LOCUS       NM_053935               1491 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SH3 domain containing GRB2 like 2, endophilin A1
            (Sh3gl2), mRNA.
ACCESSION   NM_053935 XM_001070855 XM_342857
VERSION     NM_053935.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1491)
  AUTHORS   Yin,Y., Cha,C., Wu,F., Li,J., Li,S., Zhu,X., Zhang,J. and Guo,G.
  TITLE     Endophilin 1 knockdown prevents synaptic dysfunction induced by
            oligomeric amyloid beta
  JOURNAL   Mol Med Rep 19 (6), 4897-4905 (2019)
   PUBMED   31059028
  REMARK    GeneRIF: A potential role for endophilin 1 in Abetainduced
            postsynaptic dysfunction has been identified, indicating a possible
            direction for the prevention of postsynaptic dysfunction in
            cognitive impairment and suggesting that endophilin may be a
            potential target for the clinical treatment of Alzheimer's disease.
REFERENCE   2  (bases 1 to 1491)
  AUTHORS   Hohendahl,A., Talledge,N., Galli,V., Shen,P.S., Humbert,F., De
            Camilli,P., Frost,A. and Roux,A.
  TITLE     Structural inhibition of dynamin-mediated membrane fission by
            endophilin
  JOURNAL   Elife 6, e26856 (2017)
   PUBMED   28933693
  REMARK    GeneRIF: Together, these observations suggest that while endophilin
            helps shape endocytic tubules and recruit dynamin to endocytic
            sites, it can also block membrane fission when present in excess by
            inhibiting inter-dynamin interactions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1491)
  AUTHORS   Liu,Y., Gao,M., Ma,M.M., Tang,Y.B., Zhou,J.G., Wang,G.L., Du,Y.H.
            and Guan,Y.Y.
  TITLE     Endophilin A2 protects H2O2-induced apoptosis by blockade of Bax
            translocation in rat basilar artery smooth muscle cells
  JOURNAL   J Mol Cell Cardiol 92, 122-133 (2016)
   PUBMED   26854628
  REMARK    GeneRIF: These data suggested a role of EndoII in protecting BASMCs
            apoptosis induced by H2O2, possibly by inhibiting the addressing of
            Bax to mitochondria. Targeting on EndoII may be a new strategy to
            treat apoptosis-associated diseases.
REFERENCE   4  (bases 1 to 1491)
  AUTHORS   Wuertenberger,S. and Groemping,Y.
  TITLE     A single PXXP motif in the C-terminal region of srGAP3 mediates
            binding to multiple SH3 domains
  JOURNAL   FEBS Lett 589 (10), 1156-1163 (2015)
   PUBMED   25819436
REFERENCE   5  (bases 1 to 1491)
  AUTHORS   Boucrot,E., Ferreira,A.P., Almeida-Souza,L., Debard,S., Vallis,Y.,
            Howard,G., Bertot,L., Sauvonnet,N. and McMahon,H.T.
  TITLE     Endophilin marks and controls a clathrin-independent endocytic
            pathway
  JOURNAL   Nature 517 (7535), 460-465 (2015)
   PUBMED   25517094
REFERENCE   6  (bases 1 to 1491)
  AUTHORS   Ramjaun,A.R., Angers,A., Legendre-Guillemin,V., Tong,X.K. and
            McPherson,P.S.
  TITLE     Endophilin regulates JNK activation through its interaction with
            the germinal center kinase-like kinase
  JOURNAL   J Biol Chem 276 (31), 28913-28919 (2001)
   PUBMED   11384986
REFERENCE   7  (bases 1 to 1491)
  AUTHORS   Zhang,Y., Moheban,D.B., Conway,B.R., Bhattacharyya,A. and
            Segal,R.A.
  TITLE     Cell surface Trk receptors mediate NGF-induced survival while
            internalized receptors regulate NGF-induced differentiation
  JOURNAL   J Neurosci 20 (15), 5671-5678 (2000)
   PUBMED   10908605
REFERENCE   8  (bases 1 to 1491)
  AUTHORS   Micheva,K.D., Kay,B.K. and McPherson,P.S.
  TITLE     Synaptojanin forms two separate complexes in the nerve terminal.
            Interactions with endophilin and amphiphysin
  JOURNAL   J Biol Chem 272 (43), 27239-27245 (1997)
   PUBMED   9341169
REFERENCE   9  (bases 1 to 1491)
  AUTHORS   Ringstad,N., Nemoto,Y. and De Camilli,P.
  TITLE     The SH3p4/Sh3p8/SH3p13 protein family: binding partners for
            synaptojanin and dynamin via a Grb2-like Src homology 3 domain
  JOURNAL   Proc Natl Acad Sci U S A 94 (16), 8569-8574 (1997)
   PUBMED   9238017
REFERENCE   10 (bases 1 to 1491)
  AUTHORS   de Heuvel,E., Bell,A.W., Ramjaun,A.R., Wong,K., Sossin,W.S. and
            McPherson,P.S.
