LOCUS       NM_053669               2807 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus SH2B adaptor protein 2 (Sh2b2), mRNA.
ACCESSION   NM_053669
VERSION     NM_053669.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2807)
  AUTHORS   Wu,Y. and Smas,C.M.
  TITLE     Wdnm1-like, a new adipokine with a role in MMP-2 activation
  JOURNAL   Am J Physiol Endocrinol Metab 295 (1), E205-E215 (2008)
   PUBMED   18492766
REFERENCE   2  (bases 1 to 2807)
  AUTHORS   Youngren,J.F.
  TITLE     Regulation of insulin receptor function
  JOURNAL   Cell Mol Life Sci 64 (7-8), 873-891 (2007)
   PUBMED   17347799
  REMARK    Review article
REFERENCE   3  (bases 1 to 2807)
  AUTHORS   Hu,J. and Hubbard,S.R.
  TITLE     Structural basis for phosphotyrosine recognition by the Src
            homology-2 domains of the adapter proteins SH2-B and APS
  JOURNAL   J Mol Biol 361 (1), 69-79 (2006)
   PUBMED   16824542
REFERENCE   4  (bases 1 to 2807)
  AUTHORS   Katsanakis,K.D. and Pillay,T.S.
  TITLE     Cross-talk between the two divergent insulin signaling pathways is
            revealed by the protein kinase B (Akt)-mediated phosphorylation of
            adapter protein APS on serine 588
  JOURNAL   J Biol Chem 280 (45), 37827-37832 (2005)
   PUBMED   16141217
  REMARK    GeneRIF: APS was identified as a novel substrate for protein kinase
            B/Akt.
REFERENCE   5  (bases 1 to 2807)
  AUTHORS   Barres,R., Gonzalez,T., Le Marchand-Brustel,Y. and Tanti,J.F.
  TITLE     The interaction between the adaptor protein APS and Enigma is
            involved in actin organisation
  JOURNAL   Exp Cell Res 308 (2), 334-344 (2005)
   PUBMED   15946664
REFERENCE   6  (bases 1 to 2807)
  AUTHORS   Wakioka,T., Sasaki,A., Mitsui,K., Yokouchi,M., Inoue,A., Komiya,S.
            and Yoshimura,A.
  TITLE     APS, an adaptor protein containing Pleckstrin homology (PH) and Src
            homology-2 (SH2) domains inhibits the JAK-STAT pathway in
            collaboration with c-Cbl
  JOURNAL   Leukemia 13 (5), 760-767 (1999)
   PUBMED   10374881
REFERENCE   7  (bases 1 to 2807)
  AUTHORS   Moodie,S.A., Alleman-Sposeto,J. and Gustafson,T.A.
  TITLE     Identification of the APS protein as a novel insulin receptor
            substrate
  JOURNAL   J Biol Chem 274 (16), 11186-11193 (1999)
   PUBMED   10196204
REFERENCE   8  (bases 1 to 2807)
  AUTHORS   Yokouchi,M., Wakioka,T., Sakamoto,H., Yasukawa,H., Ohtsuka,S.,
            Sasaki,A., Ohtsubo,M., Valius,M., Inoue,A., Komiya,S. and
            Yoshimura,A.
  TITLE     APS, an adaptor protein containing PH and SH2 domains, is
            associated with the PDGF receptor and c-Cbl and inhibits
            PDGF-induced mitogenesis
  JOURNAL   Oncogene 18 (3), 759-767 (1999)
   PUBMED   9989826
REFERENCE   9  (bases 1 to 2807)
  AUTHORS   Qian,X., Riccio,A., Zhang,Y. and Ginty,D.D.
  TITLE     Identification and characterization of novel substrates of Trk
            receptors in developing neurons
  JOURNAL   Neuron 21 (5), 1017-1029 (1998)
   PUBMED   9856458
REFERENCE   10 (bases 1 to 2807)
  AUTHORS   Yokouchi,M., Suzuki,R., Masuhara,M., Komiya,S., Inoue,A. and
            Yoshimura,A.
