LOCUS       NM_001107226            4220 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SH3 domain and tetratricopeptide repeats 1
            (Sh3tc1), mRNA.
ACCESSION   NM_001107226 XM_001057749 XM_001057812 XM_223527
VERSION     NM_001107226.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4220)
  AUTHORS   Senderek,J., Bergmann,C., Stendel,C., Kirfel,J., Verpoorten,N., De
            Jonghe,P., Timmerman,V., Chrast,R., Verheijen,M.H., Lemke,G.,
            Battaloglu,E., Parman,Y., Erdem,S., Tan,E., Topaloglu,H., Hahn,A.,
            Muller-Felber,W., Rizzuto,N., Fabrizi,G.M., Stuhrmann,M.,
            Rudnik-Schoneborn,S., Zuchner,S., Michael Schroder,J., Buchheim,E.,
            Straub,V., Klepper,J., Huehne,K., Rautenstrauss,B., Buttner,R.,
            Nelis,E. and Zerres,K.
  TITLE     Mutations in a gene encoding a novel SH3/TPR domain protein cause
            autosomal recessive Charcot-Marie-Tooth type 4C neuropathy
  JOURNAL   Am J Hum Genet 73 (5), 1106-1119 (2003)
   PUBMED   14574644
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473963.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001057812.1, XM_001057749.1, XM_223527.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4220
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4220
                     /gene="Sh3tc1"
                     /note="SH3 domain and tetratricopeptide repeats 1"
                     /db_xref="GeneID:305441"
                     /db_xref="RGD:1305610"
     exon            1..228
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..4085
                     /gene="Sh3tc1"
                     /note="SH3 domain and tetratricopeptide repeats-containing
                     protein 1"
                     /codon_start=1
                     /product="SH3 domain and tetratricopeptide
                     repeat-containing protein 1"
                     /protein_id="NP_001100696.1"
                     /db_xref="GeneID:305441"
                     /db_xref="RGD:1305610"
                     /translation="MRSFREEEATSEDLSTMGQGPEEPPGGCSLEDKIQSISMGLPTS
                     QERTGPEEAEATTVRGDVAPPCGMVGQAAEPPSNQMAVYPTDLTLQLLAVRRKSGLRS
                     PSLQQTLRSRLRLLENDSREVARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTY
                     HALGFTHHCLENLLVDQTFWLLSPSEEEETAILIYVNKDALKQTHKSLLAQEGSFFVL
                     CPDHCVRRTKEPQGAGKGPQTLRRASGVTLGVPVVETVSSSPTPSMSSKAEAVEAEPE
                     PLTPFHQWTLRVPWDPIDESMSGPGTPDAQFMRFGLASAIADFQGSGPEEMSFSVGDV
                     IEIVGAQVPGLPWCLGQHMASGQVGFVRTGLVRMQGPASDLESSIFLSEEERSFFRSE
                     AHFSDEDARRLLCRTSGTDVCTTCSLDWLEEAEGEQLEQQEMSLPHLNPEPHESLHMV
                     KNVLEKCKACPDHPEDPVSWSLGAVSSRVSSPDLEEPPFCLDPDDDWTDPEPPDSLLQ
                     VLSAPGYRAQFRSLYDISLPCLSTALYSFDDEEELAERLAQARGVAKKVDLGMALARL
                     CLLLGRLCARKLKLSQARVYFEEALGALEGSFGDLSLVAAVYSSLATVYLKQKNGEKC
                     VQLAPKAAALLLGTPGHSCSTDAELLKYALRRVVCGLSPQAEARACFLLARHYTHLKQ
                     PEEALPYLERLLRLNRDVGTPQASWPEDCYLLLADIYGRKCLPHLALSCLKVSSLWTR
                     CSLAGSLRSVDLVLQNAPGPNSQRSTGHSLPSQIAHYLRQALASLPPGTGQTLRGPLY
                     ASLAQLYSYHQQYGQAIAFMSQAAEADTAAGVHPVVDRLVALAWLHLLCGKSLVAMDI
                     LKCVSDAAVANKDQECVMMNMVAMALKRMGRTRQAAEGYFRALHMAYSQGHLQSQAVV
                     LANFGALCLQAGARSLAQHYLREAVGLFSQLPSGVCGRDFTQVLLWLGQLCTRRTLPQ
