ctacaaacag accaacctgg atgagaaaca gctggccaaa
      601 ctgcacacga agacggggtt gaagaagttc cttgaatatg tgcagctcgg gacgtctgac
      661 aaggtggcga ggctgctgga caaggggctg gaccccaatt accacgactc agattcagga
      721 gagacacctt tgaccctggc ggcccagact gaaggctcag tagaggtgat tcggacgctg
      781 tgcctgggcg gggcgcacat agacttcagg gcccgggatg gcatgacagc gctgcacaaa
      841 gctgcatgtg ctaggcactg cctggcactc acggcacttc tggaccttgg gggctccccc
      901 aactacaagg atcgacgagg gctgaccccc ctgttccaca cagctatggt tgggggagac
      961 ccccgctgtt gtgagctact tctgtacaac agggcccagc tgggcattgc agatgagaac
     1021 ggctggcagg aaatccacca ggcctgccaa cgagggcact ctcagcacct ggaacacctg
     1081 ctcttctatg gggctgagcc tggagcccag aatgcctcag gaaacacggc cctgcacatc
     1141 tgtgctctct acaacaagga gacctgtgcc aggatcctcc tttatcgcgg agcaaacaag
     1201 gatgtgaaaa ataacaacgg acagacaccc ttccaggtgg ctgtgattgc tgggaatttt
     1261 gagctggggg aactgattcg taaccatcgg gaacaggatg tggtaccctt ccaggagtcc
     1321 cccaagtatg cagcccggcg tcggggaccc ccaggcgcag ggctgactgt acccccagcg
     1381 ctgctgcggg ctaacagcga cacgagcatg gcgctgcctg attggatggt gttttcggcc
     1441 ccaggggcct catcctctgg gacccctggc cctacctcag gaccccaggg ccagtcacag
     1501 ccctcggccc ccagcaccaa gctcagtagt gggaccctca gaagtgccag cagcccccga
     1561 ggtgcccggg cacgctcccc atcccggggg agacatcctg aagatgccaa gagacaacct
     1621 cgaggccgac ccagctccag cgggacaccc cgagatgggc cggctggggg aactgggggc
     1681 tcagggggcc ctgggggctc cctgggtagc agaggcagac gtaggaagct ctattcagcg
     1741 gtacctggac gctccttcat ggcggtgaag tcataccagg cgcaaggcga gggggagatc
     1801 tctctgagta aaggcgaaaa gatcaaagtg ctcagcatcg gggaaggagg cttctgggaa
     1861 ggccaggtca aaggtcgagt tggctggttc ccttctgact gcctagaaga ggtggcaaac
     1921 cgttcccagg agggaagaca agaaagccga agtgacaagg caaagagact cttcaggcat
     1981 tacacagtgg gctcttacga cagcttcgat gccccaagtc tgatcgatgg gattgactca
     2041 gggagtgatt acatcatcaa ggagaagaca gtcttactgc agaagaagga cagtgagggg
     2101 ttcgggttcg tgctccgggg ggccaaggcg cagaccccca tcgaggaatt cacccccacc
     2161 ccggccttcc cggcgctgca gtacctcgag tctgtggacg agggtggcgt ggcatggcgg
     2221 gctggactac ggatgggaga cttcctcatc gaggtgaatg gacagaatgt agtgaaggtt
     2281 ggccaccgcc aggtggtcaa catgatccga cagggaggca acacactgat ggtcaaggtg
     2341 gtgatggtga ccagacaccc agacatggac gaggctgtcc acaagaaagc atcccagcag
     2401 gctaagcggc tcccgccccc agccatctcc ctgcgttcca agtctatgac ctcagagctg
     2461 gaggaaatgg tctccccctg gaagaagaaa attgaatacg agcaacagcc cgcggcagtg
     2521 cccagcatgg agaaaaagag gactgtgtat cagatggcac tcaacaaact ggatgagatc
     2581 ttggccgctg ctcagcagac catcagcgca agtgagagtc ctgggcctgg tggcctggca
     2641 tccctgggca agcaccgacc caaaggattc tttgccactg agtcgagctt tgatcctcac
     2701 caccgctccc agccaagtta tgaccggcct tctttcctgc ctcctggacc cggccttatg
     2761 ctccggcaga aatctatcgg ggctgcggaa gacgacagac cctacctagc acccccagcc
     2821 atgaaattca gtcgtagcct gtcagtcccc ggttcagagg acataccccc accacccact
