LOCUS       NM_001109313            1236 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SH2 domain containing 1A (Sh2d1a), mRNA.
ACCESSION   NM_001109313 XM_001059172 XM_576903
VERSION     NM_001109313.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1236)
  AUTHORS   Dong,Z., Cruz-Munoz,M.E., Zhong,M.C., Chen,R., Latour,S. and
            Veillette,A.
  TITLE     Essential function for SAP family adaptors in the surveillance of
            hematopoietic cells by natural killer cells
  JOURNAL   Nat Immunol 10 (9), 973-980 (2009)
   PUBMED   19648922
REFERENCE   2  (bases 1 to 1236)
  AUTHORS   Lo,K.Y., Chin,W.H., Ng,Y.P., Cheng,A.W., Cheung,Z.H. and Ip,N.Y.
  TITLE     SLAM-associated protein as a potential negative regulator in Trk
            signaling
  JOURNAL   J Biol Chem 280 (50), 41744-41752 (2005)
   PUBMED   16223723
  REMARK    GeneRIF: SAP may serve as a negative regulator of Trk receptor
            activation and downstream signaling
REFERENCE   3  (bases 1 to 1236)
  AUTHORS   Roncagalli,R., Taylor,J.E., Zhang,S., Shi,X., Chen,R.,
            Cruz-Munoz,M.E., Yin,L., Latour,S. and Veillette,A.
  TITLE     Negative regulation of natural killer cell function by EAT-2, a
            SAP-related adaptor
  JOURNAL   Nat Immunol 6 (10), 1002-1010 (2005)
   PUBMED   16127454
REFERENCE   4  (bases 1 to 1236)
  AUTHORS   Crotty,S., Kersh,E.N., Cannons,J., Schwartzberg,P.L. and Ahmed,R.
  TITLE     SAP is required for generating long-term humoral immunity
  JOURNAL   Nature 421 (6920), 282-287 (2003)
   PUBMED   12529646
REFERENCE   5  (bases 1 to 1236)
  AUTHORS   Sayos,J., Wu,C., Morra,M., Wang,N., Zhang,X., Allen,D., van
            Schaik,S., Notarangelo,L., Geha,R., Roncarolo,M.G., Oettgen,H., De
            Vries,J.E., Aversa,G. and Terhorst,C.
  TITLE     The X-linked lymphoproliferative-disease gene product SAP regulates
            signals induced through the co-receptor SLAM
  JOURNAL   Nature 395 (6701), 462-469 (1998)
   PUBMED   9774102
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC167036.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001109313.3.
            
            On May 29, 2008 this sequence version replaced NM_001109313.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167036.1, CV075525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680421
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1236
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq35"
     gene            1..1236
                     /gene="Sh2d1a"
                     /gene_synonym="RGD1562408"
                     /note="SH2 domain containing 1A"
                     /db_xref="GeneID:501502"
                     /db_xref="RGD:1562408"
     exon            1..353
                     /gene="Sh2d1a"
                     /gene_synonym="RGD1562408"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..597
                     /gene="Sh2d1a"
                     /gene_synonym="RGD1562408"
                     /note="SH2 domain protein 1A"
                     /codon_start=1
                     /product="SH2 domain-containing protein 1A"
                     /protein_id="NP_001102783.2"
                     /db_xref="GeneID:501502"
                     /db_xref="RGD:1562408"
                     /translation="MDAVTVYHGKISREMGEKLLLATGLDGSYLLRDSESVPGVYCLC
                     VLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV
                     EKSSARSPQAPTGRRDSDICLKAP"
     exon            354..417
                     /gene="Sh2d1a"
                     /gene_synonym="RGD1562408"
                     /inference="alignment:Splign:2.1.0"
     exon            418..559
                     /gene="Sh2d1a"
                     /gene_synonym="RGD1562408"
                     /inference="alignment:Splign:2.1.0"
     exon            560..634
                     /gene="Sh2d1a"
                     /gene_synonym="RGD1562408"
                     /inference="alignment:Splign:2.1.0"
     exon            635..1208
                     /gene="Sh2d1a"
                     /gene_synonym="RGD1562408"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggcctta attgaagtgt gagaagaggt tttaaggcag gtagacaaca tcctgttgtt
       61 agggtgctca tttctctctc tctttttttt catactggct gccctgggag tcaggtggct
      121 gattgtgccc agcaagccac tgcagcagca acagcagcag cgcaaagtct tcctcttacc
      181 atcgtccttc tgagcccatc aaagagtttg ctaggcatgg atgcggtgac tgtgtaccac
      241 ggcaaaatca gcagggagat gggggagaag ctcttactcg ctacggggct ggatggaagc
      301 tatctgctgc gagacagcga gagtgtccct ggcgtgtact gcctgtgtgt tttgtatcaa
      361 ggttacatct atacgtatcg agtgtcccag acagaaacag gctcttggag tgctgagaca
      421 gcacctgggg tacataaaag atttttccgg aaagtaaaaa atctcatttc agcatttcag
      481 aagccagatc aaggcatcgt aacgcctctg cagtatccag ttgaaaagtc ctcggctagg
      541 agtccacaag ctcccacagg gagaagagat tctgatatct gcttgaaagc gccatgaaga
      601 agagtaactc tgtactttat tttcaataat ttaaactaaa gaaccttaca gaaggctgtg
      661 gaagagcagt ctgagatctg aagtattagg caggtcgcta tgtatatgtg agttcctcca
      721 agaaaacaag aatggtgcat ccaatctata gccacacggt tccctacaag ctataataca
      781 cttcattcca tccagttttt cttgatactt gatgattata cttctgcttt tcattgcaat
      841 tcaactaaat tgcccttaaa agaaacaaat ctgcagaaat gcaaaaactt tgcctggact
      901 ctctggtaaa attactgtgg gaacaggtct cgtgggaaag gaagagaaaa aagaaatgta
      961 gaaataagtg atggaaatta aattctaatg aaagttgtaa tggaatgtta tacctcttta
     1021 tgtagggagt aggtgaattt caaattatac attgtcaagt gttcatatat ttggctatgt
     1081 tgtatatatt atttcatata tatgtagtct atatattata gaacttctag gtggcttgag
     1141 aataaatggc atccttattt tatacattat tttgctgggt taaaaaataa aacatatact
     1201 tatttctaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