                     QAKCYYEWAFLVAVETDHLESQLQAVQKLCHFYSKVMPNEVRCVIYHEFQLALARKTA
                     DKVLEGQLLEAISQLYLSLGTERAYKSALDYTKRSLGIFIDLQQKEKEARAWLQAGKI
                     YYILRQNELVDLYIQVAQNAALYTGDPKLGLELFEAAGDIFFNGTWEREKAVSFYRDR
                     ALPLAVTVGDQEVELRLCNKLVALLSALEAPQEGLEFAHEALALSITLGDRLNERVAY
                     HRLATLHHRLGHGELAEHFFLKALSLCTSPLEFDEETLYYVKVYLVLGDIIFYELKDP
                     FDAAGYYQLALAAAVDLGHKKAQLKIYTRLATIYHNFLMDREMSLFFYQKARTFASEL
                     NLRRTNLVPQHFCSRAPWLAPGYPS"
     exon            229..303
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..431
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..537
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..684
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..895
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..972
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1168
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1302
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1344
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..3024
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3205
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3356
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3479
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3480..3630
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3827
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..4220
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggccagca acatgcccag ctcttggcct tgaggccact gtgagtcatg aggagcttca
       61 gggaggagga ggcgacttct gaggatctgt ccaccatggg gcagggccct gaggagcctc
      121 caggaggctg tagcctggaa gacaagatcc agagtatatc catgggctta cctactagtc
      181 aggagagaac agggcctgag gaggctgagg caacaacagt cagaggtgac gttgctcctc
      241 cctgtggcat ggttgggcaa gctgctgaac ccccttccaa tcaaatggca gtgtatccga
      301 cagacctcac cctgcaattg ttggctgtga ggcggaagag tggactgcgg agccccagcc
      361 tacagcagac cctgagaagc cgactccgcc tgctggagaa tgacagccgg gaagtggccc
      421 gagtacttgg agaactgtca gccaggctgc tgtccatcca cagtgaccag gaccggatcg
      481 tggtgacgtt taagactttt gaagaaatct ggaagttttc cacctatcat gctcttggct
      541 tcacacatca ctgcctggag aacctgctgg tggaccagac cttctggctg ctttccccca
      601 gtgaggagga ggagactgcc atcctcatat atgtaaacaa ggatgccttg aagcagacac
      661 acaagagcct tctcgcacaa gaagggtcct tcttcgttct gtgtcccgac cactgtgtga
      721 ggaggacaaa ggaaccccaa ggtgcaggga agggccccca gaccctcaga cgggcttccg
      781 gggtcactct gggagtacca gttgtggaaa cagtctcctc atcccccaca cccagcatgt
      841 cctccaaagc agaagcagta gaggctgagc cagagccctt gactccattt caccagtgga
      901 ctctcagggt cccatgggat cccatcgatg aatccatgag tggacctggg acgcctgatg
      961 cccagttcat gaggtttggc ctggcctctg caatagctga cttccagggc tcaggcccgg
     1021 aagagatgtc cttcagcgtt ggtgatgtca tcgagatcgt cggtgcccag gtgcctggcc
     1081 tgccctggtg tttgggccag cacatggcct ctggccaggt gggctttgtg aggactggcc
     1141 ttgtccgcat gcagggcccg gcatctgacc tggaaagttc aattttcctc agcgaggaag
     1201 aaaggtcatt cttcagaagt gaggctcact tctcagacga ggatgcccgg cggctcctgt
     1261 gcaggacatc tggcacagat gtgtgtacca catgcagcct ggactggtta gaagaagctg
     1321 agggagaaca gctggagcaa caagaaatgt ctctgcctca cctgaaccca gagccacatg
     1381 agagtctgca catggtaaag aacgttttag agaagtgcaa ggcctgccct gaccaccctg
     1441 aagaccctgt atcctggagc cttggagcgg tgtccagcag agtgagttca ccggaccttg
     1501 aggagccccc cttctgcctg gatcctgacg atgactggac agaccctgag cctccggact