     2881 acatcaccac cagagccgcc ctatagcaca cctccggccc cctcctcctc cggccgcctc
     2941 actccctcgc ctcggggagg gccctttaac cccagttctg ggggtcccct tcccgcctcc
     3001 tccccttcat ctttcgatgg gccatctcct cctgacaccc gtggtggggg ccgagaaaag
     3061 agcctatatc acagcgcagc cctgccccct gcccaccacc atccacctca tcaccaccat
     3121 catcacgcgc cacctcccca gccccaccat caccatgcac atcctcctca cccaccggag
     3181 atggagacag gaggttcccc cgacgatccc ccacctcgat tggccctggg accccagccc
     3241 agccttcgag gctggcgagg tggaggaccc agcccgacct cgggggcccc atcaccttcc
     3301 caccacagta gcagcggagg cagcagcggc cctactcagg ctcccgccct gcgctacttc
     3361 caactgcccc cgagggcggc cagtgcggct atgtatgtac cagcacgttc cggccgcggt
     3421 cgcaagggcc cactggtcaa gcagaccaaa gtggaaggcg agccccaaaa gggcagcatc
     3481 ccttccgcgt cctctccaac atccccggcg ttgcctcggt ctgaaccacc tccggccggg
     3541 ccgtcggaga aaaattccat ccctatcccg accatcatca tcaaagcccc atctaccagt
     3601 agcagcggcc gcagcagtca gggaagcagc acagaggctg agccccccac ccagcccgat
     3661 ggcgcgggcg gcggcggatc ctcgcctagc cctgcacctg ccacgtcccc tgtgccgcca
     3721 tccccgtcgc ccgtgcccac tcccgcgtca cccagcggcc cggccaccct ggatttcact
     3781 agccagtttg gagcagccct agtaggcgcg gcgcggaggg agggaggctg gcagaacgaa
     3841 gcccggcggc ggtccacgct gttcctgtcc accgacgcag gagatgagga tggaggcgac
     3901 agcgggctgg gcccgggggg gcccccgggt ccccggctgc gccattccaa atccattgac
     3961 gaaggcatgt tctccgcaga gccgtacctc cggctggagt cagggggcag cagtgggggc
     4021 tacggggcct acgcagcggg cagccgagcc tacgggggca gcgggagcag cagcgccttc
     4081 accagcttcc tccccccgcg gcccctggtg catccgctga ccggcaaagc cttggatccc
     4141 gcctctccgc tggggttggc cttggccgcc cgggagcggg ccttgaagga gtcctcggag
     4201 ggtgggggca cccctcagcc gcccccgaga cctccatcac cacgctacga cgccccaccg
     4261 cctacccttc accaccactc gccccattca ccccattcgc cacatgcgcg tcacgagcca
     4321 gtgttgcgcc tctgggggga ccccgcgcgc cgggagctgg ggtaccgggc aggcctaggg
     4381 agtcaggaga aggcccttac cgccagtcca cctgcagctc gccgctccct actgcaccgt
     4441 ctgcccccga cggctcccgg ggtcgggccg ctcctgctgc agctggggcc ggagccccca
     4501 actccccatc ctggggtgag caaggcctgg cgcacagcag ccccggagga gccggagcgg
     4561 ctgccgctgc acgtgcgatt ccttgagaat tgccaagccc ggcctccccc agctggcacg
     4621 agagggtcct ctactgaaga tgggcctggg gtcccgcctc ccagccctcg cagagtcttg
     4681 ccaacctctc ccacctcccc acgaggcaac gaggagaacg gccttccgct actggtcctg
     4741 ccaccgccag ccccttcggt ggatgtggac gacggcgagt tcttgtttgc ggagccgctg
     4801 cctccacccc tggagttttc caatagtttc gaaaagccag agtcgcctct cacacccggg
     4861 cctcctcacc cactacctga ccctccctcc ccggctaccc ctctacccgc agccccacct
     4921 cccgctgtag ccgcagcccc tcccaccttg gactccacag catccagcct gacctcttac
     4981 gacagcgaag tggccacact gacccagggg gctcccgcgg ctcctgggga tcctccagct
     5041 ccaggcccgc cggccccggc agccccagct cccccagcac cgcagccagg ccctgatcct
     5101 ccacctggca cagattctgg aattgaggag gtggacagtc ggagtagcag tgatcacccg
     5161 ctggagacca tcagcagcgc atccacactc agcagcttgt ccgccgaagg aggaggcaat
