LOCUS       NM_022703               1260 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus small glutamine rich tetratricopeptide repeat
            co-chaperone alpha (Sgta), mRNA.
ACCESSION   NM_022703
VERSION     NM_022703.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1260)
  AUTHORS   Mock,J.Y., Chartron,J.W., Zaslaver,M., Xu,Y., Ye,Y. and
            Clemons,W.M. Jr.
  TITLE     Bag6 complex contains a minimal tail-anchor-targeting module and a
            mock BAG domain
  JOURNAL   Proc Natl Acad Sci U S A 112 (1), 106-111 (2015)
   PUBMED   25535373
REFERENCE   2  (bases 1 to 1260)
  AUTHORS   Chen,M., Xia,X., Zhu,X., Cao,J., Xu,D., Ni,Y., Liu,Y., Yan,S.,
            Cheng,X., Liu,Y. and Wang,Y.
  TITLE     Expression of SGTA correlates with neuronal apoptosis and reactive
            gliosis after spinal cord injury
  JOURNAL   Cell Tissue Res 358 (2), 277-288 (2014)
   PUBMED   25030242
  REMARK    GeneRIF: SGTA is involved in biochemical and physiological
            responses after spinal cord injury.
REFERENCE   3  (bases 1 to 1260)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   4  (bases 1 to 1260)
  AUTHORS   Xu,Y., Cai,M., Yang,Y., Huang,L. and Ye,Y.
  TITLE     SGTA recognizes a noncanonical ubiquitin-like domain in the
            Bag6-Ubl4A-Trc35 complex to promote endoplasmic
            reticulum-associated degradation
  JOURNAL   Cell Rep 2 (6), 1633-1644 (2012)
   PUBMED   23246001
REFERENCE   5  (bases 1 to 1260)
  AUTHORS   Leznicki,P. and High,S.
  TITLE     SGTA antagonizes BAG6-mediated protein triage
  JOURNAL   Proc Natl Acad Sci U S A 109 (47), 19214-19219 (2012)
   PUBMED   23129660
REFERENCE   6  (bases 1 to 1260)
  AUTHORS   Yin,H., Wang,H., Zong,H., Chen,X., Wang,Y., Yun,X., Wu,Y., Wang,J.
            and Gu,J.
  TITLE     SGT, a Hsp90beta binding partner, is accumulated in the nucleus
            during cell apoptosis
  JOURNAL   Biochem Biophys Res Commun 343 (4), 1153-1158 (2006)
   PUBMED   16580629
REFERENCE   7  (bases 1 to 1260)
  AUTHORS   Liou,S.T. and Wang,C.
  TITLE     Small glutamine-rich tetratricopeptide repeat-containing protein is
            composed of three structural units with distinct functions
  JOURNAL   Arch Biochem Biophys 435 (2), 253-263 (2005)
   PUBMED   15708368
REFERENCE   8  (bases 1 to 1260)
  AUTHORS   Tobaben,S., Varoqueaux,F., Brose,N., Stahl,B. and Meyer,G.
  TITLE     A brain-specific isoform of small glutamine-rich tetratricopeptide
            repeat-containing protein binds to Hsc70 and the cysteine string
            protein
  JOURNAL   J Biol Chem 278 (40), 38376-38383 (2003)
   PUBMED   12878599
  REMARK    GeneRIF: brain-specific isoform of small glutamine-rich
            tetratricopeptide repeat-containing protein binds to Hsc70 and the
            cysteine string protein
REFERENCE   9  (bases 1 to 1260)
  AUTHORS   Tobaben,S., Thakur,P., Fernandez-Chacon,R., Sudhof,T.C., Rettig,J.
            and Stahl,B.
  TITLE     A trimeric protein complex functions as a synaptic chaperone
            machine
  JOURNAL   Neuron 31 (6), 987-999 (2001)
   PUBMED   11580898
REFERENCE   10 (bases 1 to 1260)
  AUTHORS   Cziepluch,C., Kordes,E., Poirey,R., Grewenig,A., Rommelaere,J. and
            Jauniaux,J.C.
  TITLE     Identification of a novel cellular TPR-containing protein, SGT,
            that interacts with the nonstructural protein NS1 of parvovirus H-1
  JOURNAL   J Virol 72 (5), 4149-4156 (1998)
   PUBMED   9557704
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087642.1.
