LOCUS       NM_198787               2854 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus small G protein signaling modulator 3 (Sgsm3),
            mRNA.
ACCESSION   NM_198787 XM_343294
VERSION     NM_198787.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2854)
  AUTHORS   Lee,C.Y., Choi,J.W., Shin,S., Lee,J., Seo,H.H., Lim,S., Lee,S.,
            Joo,H.C., Kim,S.W. and Hwang,K.C.
  TITLE     Interaction of small G protein signaling modulator 3 with connexin
            43 contributes to myocardial infarction in rat hearts
  JOURNAL   Biochem Biophys Res Commun 491 (2), 429-435 (2017)
   PUBMED   28716730
  REMARK    GeneRIF: High levels of SGSM3 appeared to induce the turnover of
            Cx43 through lysosomal degradation in myocardial infarcted rat
            hearts.
REFERENCE   2  (bases 1 to 2854)
  AUTHORS   Ito,T., Ueki,T., Furukawa,H. and Sato,K.
  TITLE     The identification of novel protein, brain-derived integrating
            factor-1 (BDIF1), which interacts with astrocytic gap junctional
            protein
  JOURNAL   Neurosci Res 70 (3), 330-333 (2011)
   PUBMED   21453730
  REMARK    GeneRIF: BDIF1 potentially functions in molecular trafficking of
            astrocytes.
REFERENCE   3  (bases 1 to 2854)
  AUTHORS   Yang,H., Sasaki,T., Minoshima,S. and Shimizu,N.
  TITLE     Identification of three novel proteins (SGSM1, 2, 3) which modulate
            small G protein (RAP and RAB)-mediated signaling pathway
  JOURNAL   Genomics 90 (2), 249-260 (2007)
   PUBMED   17509819
REFERENCE   4  (bases 1 to 2854)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   5  (bases 1 to 2854)
  AUTHORS   Fuchs,E., Haas,A.K., Spooner,R.A., Yoshimura,S., Lord,J.M. and
            Barr,F.A.
  TITLE     Specific Rab GTPase-activating proteins define the Shiga toxin and
            epidermal growth factor uptake pathways
  JOURNAL   J Cell Biol 177 (6), 1133-1143 (2007)
   PUBMED   17562788
REFERENCE   6  (bases 1 to 2854)
  AUTHORS   Lan,Z., Kurata,W.E., Martyn,K.D., Jin,C. and Lau,A.F.
  TITLE     Novel rab GAP-like protein, CIP85, interacts with connexin43 and
            induces its degradation
  JOURNAL   Biochemistry 44 (7), 2385-2396 (2005)
   PUBMED   15709751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB581701.1, BC062060.1 and BM385615.1.
            
            On Mar 14, 2009 this sequence version replaced NM_198787.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                CB581701.1         1-55
            56-2834             BC062060.1         23-2801
            2835-2854           BM385615.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..2854
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2854
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /note="small G protein signaling modulator 3"
                     /db_xref="GeneID:362963"
                     /db_xref="RGD:735113"
     exon            1..54
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            55..159
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..2402
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /note="RUN and TBC1 domain-containing protein 3; RUN and
                     TBC1 domain containing 3"
                     /codon_start=1
                     /product="small G protein signaling modulator 3"
                     /protein_id="NP_942082.2"
                     /db_xref="GeneID:362963"
                     /db_xref="RGD:735113"
                     /translation="MPRSMKSCHRPQHMMSGNHTPSASGPFSALTPSIWPQEILAKSS
                     QKEDSSEPEICYDEFGFRVDKEGSEPGCSQMAGTPLVEDPPQRLRWQAHLEFTHNHDV
                     GDLTWDKIAVSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKKNSELSYREIVKN
                     SSNDETIAAKQIEKDLLRTMPSNACFANVNSIGVPRLRRVLRALAWLYPEIGYCQGTG
                     MVAACLLLFLEEEDAFWMMCAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLD
                     KLLQEHDIELSLITLHWFLTAFASVVHIRLLLRIWDLFFYEGSLVLFQTTLGMLRLKE
                     EELIQSENSASIFNTLSDIPAQMDDAELLLGEAMQLAGSLTDVAVETQRRKHLAYLIA
                     DQGQTLGTSTTTSLSQVVRRRTQRRKSGITSLLFGEDDLEALKAKNIKQTELVADLRE
                     AILRVARHFQCTDPKNCSVELTPDYSMESHQRDHENYVACLRSHRRRAKALLDFERHD
                     DDELGFRKNDIITIISQKDEHCWVGELNGLRGWFPAKFVEVLDERSKEYSIAGDDSVT
                     EGVTDLVRGTLCPALKALFEHGLKKPSLLGGACHPWLFIEEAAGREVERDFDSVYSRL
                     VLCKTYRLDEDGKVLTPEELLYRAVQSVNVTHDAAHAQMDVKLRSLICVGLNEQVLHL
                     WLEVLCSSLPTVEKWYQPWSFLRSPGWVQIKCELRVLCCFAFSLSQDWELPAKREEEK
                     QPLKEGVQDMLVKHHLFSWDIDG"
     exon            160..245
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            246..309
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            310..515
