LOCUS       NM_001421320            4406 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SH2 domain containing 1B2 (Sh2d1b2), mRNA.
ACCESSION   NM_001421320 XM_001065477
VERSION     NM_001421320.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4406)
  AUTHORS   Wang,N., Calpe,S., Westcott,J., Castro,W., Ma,C., Engel,P.,
            Schatzle,J.D. and Terhorst,C.
  TITLE     Cutting edge: The adapters EAT-2A and -2B are positive regulators
            of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse
  JOURNAL   J Immunol 185 (10), 5683-5687 (2010)
   PUBMED   20962259
REFERENCE   2  (bases 1 to 4406)
  AUTHORS   Dong,Z., Cruz-Munoz,M.E., Zhong,M.C., Chen,R., Latour,S. and
            Veillette,A.
  TITLE     Essential function for SAP family adaptors in the surveillance of
            hematopoietic cells by natural killer cells
  JOURNAL   Nat Immunol 10 (9), 973-980 (2009)
   PUBMED   19648922
REFERENCE   3  (bases 1 to 4406)
  AUTHORS   Cruz-Munoz,M.E., Dong,Z., Shi,X., Zhang,S. and Veillette,A.
  TITLE     Influence of CRACC, a SLAM family receptor coupled to the adaptor
            EAT-2, on natural killer cell function
  JOURNAL   Nat Immunol 10 (3), 297-305 (2009)
   PUBMED   19151721
REFERENCE   4  (bases 1 to 4406)
  AUTHORS   Calpe,S., Erdos,E., Liao,G., Wang,N., Rietdijk,S., Simarro,M.,
            Scholtz,B., Mooney,J., Lee,C.H., Shin,M.S., Rajnavolgyi,E.,
            Schatzle,J., Morse,H.C. 3rd, Terhorst,C. and Lanyi,A.
  TITLE     Identification and characterization of two related murine genes,
            Eat2a and Eat2b, encoding single SH2-domain adapters
  JOURNAL   Immunogenetics 58 (1), 15-25 (2006)
   PUBMED   16425036
REFERENCE   5  (bases 1 to 4406)
  AUTHORS   Roncagalli,R., Taylor,J.E., Zhang,S., Shi,X., Chen,R.,
            Cruz-Munoz,M.E., Yin,L., Latour,S. and Veillette,A.
  TITLE     Negative regulation of natural killer cell function by EAT-2, a
            SAP-related adaptor
  JOURNAL   Nat Immunol 6 (10), 1002-1010 (2005)
   PUBMED   16127454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On May 16, 2023 this sequence version replaced XM_001065477.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.16558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               JAXUCZ010000013.1  84970183-84970447
            266-329             JAXUCZ010000013.1  84985711-84985774
            330-492             JAXUCZ010000013.1  84988331-84988493
            493-4406            JAXUCZ010000013.1  84990363-84994276
FEATURES             Location/Qualifiers
     source          1..4406
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..4406
                     /gene="Sh2d1b2"
                     /note="SH2 domain containing 1B2"
                     /db_xref="GeneID:102556681"
                     /db_xref="RGD:1589042"
     exon            1..265
                     /gene="Sh2d1b2"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..530
                     /gene="Sh2d1b2"
                     /note="SH2 domain-containing protein 1B2-like; SH2 domain
                     protein 1B2"
                     /codon_start=1
                     /product="SH2 domain containing 1B2"
