LOCUS       NM_001402348            4299 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SH2B adaptor protein 3 (Sh2b3), mRNA.
ACCESSION   NM_001402348
VERSION     NM_001402348.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4299)
  AUTHORS   Pan,J., Peng,R., Cheng,N., Chen,F. and Gao,B.
  TITLE     LNK protein: Low expression in human colorectal carcinoma and
            relationship with tumor invasion
  JOURNAL   Biomed Pharmacother 121, 109467 (2020)
   PUBMED   31706103
REFERENCE   2  (bases 1 to 4299)
  AUTHORS   Wang,Y., Jin,B.J., Chen,Q., Yan,B.J. and Liu,Z.L.
  TITLE     MicroRNA-29b upregulation improves myocardial fibrosis and cardiac
            function in myocardial infarction rats through targeting SH2B3
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (22), 10115-10122 (2019)
   PUBMED   31799683
  REMARK    GeneRIF: MicroRNA-29b upregulation improves myocardial fibrosis and
            cardiac function in myocardial infarction rats through targeting
            SH2B3.
REFERENCE   3  (bases 1 to 4299)
  AUTHORS   Wang,W., Tang,Y., Wang,Y., Tascau,L., Balcerek,J., Tong,W.,
            Levine,R.L., Welch,C., Tall,A.R. and Wang,N.
  TITLE     LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis
  JOURNAL   Circ Res 119 (6), e91-e103 (2016)
   PUBMED   27430239
REFERENCE   4  (bases 1 to 4299)
  AUTHORS   Timofeeva,M.N., Kinnersley,B., Farrington,S.M., Whiffin,N.,
            Palles,C., Svinti,V., Lloyd,A., Gorman,M., Ooi,L.Y., Hosking,F.,
            Barclay,E., Zgaga,L., Dobbins,S., Martin,L., Theodoratou,E.,
            Broderick,P., Tenesa,A., Smillie,C., Grimes,G., Hayward,C.,
            Campbell,A., Porteous,D., Deary,I.J., Harris,S.E., Northwood,E.L.,
            Barrett,J.H., Smith,G., Wolf,R., Forman,D., Morreau,H., Ruano,D.,
            Tops,C., Wijnen,J., Schrumpf,M., Boot,A., Vasen,H.F., Hes,F.J., van
            Wezel,T., Franke,A., Lieb,W., Schafmayer,C., Hampe,J., Buch,S.,
            Propping,P., Hemminki,K., Forsti,A., Westers,H., Hofstra,R.,
            Pinheiro,M., Pinto,C., Teixeira,M., Ruiz-Ponte,C.,
            Fernandez-Rozadilla,C., Carracedo,A., Castells,A.,
            Castellvi-Bel,S., Campbell,H., Bishop,D.T., Tomlinson,I.P.,
            Dunlop,M.G. and Houlston,R.S.
  TITLE     Recurrent Coding Sequence Variation Explains Only A Small Fraction
            of the Genetic Architecture of Colorectal Cancer
  JOURNAL   Sci Rep 5, 16286 (2015)
   PUBMED   26553438
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4299)
  AUTHORS   Zhu,X., Fang,J., Jiang,D.S., Zhang,P., Zhao,G.N., Zhu,X., Yang,L.,
            Wei,X. and Li,H.
  TITLE     Exacerbating Pressure Overload-Induced Cardiac Hypertrophy: Novel
            Role of Adaptor Molecule Src Homology 2-B3
  JOURNAL   Hypertension 66 (3), 571-581 (2015)
   PUBMED   26101343
  REMARK    GeneRIF: SH2B3 functions as a novel and effective modulator of
            cardiac remodeling and failure.
REFERENCE   6  (bases 1 to 4299)
  AUTHORS   Tong,W. and Lodish,H.F.
  TITLE     Lnk inhibits Tpo-mpl signaling and Tpo-mediated
            megakaryocytopoiesis
  JOURNAL   J Exp Med 200 (5), 569-580 (2004)
   PUBMED   15337790
REFERENCE   7  (bases 1 to 4299)
  AUTHORS   Nobuhisa,I., Takizawa,M., Takaki,S., Inoue,H., Okita,K., Ueno,M.,
            Takatsu,K. and Taga,T.
