LOCUS       NM_198764               5059 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus SH3 domain containing ring finger 1 (Sh3rf1),
            mRNA.
ACCESSION   NM_198764 XM_017600106 XM_224802
VERSION     NM_198764.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5059)
  AUTHORS   Ono,A., Hirooka,K., Nakano,Y., Nitta,E., Nishiyama,A. and
            Tsujikawa,A.
  TITLE     Gene expression changes in the retina after systemic administration
            of aldosterone
  JOURNAL   Jpn J Ophthalmol 62 (4), 499-507 (2018)
   PUBMED   29713904
REFERENCE   2  (bases 1 to 5059)
  AUTHORS   Cunningham,C.A., Cardwell,L.N., Guan,Y., Teixeiro,E. and
            Daniels,M.A.
  TITLE     POSH Regulates CD4+ T Cell Differentiation and Survival
  JOURNAL   J Immunol 196 (10), 4003-4013 (2016)
   PUBMED   27084103
REFERENCE   3  (bases 1 to 5059)
  AUTHORS   Cunningham,C.A., Knudson,K.M., Peng,B.J., Teixeiro,E. and
            Daniels,M.A.
  TITLE     The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals
            and effector function in CD8(+) T cells
  JOURNAL   Eur J Immunol 43 (12), 3361-3371 (2013)
   PUBMED   23963642
REFERENCE   4  (bases 1 to 5059)
  AUTHORS   Yang,T., Sun,Y., Zhang,F., Zhu,Y., Shi,L., Li,H. and Xu,Z.
  TITLE     POSH localizes activated Rac1 to control the formation of
            cytoplasmic dilation of the leading process and neuronal migration
  JOURNAL   Cell Rep 2 (3), 640-651 (2012)
   PUBMED   22959435
REFERENCE   5  (bases 1 to 5059)
  AUTHORS   Wilhelm,M., Kukekov,N.V., Schmit,T.L., Biagas,K.V., Sproul,A.A.,
            Gire,S., Maes,M.E., Xu,Z. and Greene,L.A.
  TITLE     Sh3rf2/POSHER protein promotes cell survival by ring-mediated
            proteasomal degradation of the c-Jun N-terminal kinase scaffold
            POSH (Plenty of SH3s) protein
  JOURNAL   J Biol Chem 287 (3), 2247-2256 (2012)
   PUBMED   22128169
  REMARK    GeneRIF: a model in which Sh3rf2 promotes proteasomal degradation
            of pro-apoptotic POSH in healthy cells and in which apoptotic
            stimuli lead to rapid loss of Sh3rf2 expression, and consequently
            to stabilization of POSH and JNK activation and cell death
REFERENCE   6  (bases 1 to 5059)
  AUTHORS   Lin,D.H., Yue,P., Pan,C.Y., Sun,P., Zhang,X., Han,Z., Roos,M.,
            Caplan,M., Giebisch,G. and Wang,W.H.
  TITLE     POSH stimulates the ubiquitination and the clathrin-independent
            endocytosis of ROMK1 channels
  JOURNAL   J Biol Chem 284 (43), 29614-29624 (2009)
   PUBMED   19710010
  REMARK    GeneRIF: POSH inhibits ROMK channels by enhancing dynamin-dependent
            and clathrin-independent endocytosis and by stimulating
            ubiquitination of ROMK channels.
REFERENCE   7  (bases 1 to 5059)
  AUTHORS   Wilhelm,M., Xu,Z., Kukekov,N.V., Gire,S. and Greene,L.A.
  TITLE     Proapoptotic Nix activates the JNK pathway by interacting with POSH
            and mediates death in a Parkinson disease model
  JOURNAL   J Biol Chem 282 (2), 1288-1295 (2007)
   PUBMED   17095503
  REMARK    GeneRIF: Nix promotes cell death via interaction with POSH and
            activation of the JNK/c-Jun pathway and that Nix protein is induced
            and contributes to cell death in a cellular model of Parkinson
            disease
REFERENCE   8  (bases 1 to 5059)
  AUTHORS   Xu,Z., Sproul,A., Wang,W., Kukekov,N. and Greene,L.A.
