LOCUS       NM_134456               2991 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus SH2B adaptor protein 1 (Sh2b1), transcript
            variant 1, mRNA.
ACCESSION   NM_134456
VERSION     NM_134456.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2991)
  AUTHORS   Liu,B.L., Cheng,M., Hu,S., Wang,S., Wang,L., Tu,X., Huang,C.X.,
            Jiang,H. and Wu,G.
  TITLE     Overexpression of miR-142-3p improves mitochondrial function in
            cardiac hypertrophy
  JOURNAL   Biomed Pharmacother 108, 1347-1356 (2018)
   PUBMED   30372837
  REMARK    GeneRIF: miR-14 2-3 p not only mitigate cardiac hypertrophy by
            directly inhibit the expression of gene SH2B1, but also can protect
            mitochondrial function in cardiac hypertrophy of vitro and vivo.
REFERENCE   2  (bases 1 to 2991)
  AUTHORS   Yuan,J., Zeng,L., Sun,Y., Wang,N., Sun,Q., Cheng,Z. and Wang,Y.
  TITLE     SH2B1 protects against OGD/R-induced apoptosis in PC12 cells via
            activation of the JAK2/STAT3 signaling pathway
  JOURNAL   Mol Med Rep 18 (3), 2613-2620 (2018)
   PUBMED   30015896
  REMARK    GeneRIF: SH2B1 overexpression resulted in increased viability,
            reduced lactate dehydrogenase release and a reduction in the
            expression levels of proteins associated with the apoptotic cascade
            in PC12 cells under the oxygenglucose deprivation condition.
REFERENCE   3  (bases 1 to 2991)
  AUTHORS   Franquinho,F., Nogueira-Rodrigues,J., Duarte,J.M., Esteves,S.S.,
            Carter-Su,C., Monaco,A.P., Molnar,Z., Velayos-Baeza,A., Brites,P.
            and Sousa,M.M.
  TITLE     The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth
            Through Smad2 Signaling
  JOURNAL   Cereb Cortex 27 (3), 1732-1747 (2017)
   PUBMED   28334068
REFERENCE   4  (bases 1 to 2991)
  AUTHORS   Chen,C.J., Shih,C.H., Chang,Y.J., Hong,S.J., Li,T.N., Wang,L.H. and
            Chen,L.
  TITLE     SH2B1 and IRSp53 proteins promote the formation of dendrites and
            dendritic branches
  JOURNAL   J Biol Chem 290 (10), 6010-6021 (2015)
   PUBMED   25586189
  REMARK    GeneRIF: These findings suggest that SH2B1-IRSp53 complexes promote
            the formation of filopodia, neurite initiation, and neuronal
            branching.
REFERENCE   5  (bases 1 to 2991)
  AUTHORS   Shih,C.H., Chen,C.J. and Chen,L.
  TITLE     New function of the adaptor protein SH2B1 in brain-derived
            neurotrophic factor-induced neurite outgrowth
  JOURNAL   PLoS One 8 (11), e79619 (2013)
   PUBMED   24260264
  REMARK    GeneRIF: findings demonstrate that SH2B1beta promotes BDNF-induced
            neurite outgrowth through enhancing pathways involved MEK-ERK1/2
            and PI3K-AKT.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2991)
  AUTHORS   Diakonova,M., Gunter,D.R., Herrington,J. and Carter-Su,C.
  TITLE     SH2-Bbeta is a Rac-binding protein that regulates cell motility
  JOURNAL   J Biol Chem 277 (12), 10669-10677 (2002)
   PUBMED   11786545
REFERENCE   7  (bases 1 to 2991)
  AUTHORS   Riedel,H., Yousaf,N., Zhao,Y., Dai,H., Deng,Y. and Wang,J.
  TITLE     PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated
            mitogenesis
  JOURNAL   Oncogene 19 (1), 39-50 (2000)
   PUBMED   10644978
REFERENCE   8  (bases 1 to 2991)
  AUTHORS   Kasus-Jacobi,A., Perdereau,D., Auzan,C., Clauser,E., Van
            Obberghen,E., Mauvais-Jarvis,F., Girard,J. and Burnol,A.F.
  TITLE     Identification of the rat adapter Grb14 as an inhibitor of insulin
            actions
  JOURNAL   J Biol Chem 273 (40), 26026-26035 (1998)
   PUBMED   9748281
REFERENCE   9  (bases 1 to 2991)
  AUTHORS   Rui,L., Mathews,L.S., Hotta,K., Gustafson,T.A. and Carter-Su,C.
  TITLE     Identification of SH2-Bbeta as a substrate of the tyrosine kinase
            JAK2 involved in growth hormone signaling
  JOURNAL   Mol Cell Biol 17 (11), 6633-6644 (1997)
   PUBMED   9343427
REFERENCE   10 (bases 1 to 2991)
  AUTHORS   Osborne,M.A., Dalton,S. and Kochan,J.P.