                     /protein_id="NP_001408249.1"
                     /db_xref="GeneID:102556681"
                     /db_xref="RGD:1589042"
                     /translation="MDLPYYHGCLTKPECEALLLKGGADGNFLIRDSESVPGALCLCV
                     SFKKRVYNYRILREKHGYYIMEAKPSTSKEVFPTLEEIIFKFKTPGQGMVVHLSNPIM
                     RRSFCPRERRLKLELNVYENTEEEYVNVLP"
     exon            266..329
                     /gene="Sh2d1b2"
                     /inference="alignment:Splign:2.1.0"
     exon            330..492
                     /gene="Sh2d1b2"
                     /inference="alignment:Splign:2.1.0"
     exon            493..4406
                     /gene="Sh2d1b2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttgttcag accacactgg aggaagggac atttcccctc cactcgtctc tccacttccc
       61 cctgcacggc tcctccttgg cctggagcgg gatctcgggg tgacaggaca gtttaagcat
      121 aaccaccctc catggatctt ccttactatc atggctgcct gaccaagcca gagtgtgaag
      181 ccctgctcct caagggagga gcagacggca actttctgat aagagacagc gagtctgtgc
      241 ctggagccct gtgcctctgt gtctcgttta aaaagcgtgt ttataactac cgaatcttga
      301 gagagaaaca tggatattac attatggagg ctaagcccag tacttcaaaa gaggtctttc
      361 caaccctaga ggaaataatc ttcaaattta aaacaccagg tcaaggaatg gtggttcatc
      421 tttcaaaccc aataatgaga aggagcttct gcccaagaga gagaagattg aagctagagt
      481 tgaatgttta tgagaacact gaggaggagt atgtaaatgt cctgccttga agacaaggat
      541 attggacaag gcaagctaca aaagagatgg ctctgctctc agctgccaca tcgtcaagtg
      601 tgaatctaaa acaccaattt ctagtgggcc actgcgaccc tctgattcgg atagcaagat
      661 ctgttctgca gccttggagg agccatttcc cagacgcccg ccttctggca caatcctcaa
      721 gaggccctaa agccactact tactgacctc ttactcccct atcttgaaat tggacagcca
      781 taacccagtc tcctgtctgg ttagaggcgg ctggcctgct tcatggttga cagctttcaa
      841 caggacaacg ggaagtgaag tttcacacag cgagcagaaa gagcactcaa cagtgacatc
      901 agagctccca tcctgtaact gtgactttag agaaatcacc ccctcgttct cagcttcttc
      961 atctattaaa taattgggtg atgcacatgt cttggaccct ccattgagcc tggttctgtc
     1021 aggcggagca ggggtctgag cagcaggatg aggacctaag gatactgaga ggaagcaaac
     1081 atgtcctccc aacctgtgag gtcgtggtcc tgatggaggt tgtgacccac cctgtaactg
     1141 caggttttat cacatgagct ccagttccca aataatggct cattggcttg ttatttatga
     1201 atgtctaaac cttgagctag aattctgaca aagtttgtaa ctcaattaac ccgtgtattc
     1261 tattctatgt cttccgaatt cctggttacg tatcctcggt ttcatacctt tcatttactc
     1321 ccagtctgga tggtgacaaa ttgtcccatg cctgattatt tcagagttcc tgtctctcta
     1381 ccagattttc catcttctaa ttctgcctca gattattttt ttttttgcca tggttcaatg
     1441 tagcctttct ttaatttgtt tgaggaaatt tctgcttata cagattaaac aaaactgtgg
     1501 taggctttct atgcatttta tccccgaaaa caccatgact gatttgcacg tagaagggtc
     1561 cagaggagtc aagccactat aaaaaccact ttccctgtgc tgcctgctgt gggctaggcc
     1621 atggtggaca tggctttggg tatgctggtc attatgatag ctacaaccac ctattctttg
     1681 gtgattcaat gctgccacct ggcccttgct actttgtggc cccagttaaa cacattgcat
     1741 ttaatccatc cacctgagca gcactgtttc tgactctaag gtctggaaat gactgacaac
     1801 aaaactcttc aaatgtgctg gcgcccctct caccagttta tgtcttatag gattcatgaa
     1861 ggccatgtct tctgggtctt cccactctag cactgcaagt ttcctgagcc ttgaaatccc