  TITLE     Siah1 interacts with the scaffold protein POSH to promote JNK
            activation and apoptosis
  JOURNAL   J Biol Chem 281 (1), 303-312 (2006)
   PUBMED   16230351
REFERENCE   9  (bases 1 to 5059)
  AUTHORS   Zhang,Q.G., Wang,R.M., Yin,X.H., Pan,J., Xu,T.L. and Zhang,G.Y.
  TITLE     Knock-down of POSH expression is neuroprotective through
            down-regulating activation of the MLK3-MKK4-JNK pathway following
            cerebral ischaemia in the rat hippocampal CA1 subfield
  JOURNAL   J Neurochem 95 (3), 784-795 (2005)
   PUBMED   16248889
  REMARK    GeneRIF: POSH might serve as a scaffold mediating JNK signalling
            activation in the hippocampal CA1 region following cerebral
            ischaemia
REFERENCE   10 (bases 1 to 5059)
  AUTHORS   Tapon,N., Nagata,K., Lamarche,N. and Hall,A.
  TITLE     A new rac target POSH is an SH3-containing scaffold protein
            involved in the JNK and NF-kappaB signalling pathways
  JOURNAL   EMBO J 17 (5), 1395-1404 (1998)
   PUBMED   9482736
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On or before Sep 2, 2022 this sequence version replaced
            XM_017600106.2, NM_198764.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1628591.1,
                                           SRR26643297.46884.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                JAXUCZ010000016.1  33912049-33912127   c
            80-566              JAXUCZ010000016.1  33910036-33910522   c
            567-842             JAXUCZ010000016.1  33804326-33804601   c
            843-938             JAXUCZ010000016.1  33803826-33803921   c
            939-1244            JAXUCZ010000016.1  33788800-33789105   c
            1245-1355           JAXUCZ010000016.1  33784442-33784552   c
            1356-1543           JAXUCZ010000016.1  33775784-33775971   c
            1544-1714           JAXUCZ010000016.1  33774172-33774342   c
            1715-1974           JAXUCZ010000016.1  33770014-33770273   c
            1975-2336           JAXUCZ010000016.1  33768407-33768768   c
            2337-2689           JAXUCZ010000016.1  33757660-33758012   c
            2690-5059           JAXUCZ010000016.1  33746396-33748765   c
FEATURES             Location/Qualifiers
     source          1..5059
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p12"
     gene            1..5059
                     /gene="Sh3rf1"
                     /gene_synonym="Posh; Sh3md2"
                     /note="SH3 domain containing ring finger 1"
                     /db_xref="GeneID:306417"
                     /db_xref="RGD:735154"
     exon            1..79
                     /gene="Sh3rf1"
                     /gene_synonym="Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            80..566
                     /gene="Sh3rf1"
                     /gene_synonym="Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..2858
                     /gene="Sh3rf1"
                     /gene_synonym="Posh; Sh3md2"
                     /EC_number="2.3.2.27"
                     /note="putative E3 ubiquitin-protein ligase SH3RF1; plenty
                     of SH3s; SH3 multiple domains protein 2; SH3
