LOCUS       NM_207605               1587 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus SH2 domain containing 2A (Sh2d2a), mRNA.
ACCESSION   NM_207605 XM_227477
VERSION     NM_207605.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1587)
  AUTHORS   Holmes K, Roberts OL, Thomas AM and Cross MJ.
  TITLE     Vascular endothelial growth factor receptor-2: structure, function,
            intracellular signalling and therapeutic inhibition
  JOURNAL   Cell Signal 19 (10), 2003-2012 (2007)
   PUBMED   17658244
  REMARK    Review article
REFERENCE   2  (bases 1 to 1587)
  AUTHORS   Wang X and Tournier C.
  TITLE     Regulation of cellular functions by the ERK5 signalling pathway
  JOURNAL   Cell Signal 18 (6), 753-760 (2006)
   PUBMED   16376520
  REMARK    Review article
REFERENCE   3  (bases 1 to 1587)
  AUTHORS   Nejad S, Bryceson Y, Dissen E, Sundvold-Gjerstad V, Naper C,
            Rolstad B, Spurkland A and Vaage JT.
  TITLE     cDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific
            adaptor protein (TSAd): expression in T and NK cells
  JOURNAL   Immunogenetics 56 (5), 338-342 (2004)
   PUBMED   15300336
  REMARK    GeneRIF: May have a regulatory role in cellular activation of T and
            NK cells.
REFERENCE   4  (bases 1 to 1587)
  AUTHORS   Smerdel A, Dai KZ, Lorentzen AR, Flato B, Maslinski S, Thorsby E,
            Forre O and Spurkland A.
  TITLE     Genetic association between juvenile rheumatoid arthritis and
            polymorphism in the SH2D2A gene
  JOURNAL   Genes Immun 5 (4), 310-312 (2004)
   PUBMED   15129233
REFERENCE   5  (bases 1 to 1587)
  AUTHORS   Dai KZ, Harbo HF, Celius EG, Oturai A, Sorensen PS, Ryder LP, Datta
            P, Svejgaard A, Hillert J, Fredrikson S, Sandberg-Wollheim M,
            Laaksonen M, Myhr KM, Nyland H, Vartdal F and Spurkland A.
  TITLE     The T cell regulator gene SH2D2A contributes to the genetic
            susceptibility of multiple sclerosis
  JOURNAL   Genes Immun 2 (5), 263-268 (2001)
   PUBMED   11528519
REFERENCE   6  (bases 1 to 1587)
  AUTHORS   Rajagopal K, Sommers CL, Decker DC, Mitchell EO, Korthauer U,
            Sperling AI, Kozak CA, Love PE and Bluestone JA.
  TITLE     RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that
            regulates T cell activation
  JOURNAL   J Exp Med 190 (11), 1657-1668 (1999)
   PUBMED   10587356
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088087.1.
