LOCUS       NM_001393781            1769 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SH3 domain-containing GRB2-like endophilin B2
            (Sh3glb2), transcript variant 1, mRNA.
ACCESSION   NM_001393781 XM_006233820
VERSION     NM_001393781.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1769)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1769)
  AUTHORS   Loebrich,S., Benoit,M.R., Konopka,J.A., Cottrell,J.R., Gibson,J.
            and Nedivi,E.
  TITLE     CPG2 Recruits Endophilin B2 to the Cytoskeleton for
            Activity-Dependent Endocytosis of Synaptic Glutamate Receptors
  JOURNAL   Curr Biol 26 (3), 296-308 (2016)
   PUBMED   26776730
  REMARK    GeneRIF: Through direct interactions with F-actin and EndoB2, CPG2
            physically bridges the spine cytoskeleton and the endocytic
            machinery, and this tripartite association is critical specifically
            for activity-dependent clathrin-mediated endocytosis of synaptic
            glutamate receptors.
REFERENCE   3  (bases 1 to 1769)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1769)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   5  (bases 1 to 1769)
  AUTHORS   Pierrat,B., Simonen,M., Cueto,M., Mestan,J., Ferrigno,P. and
            Heim,J.
  TITLE     SH3GLB, a new endophilin-related protein family featuring an SH3
            domain
  JOURNAL   Genomics 71 (2), 222-234 (2001)
   PUBMED   11161816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 11, 2021 this sequence version replaced XM_006233820.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1610421.1,
                                           SRR26360186.2599910.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000003.1  34029431-34029566   c
            137-278             JAXUCZ010000003.1  34025498-34025639   c
            279-407             JAXUCZ010000003.1  34024789-34024917   c
            408-541             JAXUCZ010000003.1  34020467-34020600   c
            542-634             JAXUCZ010000003.1  34020200-34020292   c
            635-697             JAXUCZ010000003.1  34018416-34018478   c
            698-721             JAXUCZ010000003.1  34016966-34016989   c
            722-811             JAXUCZ010000003.1  34016512-34016601   c
            812-912             JAXUCZ010000003.1  34016254-34016354   c
            913-1153            JAXUCZ010000003.1  34015601-34015841   c
            1154-1769           JAXUCZ010000003.1  34014746-34015361   c
FEATURES             Location/Qualifiers
     source          1..1769
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..1769
                     /gene="Sh3glb2"
                     /note="SH3 domain-containing GRB2-like endophilin B2"
                     /db_xref="GeneID:311848"
                     /db_xref="RGD:1305886"
     exon            1..136
                     /gene="Sh3glb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1261
                     /gene="Sh3glb2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     endophilin-B2; SH3-domain GRB2-like endophilin B2; SH3
                     domain-containing GRB2-like protein B2; SH3-containing
                     protein SH3GLB2"
                     /codon_start=1
                     /product="endophilin-B2 isoform 1"
                     /protein_id="NP_001380710.1"
                     /db_xref="GeneID:311848"
                     /db_xref="RGD:1305886"
                     /translation="MDFNMKKLASDAGIFFTRAVQFTEEKFGQAEKTELDAHFENLLA
                     RADSTKNWTERILRQTEVLLQPNPSARVEEFLYEKLDRKVPSRVTNGELLAQYMAEAA
                     SELGPNTPYGKTLMKVSEAEKRLGAAERDFIHTASLSFLTPLRNFLEGDWKTISKERR