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            516..623
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            624..767
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            768..963
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1109
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1334
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1389
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1517
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1673
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1728
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1778
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1931
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2002
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2051
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2137
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2260
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2321
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2838
                     /gene="Sgsm3"
                     /gene_synonym="bdif-1; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taggagccag ccgctagccg gagcagctga ggtgctgagg tggccctgac acagggcaga
       61 tgaagcctga ggagcctcat gacagtcaga gatgccaatg atgaccatct atgcctagat
      121 ctatgaagag ctgccatcgt ccacagcaca tgatgtcagg aaaccacacg ccttctgcta
      181 gtggcccttt ctctgccctg actccaagca tatggcccca ggagatcctg gcaaaatcct
      241 cacagaagga agactcctca gagccagaga tctgctatga tgagtttggt ttccgagtgg
      301 acaaggaagg ttctgagcct ggatgcagcc agatggcagg cacacccctg gtagaggatc
      361 cccctcagag gctacgttgg caggctcacc tggagtttac ccacaaccat gatgttgggg
      421 atctcacctg ggacaagatt gcagtctccc tcccccgctc tgagaaactc cgttccctag
      481 tgctggctgg catcccgcat ggcatgaggc cacagttgtg gatgcggctc tctggggcac
      541 tgcagaagaa gaagaactct gagttgtcct accgtgagat tgtaaagaac agctccaatg
      601 atgagaccat cgctgccaaa cagatcgaaa aggacctgct ccgtaccatg cccagcaacg
      661 cctgctttgc caatgtgaac agcatcggag tgccccgcct gcgcagagtc cttcgagcac
      721 tggcctggct ctatccagag attggctact gccagggcac aggcatggtg gctgcctgtc
      781 tcctgctgtt cctggaggag gaggacgcct tctggatgat gtgtgccatt attgaggacc
      841 tgctgcctgc ctcctacttc agcaccaccc tgctaggtgt ccagactgac cagcgggtcc
      901 tgcgccacct gattgtccag tacctgcctc gcttagacaa gctgttgcag gagcatgaca
      961 ttgagctgtc tctgatcacg ctgcactggt tcctcacggc cttcgccagc gtggtgcaca
     1021 tcagactgct gctgcgcatc tgggacctgt tcttctacga gggctccctg gtgttgttcc
     1081 agactacgct gggcatgctg cgccttaagg aggaagagct gatacagtcg gagaactcag
     1141 cgtccatctt caacacgctg tcggacatcc ctgcccagat ggatgatgca gagctgctgc
     1201 tgggggaggc catgcagctg gctggctccc tcactgatgt ggctgtggag acccagcgcc
     1261 gcaagcatct ggcctacctc attgcagacc aaggccagac cctggggacg agcaccacca
     1321 ccagcctctc tcaggttgta cggcgaagga cccagcggag aaagtctggc atcacctccc
     1381 tgctctttgg agaggatgac ctagaagctc tcaaggcaaa gaacatcaaa caaacagagc
     1441 tggtagctga ccttcgtgaa gccattttac gtgtggcacg ccacttccag tgcacagacc
     1501 ccaagaactg tagtgtggag ctgacgccag actacagcat ggagagccac cagcgggacc
     1561 atgagaacta tgtggcatgc ttacgcagcc accggcgccg ggccaaggcc ctgctggact
     1621 ttgagcgtca tgacgatgac gagctaggct tccgcaaaaa tgacatcatc acgatcattt
     1681 ctcagaagga tgagcactgc tgggtgggtg agctgaacgg cctgagaggc tggtttccag
     1741 ccaagtttgt ggaggtcctg gatgagcgaa gtaaagagta ctccattgcg ggggatgact
     1801 ctgtgactga aggagtaaca gacctcgtgc gagggaccct ctgcccagcc ctcaaggccc
     1861 tatttgaaca tggattgaag aagccatcct tgcttggggg tgcttgccac ccctggctgt
     1921 ttattgagga ggcagcaggc cgggaagtcg agagagactt tgattctgtg tactcccgcc
     1981 tggtgctctg taagacctac aggttggatg aagacggcaa agtcctgacc cctgaagagc
     2041 tgctgtaccg ggccgtgcag tctgtgaatg tgacccatga tgcagcacac gcacagatgg
     2101 atgtcaaact ccgttcactt atctgtgtgg ggctcaatga gcaggtccta cacctgtggc
     2161 tagaggtact ctgctccagc ctgcccaccg tggagaagtg gtaccagccc tggtccttcc
     2221 tgcgcagccc tggctgggtc cagatcaagt gtgagctccg tgtcctctgc tgctttgcct
     2281 tcagcctctc ccaggactgg gagctccccg ctaagagaga ggaggagaag cagccactga
     2341 aggagggtgt tcaggacatg ctggtgaagc accatctctt cagctgggac atagatggat
     2401 gatgctcctt ctagctgctc tgtggctccc aggcctaccc atcatagact gcctggcagg
     2461 ctcctccctt ccagagaaag aaggcagagc cctggccagc ctcaggcctt cctcctcaag
     2521 ctaggaggtt cagggaaaga caccccagag cttactcagg acccatgatc aatgtctggg
     2581 cctcccctgt tgaggctccc gcagttggca aaagcatata ctggtggcca ggtcagctgc
     2641 tctccttaat atggtcctgg gggtgtcctg ccagagtcct taaggaagcc ctgggtgcca
     2701 gccatatggt gtatgaacca aaaaccacgt gaagcagcag aaagccacac acacctatgc
     2761 tgctcaggaa gtgcgtaggc taacagcaga caaaggcccc tcgaccttta ctgtaaataa
     2821 atctttttgt gagagcaaaa aaaaaaaaaa aaaa
//
