LOCUS       NM_001100684            2877 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SH3-domain binding protein 2 (Sh3bp2), transcript
            variant 1, mRNA.
ACCESSION   NM_001100684 XM_001059805 XM_223534
VERSION     NM_001100684.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2877)
  AUTHORS   Zeng,L., Ye,F., Jin,Y., Luo,Y. and Zhu,H.
  TITLE     Overexpression of DEL-1 Downregulates SH3BP2 Expression and
            Inhibits Porphyromonas gingivalis-induced Gingival Inflammation In
            Vivo and In Vitro
  JOURNAL   Oral Health Prev Dent 20 (1), 199-206 (2022)
   PUBMED   35481344
  REMARK    GeneRIF: Overexpression of DEL-1 Downregulates SH3BP2 Expression
            and Inhibits Porphyromonas gingivalis-induced Gingival Inflammation
            In Vivo and In Vitro.
REFERENCE   2  (bases 1 to 2877)
  AUTHORS   Mehlitz,A., Banhart,S., Maurer,A.P., Kaushansky,A., Gordus,A.G.,
            Zielecki,J., Macbeath,G. and Meyer,T.F.
  TITLE     Tarp regulates early Chlamydia-induced host cell survival through
            interactions with the human adaptor protein SHC1
  JOURNAL   J Cell Biol 190 (1), 143-157 (2010)
   PUBMED   20624904
REFERENCE   3  (bases 1 to 2877)
  AUTHORS   Ueki,Y., Tiziani,V., Santanna,C., Fukai,N., Maulik,C.,
            Garfinkle,J., Ninomiya,C., doAmaral,C., Peters,H., Habal,M.,
            Rhee-Morris,L., Doss,J.B., Kreiborg,S., Olsen,B.R. and
            Reichenberger,E.
  TITLE     Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause
            cherubism
  JOURNAL   Nat Genet 28 (2), 125-126 (2001)
   PUBMED   11381256
REFERENCE   4  (bases 1 to 2877)
  AUTHORS   Ren,R., Mayer,B.J., Cicchetti,P. and Baltimore,D.
  TITLE     Identification of a ten-amino acid proline-rich SH3 binding site
  JOURNAL   Science 259 (5098), 1157-1161 (1993)
   PUBMED   8438166
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB762696.1, EX490894.1, JAXUCZ010000014.1, DY320365.1, CO557208.1
            and BM384145.1.
            
            On or before Dec 20, 2009 this sequence version replaced
            XM_001059805.1, XM_223534.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760400, SAMN06680416
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               CB762696.1         9-423
            416-944             EX490894.1         178-706
            945-1174            JAXUCZ010000014.1  80404738-80404967   c
            1175-1909           DY320365.1         1-735
            1910-2397           CO557208.1         266-753
            2398-2877           BM384145.1         1-480               c
FEATURES             Location/Qualifiers
     source          1..2877
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2877
                     /gene="Sh3bp2"
                     /note="SH3-domain binding protein 2"
                     /db_xref="GeneID:305450"
                     /db_xref="RGD:1310588"
     exon            1..135
                     /gene="Sh3bp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1822
                     /gene="Sh3bp2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="SH3 domain-binding protein 2 isoform 1"
                     /protein_id="NP_001094154.1"
                     /db_xref="GeneID:305450"
                     /db_xref="RGD:1310588"
                     /translation="MGFGTGRGHARHSRVSETCLGPWNLCPAVSFMEAEEMHWPVPMK
                     AIGAQNLLTMPGGVAKAGYLHKKGGTQLQLLKWPLRFVIIHQRCIYYFKSSTSASPQG
                     AFSLSGYNRVMRAAEETTSNNVFPFKIIHISKKHRTWFFSASSEDERKSWMAMLRREI
                     GHFHEKKELPLDTSDSSSDTDSFYGAVERPIDISLSSYPTDNEDYEHEDEEDSYLEPD
                     SPGPMKLEDALTYPPAYPPPPVPVPRKPTFSDLPRAHSFTSKSPSPLLPPPPPKRGLM
                     DTGPAPEDAKKDPLGLRRVEPSLRVPATPRRMSDPPVSNVPTVPNLRKHPCFRDSANP
                     GPEPWTPGHGTSSVSSSTTMAITTSRNCDKLKSFHLSSRGPPASEPPPVPANKPKFLK
                     IVEEASPREAAKSAPVPPVAPRPPVQKMSMPEVTVRPAVLPRPEKTPLPHLQRSPPDG
                     QSFRGFSFEKARQPSQADTGEEDSDEDYEKVPLPNSVFVNTTESCEVERLFKATNPLG
                     EPQDGLYCIRNSSTKSGKVLVVWDESSNKVRNYRIFEKDSKFYLEGEVLFASVGSMVE
                     HYHTHVLPSHQSLLLRHPYGYAGPR"
     exon            136..275
                     /gene="Sh3bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..378
                     /gene="Sh3bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            379..496
                     /gene="Sh3bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..567