     5221 acagggggcg tggctggggg cggggccggg gtggccagtg ggacggagct cctggacacc
     5281 tacgttgcct acctggatgg ccaggccttc gggggcagtg gaactcctgg cccaccatat
     5341 cctccccagc tcatgactcc ttctaagctc cggggcaggg cgcttgggac tagtggaaat
     5401 ttaagacctg gtcccagtgg gggactccga gatcctgtca cccccaccag ccccactgtc
     5461 tctgtgaccg gagctggaac agatgggcta ctggccttga gtgcttgccc tggaccctca
     5521 acggcaggtg tggcaggggg tcccgtggca gttgagccag aagtcccgcc tgtacctttg
     5581 cccgctgcct catccctgcc tcggaagcta ttaccgtggg aggagggtcc gggaccacca
     5641 ccaccacccc tgccagggcc cctgtcccag cctcaggcct ctgccttggc cacggtcaaa
     5701 gccagcatca tcagcgaact cagctccaag ctccagcagt ttggtgggtc ctctaccgca
     5761 ggaggagctc tgccttgggc tcggggaggc agcgggggca gcacagacag ccaccacgga
     5821 ggagccagtt acatcccaga gaggacgtcc tccctgcagc ggcagaggct ctctgaagac
     5881 tcccagacct ctctcctctc caaacccagc agcagcatct ttcagaactg gcctaaaccc
     5941 cctctgccac cactccccac tgggtctggg gtctcctctt caacagctgc agccccggga
     6001 gctacatccc cttcagcctc atctgcctca gcttccacca gacacctgca gggtgtggaa
     6061 tttgagatgc ggcctccgct gctccgccgg gcacccagcc cctcgctgct gcctgcctcg
     6121 gatcacaagg tcagcccagc gcccaggcct tcctctttgc ccatcctgcc ttcaggaccc
     6181 atctacccgg gcctcttcga catccgtagc tctccaaccg gaggggcggg aggctcgact
     6241 gaccccttcg ctcccgtctt tgtgccacca caccccggga tatctggggg tcttggagga
     6301 gccttgtctg gggcctctcg ctccctatca cccacccgcc tgctctcgct gcccccggac
     6361 aagccgttcg gcgccaagcc tctagggttc tggaccaagt ttgacgtcgc cgattggcta
     6421 gagtggctgg gcttgtcgga gcaccgagcc cagttcctgg accacgagat tgatggctcc
     6481 catctgcctg ccttgaccaa ggaggactat gtggacctgg gtgtaaccag ggtgggccac
     6541 cgtatgaaca ttgaccgggc tctcaaattt ttcctggaga ggtgatggct ggcctggacg
     6601 gaccagcccg tccataggac ccttgagccc gctgacctct gacctctgac ccctctgacc
     6661 atcattcccc ctctcccctc agggggccag ggactctgct aaaactgtgt cctgccccgt
     6721 ctccccaagc ctgactgagg tccccaggtg gaccggatgc aggccagaca atggcacctc
     6781 gcaagaggtg ggcagctgac acaagactgc aagtggagta gatgggggat tagaaaaaaa
     6841 tgacaaaggg gtactgaaga aagagggaaa aaggctgact aggggtgggg gaacagacag
     6901 agccatagtg ggtcagtcca gagcctgacc tgatggggtc ctgggaaggt gtgccctccg
     6961 attccatcat ttgcgcctct caaataaccc ttttcacctc tctaggcccc tcagccttcc
     7021 cactctcctt ggctcactca gctgcccagc cccctgcctc ttgcacgcct gttcccctcc
     7081 ctggctgcag tttttgcaca agcttgcccc ctggctgtct tgcacacctc cggcctgtaa
     7141 ggccctctca gcttcccaac acgctgcatt cggttttttg ttttttgttt tgttttcttt
     7201 tgtttcctca agcgccacca cctttgctag cttgctctct gcatacttgc ttctggggga
     7261 ggagggtatt gcacccttta tttctctagc taccctggac ccatgctgca gacacacatg
     7321 ggactttcct tccctctcct gctcacagac ccaggcacat tcccgtagtc cctggccacc
     7381 cctgctctct gctctctctg cacactctga acacacctcc attttcatac ggggtctctt
     7441 tccggtcttg ccacccccat accgttactc tccttctcat ggtggcactc ctgtgccctg
     7501 ccttctctat tttctctgac acttagcaca cccctcccac actcgtggcc ctgaactctc
     7561 ttccaaatgt ttcactc
//