     1561 cactgctgca ggtcctgagt gcccctggtt atagggccca gttccggagc ctgtatgata
     1621 tctcacttcc ctgcctgagc accgcactct atagctttga tgatgaagaa gagttggctg
     1681 aacgcttggc acaggcccga ggagttgcca agaaagtcga tttgggcatg gccctggcaa
     1741 ggctctgcct cctgctgggg cggctgtgtg cccgaaagct caaactatcc caggcccggg
     1801 tgtactttga agaggccctg ggggctctgg agggaagttt tggggacctc tccctggtgg
     1861 cggccgtgta tagcagcttg gctactgtgt acctgaagca gaagaacggg gagaagtgtg
     1921 tgcagctggc acccaaagcc gcagcgctgc tcctgggaac gcccggccac tcctgcagca
     1981 cagatgccga gctcctgaag tacgcactgc gcagggtcgt ctgtggcctc agcccacagg
     2041 ccgaggcccg ggcctgcttc ctgctggccc ggcactacac ccacctcaaa cagcctgagg
     2101 aggcactgcc atacttggag agactgcttc gcctcaacag ggatgtgggg accccgcagg
     2161 cctcgtggcc tgaagactgt tacctgcttc tggcggacat ctatggccgg aagtgcctgc
     2221 cgcacctggc attgagctgc ctcaaggtgt cctcactgtg gacaagatgc tctctggctg
     2281 gctccttgag gagtgtggac ctggtactcc agaatgctcc tgggccaaac agccaaagga
     2341 gcacaggtca tagccttccc tcccagattg ctcactacct cagacaggca ttggcctctc
     2401 tgcctcccgg cacgggacag acactgcgag ggccactcta tgccagcctg gctcaattgt
     2461 acagttacca ccagcagtac ggccaggcca tagccttcat gtctcaggct gcagaagctg
     2521 acactgcagc tggggtccac cctgtcgtgg accgcttggt ggcgctcgcc tggctgcacc
     2581 tgctttgtgg gaaaagctta gtagccatgg acatcctgaa gtgcgtctca gacgcggccg
     2641 tggccaataa ggaccaggaa tgtgttatga tgaacatggt ggccatggcc ctgaagagga
     2701 tgggcaggac ccggcaggct gctgaaggct acttccgagc tctgcacatg gcctacagcc
     2761 agggccacct gcagagccag gcagtggtcc tagctaactt tggggccctg tgcctgcaag
     2821 ctggcgcacg cagcttggcc cagcactacc tgcgggaggc cgtggggctc ttctcccagc
     2881 tgcccagtgg cgtgtgtggc cgtgacttca cccaggtgct cctgtggttg ggccaactgt
     2941 gtacgcgccg gaccctcccc cagcaggcca agtgctacta tgagtgggcc tttctggtgg
     3001 ctgtggagac ggaccatctg gagagtcagt tacaggcggt gcaaaagctg tgccacttct
     3061 acagtaaggt catgcccaac gaggtgcgat gtgtcatcta ccatgagttc caactggctc
     3121 tggcacgcaa gaccgctgac aaggtgctgg aggggcagct cctggaggcc atcagtcagc
     3181 tctacctgtc gctgggcact gagcgggcct acaagtcggc tctggattac actaaacgga
     3241 gcctggggat tttcatcgac ctgcagcaga aggagaagga ggcacgcgcc tggctgcagg
     3301 cagggaagat ctactatatc ctccgtcaga atgagctggt ggacttgtac atccaggtgg
     3361 cacagaatgc agccctgtat accggggacc ctaagctggg gctggaactg tttgaggcag
     3421 ctggggacat cttcttcaat gggacctggg agcgggagaa agctgtgtcc ttctaccggg
     3481 accgggcact gcccctggct gtgactgtag gagaccaaga agtggagctg cgcctgtgca
     3541 acaagctggt ggccctgctg tctgcactgg aggcacccca ggagggccta gagttcgccc
     3601 atgaggccct agcactcagc atcaccctag gtgaccggct gaatgagcga gtggcctacc
     3661 acaggctagc caccctgcac caccggctgg gccacgggga actggccgag cacttcttcc
     3721 tgaaggctct gtcgctctgc acctcgcccc tggaatttga tgaggagacc ctgtactatg
     3781 tgaaggtcta cctggtactg ggtgacatca tcttctatga gctgaaggac cccttcgatg
     3841 cagctgggta ttaccagctg gctctggcag cagccgtgga cctgggccac aagaaggctc
     3901 agttgaagat ctatacacgc ctggctacca tctaccacaa cttcctcatg gaccgagaaa
     3961 tgtccctctt cttctaccaa aaagcaagga cctttgcctc agaactgaat ctccgcagga
     4021 ccaacctggt accccagcac ttctgtagcc gggcaccctg gttggcccct ggctacccat
     4081 cctgacaacc tgagaagggg cacgtacaac gggactcttc ctcttcttgg ggtatgggca
     4141 acctattgtt attattatta ttcttttgct gagggttggg ggtaactgaa ggaccaaaca
     4201 gtagtaaata tttttcagca
//