                     domain-containing RING finger protein 1; putative
                     scaffolding protein POSH; RING-type E3 ubiquitin
                     transferase SH3RF1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SH3RF1"
                     /protein_id="NP_942059.1"
                     /db_xref="GeneID:306417"
                     /db_xref="RGD:735154"
                     /translation="MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSR
                     NELRCPECRTLVGSGVDELPSNILLVRLLDGIKQRPWKPGPGGGGSTTCTNVLRAQGS
                     TVVNCGSKDLQSPQCGQQPRVQAWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDI
                     IILRRQVDENWYHGEVNGVHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDC
                     LPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPPVPGVDT
                     AECPSATAAQSSSASKHSDTKKNTRKRHSFTSLTMANKSSQASQNRHSMEISPPVLIS
                     SSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPTDVPYQAA
                     LGTMNPPLPPPPLLATTVLASTPSGATAAAVAAAAAAVAAGVGPRPAVGSTEQIAHLR
                     PQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWYKGTSMHTSKIGVFPGNY
                     VAPVTRAVTNASQAKVPMSTAGQASRGVTMVSPSTAGGPAQKPQGNGVAGNPSVVPTA
                     VVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAACI
                     GPASVGLPHHSLASQPLPPMVGPAAHIAAVNINRTSVPLACAAGASSLASPNMTTAAL
                     ETEPSGRTVTILPGLPTSPESAASACGNSSAVKPDKDSKKEKKGLLKLLSGASTKRKP
                     RVSPPASPTLDVELGSGEVPLQGAVGPELPLGGVHGRVGSCPTDGDGPVAAGTAALAQ
                     DAFHRKTSSLDSAVPIAPPPRQACSSLGPVMNEARPVVCERHRVVVSYPPQSEAELEL
                     KEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI"
     exon            567..842
                     /gene="Sh3rf1"
                     /gene_synonym="Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..938
                     /gene="Sh3rf1"
                     /gene_synonym="Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1244
                     /gene="Sh3rf1"
                     /gene_synonym="Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1355
                     /gene="Sh3rf1"
                     /gene_synonym="Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1543
                     /gene="Sh3rf1"
                     /gene_synonym="Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1714
                     /gene="Sh3rf1"
                     /gene_synonym="Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1974
                     /gene="Sh3rf1"
                     /gene_synonym="Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2336
                     /gene="Sh3rf1"
                     /gene_synonym="Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2689
                     /gene="Sh3rf1"
                     /gene_synonym="Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..5059
                     /gene="Sh3rf1"
                     /gene_synonym="Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacgggcag cgggctcggc ggggctgcat ctgccagcgc tgcggggccg cgaacaaagg