  TITLE     The yeast tribrid system--genetic detection of trans-phosphorylated
            ITAM-SH2-interactions
  JOURNAL   Biotechnology (N Y) 13 (13), 1474-1478 (1995)
   PUBMED   9636306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB742512.1, U57391.1, AF047577.1, BM389529.1 and AI029537.1.
            
            On Sep 15, 2006 this sequence version replaced NM_134456.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: U57391.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMD00132261,
                                    SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               CB742512.1         303-450
            149-217             U57391.1           191-259
            218-695             U57391.1           261-738
            696-931             AF047577.1         396-631
            932-2634            U57391.1           975-2677
            2635-2972           BM389529.1         18-355              c
            2973-2991           AI029537.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2991
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..2991
                     /gene="Sh2b1"
                     /gene_synonym="Sh2-b; Sh2b; Sh2bpsm1"
                     /note="SH2B adaptor protein 1"
                     /db_xref="GeneID:89817"
                     /db_xref="RGD:620132"
     exon            1..217
                     /gene="Sh2b1"
                     /gene_synonym="Sh2-b; Sh2b; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            218..1239
                     /gene="Sh2b1"
                     /gene_synonym="Sh2-b; Sh2b; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..2571
                     /gene="Sh2b1"
                     /gene_synonym="Sh2-b; Sh2b; Sh2bpsm1"
                     /note="isoform 1 is encoded by transcript variant 1; SH2B
                     adapter protein 1; SH2 domain-containing protein 1B; fceRI
                     gamma-chain-interacting protein SH2-B; SH2-B PH
                     domain-containing signaling mediator 1"
                     /codon_start=1
                     /product="SH2B adapter protein 1 isoform 1"
                     /protein_id="NP_604451.2"
                     /db_xref="GeneID:89817"
                     /db_xref="RGD:620132"
                     /translation="MNGAPSPEDGVFPSPPALPPPPPPSWQEFCESHARAAALDLARR
                     FRLYLASHPQYAEPGAEAAFSGRFAELFLQHFEAEVARASGSLSPPVLAPLSPGVEIP
                     PSHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSTTSSKPKLKKRFSLRSVGR
                     SVRGSVRGILQWRGAVESPSQAGPLETTSGPPVLGGNSNSNSSGGAGTVGRALANDGT
                     SPGERWTHRFERLRLSRGGGTLRDGAGVIQREELLSFMGAEEAAPDPAGVGRGGGAAG
                     LTSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSTITDVRTATA
                     LEMPDRENTFVVKVEGPSEYILETTDALHVKAWVSDIQECLSPGPCPAISPRPMTLPL
                     APGTSFLTKDNTESLELPCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASF
                     SPSSASIAASHFDSMELLPPELPPRIPIEEGPPAGTVHPLSTPYPPLDTPEAATGSFL
                     FQGEAEGGEGDQPLSGYPWFHGMLSRLKAAQLVLEGGTSSHGVFLVRQSETRRGEYVL
                     TFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSY
                     VPSQRQQERSTSRDPTQPSEPPPWTDPPHPGAEEASGAPEVAAATAAAAKERQEKEKA
                     GGGGVQEELVPMAELVPMAELEEAIAPGTEAQGGAGSSGDLEVSLMVQLQQLPLGGNG
                     EEGGHPRAINNQYSFV"
     exon            1240..1341
                     /gene="Sh2b1"
                     /gene_synonym="Sh2-b; Sh2b; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1433
                     /gene="Sh2b1"
                     /gene_synonym="Sh2-b; Sh2b; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1609
                     /gene="Sh2b1"
                     /gene_synonym="Sh2-b; Sh2b; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1813
                     /gene="Sh2b1"
                     /gene_synonym="Sh2-b; Sh2b; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2025
                     /gene="Sh2b1"
                     /gene_synonym="Sh2-b; Sh2b; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2194
