LOCUS       NM_031239               2014 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SH3 domain containing GRB2 like 1, endophilin A2
            (Sh3gl1), mRNA.
ACCESSION   NM_031239
VERSION     NM_031239.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2014)
  AUTHORS   Norin,U., Rintisch,C., Meng,L., Forster,F., Ekman,D., Tuncel,J.,
            Klocke,K., Backlund,J., Yang,M., Bonner,M.Y., Lahore,G.F.,
            James,J., Shchetynsky,K., Bergquist,M., Gjertsson,I., Hubner,N.,
            Backdahl,L. and Holmdahl,R.
  TITLE     Endophilin A2 deficiency protects rodents from autoimmune arthritis
            by modulating T cell activation
  JOURNAL   Nat Commun 12 (1), 610 (2021)
   PUBMED   33504785
  REMARK    GeneRIF: Endophilin A2 deficiency protects rodents from autoimmune
            arthritis by modulating T cell activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2014)
  AUTHORS   Liu,Y., Shen,H.J., Wang,X.Q., Liu,H.Q., Zheng,L.Y. and Luo,J.D.
  TITLE     EndophilinA2 protects against angiotensin II-induced cardiac
            hypertrophy by inhibiting angiotensin II type 1 receptor
            trafficking in neonatal rat cardiomyocytes
  JOURNAL   J Cell Biochem 119 (10), 8290-8303 (2018)
   PUBMED   29923351
  REMARK    GeneRIF: EndophilinA2 protects against angiotensin II-induced
            cardiac hypertrophy by inhibiting angiotensin II type 1 receptor
            trafficking in neonatal rat cardiomyocytes.
REFERENCE   3  (bases 1 to 2014)
  AUTHORS   Liu,Y., Liu,H.Q., Xiao,J.Y., Ma,K.T., Wang,X.Q., Shen,H.J. and
            Luo,J.D.
  TITLE     Autophagy is involved in the protective effect of endophilin A2 on
            H2O2-induced apoptosis in H9C2 cardiomyocytes
  JOURNAL   Biochem Biophys Res Commun 499 (2), 299-306 (2018)
   PUBMED   29574155
  REMARK    GeneRIF: EndoA2 inhibited hydrogen peroxide-induced apoptosis in
            H9C2 cardiomyocytes.
REFERENCE   4  (bases 1 to 2014)
  AUTHORS   Zhang,J., Yin,Y., Ji,Z., Cai,Z., Zhao,B., Li,J., Tan,M. and Guo,G.
  TITLE     Endophilin2 Interacts with GluA1 to Mediate AMPA Receptor
            Endocytosis Induced by Oligomeric Amyloid-beta
  JOURNAL   Neural Plast 2017, 8197085 (2017)
   PUBMED   28758034
  REMARK    GeneRIF: Study demonstrates that endophilin2 does not contribute to
            constitutive AMPA receptor endocytosis.
REFERENCE   5  (bases 1 to 2014)
  AUTHORS   Wuertenberger,S. and Groemping,Y.
  TITLE     A single PXXP motif in the C-terminal region of srGAP3 mediates
            binding to multiple SH3 domains
  JOURNAL   FEBS Lett 589 (10), 1156-1163 (2015)
   PUBMED   25819436
REFERENCE   6  (bases 1 to 2014)
  AUTHORS   Ralser,M., Nonhoff,U., Albrecht,M., Lengauer,T., Wanker,E.E.,
            Lehrach,H. and Krobitsch,S.
  TITLE     Ataxin-2 and huntingtin interact with endophilin-A complexes to
            function in plastin-associated pathways
  JOURNAL   Hum Mol Genet 14 (19), 2893-2909 (2005)
   PUBMED   16115810
REFERENCE   7  (bases 1 to 2014)
  AUTHORS   Chen,Y., Deng,L., Maeno-Hikichi,Y., Lai,M., Chang,S., Chen,G. and
            Zhang,J.F.