     1921 ttcatcaaca ctaagttagg ggatgttagg catctctaac tccttttcag taggctagct
     1981 tctgatagat gctttaggta atcattcaaa caaactgcct cagattattg aacatcagat
     2041 tttattgcca ggtgatcctg ccacagagta cagagattat tcctacacca tccacatttc
     2101 ctttctcttc agcttgggct agtccacgct gctttctaag cttaccttct gccagatgct
     2161 cagtcctctg gcaacagttt tcctgatccc aattccacat atgcagcact ttgctagctc
     2221 tgccttctgg taaatgtgat taaaactatt tatttttatt acttttctgg ttagcataca
     2281 aagaaatggg tgtcactcca accttttaat acctataatc attatattct gggtttttgc
     2341 tttttattgt ttcttaattt gttgtttcat tttgccttgt tttgttttca gatagaatct
     2401 tagtctagcc caagctagcc tcaaactgga ggcaatcttc ctgcctcagc ccactaagtg
     2461 ttagtcttcc aggcacaagt gaccacttgt gccttgcaag aacccctctg tctccagaga
     2521 gactctcttc tgcctatatc ccatgccttc tccattttag ctcttcctcc tgactcatag
     2581 tctactttct acactgtgat gtcctccata tgtatttgca catattaatt taaatctaga
     2641 ttttgcatat aagacaaatg tggtttgtcc ttctgaatct gacaaatttc acttaatatg
     2701 ataatctcca tgcctgtcca tctctctgtg tgattactat aagttcatta catatgtgta
     2761 ccaatgtgtg gctagtttaa agatgttctt ctttggttgg ttctattcct gcctaggttc
     2821 taagagccat cagagcatgg ctgtgcccag cttttggaaa gagatgatgc acagaaatgt
     2881 accctctttg aacacaggaa ttaagtttct gaagaactgc ttgaattgac tttaaggcac
     2941 cttgaatttt tttggctagt tcaaaatgtt aaactaaagg ctggatgaac ctgtaactca
     3001 atggtagaga acttgcttag catgtgcaaa ggccctaggg tctaatcatg agcacacata
     3061 aattaaacaa agttaattaa ggcctggtta gaacccaagt gtgttgctat acatctgaaa
     3121 tcctagctac ccaagaagat taagagtttg aggtcagggc ctgtgttcca actgctcctt
     3181 cctcaagcag aatggtgatg gcggtctttc atgaggatcc tagggaatcg ggggagtctc
     3241 tagacctgga gggtggatca atgtatcaat gtgctcatat tcactacatc gtgaagcttt
     3301 tttgtttttc tttttgcttg ctacatgctc tctgcttttc tggttcttgt ctaggaagga
     3361 gtccttcccc actccaaggt caagaaaaaa tgaggctgca ttttcttcta ttgagtttta
     3421 acttttacct tctacatttg gggagtaaca gtacagagag gctttcccct tttcactgac
     3481 atatccagtg tccagaaaac cttccacaca tagtacatac taagtatcag ttgagtaaat
     3541 gatgaattta gacttaatcc tgtatatcat aagaggttca aacctatctc tttcctcaac
     3601 tgtattaagt cagtttcata tttcactagt aaaagttcta ttcgttagta atgtatctca
     3661 gtgatggatt agcttagtaa tccaactctc caattactca gattatggct ttttcattat
     3721 aaaatatcat gtataataga tatcacaaca gttttattaa caaagctttg ttatgtctta
     3781 catcttttcc tctataaatt gtggcttgtt gcccactttg tagggcaaat tcccctctcc
     3841 aagtttttca aaactatctt agtttagcta tttatcaatc ttccaatata attgtaaggt
     3901 aacttgcttg agatgttgtg gtagaatttt gaatgaatct gccatgtgag cttaactaaa
     3961 cactttcttt aatgtgttgt cttggtcatg gtgttttgtc acagcattag aaaagtaaga
     4021 caggaatgct taaattgttt ttcaatctaa gcctactgtt aaagttcttt ttttagtaat
     4081 atttctactc tttttttttt ctcttttttt tttccggagc tggggaccga acccagggcc
     4141 ttgtgctcgc taggcaagca ctctaccgct gagctaaatc ccctagtaat atttctaatt
     4201 aaggccattt caagattttt acacgaaaaa agtctggttt attgtgctac ctttctgtgt
     4261 ttactaagat tgtcacagct cttacatctt cactgtgtta tagagtttag tcacaaagat
     4321 gaatgaaata agtatcaaac tatcctttgc atggtttaac atgatgaatt gtattttaat
     4381 aaatgattag atttaatgag ttaata
//
