LOCUS       NM_022693               5028 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus SH3-domain binding protein 4 (Sh3bp4), mRNA.
ACCESSION   NM_022693
VERSION     NM_022693.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5028)
  AUTHORS   Kim,Y.M. and Kim,D.H.
  TITLE     dRAGging amino acid-mTORC1 signaling by SH3BP4
  JOURNAL   Mol Cells 35 (1), 1-6 (2013)
   PUBMED   23274731
  REMARK    GeneRIF: SH3 binding protein 4 (SH3BP4) has been identified as a
            negative regulator of Rag GTPases under amino acid starvation. Rag
            GTPase heterodimers regulate the amino acid-mTORC1 pathway, a
            master regulator of cell growth and autophagy.
            Review article
REFERENCE   2  (bases 1 to 5028)
  AUTHORS   Kim,Y.M., Stone,M., Hwang,T.H., Kim,Y.G., Dunlevy,J.R.,
            Griffin,T.J. and Kim,D.H.
  TITLE     SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1
            signaling
  JOURNAL   Mol Cell 46 (6), 833-846 (2012)
   PUBMED   22575674
REFERENCE   3  (bases 1 to 5028)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 5028)
  AUTHORS   Tosoni,D., Puri,C., Confalonieri,S., Salcini,A.E., De Camilli,P.,
            Tacchetti,C. and Di Fiore,P.P.
  TITLE     TTP specifically regulates the internalization of the transferrin
            receptor
  JOURNAL   Cell 123 (5), 875-888 (2005)
   PUBMED   16325581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM034920.1 and JAXUCZ010000009.1.
            
            On Mar 2, 2013 this sequence version replaced NM_022693.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2068670.1,
                                           SRR26360176.2068888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               FM034920.1         1-349
            350-500             JAXUCZ010000009.1  97169527-97169677
            501-2854            JAXUCZ010000009.1  97175373-97177726
            2855-3043           JAXUCZ010000009.1  97184029-97184217
            3044-5028           JAXUCZ010000009.1  97184894-97186878
FEATURES             Location/Qualifiers
     source          1..5028
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..5028
                     /gene="Sh3bp4"
                     /note="SH3-domain binding protein 4"
                     /db_xref="GeneID:64634"
                     /db_xref="RGD:620219"
     exon            1..176
                     /gene="Sh3bp4"
                     /inference="alignment:Splign:2.1.0"
     exon            177..255
                     /gene="Sh3bp4"
                     /inference="alignment:Splign:2.1.0"
     exon            256..500
                     /gene="Sh3bp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..3268
                     /gene="Sh3bp4"
                     /codon_start=1
                     /product="SH3 domain-binding protein 4"
                     /protein_id="NP_073184.3"
                     /db_xref="GeneID:64634"
                     /db_xref="RGD:620219"
                     /translation="MAAQRIRAANSSGLPRCKSEGTLIDLSEGFSETSFNDVKVPSPS
                     ALLVDNPTPFGNAKEVIAIKDYCPNNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMG
                     YIPSSYVQPLNYRNSTLSDSGMIDNLPDSPDEVAKELDLLGGWTDDQKQSGRPYSNNP
                     FWNGVRTNPFLNGNAQPSMDELNPKSTVDLLLFDTGTSSFTESSSATTNSTGNIFDEL
                     PATNGIHLEQPVKRDNPFFRSKRSYSLSELSVLQAKSDAPPTSSFFTGLKSPAPEQFQ
                     SREDFRTAWLNHRKLARSCHDLDLLGQSPGWGQTQAVETNIVCKLDSSGGSVQLPDTS
                     ISIHVPEGHVAPGETQQISMKALLDPPLDLNSDRSTSISPVVEVKLSNLEVSTFIILE
                     MKVSAEVKGDIFSKSTVVLQCLRSDSKEGPYAPIPLAYSYGDTIQVQLDNLEPCMYLA