  TITLE     Formation of an endophilin-Ca2+ channel complex is critical for
            clathrin-mediated synaptic vesicle endocytosis
  JOURNAL   Cell 115 (1), 37-48 (2003)
   PUBMED   14532001
REFERENCE   8  (bases 1 to 2014)
  AUTHORS   Ringstad,N., Nemoto,Y. and De Camilli,P.
  TITLE     Differential expression of endophilin 1 and 2 dimers at central
            nervous system synapses
  JOURNAL   J Biol Chem 276 (44), 40424-40430 (2001)
   PUBMED   11518713
REFERENCE   9  (bases 1 to 2014)
  AUTHORS   Nemoto,Y., Wenk,M.R., Watanabe,M., Daniell,L., Murakami,T.,
            Ringstad,N., Yamada,H., Takei,K. and De Camilli,P.
  TITLE     Identification and characterization of a synaptojanin 2 splice
            isoform predominantly expressed in nerve terminals
  JOURNAL   J Biol Chem 276 (44), 41133-41142 (2001)
   PUBMED   11498538
REFERENCE   10 (bases 1 to 2014)
  AUTHORS   Ringstad,N., Nemoto,Y. and De Camilli,P.
  TITLE     The SH3p4/Sh3p8/SH3p13 protein family: binding partners for
            synaptojanin and dynamin via a Grb2-like Src homology 3 domain
  JOURNAL   Proc Natl Acad Sci U S A 94 (16), 8569-8574 (1997)
   PUBMED   9238017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB615317.1 and BC070893.1.
            
            On Sep 13, 2018 this sequence version replaced NM_031239.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070893.1, AB008161.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 CB615317.1         1-7
            8-2014              BC070893.1         1-2007
FEATURES             Location/Qualifiers
     source          1..2014
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..2014
                     /gene="Sh3gl1"
                     /gene_synonym="SH3P8"
                     /note="SH3 domain containing GRB2 like 1, endophilin A2"
                     /db_xref="GeneID:81922"
                     /db_xref="RGD:708456"
     exon            1..186
                     /gene="Sh3gl1"
                     /gene_synonym="SH3P8"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1248
                     /gene="Sh3gl1"
                     /gene_synonym="SH3P8"
                     /note="endophilin-2; SH3 domain protein 2B; SH3
                     domain-containing GRB2-like protein 1; SH3-domain
                     GRB2-like 1; SH3 domain-containing GRB2-like 1"
                     /codon_start=1
                     /product="endophilin-A2"
                     /protein_id="NP_112518.1"
                     /db_xref="GeneID:81922"
                     /db_xref="RGD:708456"
                     /translation="MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFREMEKKVDITS
                     KAVAEVLVRTIEYLQPNPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMVRHGK
                     ELGGESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEIQHHLKK
                     LEGRRLDFDYKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSAL
                     VDAQLDYHRQAVQILEELADKLKRRVREASSRPRREFKPRPQEPFELGELEQPNGGFP
                     CASAPKITASSSFRSGDKPTRTPSKSMPPLDQPSCKALYDFEPENDGELGFREGDLIT
                     LTNQIDENWYEGMLHGQSGFFPLSYVQVLVPLPQ"
     exon            187..255
                     /gene="Sh3gl1"
                     /gene_synonym="SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            256..328
                     /gene="Sh3gl1"
                     /gene_synonym="SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            329..472
