LOCUS       NM_001034187            2413 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus SH3 domain containing ring finger 2 (Sh3rf2),
            mRNA.
ACCESSION   NM_001034187 XM_225981
VERSION     NM_001034187.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2413)
  AUTHORS   Kim,T.W., Kang,Y.K., Park,Z.Y., Kim,Y.H., Hong,S.W., Oh,S.J.,
            Sohn,H.A., Yang,S.J., Jang,Y.J., Lee,D.C., Kim,S.Y., Yoo,H.S.,
            Kim,E., Yeom,Y.I. and Park,K.C.
  TITLE     SH3RF2 functions as an oncogene by mediating PAK4 protein stability
  JOURNAL   Carcinogenesis 35 (3), 624-634 (2014)
   PUBMED   24130170
REFERENCE   2  (bases 1 to 2413)
  AUTHORS   Wilhelm,M., Kukekov,N.V., Schmit,T.L., Biagas,K.V., Sproul,A.A.,
            Gire,S., Maes,M.E., Xu,Z. and Greene,L.A.
  TITLE     Sh3rf2/POSHER protein promotes cell survival by ring-mediated
            proteasomal degradation of the c-Jun N-terminal kinase scaffold
            POSH (Plenty of SH3s) protein
  JOURNAL   J Biol Chem 287 (3), 2247-2256 (2012)
   PUBMED   22128169
  REMARK    GeneRIF: a model in which Sh3rf2 promotes proteasomal degradation
            of pro-apoptotic POSH in healthy cells and in which apoptotic
            stimuli lead to rapid loss of Sh3rf2 expression, and consequently
            to stabilization of POSH and JNK activation and cell death
REFERENCE   3  (bases 1 to 2413)
  AUTHORS   Chen,C.Y., Lai,N.S., Yang,J.J., Huang,H.L., Hung,W.C., Li,C.,
            Lin,T.H. and Huang,H.B.
  TITLE     FLJ23654 encodes a heart protein phosphatase 1-binding protein
            (Hepp1)
  JOURNAL   Biochem Biophys Res Commun 391 (1), 698-702 (2010)
   PUBMED   19945436
REFERENCE   4  (bases 1 to 2413)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   5  (bases 1 to 2413)
  AUTHORS   Wilhelm,M., Kukekov,N.V., Xu,Z. and Greene,L.A.
  TITLE     Identification of POSH2, a novel homologue of the c-Jun N-terminal
            kinase scaffold protein POSH
  JOURNAL   Dev Neurosci 29 (4-5), 355-362 (2007)
   PUBMED   17762203
  REMARK    GeneRIF: These results indicate that POSH2 may regulate JNK
            activation and consequent apoptosis under conditions of increased
            expression.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 2, 2020 this sequence version replaced NM_001034187.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100155.1, SRR26643291.40502.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-512               JAXUCZ010000018.1  34297922-34298433
            513-782             JAXUCZ010000018.1  34345071-34345340
            783-878             JAXUCZ010000018.1  34347766-34347861
            879-1202            JAXUCZ010000018.1  34354536-34354859
            1203-1294           JAXUCZ010000018.1  34381828-34381919
            1295-1465           JAXUCZ010000018.1  34383284-34383454
            1466-1707           JAXUCZ010000018.1  34390983-34391224
            1708-2066           JAXUCZ010000018.1  34394099-34394457
            2067-2413           JAXUCZ010000018.1  34397534-34397880
FEATURES             Location/Qualifiers
     source          1..2413
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..2413