                     IVAQGSNILYPSTVWDFIHKRVTVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVTEVT
                     RQAPSPAPVALQLWGKHQFILSRPQDLRVCMFSNMTNYDVKSNEQAKVVRGFQMKLGK
                     VSRLIFSVISQNPNELSDFTLRVQVKDDQDAILTQFCVQTPQPPPKSAIKPSGQRRFL
                     KKNEVGKIILSPFVVTTKYPTFQDRPVSSLKFGKLLKTVVRQNKSHYLLEYKKGDVVA
                     LLSEERIRLKGQLWTKEWYIGYYQGKVGLVHTKNVLVVGKARPSLFSGPELSTSVLLE
                     QILRPCKFLTYIYASVRTLLMENISSWRAFADALGYGNLPLTFFCRAELDSEPERVAS
                     VLEKLKEDCNNPDNKDRKSFQKELVMALLKMDCQGLVVRLIQDFVLLTTAVEVAQRWR
                     ELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVIQE
                     LHIGLDKMKNPITRRWKHLTGTLILVNSLDILRAAAFSPADHDDFVI"
     exon            501..2854
                     /gene="Sh3bp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..3043
                     /gene="Sh3bp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..5028
                     /gene="Sh3bp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgcgccc gccggcgggg gctgagcgct ctgggccgtc gcggtgtctg ggtacctcac
       61 cacctccgct gcctcgatcg ctgtgactgt ggttctcgga gcggtgcgcg cccccggccg
      121 ggtgagcccc acaggacaag ggagccgcag gacccgtggg gcgccatgcg agccagggca
      181 tccctcttct cctggacgga aggtcaggtc ttggagttct tcctctgaca tcaggaggcc
      241 aacatccccc agcaggaaga agcacactgc caagtggagc ctgccgtgta gcgtgactgt
      301 atgagacagc agctgccgtc cgtgctggaa ctaggggagg agacatgaga ccatagtacc
      361 tcacccaccc aagaggttcg ccatggcagc ccagcgcatc cgggcagcca actccagtgg
      421 cctccctcgg tgcaagtcgg aggggactct gatcgacctg agcgagggct tctcagagac
      481 aagctttaat gatgtcaaag tgccttcccc cagtgccttg ctagtagaca accccacgcc
      541 tttcgggaac gcaaaggaag tgattgcgat caaagactat tgcccaaaca acttcaccac
      601 cctgaagttc tccaagggcg accacctcta cgtcttggac acgtctggcg gggagtggtg
      661 gtacgctcac aacaccactg agatgggcta catcccttcc tcctacgtgc agccattgaa
      721 ctaccggaat tctaccctga gtgacagtgg catgattgac aatctccctg acagccccga
      781 tgaagttgcc aaggagctag atctcctagg gggctggaca gatgaccaga aacagtctgg
      841 cagaccctat agtaacaacc ccttctggaa tggagtccga acaaaccctt ttctgaatgg
      901 gaacgcacag cccagtatgg atgaactaaa ccccaagagt actgtggatt tgctcctgtt
      961 tgacaccggc acatcttcct tcactgaatc cagctcagcg accaccaaca gcaccggcaa
     1021 catcttcgac gagctcccag ccaccaatgg aatccacttg gagcagcctg tcaagcgaga
     1081 caaccccttc ttcagaagca agcgctccta cagcctttcg gaactctccg tcctgcaagc
     1141 caaatcagat gctcccccaa catccagctt cttcacaggc ttgaagtcac ccgccccgga
     1201 acagtttcaa agccgagaag acttccgaac cgcctggctg aatcaccgga agctggcccg
     1261 ttcctgccat gacttggacc tgctcggcca aagcccaggt tggggccaga cccaagcagt
     1321 ggagacaaat atcgtgtgca agcttgatag ttctgggggc tctgtgcagc ttcctgacac
     1381 cagcatcagt atccacgtgc cagagggcca cgtcgctcct ggggagacac agcagatttc
     1441 catgaaggcc ttgctggacc ctccgctgga cctcaacagt gacaggtcca ccagcataag
     1501 ccccgtggtg gaggtgaaac tgagcaactt agaggtgagt accttcatca tcttggagat
     1561 gaaggtctcc gccgaggtga agggcgacat ctttagcaaa agcacagtgg tcctgcagtg
     1621 cctgagaagc gactcaaagg aggggcctta tgcacccatc cccctcgcct acagctacgg
     1681 ggacaccata caggtgcagc tggacaacct ggaaccctgc atgtacctgg ccatcgtcgc
     1741 ccagggctcc aacattctct acccttccac cgtgtgggat ttcatccaca agagggtcac
     1801 cgtgggtctc tatggcccca aacacatcca cccatccttc aagacggtgg tgaccatttt
     1861 tggacatgat tgcgccccta agaccctcct ggtcactgag gttacccgac aggctcccag
     1921 tcctgccccc gtggccctac agctgtgggg caaacaccag ttcatcctgt ccaggcctca
     1981 ggatctcagg gtgtgtatgt tctccaatat gaccaactat gacgtcaagt ccaacgagca
     2041 agccaaggtg gtcagagggt tccagatgaa gctgggcaag gtcagccgtc tgatcttctc