                     /gene="Sh3gl1"
                     /gene_synonym="SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            473..606
                     /gene="Sh3gl1"
                     /gene_synonym="SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            607..765
                     /gene="Sh3gl1"
                     /gene_synonym="SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            766..869
                     /gene="Sh3gl1"
                     /gene_synonym="SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            870..994
                     /gene="Sh3gl1"
                     /gene_synonym="SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1051
                     /gene="Sh3gl1"
                     /gene_synonym="SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..2014
                     /gene="Sh3gl1"
                     /gene_synonym="SH3P8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggctctg gggcgggggc gcagagctgg caagttgatt tggcggtggc ggcgcctacc
       61 cccgcgcgga ggaacgaaat cggttcggcg acgccggcgg aaaccttagt tcgagcggga
      121 agcctgacag tggcaggcgg catgtcggtg gcggggctga agaagcagtt ctacaaggcg
      181 agccagctgg tcagcgagaa agttggtggg gccgaaggga ccaaactgga tgatgacttc
      241 agagagatgg aaaagaaagt ggatatcacc agtaaggccg tggcagaggt gctggtcaga
      301 accatagaat atctgcaacc taacccagcc tcgagggcca agctgactat gctgaatact
      361 gtatccaaga tccggggcca agtgaagaat cctggctacc cacagtcaga gggtctgctg
      421 ggagagtgca tggtccgcca tggcaaggaa ctaggcggag agtccaactt tggcgatgct
      481 ctgctagatg caggtgagtc tatgaagcgc ctggctgagg tgaaggactc actggacatc
      541 gaggtcaagc agaacttcat cgacccactg cagaacctgt gtgacaagga tctgaaggag
      601 atccagcacc acctgaagaa gttggagggc cgccgccttg actttgacta caagaagaag
      661 cgccagggca agatccctga tgaggagctg cgtcaggccc tagagaagtt tgaggagtcc
      721 aaggaggtgg cggagaccag tatgcacaac ctcctggaga ctgatattga gcaggtgagc
      781 cagctctcag ccctagtgga tgcccagctg gactaccacc ggcaggcagt gcagatcctg
      841 gaggagctgg ctgataagct gaagcgcagg gtgagagaag cctcctcacg ccccaggagg
      901 gagttcaagc ccaggcccca ggagcccttt gagcttggag agctggagca gcccaatggg
      961 ggattcccct gtgcctcagc acccaagatc acagcttcgt catcatttag atcaggggac
     1021 aagcccacca ggacgcccag caagagtatg ccacccctgg accagccaag ctgcaaggcg
     1081 ctgtatgact ttgagccaga gaacgatggc gagctgggct tccgagaggg tgacctcatc
     1141 acgcttacca accagatcga tgagaactgg tatgagggga tgctgcatgg ccagtcaggc
     1201 ttcttcccac ttagctatgt gcaggtgctg gtgcctctgc ctcagtgact gcgcttgcac
     1261 actgactagc gcctgcacac gctgccagtc acagtgtggc agtagtctaa tgccaaggtg
     1321 ctctataaac actaatgttc ctccagggga gacctcttcc ctcctccctc agccctgggg
     1381 ccccccatcc taagactcag aaaggcccac cctgaggttc tattaccttt ctggtggtgg
     1441 cagctcccac ctatttcaac ccttcccagc ccgttgctgg cgatgggccc atgcccctct
     1501 ccaggctccc taggggaggc aggtccttgg gatccccagc ctgcaagcac agccagctca
     1561 gcatatggag acacctggca cctgctgctc attcagaagt gcacaaggca tgaacgtgta
     1621 cacttcccat gggaccacag acccagctca gccctgttga agaccaagca caaaggccct
     1681 gaagagtgga cattcccagg tccctggcac cttcccctga gccagctcca ctgctacctg
     1741 ctcatgtgac tctacagctg gccacaggca gttggcaggt cccttttcaa ccagcatgcg
     1801 aggctggcca cagccgcggc tctgcatcat gagggaggct ttggctggac tcagttacac
     1861 tcttctctac agctgcccca caacccgtgg cttgtccctg gtacgtgggg ccacacccat
     1921 gccccctaga tgggcaacac tgtcctccag cctgtgaagt ggactttact cctaattttt
     1981 ttttttttaa aagtattaaa tatctctttc tata
//