                     /gene="Sh3rf2"
                     /gene_synonym="Posh2; Ppp1r39"
                     /note="SH3 domain containing ring finger 2"
                     /db_xref="GeneID:307472"
                     /db_xref="RGD:1308415"
     exon            1..512
                     /gene="Sh3rf2"
                     /gene_synonym="Posh2; Ppp1r39"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2342
                     /gene="Sh3rf2"
                     /gene_synonym="Posh2; Ppp1r39"
                     /EC_number="2.3.2.27"
                     /note="putative E3 ubiquitin-protein ligase SH3RF2; SH3
                     domain-containing RING finger protein 2; protein
                     phosphatase 1 regulatory subunit 39; RING finger protein
                     158; RING-type E3 ubiquitin transferase SH3RF2;
                     POSH-eliminating RING protein"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SH3RF2"
                     /protein_id="NP_001029359.1"
                     /db_xref="GeneID:307472"
                     /db_xref="RGD:1308415"
                     /translation="MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRIFKAH
                     KELRCPECRTLVFCSIEALPANLLLVRLLDGVRSGHNSWRGGSFRRPRILTLQDNRKA
                     KSSPRSLQASPFRLGPTVRIHMDGVPRAKALCNYRGKNPGDLKFNKGDVILLQRQLDE
                     NWYQGEINGVSGFFPASSVEVIKQLPQPPPLCRALYNFDLRDKDKSENQDCLTFLKDD
                     VITVISRVDENWAEGKLGDKVGIFPILFVEPNLSARHLLEKSKGHQLSRTKHLSLMSS
                     PSRGKATNTSTLRKSPGSRRKGSGQFAMTTALNTLNRMVHSPEGHQMVEISTPVLISS
                     TSPSMLTQHGDRADFPASSAGQVSTSHPAPASPGHSTAMVSVPSSQQHLSTNMFVALH
                     TYSAQGPEELDLKKGEGIRVLGKNQDGWLRGVSLVTGRTGIFPSDYVIPVFSSTARKT
                     SSFPDSRHPTVCTTWALSTSSVSSQGSFSEGDPRQSGPFRSVFVPTAVNPPRSTSGPG
                     TSGQGSLRKVRSSMRKNGSLQRPVQSGIPTFMVGSLRCSPAMVIRPQKFQFYQPQGMT
                     PSPTPIMVEIGSKSISTGEPALTCINRGGKTRTHSAGNSIIMEGKETPIKSEPPPKPP
                     ASAPPSILVKPENSKNGIEKQVKTVRFQNYSPPPTKHSASGPTSGKHEQPATLKGSQP
                     EAVSSEGEMTILFAHRSGCHSGQQTDLRRKSAFSKTTPPVSTASVSQTLFPSK"
     exon            513..782
                     /gene="Sh3rf2"
                     /gene_synonym="Posh2; Ppp1r39"
                     /inference="alignment:Splign:2.1.0"
     exon            783..878
                     /gene="Sh3rf2"
                     /gene_synonym="Posh2; Ppp1r39"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1202
                     /gene="Sh3rf2"
                     /gene_synonym="Posh2; Ppp1r39"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1294
                     /gene="Sh3rf2"
                     /gene_synonym="Posh2; Ppp1r39"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1465
                     /gene="Sh3rf2"
                     /gene_synonym="Posh2; Ppp1r39"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1707
                     /gene="Sh3rf2"
                     /gene_synonym="Posh2; Ppp1r39"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..2066
                     /gene="Sh3rf2"
                     /gene_synonym="Posh2; Ppp1r39"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2413