  TITLE     Regulation of hematopoietic development in the
            aorta-gonad-mesonephros region mediated by Lnk adaptor protein
  JOURNAL   Mol Cell Biol 23 (23), 8486-8494 (2003)
   PUBMED   14612394
REFERENCE   8  (bases 1 to 4299)
  AUTHORS   Takaki,S., Morita,H., Tezuka,Y. and Takatsu,K.
  TITLE     Enhanced hematopoiesis by hematopoietic progenitor cells lacking
            intracellular adaptor protein, Lnk
  JOURNAL   J Exp Med 195 (2), 151-160 (2002)
   PUBMED   11805142
  REMARK    Erratum:[J Exp Med 2002 May 6;195(9):1229]
REFERENCE   9  (bases 1 to 4299)
  AUTHORS   Manes,G., Leducq,R., Kucharczak,J., Pages,A., Schmitt-Bernard,C.F.
            and Hamel,C.P.
  TITLE     Rat messenger RNA for the retinal pigment epithelium-specific
            protein RPE65 gradually accumulates in two weeks from late
            embryonic days
  JOURNAL   FEBS Lett 423 (2), 133-137 (1998)
   PUBMED   9512345
REFERENCE   10 (bases 1 to 4299)
  AUTHORS   Huang,X., Li,Y., Tanaka,K., Moore,K.G. and Hayashi,J.I.
  TITLE     Cloning and characterization of Lnk, a signal transduction protein
            that links T-cell receptor activation signal to phospholipase C
            gamma 1, Grb2, and phosphatidylinositol 3-kinase
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11618-11622 (1995)
   PUBMED   8524815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JX215366.1, SRR26643292.48113.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               JAXUCZ010000012.1  40392656-40392937
            283-957             JAXUCZ010000012.1  40400407-40401081
            958-1059            JAXUCZ010000012.1  40410574-40410675
            1060-1151           JAXUCZ010000012.1  40410754-40410845
            1152-1246           JAXUCZ010000012.1  40410921-40411015
            1247-1461           JAXUCZ010000012.1  40411096-40411310
            1462-1633           JAXUCZ010000012.1  40411388-40411559
            1634-4299           JAXUCZ010000012.1  40411671-40414336
FEATURES             Location/Qualifiers
     source          1..4299
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..4299
                     /gene="Sh2b3"
                     /gene_synonym="Lnk"
                     /note="SH2B adaptor protein 3"
                     /db_xref="GeneID:58838"
                     /db_xref="RGD:68411"
     exon            1..282
                     /gene="Sh2b3"
                     /gene_synonym="Lnk"
                     /inference="alignment:Splign:2.1.0"
     exon            283..957
                     /gene="Sh2b3"
                     /gene_synonym="Lnk"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..1956
                     /gene="Sh2b3"
                     /gene_synonym="Lnk"
                     /note="linker of T-cell receptor pathways; lymphocyte
                     adapter protein; signal transduction protein Lnk;
                     lymphocyte-specific adapter protein Lnk"
                     /codon_start=1
                     /product="SH2B adapter protein 3"
                     /protein_id="NP_001389277.1"
                     /db_xref="GeneID:58838"
                     /db_xref="RGD:68411"
                     /translation="MNEPTVQPSRTSSAPASPASPRGWSDFCERHAAAAARDLARQYW
                     LFARAHPQPPRADLVSLQFAELFQRHFCREVREGLAGPPGHDYRATAPPRPALPKARS
                     SEDLGPRPSCALQHLRRGLRQLFRRRSAGELPGATSDTNDTDAIATTRPGPARKLLPW