       61 cgagcagcgg aggcgcgaga gcaaagtctg aaatggatgt tacatgaatc actttaaggg
      121 ctgcgcacga ctatgaacgt tctgaggccg ttttctcact aaagtagctc aagatggatg
      181 agtctgcctt gttggacctt ctggagtgcc ctgtgtgtct agaacgcttg gatgcttccg
      241 caaaggtctt accctgccag cacacgtttt gcaaacgatg tttgctgggg attgtgggtt
      301 cccggaatga actcagatgt cccgaatgcc ggactcttgt tggctctggg gttgacgagc
      361 tccccagtaa catcctactg gtcagacttc tggatggcat caagcagagg ccttggaaac
      421 ccggccctgg tgggggcggc tcgaccacct gcacaaatgt attaagggcg cagggcagca
      481 ctgtggttaa ttgtggctca aaagatctgc agagccccca gtgtggacag caacctcggg
      541 tgcaagcctg gagcccccca gtgaggggaa tacctcagtt accgtgtgcc aaagcattat
      601 ataactacga aggaaaagag cccggagacc ttaagttcag caaaggcgac atcatcattt
      661 tgcgacgaca agtggatgaa aattggtacc atggagaagt caacggggtc cacggctttt
      721 tccccaccaa ctttgtgcag atcatcaaac ctttacctca gcccccacct cagtgcaaag
      781 cactttatga ctttgaagtg aaagacaagg aagctgacaa agattgcctt ccctttgcaa
      841 aggatgacgt actgactgtg atccgcagag tggatgaaaa ctgggctgaa ggaatgctgg
      901 cagataaaat agggatattt ccaatttcat atgttgagtt taactcagct gccaagcagc
      961 tgatagagtg ggataagcct ccggtaccag gagtggacac tgcagaatgc ccttcagcga
     1021 cagcggcgca gagcagctct gcctcaaagc actccgatac caagaagaac accaggaagc
     1081 gacactcctt cacctccctc accatggcca acaagtcttc ccaggcgtcc cagaaccgcc
     1141 actccatgga gatcagccct cctgtgctta tcagctccag caaccccacg gccgcagccc
     1201 gcatcagcga gctctccggg ctctcctgca gcgccccgtc tcaggttcat ataagcacca
     1261 ctgggttaat tgtgacccca ccccctagca gcccagtgac aactggccct tcgttcacgt
     1321 tcccaaccga cgtcccctac caagctgccc ttggaacgat gaatcctcct ctccccccac
     1381 cccctctcct ggccaccact gtactcgcct ctacaccgtc aggcgctact gctgctgccg
     1441 ttgctgctgc tgctgctgct gttgctgctg gagtgggacc caggcctgca gtgggatcca
     1501 cggaacagat cgcacattta cggccgcaga cccgtcccag tgtatatgtt gctatatatc
     1561 catacactcc ccggaaggaa gacgaactgg agctgaggaa aggcgagatg tttttggtct
     1621 tcgagcgttg ccaggacggc tggtacaaag gaacgtcaat gcacaccagc aagatcggcg
     1681 ttttccccgg caactatgtg gcacccgtca caagggcggt gacaaatgcc tcccaagcta
     1741 aagtccctat gtctacagcg ggtcaggcaa gtcgtggggt gactatggtc agtccttcca
     1801 ccgcaggagg gcctgcacag aagccccaag gaaatggcgt ggctgggaat cccagcgtcg
     1861 tccccacagc tgtggtgtca gcagctcata tccagacaag tccccaggct aaggtcctgc
     1921 tgcacatgac tgggcagatg acagtcaacc aggcccgaaa tgctgtgagg acagttgcag
     1981 cacataacca ggagcgcccc acagcagcag tgactcccat ccaggtccag aatgcagcct
     2041 gcatcggtcc tgcatctgta ggcctgcccc atcattctct ggcctcccaa cctctgcctc
     2101 caatggtagg tcctgctgcc cacattgctg ccgtcaacat caatcgaacc agtgtccccc
     2161 tggcctgcgc tgcaggggca tcctctctgg cctccccaaa catgaccact gctgctttgg
     2221 agacggagcc cagtggtcgg acagtgacca tcctccctgg actccccaca tctcctgaga
     2281 gtgctgcatc ggcctgtggg aacagttcag ctgtgaaacc agacaaggac agtaagaaag
     2341 aaaaaaaggg cctattgaag ctgctttctg gcgcctccac caaacgcaag ccccgagtct
     2401 cccctccagc atcacctacc ctggacgtgg agctgggttc aggggaggtt cccttgcagg
     2461 gagcagtggg tcctgagttg ccgctagggg gcgtccatgg cagagtgggg tcctgcccca
     2521 ccgatgggga tggtccagtg gccgcaggga cagcagcctt agcccaggat gccttccatc