            
            On Jun 10, 2007 this sequence version replaced NM_022703.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087642.1, AF368278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1260
                     /gene="Sgta"
                     /gene_synonym="Stg"
                     /note="small glutamine rich tetratricopeptide repeat
                     co-chaperone alpha"
                     /db_xref="GeneID:64667"
                     /db_xref="RGD:620815"
     exon            1..28
                     /gene="Sgta"
                     /gene_synonym="Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            29..160
                     /gene="Sgta"
                     /gene_synonym="Stg"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1005
                     /gene="Sgta"
                     /gene_synonym="Stg"
                     /note="alpha-SGT; small glutamine-rich protein with
                     tetratricopeptide repeats 1; small glutamine rich
                     tetratricopeptide repeat containing alpha; small
                     glutamine-rich tetratricopeptide repeat (TPR) containing
                     protein (SGT); small glutamine-rich tetratricopeptide
                     repeat (TPR)-containing, alpha"
                     /codon_start=1
                     /product="small glutamine-rich tetratricopeptide
                     repeat-containing protein alpha"
                     /protein_id="NP_073194.1"
                     /db_xref="GeneID:64667"
                     /db_xref="RGD:620815"
                     /translation="MDNRKRLAYAIIQFLHGQLRHGGLSSDAQESLEVAIQCLETAFG
                     VTLEDSDLALPQTLPEIFEAATASKEMPQDPRGPDRTPPSEEDSAEAERLKTEGNEQM
                     KLENFEAAVHLYGKAIELNPANAVYFCNRAAAYSKLGNYVGAVQDCERAIGIDPGYSK
                     AYGRMGLALSSLNKHAEAVAYYKKALELDPDNDTYKSNLKIAELKLREAPSPTGGVGS
                     LDIAGLLNNPHFITMASSLMNSPQLQQLMSGMISGGHNPLGTPGSSPQHSDLASLIQA
                     GQQFAQQMQQQNPEFVEQIRSQVVRSRTPSASHEEQQE"
     exon            161..267
                     /gene="Sgta"
                     /gene_synonym="Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            268..352
                     /gene="Sgta"
                     /gene_synonym="Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            353..452
                     /gene="Sgta"
                     /gene_synonym="Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            453..557
                     /gene="Sgta"
                     /gene_synonym="Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            558..696
                     /gene="Sgta"
                     /gene_synonym="Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            697..759
                     /gene="Sgta"
                     /gene_synonym="Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            760..797
                     /gene="Sgta"
                     /gene_synonym="Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            798..887
                     /gene="Sgta"
                     /gene_synonym="Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1010
                     /gene="Sgta"
                     /gene_synonym="Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1215
                     /gene="Sgta"
                     /gene_synonym="Stg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggtcggg tcttcggtcg actgagagat cctgagcagt gccacctcac cagcctcgag
       61 atggacaaca ggaagcgcct ggcctatgcc atcatccagt tcctgcatgg ccagctgcgg
      121 cacggtgggc tctcgtccga cgcccaggag agcctagagg ttgccatcca gtgtctggaa
      181 acagcctttg gggtgacgct ggaggacagt gaccttgctc tcccgcagac cctgccagag
      241 atatttgaag cagccactgc cagcaaggag atgccacagg acccgagggg ccctgacagg
      301 acaccaccct ctgaggagga ctcagctgag gcagagcgcc ttaaaacaga aggtaacgag
      361 cagatgaagt tggaaaactt tgaggcagca gtgcacctct atggcaaagc cattgagctc
      421 aaccccgcca acgccgttta cttctgtaac agagctgcgg cctacagcaa gctgggaaac
      481 tacgtggggg cggtacagga ctgtgagcgc gccattggca ttgatcccgg gtacagcaag
      541 gcctatggcc gcatgggcct tgcgctgtcc agcctgaaca aacatgcgga ggctgtggcg
      601 tactacaaga aggccctgga gctggaccct gacaacgaca cgtacaagtc caacctcaag
      661 atcgcagagc tgaagttacg ggaggcgccg agccctacgg gcggcgtggg cagcttagac
      721 atcgctggcc tgctgaacaa cccgcacttc atcactatgg cttcgagctt aatgaacagc
      781 ccccagctcc agcagctcat gtcgggaatg atctctggag gccataaccc tctgggcacc
      841 ccaggcagca gtccacagca cagtgacctg gccagtctca tccaggcggg ccagcagttt
      901 gcacagcaga tgcagcagca gaacccagag ttcgtggagc aaatccggag ccaggtggtg
      961 cgcagccgga cacccagtgc cagccacgag gagcagcaag agtgacaacg ctgacccgag
     1021 tggcccctct gctccgcgcg cggcctcctg gtgttttagc aatttctcca tcgggctgct
     1081 caagagagaa actggacctg catgttaaga cggactcatc cccccgccct gtgttctctt
     1141 catccctccc cctttgtttt ttgtactcgt aactggctcc acaccttcct ggaagagtct
     1201 acatttgact acaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