            
            On Jan 12, 2005 this sequence version replaced NM_207605.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088087.1, AF468787.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1587
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1587
                     /gene="Sh2d2a"
                     /note="SH2 domain containing 2A"
                     /db_xref="GeneID:310688"
                     /db_xref="RGD:1303076"
     exon            1..64
                     /gene="Sh2d2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1161
                     /gene="Sh2d2a"
                     /note="SH2 domain protein 2A"
                     /codon_start=1
                     /product="SH2 domain-containing protein 2A"
                     /protein_id="NP_997488.2"
                     /db_xref="GeneID:310688"
                     /db_xref="RGD:1303076"
                     /translation="MEFCLAQTCPQGNHEATSPTFSTFQPMNLTQGRCQDLGCGGKPS
                     MQALREQEVQLSPRVTHTVASASAPGAAWVLESVNREEEEPGKGELSLQAETRAWVQK
                     TQAHWLLLRTAPLWFHGFITRREAERLLQSQPLGCYLVRFSESAVTFVLSYRSRTCCR
                     HFLLAQLGDGRHVVLGEDSAHSQLQDLLQHYTECPLSPYGEMLTQPLARQTAEPAGLS
                     LRGESDSGSRRQDPDTQHSLFIQQGQAHAQAPGHKEKVRASQQKKTSQASRPRPPIPA
                     KPQLPLEVYTSPAPRPHQALPINPVYQEPDEPIAFYAMGRGSPGDAPSNIYAEVDGPR
                     EMLPIGHPTLHKCWSRPISGGQGKGVQGKKSSRRPAGRGSPS"
     exon            65..219
                     /gene="Sh2d2a"
                     /inference="alignment:Splign:2.1.0"
     exon            220..401
                     /gene="Sh2d2a"
                     /inference="alignment:Splign:2.1.0"
     exon            402..491
                     /gene="Sh2d2a"
                     /inference="alignment:Splign:2.1.0"
     exon            492..660
                     /gene="Sh2d2a"
                     /inference="alignment:Splign:2.1.0"
     exon            661..819
                     /gene="Sh2d2a"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1562
                     /gene="Sh2d2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcttttga gagcacacac acctgcttct atggagttct gcttggccca gacatgtccc
       61 caagggaatc atgaagccac ctccccaacc ttcagcacct tccagcccat gaacctgacc
      121 caggggagat gccaggactt gggttgtggg ggcaagccca gcatgcaggc tctgagggaa
      181 caggaggttc agctcagccc cagggtcacc cacacggtgg cctctgcctc agccccagga
      241 gctgcctggg tcctagagag tgtcaacagg gaggaagagg aacctgggaa aggtgaactg
      301 tcattgcaag ctgagaccag agcatgggtt cagaagaccc aggcccactg gctcttgctc
      361 aggactgccc cgctttggtt ccatggcttc attaccagaa gggaagctga gaggctactg
      421 cagtcccaac ctctaggatg ctatctggtg cgcttcagcg agagcgctgt gaccttcgtg
      481 ctgtcctaca ggagccgaac ctgctgccgt cacttcctcc ttgctcagct aggggatggg
      541 cgccacgtgg tgctgggtga agacagtgcc cactcgcagc ttcaggacct gcttcaacac
      601 tacacagagt gccccctcag cccctacggg gagatgctca cccaacccct tgctcgccag
      661 acagctgagc ctgccggtct ttccctaagg ggtgaatcag actctggaag cagaagacag
      721 gacccagaca cccagcacag cctgttcatc caacaggggc aggcccatgc ccaggcccca
      781 ggacataaag agaaagtgag ggcctcccaa cagaagaaga cttcccaggc atccagaccc
      841 aggcccccca ttcctgccaa gcctcagcta cctcttgaag tctacacaag tcctgctcca
      901 cgacctcatc aggccctacc cattaacccc gtctaccagg agcctgatga acccatagcc
      961 ttctatgcca tggggcgggg cagccctggg gatgctccta gtaatatcta tgctgaggtg
     1021 gatggcccac gggaaatgct acccattggg caccccaccc tccataagtg ctggtccagg
     1081 cctatctcag gaggccaggg aaagggggta cagggaaaga aaagctcaag aaggccagca
     1141 ggaagaggga gcccctcctg aacggcaggc aaggcgaagg aagaagcagg ctgaaccaaa
     1201 atggaatgga ccatgctact gaaaaccttt gcccagcccc aggcctgagg ttgttcctgg
     1261 acatgcacat ggactcagct ttgtcaagct ctacctgccc ctactcctga gaacattaaa
     1321 ggtgatgggt ttccttcaac ctttctccat cccaggctgc ctcttgtcag tcaggccttc
     1381 ctcagataca tgtggcactg atccagttcc tcggagaaga gcgcttagga gcccatgcat
     1441 tgccaccagt gggctcagag gaggaggcca cccattgtgt gcttgccctc acagtttccc
     1501 ccacagatag tttcatgtct gaatgtggta ttaatattaa atgagttgga ctcttgcccc
     1561 tgaaaaaaaa aaaaaaaaaa aaaaaaa
//