                     /gene="Sh3rf2"
                     /gene_synonym="Posh2; Ppp1r39"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttttttc ctccttcttt caaacaggca gggagttctg atgctcccaa aagactggct
       61 ctaccccttc ggttcggctg cccctacaat gtggatcctg cttctccagg ttgggactgg
      121 agttttaaaa taaaatggat gatttgacgt tacttgatct cctggagtgc cccgtgtgct
      181 ttgaaaagct cgatgttaca gccaaagttc tcccctgcca gcacaccttc tgcaaaccat
      241 gtctacagcg gattttcaag gcccacaagg agctgaggtg cccggaatgc aggaccctgg
      301 tgttctgcag catcgaggct ctgccagcca acctgttgct ggtgcgtctg ctggatggag
      361 tgcgctccgg gcacaactcg tggagaggag gctcctttcg aaggcctcga atactaacct
      421 tgcaggacaa caggaaagcc aagagcagcc ccagaagtct gcaggccagc cctttccggc
      481 tggggcccac tgtcaggatc cacatggatg gggtgcctcg agccaaggcc ttgtgcaact
      541 acagagggaa gaatcctggc gacctgaagt ttaataaagg agatgtcatc ctccttcaga
      601 gacagcttga tgagaactgg taccaggggg agatcaatgg ggtcagtggg ttcttcccag
      661 ccagctctgt ggaagtcatc aagcagctgc cccagccacc ccctctctgc agagccctct
      721 acaactttga ccttcgagat aaggataaga gtgagaacca ggattgcctg accttcctca
      781 aggatgatgt catcacagtg atcagccgag tagacgagaa ctgggcagaa ggaaaactcg
      841 gagataaagt aggcatcttc cccatcttgt ttgtagagcc aaacctctct gcaagacacc
      901 tcctagagaa gagcaaaggg catcagttat cacgcacaaa acatctgtcc ctgatgtcct
      961 caccatctag aggcaaagca accaacacat ccactctccg caagagccca gggtccagga
     1021 ggaaaggatc cgggcagttc gccatgacta cagctttgaa tacactcaac cgcatggtcc
     1081 attctcctga aggtcaccag atggtggaaa tcagcacccc agtgctcatc agctctacca
     1141 gtccctctat gctcacccag catggggaca gggccgattt ccctgccagc tctgcaggac
     1201 aggtcagcac ttctcaccct gctcctgcct ccccaggaca ttccacagcc atggtcagtg
     1261 tgcccagctc ccagcaacac ctctcaacga acatgtttgt agccctgcac acttactcag
     1321 cccagggacc tgaagagctg gacctgaaga agggagaagg tatcagggtt ctgggcaaga
     1381 atcaggatgg ctggctgagg ggcgtctcct tagtcactgg acgaactggc atctttccaa
     1441 gcgactatgt catccccgtt ttcagctcaa cagctagaaa gacatctagt tttcctgatt
     1501 cccggcaccc cactgtctgc accacatggg cgttatccac ctcctctgtg tcctcccagg
     1561 gtagcttttc agaaggcgat ccccggcaaa gtggaccctt cagatctgtc tttgtgccca
     1621 ctgccgttaa ccctccaagg agcacatctg gccctgggac ttctggacaa gggtctctta
     1681 ggaaagtgcg gagcagcatg agaaagaatg gatccctgca gagaccagtt caatcaggga
     1741 tccccacttt catggtgggc tccctcaggt gcagtcctgc catggtgatc cggcctcaga
     1801 agttccagtt ttatcagcca caggggatga ccccttcccc aacacccata atggtggaga
     1861 tagggtctaa atctatttcc actggggagc ctgccctgac ctgcatcaac agaggtggca
     1921 agaccaggac ccactccgca ggcaattcca tcatcatgga aggcaaagaa acacccatca
     1981 agagtgagcc tccacccaag ccgcctgcgt ctgcaccacc ctccatcctc gtgaaaccag
     2041 aaaattcaaa aaatggtatt gaaaagcaag tcaaaaccgt gagatttcag aattacagcc
     2101 ctccgcccac caaacactct gcctccggtc ccacctctgg aaagcatgaa cagccagcca
     2161 ccttgaaggg gtcccaacct gaagcagtct cctcagaagg agagatgacc attctatttg
     2221 cccaccgaag tggctgccac tccgggcaac agacagacct tcggagaaag tcagccttta
     2281 gcaagaccac acccccagtg tccactgctt cagtctcaca gaccttattt cccagcaaat
     2341 gattcttcaa gtggcttttc ttagtcacaa aaggggtaaa ttgcatataa atacagtctg
     2401 cctccaccac aaa
//