     2581 gcaagacaag ctccctggac tccgcagtgc ccatcgctcc accacctcgc caggcctgct
     2641 cctccctggg tccagtaatg aatgaggcca ggcctgttgt ttgtgaaagg cacagagtgg
     2701 tggtttccta tcctcctcag agtgaggcag aacttgaact gaaagaagga gatattgtgt
     2761 ttgttcataa gaaacgagag gacggctggt tcaaaggcac gttacaaaga aacgggaaga
     2821 ctggtctttt cccagggagc tttgtggaga acatctgagg aaactgaacg aggagaaagc
     2881 ttcacatcgc atcacgtgac tgaagagcac aaagcagttg cattgaaaga gcacatctgt
     2941 ggacttccag atcttcagga gctgagcaga agatgggcac ctgactccag agccccggcc
     3001 tggttacccc aggggcagag cagaggcggc cacaccgtgt gggttccgtc cgtctgggtt
     3061 ctgatatgta aagtgtgcct tgtactgtct aatggactat acagataaat gtcttttttt
     3121 tttaagatgt gtaactaaaa tggacaattg tttacaaggc ttaactaatt tatttgcttt
     3181 ttttaaaact tgaactttct tgtaatagca aattctttgg gttatggttt ttaagaaata
     3241 ttaatttatg aaatgatggt taaggagaag ctgggttctc tcctgtctgt tgggagcaag
     3301 agattctttt tgacacagac tgcatctccc tcccctgctt gctgccctcc tcccgccgtt
     3361 atacttgtct ccgtttagac aaaaatatca gttttccaag cagacagctg aatcagtacc
     3421 ggaaggacct ggggagggga gacagcagac tccagataga ggaatttagt aggtccccat
     3481 ctgcctgctt tgattagaaa tcaacctgaa gacctaatcc tcgatttcat tttgtgggtt
     3541 tttcattttc ctgaaacaaa acgggcaaaa gtaagaagca aactaaagca cagccattga
     3601 ctgcaaacac gagtctgtct gctagcacaa gtagcaacgt gttgggaagt aagagaagct
     3661 gaagaggtag tcgctgtgtg tgtgaatggc tttgaaccgt attcccattc tatcccccaa
     3721 gtgatctgca tgcccaagac acagtaaaag tttgtgagac agtggtggta agagatgcat
     3781 tcgtgttaaa gtcaaaggct gttagaaaca ctgtgaacgt ttccattcat ccatcgtgat
     3841 ttctccgcca tcttgcatgt gtaaccggat tcccacagtg gtatggactg tgcatggtgt
     3901 gtgtatttca tagcaatttt cactcagaac tgaccgatac aggaggttta acatacacag
     3961 cagtctcttc cctgccccac gaccactact gaccaagaag tctttagtgt gcttgctccc
     4021 ctctggtgaa ggcacacgct agtcagcaca ccagtcgtta gttaaaatgc tcgtccacag
     4081 gtgtcctccc agcggacccg tgtaaagggc gagcttatcc tggagacctc tcactcctgt
     4141 gactgtgttg aaactctgcg aggcttcctg ggcgtggctg tgcccacacc ttacagttgt
     4201 gacggggccc atctttttat atccaccctc tgatgccctc ttccaatttc accctagctg
     4261 tggttctagc tagtcctgag aacagatgga ggagagacag cctagtagtg aatgaccttg
     4321 ttctacagtt tctcttctag gtaagataag gaagccaacg gccaaccaac cttttccttt
     4381 ttgtttttta actttaagat aaaagtagct gggaaatatt gacgtgaatg gaagaatcac
     4441 agaatggcaa cagatcccat tgtctttaaa agattatgta atgtggttag aaatggaatc
     4501 attcctgtta actgattttt tttatatctg taagaacact gtatattatg ttcctttgtg
     4561 ttgaattttt tttttaaaga aatactttac ttggatattt ctgtaatata taaaggtttg
     4621 gtgagatgaa ttttagttag gaaaaaaagc tgacatcagc tttcatgtgt gtgagttgac
     4681 accaatgtgt cataatattc tttattttgg gatattagtg tattttatag aaattttaaa
     4741 aaagcaaaaa gactactaca agttaagatg atttttttta cctgtccttt ctccatgttt
     4801 tcagctatgt gatttgaagt atccgtggta atagcttcct ggtataacgt gggttaaact
     4861 ctcatctgtt ggtagaacat taggtggtat aatgtgtggg ttttgtattg ggctttttgg
     4921 agacagtaga tggatgttgt aacaaaggat tgttacaccg tggtggggat gagaagtggt
     4981 caatttctca tgccttttat gttaattttg aggactggat aaaagtttca ttattaaaaa
     5041 ttgatgttca acccttcta
//
