LOCUS       XP_038964637             390 aa            linear   ROD 22-FEB-2024
DEFINITION  SH2 domain-containing protein 6 isoform X1 [Rattus norvegicus].
ACCESSION   XP_038964637
VERSION     XP_038964637.1
DBLINK      BioProject: PRJNA1074393
DBSOURCE    REFSEQ: accession XM_039108709.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_086022) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_036323735.1-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/09/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Rattus norvegicus"
                     /strain="BN/NHsdMcwi"
                     /bio_material="RGD 61498"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /sex="male"
                     /tissue_type="kidney, spleen, liver"
                     /geo_loc_name="USA: Wisconsin, Milwaukee"
                     /lat_lon="43.05 N 88.04 W"
                     /collected_by="Rebecca Schilling, Melinda Dwinell"
     Protein         1..390
                     /product="SH2 domain-containing protein 6 isoform X1"
                     /calculated_mol_wt=42403
     Region          271..389
                     /region_name="SH2"
                     /note="Src homology 2 (SH2) domain; cl15255"
                     /db_xref="CDD:472789"
     Site            order(287,306,329,331)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198173"
     Site            order(330,363)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198173"
     CDS             1..390
                     /gene="Sh2d6"
                     /coded_by="XM_039108709.2:7..1179"
                     /db_xref="GeneID:691161"
                     /db_xref="RGD:1587427"
ORIGIN      
        1 mqimgttgpl slrtfvavpg lwrgkgslli ylamdrfsgs karlgpplvp arcadtqvwr
       61 envastsfpt gpetwrqrhp flkaqeevee edkyelppce vlslslapaq sfgsnensly
      121 ldrsgpldps klpppppqpt kasglpinps fpnrptsgyh fplktamnlq patpkqgpif
      181 grrgrgtpar vatdraekpd ediylecepd pppaltrsls skalmppvpl prtsglpkpv
      241 vghqearnea vdaalkagrk lsassaasaa edgsllgqpw ysgncdrqsv erallhfqkd
      301 gaytvrlssg phssqpftla vllrgrvfni pirqldgghh yalgregrnh eeifssvtam
      361 vqhymkhplp lvdrhsgsrg ftcllfptkp
//
