LOCUS       NM_001108579            3078 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus SH2 domain containing 3C (Sh2d3c), mRNA.
ACCESSION   NM_001108579 XM_001078303 XM_342414
VERSION     NM_001108579.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3078)
  AUTHORS   Gomi F, Uchida Y and Endo S.
  TITLE     Up-regulation of NSP3 by Oligomeric Abeta Accelerates Neuronal
            Death Through Cas-independent Rap1A Activation
  JOURNAL   Neuroscience 386, 182-193 (2018)
   PUBMED   29966723
  REMARK    GeneRIF: NSP3 RNAi knock-down partially rescued
            amyloid-Beta-oligomer-treated neurons.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474001.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001078303.1, XM_342414.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3078
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..3078
                     /gene="Sh2d3c"
                     /gene_synonym="NSP3"
                     /note="SH2 domain containing 3C"
                     /db_xref="GeneID:362111"
                     /db_xref="RGD:1307287"
     exon            1..123
                     /gene="Sh2d3c"
                     /gene_synonym="NSP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2648
                     /gene="Sh2d3c"
                     /gene_synonym="NSP3"
                     /codon_start=1
                     /product="SH2 domain-containing protein 3C"
                     /protein_id="NP_001102049.1"
                     /db_xref="GeneID:362111"
                     /db_xref="RGD:1307287"
                     /translation="MTEMPKKTGKKFKFFKFKGLGSLSNLPRSFSLRRSSASPSIRSC
                     PEPDTFEATQDDLVTLPKSPPAYARSSDMYSHMGTMPRPNIKKAQKQKAVQKAQEVSR
                     ESHLVSRGLPEPPDFEAAKEAEKGTETPLEDTTPSAVEVDPMRKLAGLTVDTAEKQIP
                     GDAYPERAAAELEAAGDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHG
                     RIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWHNQTLHFKINKVVVEAGESYTHI
                     RYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLSQGSS
                     KAASPASPSGPKGSHMKRRSVTMTDGLTSDKVTRGDGCPNSTSLPHPRDSIRNCALSM
                     DQIPDLHSPLSPISESPSSPAYSTVTRVHAASAAPCTAQPASPVARRSSEPQLCPGGA
                     PKPPGESDRGPHASPSHTLCKASPSPSLSSYSDPDSGHYCQLQPPVRCSREPTAGETP
                     RKARSSAERQKELSENGVPEGEWGKTFTAPVAEATSSFNLATFQSQLIPKENRPLEVG
                     LLRKVKELLSEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQ
                     LRQDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVM
                     GALEMAQISRLEQTWMTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVL
                     PFITLLECDSAPAEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQ
                     ARPELLEVFSTEFQMRLLWGSQGANSSQAWRYEKFDKVLTALSHKLEPAIRSSEL"
     exon            124..586
                     /gene="Sh2d3c"
                     /gene_synonym="NSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            587..626
                     /gene="Sh2d3c"
                     /gene_synonym="NSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            627..755
                     /gene="Sh2d3c"
                     /gene_synonym="NSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1210
                     /gene="Sh2d3c"
                     /gene_synonym="NSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1335
                     /gene="Sh2d3c"
                     /gene_synonym="NSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1865
                     /gene="Sh2d3c"
                     /gene_synonym="NSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1981
                     /gene="Sh2d3c"
                     /gene_synonym="NSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2153
                     /gene="Sh2d3c"
                     /gene_synonym="NSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2265
                     /gene="Sh2d3c"
                     /gene_synonym="NSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2472
                     /gene="Sh2d3c"