     2101 tgtcatctcc cagaacccca acgagctgtc cgacttcacg ctgcgggtgc aggtcaagga
     2161 tgatcaggac gccatcctca cacagttttg cgtccagact ccacagccac cccctaaaag
     2221 cgccattaag ccatccgggc agaggaggtt tcttaagaag aatgaagttg ggaagatcat
     2281 cttgtcccca tttgttgtca ctaccaagta tccgacgttt caggaccgcc ccgtgtctag
     2341 tctcaagttt ggcaagcttc taaagacagt ggtgcgacag aacaagagtc actacctgct
     2401 ggagtacaag aagggcgacg tcgtggccct gctcagcgag gagcgcatcc ggctcaaggg
     2461 acaactgtgg accaaggagt ggtacattgg ctactatcag ggcaaggtgg gcctggtgca
     2521 caccaagaac gtgctggttg tcggcaaggc ccggcccagc ctgttctcag ggcccgagct
     2581 gagcacctcg gtgttgctgg agcaaatcct gcggccctgc aagttcctca cctacatcta
     2641 cgcctccgtg cggaccttgc tcatggagaa catcagcagc tggcgggcct ttgctgacgc
     2701 cctgggttac ggaaacctgc ccctcacctt cttctgccgg gcagagctgg acagcgagcc
     2761 ggagcgggtg gcgtctgttc tagaaaagct gaaggaagat tgtaacaacc ctgacaacaa
     2821 ggaccggaag tccttccaga aggagctggt gatggctttg ctgaaaatgg actgtcaggg
     2881 cctggtggtc agactcatcc aggactttgt gctcctgacc acagccgtcg aagtggcaca
     2941 gcgctggagg gaactggccg agaagctagc caaggtctcc aagcaacaga tggatgccta
     3001 tgagtctcct caccgagaca ggaatggggt ggtagacagt gaggccatgt ggaaacccgc
     3061 ctatgacttt ttactcacct ggagccacca gattggggac agctaccgag atgtcatcca
     3121 agagctgcac ataggcctgg acaagatgaa gaaccccatc accaggcgct ggaagcacct
     3181 cacggggaca ctgatcctgg tgaactcact ggacatcctg agggcagctg ccttcagccc
     3241 cgcggaccat gatgactttg tgatctgagc agggcccctg ccctactgct caccagggct
     3301 ggggctccac ccagtagtac tgggactcct cctactactg ctgagactcc gcccactagt
     3361 gctgggactc cgcctaccag ggctgagact ccacccatca tctgtccaca gggggcgccc
     3421 atgccatcac ccggtggtgc agggagggat ggccgctcag gtccaggccc atctaccagc
     3481 catgcccagg agggactgag gactttgact ctcttcccct cccctttatc caggggcagg
     3541 tcccaggggg ctttctactt ccagttgcca attgtgttgc tttctatatg ttgaaatgta
     3601 ctttaaattt aaaatcactt tttttaacag aagacttaga gagaacgtga gaaaggcggt
     3661 atctaatttt ttaatggact gtaaaggtta tttaaaaaaa atccacctta gtaaaagcaa
     3721 atgctgttga ggtctatgtg ttctttaaag gcctttgtaa attatgtccc aggtgtatat
     3781 ggatatgtta aggccatggg tgttttctga gtcccagaca tatcttgcat tttgacattc
     3841 aaagtgggaa cgatactggc ttcatgcaga catgttccac tagtcacctg tgagaaggca
     3901 agtttgtggg cctggtggct ttcagtaggt ggccctgagg ctgcccacct tccctccttt
     3961 cttgctgtcc tcagcggcca tccacacagc atgttgctct gtgtgcttcg gtgaactgca
     4021 aagtccctgc acggtagctc ggtaccattg agattcttcc aacaaataag aaatcagctg
     4081 gagttggggg tccctgtcac ccctgtgtgt ttggttattt gcagtaacca gtctgaagaa
     4141 caatgccccg agagcaaggt ggtccctgcc actctgggcc attgaatgct gcctccctca
     4201 gggcagtccc acctctgcta taggtgggag ggacgcccta gcacccagcc agaacctggt
     4261 ggcccctggc tcttcccaag tccaccacgg tcacctggtg acttttcagg tgacatcaca
     4321 tgctggcatg tagaggtgtc atctgccatt gccaaactcc atacctgatc tctcacgttt
     4381 aacctcctcc ttcctggtgc gcccacatct ccttaggata acagtacaag gggatagtgt
     4441 agttgtataa atgttagcag ggggaacgtt ttccctgagt gatgctctct ggaaagctgg
     4501 gagcttgcag acgattatat tgaacatcaa ggtgatgttg acttccaggc tcacacagaa
     4561 gccgtggcat ttgtggagga aacagagagt agaacacata ccagaaagac cagcagttaa
     4621 gtgaccctgg taatgggaaa aactcgagct gtctgtttac agggccagtt ccagacccgc
     4681 catctgcttt gcaagcgcgg gctgatgacc ggtgtacagc ctccgcactg agctgaaatg
     4741 tctatagctt ctgaagcggc acctgcagac cccgactcag aagtaaacag tgggcattag
     4801 tgctgcaaga acgaagtcac aggaccccct ggtcaccgca gtaacgaagg cctgtcacgc
     4861 tgtaccttca ttttgtccag agagcatctc ttttggcctt tttcccccaa agaagaaaca
     4921 aaaccagtcg caccttaaac catggatatt tttcctcagg ggctttgaat agtttcctat
     4981 gcaacaagtc ttgtagcaca aattaaattc tacaaaagtt gcggtaaa
//