  TITLE     Cloning and characterization of APS, an adaptor molecule containing
            PH and SH2 domains that is tyrosine phosphorylated upon B-cell
            receptor stimulation
  JOURNAL   Oncogene 15 (1), 7-15 (1997)
   PUBMED   9233773
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053669.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF095576.1, SRR22582416.870836.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               JAXUCZ010000012.1  26065672-26065908
            238-971             JAXUCZ010000012.1  26078436-26079169
            972-1073            JAXUCZ010000012.1  26084068-26084169
            1074-1165           JAXUCZ010000012.1  26085978-26086069
            1166-1257           JAXUCZ010000012.1  26086872-26086963
            1258-1425           JAXUCZ010000012.1  26087052-26087219
            1426-1634           JAXUCZ010000012.1  26088764-26088972
            1635-1806           JAXUCZ010000012.1  26091658-26091829
            1807-2807           JAXUCZ010000012.1  26092468-26093468
FEATURES             Location/Qualifiers
     source          1..2807
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2807
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /note="SH2B adaptor protein 2"
                     /db_xref="GeneID:114203"
                     /db_xref="RGD:69284"
     exon            1..237
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     exon            238..971
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..2129
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /note="adaptor protein with pleckstrin homology and src
                     homology 2 domains; SH2 and PH domain-containing adapter
                     protein APS; adapter protein with pleckstrin homology and
                     Src homology 2 domains"
                     /codon_start=1
                     /product="SH2B adapter protein 2"
                     /protein_id="NP_446121.1"
                     /db_xref="GeneID:114203"
                     /db_xref="RGD:69284"
                     /translation="MNGATPGSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDN
                     PTYDTPDAGTSFSRHFAANFLAVFSEEVRRVLGTAADTMEPEPAVTSVTSALKTATYG
                     HSRSSEDVSAHVATKARVRKGFSLRNMSLCVVDGVRDLWHRRASPEPEGGATPKTTEP
                     VSEPRDKWTRRLRLARTLAAKVELVDIQREGALRFMVADDAASGPGGTAQWQKCRLLL
                     RRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAE
                     YILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVTSCSCELLTEADM
                     PRPPETMTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSESNNTGDEGA
                     ELDPDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTF
                     NFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVR
                     AQGPPPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPTSPSNGAGASSSSGSSS
                     SATSVPPRPAEGPLSARSRSNSTEHLLEAASGATEEPADATLGRARAVENQYSFY"
     exon            972..1073
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1165
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1257
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1425
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1634
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1806
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2807
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaagaggga gagaacctca aggggcccgc cccgggactg ctaagagcgc acgagcctcg