                     /gene_synonym="NSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..3078
                     /gene="Sh2d3c"
                     /gene_synonym="NSP3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccgagga ggctggtcag ccccgatgcc ttgagcctgg aacagccaca tgctagcaaa
       61 ccagggactt tgcacaactt gccaagatga cagaaatgcc caagaaaaca ggcaaaaagt
      121 tcaagttctt caagttcaag ggcctcggga gcctttccaa tctccctcgg tccttttctc
      181 tgagacggtc ttcagcctcc cctagcatcc ggtcctgtcc ggagcctgac acctttgaag
      241 ccacacagga tgacttggtg acactcccaa agagtcctcc tgcctatgca cgttccagtg
      301 acatgtacag ccacatgggc accatgcccc gccctaacat caagaaggct cagaaacaaa
      361 aggctgtcca gaaggcccag gaagtcagcc gagaatccca cctggtgtct cgagggctgc
      421 cagagccacc agacttcgag gcagccaagg aggcggagaa gggaactgaa accccactgg
      481 aggacaccac accttcagca gtagaagtgg accctatgag gaaactcgcg ggcctcacag
      541 tagacacagc ggagaagcaa atccctgggg atgcgtaccc agaaagggct gctgcagaac
      601 tggaggctgc tggggactat gtgaagttct ccaaggagaa gtacattctc gactcctcgc
      661 cagagaagct gcacaaggag ctggaggaag agctgaagct cagcagtaca gacctccgca
      721 gccatgcctg gtatcatgga cgtatccctc gtgaggtctc cgagaccctg gtgcagcgga
      781 acggcgactt cctcatccgt gactctctca ccagtctggg ggactatgtg ctcacgtgcc
      841 gctggcacaa tcagaccttg cacttcaaga tcaacaaggt ggtggtggag gctggcgaga
      901 gctacaccca catccggtac ctcttcgagc aggagagctt cgaccacgtg cccgcccttg
      961 tgcgctatca tgtgggcagc cgtaaggccg tgtccgaaca gagtggggcc atcatctact
     1021 gccccgtcaa ccgcaccttc ccactgcgct acctcgaggc cagctacggc ctgagccagg
     1081 gcagcagcaa ggctgccagc ccagccagcc cctcaggccc caagggcagc cacatgaaaa
     1141 gacgcagcgt taccatgact gatgggctca cctctgacaa ggtcacccgc ggagatggct
     1201 gccccaacag cacctcacta ccccatcctc gagactccat ccgaaactgc gccctcagca
     1261 tggaccagat cccagatcta cactctccgc tgtctcctat ctccgagagt cccagctccc
     1321 ctgcctatag caccgtaacc cgcgtccatg ctgcttctgc tgccccctgt acagcacagc
     1381 ccgcctcccc agttgcccgc cgctccagtg aacctcagct atgtcctgga ggtgctccaa
     1441 agcctcctgg ggagtcagac aggggccctc acgcaagccc gtcccacacc ctctgcaagg
     1501 cctcgccatc accgtcactc agcagctaca gtgacccaga ctctggccac tattgtcagc
     1561 tccagcctcc tgtgcgctgt agccgagagc cgacagcagg agagaccccc cggaaggctc
     1621 ggagctctgc agagaggcaa aaggaactgt cagaaaatgg agtccctgag ggggagtggg
     1681 gcaagacctt cacagcccct gtagcagaag ccacctcatc tttcaacctg gctaccttcc
     1741 agtcccagct gatccccaag gagaaccggc ctctggaggt gggcctgctg cgcaaagtca
     1801 aggagctgct gtcggaggtg gatgcccgga cgctggcccg gcatgtcacc aaggttgact
     1861 gcctggttgc taggatactg ggcgttacca aggagatgca gaccctaatg ggagtccgct
     1921 ggggcatgga gctgctcacc ctcccccatg gccggcagct aagacaagac ctgctggaaa
     1981 ggttccacac catgtccatc atgctggcgg tggatatcct gggctgcaca ggctctgcgg
     2041 aggagcgggc ggcgctgctg cacaagacca tccagctggc agctgagctg cgggggacga
     2101 tgggcaacat gttcagcttc gctgctgtca tgggcgccct ggagatggcc cagatttcaa
     2161 ggctggagca gacgtggatg actctgcggc aacgacacac ggagggtgcc attctgtatg
     2221 agaagaaact caagcctttc ctcaagagcc tgaacgaggg caaagaaggc ccgccattga
     2281 gcaacaccac ctttccacac gtgctgccct tcattaccct gctggagtgt gactccgccc
     2341 ccgccgaggg ccctgaacct tggggcagca cagaacatgg tgtggaggtt gtgctagccc
     2401 acctggaggc tgcccgcact gtggcacacc acgggggcct ctaccacacc aacgctgaag
     2461 tcaagctgca ggggttccag gcccgaccgg agctcctgga agtgttcagc acagagttcc
     2521 agatgcgtct cctctggggc agccagggtg ccaacagcag ccaggcctgg cgctatgaga
     2581 agtttgacaa agtcctcact gccttgtccc acaagctgga acctgccatc cgctctagtg
     2641 aactgtgacc ccggagatct tgcctctctg cagctgctga cagcatcggg ggcagagggg
     2701 ctcaggacat ttcctccaga gcaccacagg gacactgtga ccagcccaag aatgttctgg
     2761 gttcaaatcc aggatctctc ttgcacttcc agggtcttga atggactctg agctccactc
     2821 ttccaccaca cgtgcaccaa gtctcccttc caaagggaca ggaacctctt ctcctcccgc
     2881 cggctttcgg ctttcgctgg ctcccatttt gccgaggttc cctgtttttg agccatggga
     2941 ggctccccac ccctcttcct tcctcccggc atctatgcct agaggtgcca cggcctctat
     3001 cttactgtaa ataagcctgg tgtacatgta tgtacagaag ccatgatctc tttcatataa
     3061 taaactttaa tgactctt
//