                     SLREPSAEALKEVVLRYSLADEAAMDSGAHWQRGRLVLRSPGPGHGHLLQLFDPPKSS
                     KPKLQEACSSIQEVRPCTRLEMPDNLYTFVLKVQGQTDIIFEVGDEQQLNSWLAELRA
                     STGLGLEHLDTELPLSLVAEPGPAISPRGSTDSLDQGASPGVMLDPACQKTDHFLSCY
                     PWFHGPISRVRAAQLVQLQGPDAHGVFLVRQSESRRGEYVLTFNLQGRAKHLRLVLTE
                     RGQCRVQHLHFPSVVDMLRHFQRSPIPLECGAACDVRLSGYVVVVSQAPGSSNTVLFP
                     FSLPHWDSELGHPHLSSAGCPPGHGAEALRGQVTPPEQIFHLVPSPEELANSLRQLEL
                     ESVSSARDSDYEMDSSSRSHLRAIDNQYTPLSQLCREANL"
     exon            958..1059
                     /gene="Sh2b3"
                     /gene_synonym="Lnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1151
                     /gene="Sh2b3"
                     /gene_synonym="Lnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1246
                     /gene="Sh2b3"
                     /gene_synonym="Lnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1461
                     /gene="Sh2b3"
                     /gene_synonym="Lnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1633
                     /gene="Sh2b3"
                     /gene_synonym="Lnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..4299
                     /gene="Sh2b3"
                     /gene_synonym="Lnk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctttacat aacggcgtgg ggcggcatgg gctcgggccg tcgtcgcctc cgcctggccg
       61 ctctcccgcc cagactgtca cgggccacgg ggtccacagc agcggcggca gcagcagcag
      121 cgtcccgggg gcgtcccggg gccgcgtccc ctggctgctg tcaggagctg gcggcggaaa
      181 tgaggcgctg gccgttttcc gagccggggt ttcctgcctg agctccgaga ggccgtgcaa
      241 cgacgccatg ggccggctgg gccccgaccc gcagcttgcg cgcccggctg ccccgcctcg
      301 ctctccacca tgaacgagcc caccgtgcag ccgtcccgca cgtcctcggc acccgcctcg
      361 ccagcatccc cgcgcggctg gagtgacttc tgcgagcgac acgcagcagc cgcggcgcgg
      421 gatctggccc gccagtactg gctgtttgcg cgtgcgcacc cacagccgcc gcgcgccgac
      481 ctagtgtcgc tgcagttcgc cgagctcttc cagcgccact tctgtcggga ggtgcgcgag
      541 ggcctcgcgg ggccgccagg tcacgactac cgtgctactg ccccgccccg ccccgcgctg
      601 cccaaggcac gcagctccga ggacctgggc ccacggccct cctgcgccct gcagcacctg
      661 cgccgcggcc tgcgccagct cttccgccgc cgctcggctg gggagctgcc gggggctacc
      721 agtgacacca atgacaccga cgccatcgcc accaccaggc cgggccctgc ccgcaagttg
      781 ctaccctgga gcctgcgaga gccgtccgcc gaggcgctca aggaggtggt attgcgctac
      841 agcctggcgg atgaggcggc aatggacagc ggcgcgcact ggcagcgggg tcgcctggtg
      901 cttcggtctc caggtccagg ccacggccac cttctgcagc tcttcgatcc gcccaagagc
      961 tcaaagccca agctccaaga ggcctgctcc agcatccagg aggtccgacc ctgcacacgc
     1021 ctggagatgc cggacaacct ctacaccttt gtgttgaagg tgcagggcca gacagacatc
     1081 atctttgagg tgggagatga acagcagctg aactcatggc tggcagaact cagggcaagc
     1141 acaggcctag ggttggagca cctggacaca gagttacctc tttccttagt ggcagagcct
     1201 ggcccagcta tatccccaag gggaagcacg gactccctgg accaaggtgc ttcacctggg
     1261 gtgatgttgg acccagcctg ccagaaaaca gatcacttcc tgtcctgcta cccctggttc
     1321 cacggcccca tctccagggt gagggctgca cagctggttc agctgcaggg ccctgatgcc
     1381 cacggtgtgt tcctggtgcg gcagagtgag tcccggagag gggaatatgt actcacattc
     1441 aacttacagg gcagagccaa gcacctccgc ctggtgctca cagagcgtgg acagtgccgg
     1501 gtgcaacacc tgcacttccc ctcggtggtg gatatgctcc gccacttcca gcgctccccc
     1561 atcccacttg aatgtggagc agcctgtgat gtccgactct ctggctatgt ggtagtcgtc
