LOCUS       NM_001171981            2407 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SH3-domain binding protein 1 (Sh3bp1), mRNA.
ACCESSION   NM_001171981
VERSION     NM_001171981.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2407)
  AUTHORS   Schlam,D., Bagshaw,R.D., Freeman,S.A., Collins,R.F., Pawson,T.,
            Fairn,G.D. and Grinstein,S.
  TITLE     Phosphoinositide 3-kinase enables phagocytosis of large particles
            by terminating actin assembly through Rac/Cdc42 GTPase-activating
            proteins
  JOURNAL   Nat Commun 6, 8623 (2015)
   PUBMED   26465210
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2407)
  AUTHORS   Tata,A., Stoppel,D.C., Hong,S., Ben-Zvi,A., Xie,T. and Gu,C.
  TITLE     An image-based RNAi screen identifies SH3BP1 as a key effector of
            Semaphorin 3E-PlexinD1 signaling
  JOURNAL   J Cell Biol 205 (4), 573-590 (2014)
   PUBMED   24841563
REFERENCE   3  (bases 1 to 2407)
  AUTHORS   Elbediwy,A., Zihni,C., Terry,S.J., Clark,P., Matter,K. and
            Balda,M.S.
  TITLE     Epithelial junction formation requires confinement of Cdc42
            activity by a novel SH3BP1 complex
  JOURNAL   J Cell Biol 198 (4), 677-693 (2012)
   PUBMED   22891260
REFERENCE   4  (bases 1 to 2407)
  AUTHORS   Parrini,M.C., Sadou-Dubourgnoux,A., Aoki,K., Kunida,K.,
            Biondini,M., Hatzoglou,A., Poullet,P., Formstecher,E., Yeaman,C.,
            Matsuda,M., Rosse,C. and Camonis,J.
  TITLE     SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front
            to drive cell motility
  JOURNAL   Mol Cell 42 (5), 650-661 (2011)
   PUBMED   21658605
  REMARK    GeneRIF: SH3BP1 downregulates Rac1 at the motile-cell front and is
            required for cell motility.
REFERENCE   5  (bases 1 to 2407)
  AUTHORS   Cicchetti,P., Ridley,A.J., Zheng,Y., Cerione,R.A. and Baltimore,D.
  TITLE     3BP-1, an SH3 domain binding protein, has GAP activity for Rac and
            inhibits growth factor-induced membrane ruffling in fibroblasts
  JOURNAL   EMBO J 14 (13), 3127-3135 (1995)
   PUBMED   7621827
REFERENCE   6  (bases 1 to 2407)
  AUTHORS   Ren,R., Mayer,B.J., Cicchetti,P. and Baltimore,D.
  TITLE     Identification of a ten-amino acid proline-rich SH3 binding site
  JOURNAL   Science 259 (5098), 1157-1161 (1993)
   PUBMED   8438166
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.21333.1,
                                           SRR26643298.40810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                JAXUCZ010000007.1  112338258-112338316
            60-102              JAXUCZ010000007.1  112339479-112339521
            103-207             JAXUCZ010000007.1  112339766-112339870
            208-284             JAXUCZ010000007.1  112340908-112340984
            285-396             JAXUCZ010000007.1  112341142-112341253
            397-473             JAXUCZ010000007.1  112341347-112341423
            474-618             JAXUCZ010000007.1  112341842-112341986
            619-687             JAXUCZ010000007.1  112342568-112342636
            688-778             JAXUCZ010000007.1  112342770-112342860
            779-924             JAXUCZ010000007.1  112343351-112343496
            925-1036            JAXUCZ010000007.1  112344087-112344198
            1037-1118           JAXUCZ010000007.1  112344529-112344610
            1119-1199           JAXUCZ010000007.1  112344704-112344784
            1200-1316           JAXUCZ010000007.1  112345546-112345662
            1317-1414           JAXUCZ010000007.1  112346257-112346354
            1415-1586           JAXUCZ010000007.1  112346652-112346823
            1587-1678           JAXUCZ010000007.1  112348610-112348701
            1679-2407           JAXUCZ010000007.1  112349931-112350659
FEATURES             Location/Qualifiers
     source          1..2407
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2407
                     /gene="Sh3bp1"
                     /note="SH3-domain binding protein 1"
                     /db_xref="GeneID:300067"
                     /db_xref="RGD:1306275"
     CDS             1..2070
                     /gene="Sh3bp1"
                     /codon_start=1
                     /product="SH3 domain-binding protein 1"
                     /protein_id="NP_001165452.1"
                     /db_xref="GeneID:300067"
                     /db_xref="RGD:1306275"
                     /translation="MMKRQLHRMRQLAHTGSSGRTPETAEFLGEDLLQVEQRLEPAKR
                     AAHNVHKRLQACLQGQSGADMDKRVKKLPLMALSTAMAESFKELDPDSSMGKALEMSC
                     AIQNQLARILAEFEMTLERDVLQPLNRLSEEELPAILKRKKSLQKLVSDWNTLKSRLS
                     QAAKNSGSSQSLGGGSSSHTHMATANKVETLKEDEEELKRKVEQCKDEYLADLYHFST
                     KEDSYANYFTHLLEIQADYHRKSLTSLDTALAELRDNHSQADSSPLTTAAPFSRVYGV
