LOCUS       NM_001414376            1602 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus SH3 domain containing GRB2 like 3, endophilin A3
            (Sh3gl3), transcript variant 1, mRNA.
ACCESSION   NM_001414376 XM_006229480
VERSION     NM_001414376.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1602)
  AUTHORS   Tian,Q., Zhang,J.F., Fan,J., Song,Z. and Chen,Y.
  TITLE     Endophilin isoforms have distinct characteristics in interactions
            with N-type Ca2+ channels and dynamin I
  JOURNAL   Neurosci Bull 28 (5), 483-492 (2012)
   PUBMED   22961472
  REMARK    GeneRIF: Endophilin III binding to N-type Ca2+ channel
            carboxy-terminal fragments is Ca2+-independent in clathrin-mediated
            endocytosis.
REFERENCE   2  (bases 1 to 1602)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1602)
  AUTHORS   Milosevic,I., Giovedi,S., Lou,X., Raimondi,A., Collesi,C., Shen,H.,
            Paradise,S., O'Toole,E., Ferguson,S., Cremona,O. and De Camilli,P.
  TITLE     Recruitment of endophilin to clathrin-coated pit necks is required
            for efficient vesicle uncoating after fission
  JOURNAL   Neuron 72 (4), 587-601 (2011)
   PUBMED   22099461
REFERENCE   4  (bases 1 to 1602)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   5  (bases 1 to 1602)
  AUTHORS   Chowdhury,S., Shepherd,J.D., Okuno,H., Lyford,G., Petralia,R.S.,
            Plath,N., Kuhl,D., Huganir,R.L. and Worley,P.F.
  TITLE     Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA
            receptor trafficking
  JOURNAL   Neuron 52 (3), 445-459 (2006)
   PUBMED   17088211
REFERENCE   6  (bases 1 to 1602)
  AUTHORS   Aramaki,Y., Ogawa,K., Toh,Y., Ito,T., Akimitsu,N., Hamamoto,H.,
            Sekimizu,K., Matsusue,K., Kono,A., Iguchi,H. and Takiguchi,S.
  TITLE     Direct interaction between metastasis-associated protein 1 and
            endophilin 3
  JOURNAL   FEBS Lett 579 (17), 3731-3736 (2005)
   PUBMED   15978591
REFERENCE   7  (bases 1 to 1602)
  AUTHORS   Qiao,Y., Yang,J.X., Zhang,X.D., Liu,Y., Zhang,J.C., Zong,S.D.,
            Miao,S.Y., Wang,L.F. and Koide,S.S.
  TITLE     Characterization of rtSH3p13 gene encoding a development protein
            involved in vesicular traffic in spermiogenesis
  JOURNAL   Cell Res 14 (3), 197-207 (2004)
   PUBMED   15225413
REFERENCE   8  (bases 1 to 1602)
  AUTHORS   Sugiura,H., Iwata,K., Matsuoka,M., Hayashi,H., Takemiya,T.,
            Yasuda,S., Ichikawa,M., Yamauchi,T., Mehlen,P., Haga,T. and
            Yamagata,K.
  TITLE     Inhibitory role of endophilin 3 in receptor-mediated endocytosis
  JOURNAL   J Biol Chem 279 (22), 23343-23348 (2004)
   PUBMED   15066995
REFERENCE   9  (bases 1 to 1602)
  AUTHORS   Nemoto,Y., Wenk,M.R., Watanabe,M., Daniell,L., Murakami,T.,
            Ringstad,N., Yamada,H., Takei,K. and De Camilli,P.
  TITLE     Identification and characterization of a synaptojanin 2 splice
            isoform predominantly expressed in nerve terminals
  JOURNAL   J Biol Chem 276 (44), 41133-41142 (2001)
   PUBMED   11498538
REFERENCE   10 (bases 1 to 1602)
  AUTHORS   Ringstad,N., Nemoto,Y. and De Camilli,P.