                     LLQNRRLDLDACKARLKKAKAAEAKATTVPDFQETRPRNYILSASASALWNDEVDKAE
                     QELRAAQTEFDRQAEVTRLLLEGISSAHVNHLRCLHEFVKSQTTYYAQCYRHMLDLQK
                     QLGRFPGTFVGTTEPASPPLSSTSPTTTAATMPVVPTGAGLAPPEEAALCLEEVAPPA
                     SGTRKARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLE
                     LLS"
     exon            137..278
                     /gene="Sh3glb2"
                     /inference="alignment:Splign:2.1.0"
     exon            279..407
                     /gene="Sh3glb2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..541
                     /gene="Sh3glb2"
                     /inference="alignment:Splign:2.1.0"
     exon            542..634
                     /gene="Sh3glb2"
                     /inference="alignment:Splign:2.1.0"
     exon            635..697
                     /gene="Sh3glb2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..721
                     /gene="Sh3glb2"
                     /inference="alignment:Splign:2.1.0"
     exon            722..811
                     /gene="Sh3glb2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..912
                     /gene="Sh3glb2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1153
                     /gene="Sh3glb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1769
                     /gene="Sh3glb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagcgcga ggcggggcgg ggggctgccg gctacactgg ggccggcgcg gcggccctgc
       61 gtacgggcgc gccatggact tcaatatgaa gaagctggcg tcggacgcgg gcatcttctt
      121 cactcgggca gtgcagttca cagaagagaa gtttggccaa gctgagaaga ctgaacttga
      181 tgcccacttt gaaaacctcc tagctcgggc agacagcacc aagaactgga cggagcggat
      241 cctgaggcag actgaggtgc tgctgcagcc caatcccagt gctcgagtgg aggagttcct
      301 gtatgagaag ctggacagaa aggtgccctc aagagtcacc aatggggagc tgctggctca
      361 gtacatggca gaggcagcca gcgaactggg ccccaacact ccctatggga agacactgat
      421 gaaggtgtca gaagctgaaa agcgtctggg agccgcagaa cgggatttca ttcacactgc
      481 ctccctcagc ttcctcacac ccttgcgcaa cttcctggaa ggggactgga aaacgatttc
      541 gaaggagagg cggcttctgc agaaccggcg ccttgacttg gatgcctgca aagcccggct
      601 aaagaaggcc aaggcggcag aagccaaagc cacgacggtg cctgactttc aggagactag
      661 acctcgtaat tacattctct cggccagcgc ctccgcgctt tggaacgatg aggtagacaa
      721 ggctgagcag gagcttcgag cggcccagac cgagtttgac cggcaggcag aagttactcg
      781 tctcctgctg gaggggatca gcagtgccca tgtgaaccac cttcgctgcc tccatgagtt
      841 cgtcaagtct cagaccacct actatgcaca gtgctaccgc cacatgctgg atctgcagaa
      901 acagctaggc agatttccag gcaccttcgt gggcactaca gagcctgcct ccccacccct
      961 gagcagcacc tcacccacca ccactgcggc caccatgcct gtggtaccta ctggggctgg
     1021 cttggcccct ccagaagagg cagcactgtg cctggaggag gtggctccac cagccagcgg
     1081 gactcgaaag gcccgggtgc tctacgacta tgaggcagct gacagcagtg agctggccct
     1141 gctggctgac gagctcatca ctgtctacag cctgccgggc atggaccccg actggctcat
     1201 tggtgagaga ggcaacaaga agggcaaggt tcctgtcacc tacctggaac ttctcagtta
     1261 agcagcccct tcccaggctc tgccacttag ttgtctgctg gtgacagagc tgcttaggat
     1321 aagggaccta accccttctg gctgtgcccg tcactcagct attaaggacc ccacaagaca
     1381 gaatggctcc aggcccctct gctagccctg cttctgacct gcaaccctgc acaccccagg
     1441 cttcccagct cccttgaggc cgcgggtcac aacatttgac accaccacgg gcccaggata
     1501 tgctggggat gtgctcttgg catgagagaa acatctgcct tccatctgag gaagttgagg
     1561 gttcagcagc aaacaggcag ggctgggaca gtgtggcagg agaccagaag ggtcagccag
     1621 agcagcagca ccaagtgctg cctccccact cccctcaggg ctctggctgg gtgcagtggc
     1681 cacagccagc gtcccctcag tttctagctg acattcttct gcctgtctgc ttgctctctg
     1741 gcaaataaac cctcctttgt gtgcaaata
//