                     SLRTHLQDLGRDIALPIEACVLLLLSEGMQEEGLFRLAAGASVLKRLKQTMASDPHSL
                     EEFCSDPHAVAGALKSYLRELPEPLMTSDLYDDWMRAASLKEPGARLEALHDVCSRLP
                     QENFNNLRYLMKFLALLAEEQDVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVS
                     SIQVVGVVEVLIQNADTLFPGDINFSVSGIFSGLAPQEKPNSQQVSEELAPVAVPATA
                     ATPTPTPAPTPAPASMTVKERTESELPKPASPKVSRSPTDTTALAEDMTRKTKRPAPA
                     RPTMPPPQPSSSRSSPPALSLPAGSVSPGTPQALPRRLVGTSLRAPTVPPPLPPAPPQ
                     PARRQSRRLPVSPCPASPVISNMPAQVDQGAATEDRGGPEAVGGHPPTPVLPPQPRPR
                     GLISETD"
     exon            1..59
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            60..102
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            103..207
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..284
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..396
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            397..473
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            474..618
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..687
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..778
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..924
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1036
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1118
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1199
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1316
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1414
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1586
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1678
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..2407
                     /gene="Sh3bp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatgaaga ggcagctgca ccgcatgcgg cagctggccc acacgggcag ctcgggacgc
       61 acccctgaga ctgccgagtt cttgggtgag gacctgctgc aggtagagca gcggttggaa
      121 ccagctaagc gagcagccca caatgttcac aaaaggctgc aggcctgtct gcagggccaa
      181 agcggggctg acatggacaa gcgggtgaag aagcttcccc tcatggctct ttctaccgca
      241 atggctgaaa gcttcaagga gttggatccc gattccagca tggggaaagc cttagagatg
      301 agctgtgcca tccagaacca gctggccaga atcctagcag agtttgagat gaccctggag
      361 agagatgtcc tgcagccgct caacaggctg agcgaggagg agctgcctgc catcctcaag
      421 cgcaagaaga gccttcagaa gctggtgtct gactggaaca ccctcaaaag caggctcagc
      481 caggcagcca agaactcggg aagcagccaa agcctgggtg gtggctcaag cagtcacacc
      541 cacatggcca ctgccaacaa ggtggagacg ctgaaggaag acgaggagga gctgaagaga
      601 aaggtggaac agtgcaagga tgagtacctg gctgatctct accacttctc caccaaggag
      661 gactcatatg ccaactactt tactcatctc ctggagattc aggctgacta ccatcgcaag
      721 tcactaacct cccttgacac ggccctagct gagctgaggg acaaccacag ccaagcagac
      781 tcctccccct tgacgacggc tgcccccttc tccagagtat atggggtgtc cctgagaacc
      841 cacctgcaag atctaggccg tgacattgcc ctgcccatcg aggcttgtgt cctgttgctg
      901 ctgtcggagg gcatgcagga ggagggcctc ttccgtctgg ctgctggggc ctctgtgctg
      961 aagcgcctta agcagaccat ggcctcagat ccccacagcc tggaggaatt ctgctcggac
     1021 ccccatgctg tagcaggtgc cctcaagtcc tatctccggg agctgccaga gcccctgatg
     1081 acctctgacc tctatgatga ctggatgaga gcagccagcc tgaaggaacc aggagcccgc
     1141 ctggaggccc ttcatgatgt ttgcagccgt ctaccccagg agaacttcaa caacctccgg
     1201 tacctgatga agttcttggc actgctggcc gaggagcagg acgtgaacaa gatgacaccc
     1261 agcaacatcg ccattgtctt ggggcccaac ctgctgtggc ctcctgagaa agaaggggac
     1321 caggctcaac tggacgctgc ctctgtgtcc tccattcagg tggtgggtgt tgtcgaggtg
     1381 ctgatacaga atgcagacac cctctttcct ggagatatca acttcagtgt atcaggcatc
     1441 ttctcaggcc tggcccccca ggagaagccc aatagtcaac aggtctcaga ggaattggca
     1501 cctgttgctg tgcctgccac agccgctacc ccaactccca ccccagctcc taccccagct
     1561 ccagcctcca tgacagtaaa agaaaggaca gagtctgaat tgcccaaacc agcttccccc
     1621 aaggtcagca ggagccccac agatacaact gctttggcag aggacatgac tcggaagacc
     1681 aagcgcccag caccagcccg gcctaccatg ccacctcccc agccttccag ctcacgctca
     1741 tcccctccag ctctatccct gcccgctggc tcggtcagcc ctggcactcc ccaagctttg
     1801 ccacgccgtc tggtgggcac cagcctccgg gcccccaccg tacctccccc attaccccct
     1861 gctcctccac aacctgcccg gcgacagagc cggcgtttac cagtctcccc ctgcccagcc
     1921 tcccctgtca tttcaaacat gcctgctcag gtggaccagg gagcggctac agaggacaga
     1981 ggaggccctg aggctgtggg tgggcatccc cctaccccag ttctgccacc ccagccccgg
     2041 cccaggggcc tcatttcaga gacagattaa gcaggccctc ctgcctggca agtcttcagt
     2101 gtcccctttc tctcctcctc tccccttcct cccttgtctc ccatgatagc cctcaccatg
     2161 tgcctaggtg cctgctgggc cggcccctat ggccaggagg gctcaagcca gccctctaaa
     2221 tttcaaacct ttcctcttcc actttgagct tggagttccc acccgactcc ccactctctg
     2281 gcagggtttc aagggagcta ccagaaggaa ggacaacaga catgcctgtt cctacgggac
     2341 ttttattttt ctcttgccaa tgtatttttg taaggctcgt aaataaatta tttttaacaa
     2401 aactgga
//