                     /gene="Sh3bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            568..656
                     /gene="Sh3bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            657..725
                     /gene="Sh3bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..1377
                     /gene="Sh3bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1486
                     /gene="Sh3bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1542
                     /gene="Sh3bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1624
                     /gene="Sh3bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1684
                     /gene="Sh3bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..2860
                     /gene="Sh3bp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggacgcag agtcggtggg ctgggaaccg gcgggtaagg cactgcatgg gttttgggac
       61 cggtcgtgga catgcgcggc acagtcgtgt ctcagagacc tgcctgggtc cctggaacct
      121 gtgtcccgct gtgagcttca tggaggctga ggaaatgcat tggcctgtcc ccatgaaggc
      181 cattggtgcc cagaatttgc tgactatgcc tggtggtgtg gccaaggctg gttacttgca
      241 caagaagggt ggcacccagc tgcaactgct caaatggccc ctccgctttg tgatcatcca
      301 ccagcgctgc atctactact tcaagagcag cacatctgcc tccccgcagg gcgccttctc
      361 actgagcggc tacaacagag tgatgcgggc agctgaggag accacatcca acaatgtctt
      421 cccgttcaag atcattcaca tcagcaagaa acaccgcacg tggttcttct cagcctcctc
      481 tgaggacgag cgcaagagct ggatggccat gctacgcagg gaaattggcc acttccatga
      541 gaagaaggaa ctacctctgg ataccagcga ctctagctca gacacggaca gcttctatgg
      601 tgcagttgag cgacctatag atatcagcct gtcttcatat cccacagaca acgaagatta
      661 cgaacatgag gatgaagaag actcgtactt ggagcctgat tccccgggac ccatgaaact
      721 tgaagatgcc ctgacctatc caccagccta cccaccaccc cctgtacctg tacctcggaa
      781 gccaaccttc tctgacttgc cccgtgccca ctctttcacc tccaaaagcc caagcccctt
      841 actgccaccc ccacctccta agcgaggcct tatggacact ggccctgccc ctgaggatgc
      901 taagaaggac cccctgggcc tgaggcgagt agagcctagc ctcagggtgc ctgctacccc
      961 tcggaggatg agtgaccccc cagtgagcaa cgtacccact gtgcccaacc tccggaaaca
     1021 tccttgcttc cgagacagtg cgaatcctgg cccagaaccc tggacccctg gccacgggac
     1081 tagctctgtc tccagctcta ccaccatggc cattaccacc tctaggaact gtgacaaact
     1141 caagtcattt cacctgtctt cccgagggcc acctgcatct gagcccccac ctgtgcctgc
     1201 caataaaccc aagttcctga agatagttga agaagcttct ccaagggaag cagccaagtc
     1261 tgcacctgtg ccccctgtgg cccccaggcc tccggtgcag aagatgtcca tgcctgaggt
     1321 taccgttcgg cctgcagtgc tgcctagacc agagaagaca cctcttcccc acctccagcg
     1381 atcccctccg gatggacaga gtttcagggg cttctccttt gaaaaggccc gtcagccctc
     1441 acaggctgac actggcgagg aggactcaga tgaagactat gagaaggtgc cgctgcctaa
     1501 ctcagtgttt gtcaacacca cagagtcctg cgaggtggaa aggttgttca aagccacaaa
     1561 ccctctcgga gagcctcagg atgggctgta ttgtattcgg aactcctcta ccaagtcagg
     1621 gaaggtcttg gtcgtgtggg atgaatcttc aaacaaagtg aggaattatc gcatctttga
     1681 gaaggattct aagttctacc tggaaggtga ggttctgttt gcaagtgtgg gcagcatggt
     1741 ggagcactac cacacccacg tgctgcctag ccaccagagc ctgttgctgc ggcacccgta
     1801 cggctacgct gggcccaggt gacatcattt cacacagctg ttgggtggaa gcatccacag
     1861 ggccacagcc ctgccacata gatggagacc ggcttgcatg ggaagatgaa caggagtggc
     1921 cttgatgtca gacacctagc ctcagtgagc aggctgggtt ccaggctgga gcaggccaca
     1981 actaaaggac tggtggatga cttgacccat ccagcccctc cacggcccac ctctcaagaa
     2041 cccaggtctg gtgctaagtg ctgcctgggt tttgatggca caagagctag tctctattac
     2101 atgcccactc tggagtgggc tgggaccaag caaggctggg ttagttgaat ggtacctaag
     2161 ccttgtcccg ggacccatag gaatgctaag acataggaat gctcaaggag gggccattgc
     2221 ctctctataa atcagagatg acctttgtct caaatgacca gggcttgatt ggcacagagc
     2281 aggcagcagg ctctactgag caccaccagt gtccaggtag agagctacca gaggcagccc
     2341 taatgggtgg tctttagtct tccagggcac aggctgctga gggagctaac tggatccacc
     2401 tggatctctc agtcttgcct ggagcctgac cttgaaaggc ccagttagca gttattaacc
     2461 acctatgtga ctggcctggt gctggagctg gttgccggct gtaagcagcc cctagtccag
     2521 cctggccaag cttagtctag agcactctat gagatgctgc cgctggaggt gctgtattct
     2581 gggatccagg agcttagaat ccagtggggt tggtgggtcg ggggtcaggg gaaggttcca
     2641 gttacacttc ttcctgaagt gctgacgaga gtgaagtggg acaggccaag gaaaggtggg
     2701 gctagtggca tccacatacc cccaagtagt ttgggtaatc ccagttggtc caggccacac
     2761 ccctggcaca gctgtttaga ctgggctttt tctgtgaaaa taaacgcatc tggatgtcag
     2821 ggccggcaga gaccttggca ccattgcact ttatgttgga aaaaaaaaaa aaaaaaa
//