       61 cagactgcag gccagggaag cgggagccag cccccgccgc cgccgccacc accggccacc
      121 aagggcggag ctacggcccg gagggccatg cgccaccggg tccgaggatc ccggccgcgg
      181 tccgggcagc gcttctccgg cgccccggcc ggcgcggccg aagctgcgcg cctgtagtcc
      241 gaggctgcca tgggaccaaa gccatgaatg gtgccacccc cggctcggca gccgcccccg
      301 ccccagtccc cgactggagg caattctgcg agctgcacgc tcaggtagct gctgtggact
      361 tcgctcacaa gttctgccgc ttccttcggg acaacccgac ctacgacacg cctgacgctg
      421 ggacctcgtt ctcccgccac tttgcagcca acttcttggc agtcttcagc gaggaagtgc
      481 gccgcgtgct ggggacagca gctgacacca tggaacccga gcctgcggtg acctccgtga
      541 cctcggcgct caagactgca acctatggcc actctcgcag ctccgaagat gtgtctgctc
      601 acgtggctac caaggcccgt gtccgcaaag gcttctcact gcgtaacatg agcctgtgtg
      661 tagtggacgg agtgcgcgac ctatggcacc ggcgcgcatc cccagagccc gagggtgggg
      721 ccaccccgaa aaccaccgag cctgtgtccg agcctcgtga caaatggacg cgacgtctgc
      781 ggctggcacg aaccctggca gccaaagtgg agttagtgga catccagcgc gagggcgcac
      841 tgcgcttcat ggtggcagat gatgcagcct ccggccctgg gggcacggca cagtggcaga
      901 aatgtcgcct gctcctccga agggctgtgg ccggagagcg cttccgcctg gagttcttcg
      961 tgccacccaa ggcttccaga cccaaggtca gcatccccct gtcggccatc atcgaggtcc
     1021 gaaccaccat gcccctggaa atgcctgaga aggacaacac atttgtgctc aaggtggaga
     1081 acggagcgga gtacattctg gagacgatag actcactaca gaagcactcg tgggtggctg
     1141 acatccaggg ctgtgtggat cctggggaca gtgaggaaga cacagggctg tcttgtgcac
     1201 ggggaggctg tctggccagc cgcgtgacct cctgcagctg tgagctcctg acagaagcag
     1261 acatgccccg gcccccagag acgatgacag cagtgggtgc tgtggttaca gctccacatg
     1321 gccgagctcg tgacaccgtg ggagagtccc tggctcacgt tcccctggag actttcctgc
     1381 aaaccctgga gtcttcaggt ggtgtcagtg agagcaataa cacaggggat gaaggagctg
     1441 agctggaccc cgatgctgag gctgagctgg aactctccga ctacccctgg ttccatggga
     1501 cactgtcccg ggtgaaggcc gcccagctgg tgttggctgg tgggccccgg agtcacggcc
     1561 tctttgtgat ccgccaaagc gagactcggc ctggggagtg tgtgctgacc ttcaacttcc
     1621 agggcaaggc caagcacctt cgcctttctc tgaatggtca cggccagtgt catgtccaac
     1681 acctgtggtt ccagtcggtg tttgacatgc ttcgacactt ccacacccac cccattcccc
     1741 tggagtcagg aggatccgct gacatcaccc tacgaagcta cgtgcgtgcc caaggtccac
     1801 ctcctgatcc aggaccagcg cccaacactg cagccccggt cccggcctgc tggacggagc
     1861 cggctggcca gcactacttc tccagcctgg ccacggccac ctgcccaccc acttcaccct
     1921 ccaatggcgc tggagcatcg tcgtcatccg gttcatcatc ctctgctacg tccgtgcccc
     1981 cacgcccagc cgaggggcca ctcagtgcgc gcagtcgcag caacagcaca gagcacctgc
     2041 tagaggctgc atccggagcc actgaggagc ccgcagatgc cacgctgggc cgcgctcgcg
     2101 ctgtggagaa tcagtactcc ttttactagc tgccatgcct attacccacg ggtgtcacgc
     2161 acaacacagc aggccacgaa cacctgctgt ctgtcctgcc cacccacagc ctggctagcc
     2221 catgacggtc aacaacacct aacaaatggc tagacacacc tatccatggt ctagcatggc
     2281 caagacagat ggccagccta gccacttcaa accccagggg cccattatga ccgtgtgtgg
     2341 caggccaagg ctaagtccat ggtcgatcaa acccatgata gccctccaat gatttcacgc
     2401 cccgcccact ggtggttggc cacgcccacc agcagctatt tctatacagt ccatcgtatc
     2461 cacgacaggc agctcactga caactaacca catttggtga cttcaggccc tgcctactgt
     2521 tggttggtta ctcctacagt ggcatcatgg ccaacccact ggctgcctgc tttgctcgag
     2581 ggtagcaagc cacgtctatc aagcccatga aggcttaccc actgattcct aacaacctca
     2641 ggccctgccc acccatgttg ggtcacatac tccaatagcc caccaggctg tggtccgcct
     2701 agcctaggac agcctgtcac gcccaccagc cccagcccaa cgctgggggg aaaagccaag
     2761 ctcttcagtg aagacaaaca ttattaaaga gcctgtttta gggacta
//