                     /gene="Sh2b1"
                     /gene_synonym="Sh2-b; Sh2b; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2975
                     /gene="Sh2b1"
                     /gene_synonym="Sh2-b; Sh2b; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcccaggg gcatgtggag ggtgtccaac gattaggatc gggtccgagt gattgaccac
       61 ggggcccgga gggtccgaac ctggagcgca gcctgcaccc tccaccaccc gcccttctgg
      121 aatgtcagaa ctaagccaag aggcaggtgc accggaaaat tgtgactgag ccttcttggc
      181 agaagagaaa ctgagtcacc agtccaggaa ccgcaggctg ttggcgctca cctcgagtct
      241 tctggctgct ttcctatttg ctccctgcag gctccccctg tcctcctcct ggggcacatc
      301 atgaatggtg ccccttcccc agaggatggg gttttccctt ctccaccagc gctgccacca
      361 ccccctcccc caagttggca agagttctgt gagtcccatg cgagggctgc tgccctggat
      421 cttgctcgcc gttttcgcct ctatctggcc tcccacccac aatatgcaga gccgggagca
      481 gaggctgcct tttctggccg ttttgctgag ctcttcctgc agcacttcga agctgaggtg
      541 gctcgggcct cgggctcact ctccccacct gtcttggctc cattgagccc tggtgtggaa
      601 atcccaccat cacatgacct gtcccttgag agctgcaggg tgggtgggcc cctggcagtg
      661 ttgggccctt ctcgatcttc tgaggacctg gctggccccc ttccttcctc agtctcttcc
      721 tctacaacgt cctcaaagcc gaagctcaag aaacgcttct ccctccgctc ggtgggtcgt
      781 tcagtcagag gttctgtccg aggcatcctg cagtggcggg gggctgttga atctccctcc
      841 caagctgggc ctctggagac cacatcaggt cctccagttc taggtggaaa cagcaactcc
      901 aactcctctg gtggtgctgg gacagttggt agggcattgg ccaacgatgg cacatcccct
      961 ggggagagat ggactcatcg ctttgagagg ctaaggctaa gtcgtggagg gggaaccttg
     1021 agagacggag caggagtgat acagagagaa gagctgctga gtttcatggg ggctgaagag
     1081 gctgcccctg acccagcagg agtaggtcgt ggaggagggg cagctgggct gacctcggga
     1141 ggaggagggc agcctcagtg gcagaaatgt cgattactgc tccggagtga aggagaagga
     1201 ggaggaggaa gtcgcttgga gttctttgta ccacccaagg catcccggcc ccgtcttagc
     1261 attccctgtt ctactattac tgatgtccgc acagccacag ccctggagat gcctgacagg
     1321 gagaacacgt ttgtggttaa ggtagaaggc ccttcagagt acatcctgga gacaactgat
     1381 gcacttcatg tgaaggcctg ggtgtctgac atccaagagt gcctaagccc aggaccctgc
     1441 cctgctatca gcccccgtcc catgaccctt cccctggccc ctgggacctc cttcctcaca
     1501 aaggataaca cagagagcct ggagttgccc tgcctgaatc attcagagag tctgcctagc
     1561 caggatcttc ttctgggacc cagcgagagt aacgaccgcc tgtcgcaggg agcttatgga
     1621 ggcctctcag accggccgtc agcgtccttc tcccctagtt ctgcctccat tgctgcttcc
     1681 cattttgact caatggaact gcttcctcca gagttgcccc ctcggattcc cattgaggag
     1741 gggcctccag cagggacagt tcatcccctc tctaccccgt accctcccct ggatactcct
     1801 gaagcagcca cagggtcatt cctctttcaa ggggaggcag aggggggtga gggggaccag
     1861 cccctctcag gctacccttg gttccacggc atgctctctc ggctcaaagc tgcccagtta
     1921 gtgttagaag gaggtaccag ctcccatggt gtcttcttgg tacgccagag tgagacaaga
     1981 cgtggtgaat atgtcctcac tttcaacttc cagggcaagg ctaagcacct gcgtttgtca
     2041 ctaaatgagg agggtcagtg ccgggtccaa catctgtggt tccagtccat tttcgatatg
     2101 cttgagcact tccgggtgca ccccatccct ctggagtctg gaggctccag tgatgttgtc
     2161 cttgtcagct atgtgccctc ccagcggcag caggaacgga gcacctcccg tgatccaacc
     2221 cagccctctg aaccccctcc atggacagat cccccacatc ctggggcaga agaggcgtcg
     2281 ggggcgccag aagtggcggc agccacagcc gcagcagcca aagagaggca agagaaggag
     2341 aaagcgggcg gcggaggggt ccaggaagag ctggtcccca tggctgagct ggtccccatg
     2401 gctgaattgg aagaggccat agcaccaggc actgaggctc agggtggtgc tggctctagt
     2461 ggggacttgg aggtgtccct aatggttcag ctccagcagt taccactagg gggcaacgga
     2521 gaagaagggg gtcacccccg agccattaat aaccagtact catttgtctg agatacctgc
     2581 ccaccctcca ttttcctgct cccagcctta agttgtgaga ctgggctggg taagaacaca
     2641 gaggaaagtg ggagtcccct ccctacatgc ttcctgaccc ttgtcagcca agggtgtgta
     2701 tgttggtaca agtagaggtt caagagccct gttaagtccc cagttactac actacaggtg
     2761 cccttgcccc gaggccaagg acttgggctc cattacctcc ctgaggggct cttatggtca
     2821 gccccatccc tgggggctgt ttcccccact aataaccccc aacccaagca agggtgaggg
     2881 ggaagggctg tcagttatat taaggttgtt gttgttgttt taaacaaaat ggaaaagcat
     2941 aaataaataa agggtttatc tcagttccat cacgaaaaaa aaaaaaaaaa a
//