  TITLE     Identification of the major synaptojanin-binding proteins in brain
  JOURNAL   J Biol Chem 272 (13), 8710-8716 (1997)
   PUBMED   9079704
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Jul 29, 2012 this sequence version replaced
            XM_001070855.2, XM_342857.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.21687.1,
                                           SRR26643299.23220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JAXUCZ010000005.1  104699270-104699400
            132-200             JAXUCZ010000005.1  104834115-104834183
            201-273             JAXUCZ010000005.1  104842208-104842280
            274-417             JAXUCZ010000005.1  104860853-104860996
            418-551             JAXUCZ010000005.1  104861905-104862038
            552-710             JAXUCZ010000005.1  104864144-104864302
            711-814             JAXUCZ010000005.1  104866257-104866360
            815-945             JAXUCZ010000005.1  104870520-104870650
            946-1491            JAXUCZ010000005.1  104873030-104873575
FEATURES             Location/Qualifiers
     source          1..1491
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..1491
                     /gene="Sh3gl2"
                     /gene_synonym="Sh3d2a; Sh3p4"
                     /note="SH3 domain containing GRB2 like 2, endophilin A1"
                     /db_xref="GeneID:116743"
                     /db_xref="RGD:620276"
     exon            1..131
                     /gene="Sh3gl2"
                     /gene_synonym="Sh3d2a; Sh3p4"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1145
                     /gene="Sh3gl2"
                     /gene_synonym="Sh3d2a; Sh3p4"
                     /note="endophilin-1; SH3 domain-containing GRB2-like
                     protein 2; SH3 domain protein 2A; SH3-domain GRB2-like 2;
                     SH3 domain-containing GRB2-like 2"
                     /codon_start=1
                     /product="endophilin-A1"
                     /protein_id="NP_446387.1"
                     /db_xref="GeneID:116743"
                     /db_xref="RGD:620276"
                     /translation="MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTS
                     RAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGR
                     ELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKK
                     LEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSAL
                     VQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDGTQPNGG
                     LSHTGTPKPAGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHG
                     QSGFFPINYVEILVALPH"
     exon            132..200
                     /gene="Sh3gl2"
                     /gene_synonym="Sh3d2a; Sh3p4"
                     /inference="alignment:Splign:2.1.0"
     exon            201..273
                     /gene="Sh3gl2"
                     /gene_synonym="Sh3d2a; Sh3p4"
                     /inference="alignment:Splign:2.1.0"
     exon            274..417
                     /gene="Sh3gl2"
                     /gene_synonym="Sh3d2a; Sh3p4"
                     /inference="alignment:Splign:2.1.0"
     exon            418..551
                     /gene="Sh3gl2"
                     /gene_synonym="Sh3d2a; Sh3p4"
                     /inference="alignment:Splign:2.1.0"
     exon            552..710
                     /gene="Sh3gl2"
                     /gene_synonym="Sh3d2a; Sh3p4"
                     /inference="alignment:Splign:2.1.0"
     exon            711..814
                     /gene="Sh3gl2"
                     /gene_synonym="Sh3d2a; Sh3p4"
                     /inference="alignment:Splign:2.1.0"
     exon            815..945
                     /gene="Sh3gl2"
                     /gene_synonym="Sh3d2a; Sh3p4"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1491
                     /gene="Sh3gl2"
                     /gene_synonym="Sh3d2a; Sh3p4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcacg accagcggcg gccaggcgac ccccgccgcc tctccgcatc cgcagctacc
       61 agccgcgcgg cctctcgcat cccatcatgt cggtggcagg gctgaagaag cagttccaca
      121 aagccactca gaaagtgagt gagaaggtgg gaggagccga aggcaccaag ctcgatgatg
      181 acttcaaaga gatggagagg aaagtggatg ttaccagcag ggccgtgatg gagataatga
      241 cgaaaacaat tgaatacctc caacccaatc cagcttccag ggctaaactc agtatgatca
      301 acaccatgtc gaaaatccgt ggccaagaga aggggccagg ctatcctcag gcagaagcac
      361 tgctggcaga ggctatgctc aagttcggca gggagctcgg cgatgattgc aactttggtc
      421 cggctcttgg tgaggtagga gaagccatga gggagctctc ggaggtcaag gactctttgg
      481 acatggaagt gaagcagaac ttcatcgacc cccttcagaa tcttcatgac aaagatctga
      541 gggagattca gcatcacctg aaaaagctgg aaggccgacg cttagacttt gattataaga
      601 agaagcgaca aggaaagatt ccagacgaag aactccgcca agctctggag aaatttgatg
      661 agtctaaaga aatcgctgag tcgagcatgt tcaacctctt ggagatggat attgaacagg
      721 tgagccagct ctctgcactt gttcaggctc agctggagta ccacaaacag gctgtgcaga
      781 tcctgcaaca ggtcactgtc aggctggaag agagaataag acaagcttca tctcaaccaa
      841 gaagggaata tcagcccaaa ccacgaatga gcctagagtt tgccactgga gacggtacgc
      901 agcccaacgg gggtctctcc cacacaggca cacccaaacc tgcaggtgtc caaatggatc
      961 agccttgctg ccgagccctg tatgactttg aacctgaaaa tgaaggggag ttgggtttta
     1021 aagagggtga tatcatcacg ctcactaatc agattgatga gaactggtat gaggggatgc
     1081 ttcatggcca gtccggcttt ttccccatca actatgtaga aattctggtt gctctgcccc
     1141 attagggtcc tgtgctggct ggctcacctc cttctgaccc agatagttaa gtttaaccac
     1201 tgctttggta atgccgcttc caatacatca cgaatgcagg ccgcagtgga tgattcatca
     1261 agcccacacg tgccctgggt tggcctgtgt gctcctacag gagacacggt gatagatggt
     1321 atcttccaag gccactgggc ctggcacatg ctttaaaaca ccatctgaga ctagcccgtg
     1381 gtcacagaac tggctatgcc gttctcagga ggctgtggtt cctgatgacc cacaccacag
     1441 aaaacctctc ctcactgaag atattgtctc tcacccaagg gccatctcaa g
//