     1621 tctcaggcac caggttcctc caacaccgtt ctcttcccct tttcccttcc tcactgggac
     1681 tcagagctgg gccatcccca cctcagctct gctggctgtc cccctggcca tggtgcagag
     1741 gctctccgtg gccaagtgac acctcctgag cagatcttcc acctggtgcc ttctcctgag
     1801 gaactggcca acagtctgcg gcagctggag cttgagtctg tgagcagtgc ccgggactca
     1861 gactatgaaa tggactcctc ctcacggagc caccttcggg ccattgacaa ccagtacacc
     1921 cctctctcac agctgtgcag agaggcaaac ttgtgaatgt aaccattttc cttccctcca
     1981 gagaactaca ggctgctgct gtcagccttc cccagctcag atgtgccctg cttccaccac
     2041 acacaaggct gtcacaggct tcctgtcagc cacagctagc cctggcttct tcccactgtc
     2101 tgtagatgta gttcttgtgc acaggtgcca ctagctggca cccaaggcct cgttcccaac
     2161 ccagaggagg cggggctgca ggcccagagc tggcagtgga aactgacaga gctgatgaca
     2221 gacttcttac caggtagggt catcgggaag cacaaaacac taacagtccc tggattctca
     2281 catggtgtcc ttccctgtag cttcattctg tggcaagtct aagtcccatg tcacaggcga
     2341 tggacacttc ataatcctgc ttctactctt agctttggac agaagctctg ccagaggggc
     2401 aagcttaaag atcaaaaatg atttaaacat tttacctcag agtaattatt tttaaagggt
     2461 tcaggtttcc acttgatatt atagcttact tcactgcact gccctgctac cccctgccac
     2521 tgtaaagttg ggggcagctg agtccccctg ctttgcttac cttgagccag gctagcatgc
     2581 tagtgtcctt gtctgctcac cctcaggaca gttgcctgct acggggtagc cactgtcctc
     2641 cctaatgtag agaatgaagt gtgtcaccct ttcagggaaa tccaggcagc ttgcagagag
     2701 aggagggtgg caggggacat tccaccccag tgccttatgc attaaaaaca aaatcaggac
     2761 tgtggtttac agcagcgtta gaggatgaga tgaatgggtg ggggaagaca aacacagatg
     2821 gaaggcctct aggcttcttt agtgaaccca cattttactc cccccaaccc cctcccagca
     2881 tctaggggct tagtgagttt ggcccatgct atgaagaaac tcctgtaacc gctcctaggt
     2941 gttcttatcc atacaatctt tccatctaga cagagccaaa actgtcatct ttcctaaggg
     3001 atgcagttca cagggactgg agcaggctgt tcatggcaca aacagtgctt acagcagtgg
     3061 ctttgggaaa ccacaactta attccttgaa cattgagagg cagccatgct gctgccctgc
     3121 tgcagacagc agtgctgact ccccctctgc tcaccttgca ctcgggaagc ctgcgtgggc
     3181 tttggtgagg gaagcagctg cacctcagct tcgacaccca ccacaggtgt ggacctgtgc
     3241 tcatcttagg acagcgcctt ccttcactgc acatcaggta tgaaccagag acgtgagcag
     3301 taacagccag tgggccaggc cggctctaat ccacacagga tgcgtggacg gctgtgccct
     3361 gcacctggcc aggagctaaa cccacttcaa acttggggca ctcatttctc ctgggccttc
     3421 aaagagagac ttgctaggtg ctgtaagcca gcaccttggc cccttagtgc tgggattcac
     3481 tcactgtgga cagctttgtt tcaaaaaatg tccaagatat cagaaaacaa ggtaaaaaag
     3541 tctcatgact ctgtgacaga gtgacaacac taagccagca ccttttcttt aagctaaagt
     3601 aggtccagtt ggctgacggg gacagacggg taccgggtat gagaactcct gggccagata
     3661 ccctgtgtca aagccaggcc ccactcccac cctcagcagt gtcttctggc cacacaaggc
     3721 aggatgggtc agttggccac tagagacaga gcagctcaac agtcctgaac ccctgctccc
     3781 ttctcccgag tactcaactc agactaacaa gcaccagcac caaagagtta ggtcaactaa
     3841 cctgccttgt ctttaccagc atccacatgg ctttatctgt ataaatcttc tgcctttgat
     3901 catttctgga tggtgtagga aaaaaggaat agtgaccatt acagtcttgg gccagacaac
     3961 actattttta cctaagtctc ttaacctaaa ttaaggcttc acctcttccc tgagggctca
     4021 gtctcttgtt taaatgttac cttggtgcaa ataaaagtga taaactgtcc cccactgcct
     4081 cctgacgagg acacatctgt ctaatggcca gcgtgtggct ggaataagca gcattgtgac
     4141 cacaggatca ggggacttca tcttctatca ttagagcaga aggtatttgg caaatctttg
     4201 ttttatgtac tgtacgagta acttattctt gaataatgca aattttccta caatgtacaa
     4261 attgctgtat gtgaattaaa aaggttttca gaattacaa
//
