LOCUS       NM_181629               1478 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus small glutamine rich tetratricopeptide repeat
            co-chaperone beta (Sgtb), mRNA.
ACCESSION   NM_181629
VERSION     NM_181629.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1478)
  AUTHORS   Cao,M., Xu,W., Yu,J., Zheng,H., Tan,X., Li,L., Rui,Y., Xu,G.,
            Cui,G., Xu,J., Cao,J., Tao,T., Ke,K. and Wu,Q.
  TITLE     Up-regulation of SGTB is associated with neuronal apoptosis after
            neuroinflammation induced by lipopolysaccharide
  JOURNAL   J Mol Histol 44 (5), 507-518 (2013)
   PUBMED   23820636
  REMARK    GeneRIF: Up-regulation of SGTB is associated with neuronal
            apoptosis in the rat neuroinflammation model.
REFERENCE   2  (bases 1 to 1478)
  AUTHORS   Tobaben,S., Varoqueaux,F., Brose,N., Stahl,B. and Meyer,G.
  TITLE     A brain-specific isoform of small glutamine-rich tetratricopeptide
            repeat-containing protein binds to Hsc70 and the cysteine string
            protein
  JOURNAL   J Biol Chem 278 (40), 38376-38383 (2003)
   PUBMED   12878599
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF368280.1.
            
            On Aug 31, 2012 this sequence version replaced NM_181629.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF368280.1, FQ212215.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132264, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1478              AF368280.1         2-1479
FEATURES             Location/Qualifiers
     source          1..1478
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q13"
     gene            1..1478
                     /gene="Sgtb"
                     /gene_synonym="Sgt2"
                     /note="small glutamine rich tetratricopeptide repeat
                     co-chaperone beta"
                     /db_xref="GeneID:294708"
                     /db_xref="RGD:727976"
     exon            1..81
                     /gene="Sgtb"
                     /gene_synonym="Sgt2"
                     /inference="alignment:Splign:2.1.0"
     exon            82..201
                     /gene="Sgtb"
                     /gene_synonym="Sgt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1016
                     /gene="Sgtb"
                     /gene_synonym="Sgt2"
                     /note="beta-SGT; small glutamine-rich tetratricopeptide
                     repeat (TPR)-containing, beta; small glutamine rich
                     tetratricopeptide repeat containing beta; small
                     glutamine-rich protein with tetratricopeptide repeats 2"
                     /codon_start=1
                     /product="small glutamine-rich tetratricopeptide
                     repeat-containing protein beta"
                     /protein_id="NP_853660.1"
                     /db_xref="GeneID:294708"
                     /db_xref="RGD:727976"
                     /translation="MSSVKPLVYAVIRFLREQSQMDAYTSDEQESLEVAIQCLETVFK
                     ISPEDTHLAVSQPLTEMFTNSVCKNDIRPLSNSVPEDVGKADQLKDEGNNHMKEENYA
                     AAVDCYTQAIELDPNNAVYYCNRAAAQSKLSHYTDAIKDCEKAIAIDSKYSKAYGRMG
                     LALTAMNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQKLREVSSPTGTGLTFDMASL
                     INNPAFITMAASLMQNPQVQQLMSGMMTNAIGGPAAGVGGLTDLSSLIQAGQQFAQQI
                     QQQNPELIEQLRNHIRSRSFSSSTEEHS"
     exon            202..305
                     /gene="Sgtb"
                     /gene_synonym="Sgt2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..375
                     /gene="Sgtb"
                     /gene_synonym="Sgt2"
                     /inference="alignment:Splign:2.1.0"
     exon            376..475
                     /gene="Sgtb"
                     /gene_synonym="Sgt2"
                     /inference="alignment:Splign:2.1.0"
     exon            476..580
                     /gene="Sgtb"
                     /gene_synonym="Sgt2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..719
                     /gene="Sgtb"
                     /gene_synonym="Sgt2"
                     /inference="alignment:Splign:2.1.0"
     exon            720..782
                     /gene="Sgtb"
                     /gene_synonym="Sgt2"
                     /inference="alignment:Splign:2.1.0"
     exon            783..820
                     /gene="Sgtb"
                     /gene_synonym="Sgt2"
                     /inference="alignment:Splign:2.1.0"
     exon            821..904
                     /gene="Sgtb"
                     /gene_synonym="Sgt2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1478
                     /gene="Sgtb"
                     /gene_synonym="Sgt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccgagga ccgcgggggc aggcggaccc gcttcccgac gcccccgggc ccgcagccgt
       61 catctcgtgc tctcttagct ggaggtattt aggcatctaa aatgtcatct gtgaagcccc
      121 tagtttatgc agttattcgt ttcttgcggg aacaaagcca gatggatgct tacacttctg
      181 atgaacaaga aagtttggaa gttgcaatcc agtgtttgga gaccgtcttt aagatcagtc
      241 ccgaagatac acatctggcc gtttcacagc ctttgacaga aatgttcacc aactccgtct
      301 gtaagaatga catacggccg ctttctaact cagtgcccga agatgtggga aaggccgacc
      361 agctgaagga tgaaggcaat aaccacatga aagaagaaaa ctacgcggcc gcggtggact
      421 gttacacgca ggcaatagaa ctggatccga acaatgccgt ttattattgt aacagggcgg
      481 ccgctcaaag caaactaagt cactacacag atgcaatcaa ggactgtgag aaagccatcg
      541 caattgattc aaaatacagc aaggcctacg gaaggatggg gctagctctc actgccatga
      601 ataagtttga agaggcagtt acaagctacc agaaggcact ggatcttgat cctgaaaacg
      661 actcctataa gtcaaatctg aaaatagcag agcagaagtt aagagaggta tctagtccta
      721 caggaactgg gttgaccttt gacatggcca gcttgataaa taacccggcc ttcatcacca
      781 tggctgcaag tttaatgcag aaccctcaag ttcagcagct gatgtcaggg atgatgacaa
      841 atgccatcgg aggacctgct gctggagttg gaggcctaac agacctgtct agccttatcc
      901 aagcggggca gcagtttgca cagcagatac agcaacagaa tcctgaactc atagagcagc
      961 tgagaaatca catccggagc agatccttca gcagcagcac tgaggaacac tcctgacttg
     1021 accaggaccc tcgccccagt acaaacatcc cgacatgtac acttgtagat aatagccaaa
     1081 aacaaagtaa caaaaaccac cctgtacaat gtctgaaaat aacgaggaaa gtctcctgtg
     1141 taaacctgag aacatacatc tgtttaggta atagtttatc acaagcagac ttgaacataa
     1201 tacagactcc tctggaaaga aatggtcagt aaccttgtta agggcaaata cagccttggg
     1261 acaagggtcc atccatttta aaacttttat catcctattt gtatattaga cttagcacag
     1321 agtatattta ttgaatagta gggctattta ttggaaagtt ctttagccac aggtttccct
     1381 aggcagtggt tttgagtggg gtgatgctgg tttagaagac atgtgcttgg tagcacgtcg
     1441 ggagagaagc gttggcatgt gctaccgtca gtgacacg
//