  TITLE     The SH3p4/Sh3p8/SH3p13 protein family: binding partners for
            synaptojanin and dynamin via a Grb2-like Src homology 3 domain
  JOURNAL   Proc Natl Acad Sci U S A 94 (16), 8569-8574 (1997)
   PUBMED   9238017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 18, 2022 this sequence version replaced XM_006229480.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399492.762927.1,
                                           SRR22399492.2207261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JAXUCZ010000001.1  145534755-145534933
            180-248             JAXUCZ010000001.1  145618934-145619002
            249-321             JAXUCZ010000001.1  145625936-145626008
            322-465             JAXUCZ010000001.1  145628222-145628365
            466-599             JAXUCZ010000001.1  145630686-145630819
            600-758             JAXUCZ010000001.1  145633329-145633487
            759-862             JAXUCZ010000001.1  145640798-145640901
            863-972             JAXUCZ010000001.1  145641924-145642033
            973-1602            JAXUCZ010000001.1  145664252-145664881
FEATURES             Location/Qualifiers
     source          1..1602
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..1602
                     /gene="Sh3gl3"
                     /gene_synonym="Sh3d2c1; SH3P13"
                     /note="SH3 domain containing GRB2 like 3, endophilin A3"
                     /db_xref="GeneID:81921"
                     /db_xref="RGD:620578"
     exon            1..179
                     /gene="Sh3gl3"
                     /gene_synonym="Sh3d2c1; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1178
                     /gene="Sh3gl3"
                     /gene_synonym="Sh3d2c1; SH3P13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     endophilin-A3; endophilin-3; SH3 domain protein 2C; SH3
                     domain-containing GRB2-like protein 3; SH3 domain protein
                     2 C1; SH3-domain GRB2-like 3; SH3 domain-containing
                     GRB2-like 3"
                     /codon_start=1
                     /product="endophilin-A3 isoform 1"
                     /protein_id="NP_001401305.1"
                     /db_xref="GeneID:81921"
                     /db_xref="RGD:620578"
                     /translation="MSVAGLKKQFHKASQLFSEKISGAEGTKLDEEFLDMEKKIDITS
                     KAVAEILSKATEYLQPNPAYRAKLGMLNTMSKLRGQVKATGYPQTEGLLGDCMLKYGR
                     ELGEDSAFGNSLVEVGEALKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLRK
                     LEGRRLDYDYKKKRVGKIPEEEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVF
                     VEAALDYHRQSTEILQELQNKLELRIALASQVPRRDYMPKPVNTSSTNANGVEPSSSS
                     KLTGTDIPSDQPCCRGLYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLRGESGFF
                     PINYVEVIVPLPR"
     exon            180..248
                     /gene="Sh3gl3"
                     /gene_synonym="Sh3d2c1; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            249..321
                     /gene="Sh3gl3"
                     /gene_synonym="Sh3d2c1; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            322..465
                     /gene="Sh3gl3"
                     /gene_synonym="Sh3d2c1; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            466..599
                     /gene="Sh3gl3"
                     /gene_synonym="Sh3d2c1; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            600..758
                     /gene="Sh3gl3"
                     /gene_synonym="Sh3d2c1; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            759..862
                     /gene="Sh3gl3"
                     /gene_synonym="Sh3d2c1; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            863..972
                     /gene="Sh3gl3"
                     /gene_synonym="Sh3d2c1; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1602
                     /gene="Sh3gl3"
                     /gene_synonym="Sh3d2c1; SH3P13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtgacag cgccgtggcg gtggccgtgg ccgtggagcg cgcggcgacc gcccggggtg
       61 cccgctccgc tcagcgtcgc ggccgcgtgg cccggcggag ccccgagacc acccccgggc
      121 ggggcgccgc cgcgatgtcg gtggctgggc tcaagaagca gttccacaaa gccagccagc
      181 tgtttagtga aaaaataagt ggtgcagaag gaacgaagct agatgaagag tttctggata
      241 tggaaaagaa aatagatatt accagtaaag ctgttgcaga aattctttca aaagccacag
      301 agtatctcca gcccaatcca gcatacagag ctaagctagg aatgctgaac actatgtcga
      361 agctccgagg gcaggtgaag gccaccggct acccacagac cgaaggcttg ctgggggact
      421 gcatgctcaa gtacggcagg gagcttggag aagactctgc ttttggcaac tcattggtag
      481 aagttggtga ggccctgaaa ctcatggctg aggtgaagga ctctctggat attaatgtga
      541 agcagacttt tattgaccca ctacagctac tgcaagacaa agatttaaaa gagattgggc
      601 accacctgag aaagctagaa ggccgccgtc tggactatga ttataaaaag aagcgggtgg
      661 gtaagatccc cgaggaagaa atcagacaag cagtagaaaa gtttgaagag tcaaaggagt
      721 tggccgaaag aagcatgttt aattttttag aaaatgacgt agagcaagtg agtcagctgg
      781 ccgtgtttgt agaggcggcg ttagactatc acaggcagtc caccgagatc ctgcaggagc
      841 tgcagaacaa gctagagctg cgaatagctc ttgcatccca agtccctagg cgagactaca
      901 tgccaaagcc tgtgaacacg agttccacca atgccaacgg ggtcgaaccc agctcttcgt
      961 caaagttaac aggtactgac attccctcgg accagccctg ctgtcgtggt ctctatgact
     1021 ttgagccaga aaacgaagga gaattgggat ttaaagaagg ggacatcatt acattaacca
     1081 atcagataga tgaaaactgg tatgaaggaa tgctccgtgg ggaatccggc ttcttcccta
     1141 ttaattacgt ggaagtcatt gtgcctttac ctcggtaaat gtgtcttttg gacctgactt
     1201 cagaactgaa atgaattggc accagtgttc tctcagtgtg gtgttctgtg acatcctcgc
     1261 tctctggccc acttaatcac ttttgtatgt gtgttttctt tataatgtat tttgtatcaa
     1321 tttaatttgt ataactgatt tctttgtcct aactcataaa aatagttttc ttcttgttct
     1381 aaaaagtcat tgcttaaatg tatttgcttc ctgttgctaa gaaaagtaaa ttgcgcccat
     1441 tcgaatgtcc tgggtagtcc ttagctgcag tgggaacgcg ccctttgcgg ctatgaaagc
     1501 taaagatttt gtttcttgac attattgacg gcatttggtc ttttcctgtt ttaagcttac
     1561 ctgtgaacag cccaataaac atggcacact gtgttcataa aa
//
